Amides

<p>Stability Hygroscopic<br>Applications Used as an intermediate in the industrial preparation of non-ionic X-ray contrast agents such as Iohexol (I729500), Ioversol (I737000), Ioxilan (I737500), Iopamidol (I735600).<br>References Rongved, P., et al.: Carbohydrate Res., 297, 325 (1997),<br></p>

<p>Impurity Albendazole Impurity 6 Calcium<br>Applications Cyanamide is used in the synthesis of H2 receptor histamine antagonists. Also use in the synthesis of oxadiazoles and 1,2,4-thiaziazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors. (Albendazole Impurity 6)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, R. et al.: J. Med. CHem., 31, 656 (1988); Unangst, P. et al.: J. Med. CHem., 35, 3691 (1992);<br></p>

<p>Applications N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.<br>References Boschi, D., et al.: Bioorg. Med. Chem., 8, 1727 (2000); Nagai, H., et al.: Chem. Pharm. Bull., 32, 1063 (1984); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)<br></p>

<p>Applications 2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).<br>References Carter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013);<br></p>

<p>Applications Octadecanamide (cas# 124-26-5) is a useful research chemical.<br></p>

<p>M06239 - Fmoc-D-isoGln-OH</p>

<p>Applications Intermediate in the production of Cyclophosphamide metabolites.<br>References Takamizawa, A., et al.: Chem. Pharm. Bull., 20, 1612 (1972),<br></p>

<p>Applications Benzamide is a compound that is widely used as a starting material for various organic syntheses and reactions. Benzamide derivatives are prevalent in the pharmaceutical industry, for example Raclopride (R070800), a Dopamine (D533780) D-2 agonist that is used to treat patients with Parkinson’s Disease. Benzamide derivatives are also used in chemistry, for example N-nitrophenyl benzamide derivatives are used as chromosensors to detect cyanide in aqueous environments.<br>References Ehrin, E., et al.: Int. J. Appl. Rad. Isot., 36, 269 (1985); Sun, Y., et al.: Tetrahedron, 65, 3480 (2009); Terai, M., et al.: Eur. J. Pharm., 173, 177 (1989)<br></p>

<p>M04120 - 4-Methylumbelliferyl N-acetyl-beta-D-galactosaminide</p>

<p>Applications 1,1-Cyclohexanediacetic acid monoamide is an impurity of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Gabapentin is used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>