Acids and Synthetic Reagents

<p>Applications It is used in the synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations.<br>References Vince, R., et al.: J. Med. Chem., 14, 402 (1971), Melander, W., et al.: Arch. Biochem. Biophys., 183, 200 (1977),<br></p>

<p>Applications Calcium Sulfate is used in the biofilm prevention and management of gram-negative bacterial pathogens involved in periprosthetic infection by using antibiotic-loaded calcium sulfate beads in vitro. Calcium Sulfate is used in the bioactive calcium sulfate-based formulation “Biocas” for bone filler applications. Calcium Sulfate is also used as an antibiotic impregnated calcium sulphate in combination with internal fixation for the treatment of open fractures of extremities that prevents infections and promotes the healing of fractures.<br>References Howlin, R., et al.: Biomed.l Mater., 12, 1 (2017); Sandhya, S., et al.: Biomedical Materials, 12, 015022 (2017); Liao, H., et al.: Guangxi Yixue, 37, 1491 (2015)<br></p>

<p>Applications (+)-Biotinyl 3,6,9-Trioxaundecanediamine is a biotin derivative and is used as a reagent in the synthesis of a potent, covalent BTK inhibitor for B-cell lymphoma.<br>References Wu, H., et al.: ACS Chem. Biol., 9, 1086 (2014)<br></p>

<p>Applications (Ethoxycarbonylmethyl)triphenylphosphonium-13C2 bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.<br>References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),<br></p>

<p>Applications (S)​-​(+)​-​Pantolactone is a versatile cyclic ester reactant used in the preparation of tunable ligands carbohydrate-derived diarylphosphinites for asymetric catalysis hydrovinylation of styrene derivatives.<br>References Park, H., RajanBabu, T.: J. Am. Chem. Soc., 124, 734 (2002);<br></p>

<p>Applications Oprozomib is the second class of proteasome inhibitors with higher specificities and reduced toxicities, against head and neck squamous cell carcinoma.<br>References Zang, Y., et al.: Autophagy., 8, 1837 (2012); Zang, Y., et al.: Clin. Cancer. Res., 18, 5639 (2012); Mato, A.R., et al.: Oncologist., 17, 694 (2012); Zhou, H.J., et al.: J. Med. Chem., 52, 3028 (2009);<br></p>

<p>Applications D-(-)-Diisopropyl Tartrate is a reagent for kinetic resolution of racemic allylic alcohols and α-furfuryl amides by enantioselective epoxidation.<br>References Lee, E., et al.: J. Org. Chem., 1994, 59 1444; Jung, M., et al.: J. Am. Chem. Soc., 115, 12208 (1993); Wang, Z., et al.: Tetrahedron, 49, 2641 (1993)<br></p>

<p>Applications 2-Methoxybenzenemethanol is used in the synthesis of antimycobacterial and antibacterial derivatives. Also used in the synthesis of phthalazines and analogues as benzodiazepine receptor ligands with specific activity.<br>References Wei, Z. et al.: Molecules., 18, 3872 (2013); Carling, R. et al.: J. Med. Chem., 47, 1807 (2004);<br></p>

<p>Applications (R)-α-Phenethyl Alcohol, is a chiral building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of biologically active cyclitols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Redgrave, A. J., et al.: No pp., Dissertation (1991);<br></p>

<p>Applications ent-Ticagrelor is the enantiomer of Ticagrelor (T437700); the first reversible oral P2Y12 receptor antagonist that provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 4,4’,(5’)-Di-(tert-butylcyclohexano)-18-crown-6 is a crown ether-based sorbent used in the analysis and separation of minerals.<br>References Yankovskaya, V. et al: J. Radioanal. Nucl. Chem., 314, 119 (2017);<br></p>

<p>Applications Chlorotripyrrolidinophosphonium Hexafluorophosphate acts as a peptide coupling reagent or condensing agent for phosphinate ester formation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prasad, K. et al.: Int. J. Pharm. Sci. Rev. Res., 8, 108 (2011); Winqvist, A. et al.: Eur. J. Org. Chem. 10, 1705 (2008);<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N-Dimethylphosphoramidodichloridate functions as a reagent used in the inhibition of acetylcholinestrase and butyryl cholinestrase by nerve agent surrogates. Also, the are used as reagents in the synthesis and in the antitumor activity of nonsymmetric phosphoric acid triamides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meek, E. C., et al.: Toxicol. Sci., 126, 525 (2012); Kosykhova, L., et al.: Pharm. Chem., 34, 525 (2000)<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Applications Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Potent PI3K/mTOR Dual Inhibitor.<br>References Konstantinidou, G., et al.: Cancer Res., 69, 7644 (2009), Frederick, R., et al.: Bioorg. Med. Chem. Lett., 19, 5842 (2009), Pollizzi, K., et al.: Mol. Cancer, 8 (2009),<br></p>

<p>Applications Rhenium Carbonyl, is used as a catalyst and in material science. iIt is also a key starting material used for the synthesis of other rhenium carbonyl complexes. It plays an important role in metathesis, reforming and hydrogenation reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kremlev, K. V., et al.: J. Surf. Ingestig.-X-Ray Synchro. 2015, 9 (4), 694-698.; Di, X., et al.: Catal. Sci. Technol. 2015, 5 (4), 2441-2448.;<br></p>

<p>Applications Piperonylamine is a metabolite of dopamine analogs.<br>References Goodwin, B.L., et al.: Xenobiotica, 24, 129 (1994),<br></p>

<p>Stability Moisture Sensitive<br>Applications Tricyclohexyl Phosphine is a ligand catalyst used primarily in organometallic chemistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sanford, M. et al.: J. Am. CHem. Soc., 123, 6543 (2001);<br></p>

<p>Applications 4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lv, Y. et al.: Chem. Comm., 49, 6349 (2013); Yang, X. et al.: J. Med. Chem., 53, 1015 (2010);<br></p>

<p>Applications rac-Clopidogrel Hydrogen Sulfate is used in the synthesis of Clopidogrel derivatives as platelet aggregation inhibitors.<br>References Chen, J., et. al.: Hecheng Huaxue, 18, 586 (2010); Defreyn, G. et al.: Thromb. Haemo., 65, 186 (1991);<br></p>

<p>Applications Triphenylsilylamine is used as a reagent to produce 2-Amino-3-hydroxy-indoles with potent in vivo antimalarial activity. Triphenylsilylamine is also used to modify Mo/HZSM-5 catalysts and is predicted to have effects on selectivity in the methane-to-benzene (MTB) reaction.<br>References Kikuchi, S., et al.: J. Catal., 242, 349 (2006); Urgaonkar, S., et al.: Org. Lett., 12, 3998 (2010);<br></p>

<p>Applications Volasertib (BI 6727) is a highly potent Polo-like kinase (PLK) inhibitor.<br>References Rudolph, D., et al.: Clin. Cancer Res., 15, 3094 (2009); Grinshtein, N., et al.: 71, 1385 (2011)<br></p>

<p>Applications 4-benzylmorpholine-2-carbonitrile (cas# 126645-52-1) is a useful research chemical.<br></p>

<p>Applications 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.<br>References Wei, P., et al.: Diabetologia, 52, 2142 (2009); McGlasson, L., et al.: Mol. Cell. Endo., 342, 48, (2011);<br></p>

<p>Applications Vitamin D3 (V676045) analog.<br>References Roy, A., et al.: Steroids, 60, 530 (1995);<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-Butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate, is a building block used foe the synthesis of novel nicotinic acetylcholine receptor ligands with cognition-enhancing properties. It can also be used in the synthesis of chiral β-amino sulfides and β-amino thiols.<br>References Elliiot, R. L., et al.: Bioorg. Med. Chem. Lett., 6, 2283 (1996); Abreo, M. A., et al.: J. Med. Chem., 39(4), 817 (1996);<br></p>

<p>Stability Hygroscopic<br>Applications R-(-)-3-Quinuclidinol Hydrochloride is shown to have weak in vitro acetylcholinesterase inhibitory activity.<br>References Bosak, A., et al.: Croat. Chem. Acta, 78, 121 (2005); Pyttel, R., et al.: J. Pharm. Sci., 62, 684 (1973)<br></p>

<p>Applications (1,​5-​Cyclooctadiene)​(hexafluoroacetylace​tonato)​iridium(I) is a catalyst used in hydrogenation reactions in organic synthesis.<br>References Maj, A. et al.: Tetrahedron, 72, 1375 (2016);<br></p>

<p>Applications Bismuth(III) Trifluoromethanesulfonate (3:1) is a catalyst used in Friedel-Crafts acylation and cycloisomerization of allene-enol ethers.<br>References Repichet, S., et. al.: Eur. J. Org. Chem., 12, 2743 (1998); Ondet, P., et. al.: Org. Lett., 17, 1002 (2015)<br></p>

<p>Applications Methyl 4-Acetylbenzoate is used in the preparation of trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors.<br>References Hwang, J.Y., et al.: Bioorg. Med. Chem. Lett., 23, 6467 (2013); Simmonds, P., et al.: Hepatology, 42, 962 (2005)<br></p>

<p>Applications (Z)-2-((Furan-2-ylmethyl)sulfinyl)-n-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide is a Histaminic H2 receptor antagonists in ulcer disease. Also, it is a model compound used to investigate the binding mechanism between antiulcer drugs and human serum albumin (HSA).<br>References Patel, P. B., et al.: World J. Pharm. Sci., 5, 532-540 (2016); Yang, h., et al.: Arch. Biochem. Biophys., 606, 81-89 (2016);<br></p>

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications 2-Amino-4-methylphenylboronic acid, pinacol ester<br></p>

<p>Applications 5-Bromopentyltrimethylammonium Bromide (cas# 15008-33-0) is a compound useful in organic synthesis.<br></p>

<p>Applications A useful intermediate in the synthesis of polypeptides.<br></p>

<p>Applications Sch 527123 is a potent CXCR2 antagonist. It can potentially inhibits human colon cancer liver metastasis.<br>References Varney, M. L., et al.: Cancer Lett 300, 180 (2011); Arshi, K., et al.: Front Immunol. 8, 464 (2017)<br></p>

<p>Applications An optically active resolving agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Helv. Chim. Acta, 61, 2773 (1978)<br></p>

<p>Applications Methyl 11-bromoundecanoate is a brominated fatty acid building block, used in the synthesis of Emmyguyacins A and B, which are proposed inhibitors of the influenza virus.<br>References Jana, S.; et al.: Org. Lett., 20, 6938 (2018).<br></p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications BDP 37 is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4). It is also an ampakine drug that facilitates activation of glutamatergic AMPA receptors.<br>References (1) Arai, A., et al.: J. Pharmacol. Exp. Ther., 278, 627 (1996)(2) Marini, A., et al.: J. Biol. Chem., 273, 29394 (1998)(3) Balkowiec, A., et al.: J. Neurosci., 22, 10399 (2002) (4) Dicou, E., et al.: Brain Res., 970, 221 (2003)<br></p>

<p>Applications 2-Bromoacetic Acid Phenylmethyl Ester is used in the synthesis of somatostatin analogues with tumor-targeting properties . Also used in the synthesis of inhibitors of phospholipase A2, indolizine and indene derivatives.<br>References Heppeler, A. et al.: Chem. A. Eur. J., 5, 1974 (1999); Hagishita, S. et al.: J. Med. Chem., 39, 3636 (1996);<br></p>

<p>Applications Copper (I) bromide is used as a reagent to brominate electron-rich aromatic compounds (e.g. Phenol: P318000). Copper (I) bromide is also used to brominate aliphatic ketones (e.g. Acetone: A163800).<br>References Bhatt, S. &amp; Nayak, S.: Synth. Comm., 37, 1381 (2007); Kojima, Y. &amp; Kawaguchi, S.: Bull. Chem. Soc. Jpn., 45, 1293 (1972)<br></p>

<p>Applications Ammonium Hexafluorophosphate is commonly available form of the hexafluorophosphate anion, inert and hence a suitable counterion. It is a useful synthetic intermediate. It can be used to prepare organometallic diphenols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Powell, C., et al.: J. Am. Chem. Soc., 125, 602 (2003); Macchioni, A., et al.: Organometallics, 18, 3061 (1999)<br></p>

<p>Applications Copper oxychloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,3-Dibromopropene is used in preparation of Quaternary Ammonium Salt derivatives for use as Trimethylamine production inhibitors.Also, used in preparation of Boron containing compounds as Phosphodiesterase PDE4 inhibitors.<br>References Nudel, K., et al.:PCT Int. Appl., (2020); Strohbach, Joseph W., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications (S)-(-)-Propylene Carbonate is used in the synthesis of β-hydroxy sulfides.<br>References Upare, P. et al.: Green, Chem. Lett. Rev. et al.: 5, 19 (2012<br></p>

<p>Applications Diethyl D-(-)-Tartrate is used as a chiral reagent in a host of chemical reactions, suhc as marin toxin and antitumor agent phorboxazole A, or asymmetric syntheses of S,S-dialkyl-substituted sulfoximines.<br>References Pandey, A. et al.: Synthesis, 23, 3827 (2011); Kuntiyong, P. et al.: Org. Biomol. Chem., 10, 7884 (2012);<br></p>

<p>Applications N4-Benzoylcytosine is a reactant in the synthesis of 1',2'-cyclopentyl nucleosides as potential antiviral agents.<br>References Dang, Q., et. al.: Tetrahedron Lett., 55, 5092 (2014)<br></p>

<p>Applications Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Neuroresearch &amp; Neuroprotective Product.<br>References Yuksel, M. et al.: J. Pharmacol. Exp. Therap., 305, 298 (2003); Tamura, Y. et al.: Biochim. Biophys. Acta, 484, 417 (1977); Ohno, H. et al.: Thromb. Res., 24, 445 (1981);<br></p>

<p>Applications 2-amino-3-methylpentan-1-ol (cas# 24629-25-2) is a useful research chemical.<br></p>

<p>Applications Intermediate in the production of mutagenic pyrolyzates.<br>References Grassy, G., et al.: Eur. J. Med. Chem., 17, 109 (1982),<br></p>

<p>Applications Antineoplastic adjunct (chemosensitizer).<br>References Boesch, D., et al.: exp. Cell Res., 196, 26 (1991), Lush, R.M., et al.: J. Clin. Pharmacol., 37, 123 (1997), Scott, M.G., et al.: Clin. Chem., 43, 505 (1997), Advani, R., et al.: Blood, 93, 787 (1999),<br></p>

<p>Applications Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).<br>References Yue, Eddy W., et al.: ACS Med. Chem. Lett., 8, 486 (2017);<br></p>

<p>Applications KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.<br>References Zeng, Z., et al.: Cancer Res, 66, 3737-3746 (2006); Mandal, M., et al.: Br. J. Cancer, BJC, 92, 1899-1905 (2005)<br></p>

<p>Applications 3'-Bromo-4'-methylacetophenone is used as a starting material in the synthesis of mansonone E which is used to make mansonone E dervivatives. These derivatives are potent inhibitors of topoisomerase II (Topo II) and topoisomerase I (Topo I) and are also potent antitumor agents. 3'-Bromo-4'-methylacetophenone is also used as a reagent in the synthesis of BAF312, Siponimod which has been tested in the treatment of patients suffering from relapsing-remitting multiple sclerosis.<br>References Fang, X., et al.: J. Chem. Res., 38, 137 (2014); Huang, Z., et al.: Eur. J. Med. Chem., 68, 58 (2013); Pan, S., et al.: ACS Med. Chem. Lett., 4, 333 (2013)<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Applications 2-{[2-(Dimethylamino)ethyl]methylamino}ethanol is a reagent in the preparation of diamino(aminoalkoxy)quinazolines.<br>References Liu, F., et al.: J. Med. Chem., 53, 5844 (2010);<br></p>

<p>Applications Sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, also known as the BARF anion, is a compound used in catalytic cycles due to its inability to coordinate to metal centres.<br>References Brookhart, M.; et al.: J. Am. Chem. Soc., 114, 5894 (1992).<br></p>

<p>Applications A MEK inhibitor with antitumor activity.<br>References Lee, W., et al.: Bioorg. Med. Chem. Lett., 15, 3573 (2005), Normanno, N., et al.: J. Cell. Physiology, 207, 420 (2006), Narlawar, R., et al.: J. Med. Chem., 49, 7588 (2006),<br></p>

<p>Stability Volatile<br>Applications Cyclobutanone is a member of cycloketone compounds that have potential genotoxic and cytotoxic effects and are most commonly found in irradiated food.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anandon, A., et al.: EFSA Journal, 9, 1930 (2011); Delincee, H., et al.: Radiat. Phys. Chem., 63, 431 (2002); Obana, H. ,et al.: J. Health Sci., 52, 375 (2006)<br></p>