Carboxylic Acids

<p>Applications Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.<br>References Qi, J.L., et al.: Euro. J. Medn. Chem., 46, 934 (2011); Schirlin, D., et al.: J. Enzymes. Inhibition., 1, 243 (1987);<br></p>

<p>Applications Ethoxyacetic acid<br></p>

<p>Applications 1,2-Diaminopropane-N,N,N',N'-tetraacetic Acid is an aminopolycarboxylic acids found at ultra-trace levels in water; Also, it is used in the construction of Eu3+ ion-selective membrane electrode as suitable ionophore.<br>References Nette, D., et al.: Anal. Chim. Acta, 884, 124-132 (2015); Abedi, M. R., et al.: E-J. Chem., 8, S467-S473 (2011)<br></p>

<p>Applications 6-Bromohexanoic Acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosen, D. B., et al.: PCT Int. Appl. (2020), WO 2020254617 A1<br></p>

<p>Applications Ethyl (pentafluorobenzoyl)acetate (cas# 3516-87-8) is a useful research chemical.<br></p>

<p>Applications 2-(prop-2-ynyloxy)propanoic acid (cas# 134126-59-3) is a useful research chemical.<br></p>

<p>Applications 10-Undecynoic Acid is a fatty acid used in the synthesis of copolyesters.<br>References Beyazkilic, Z. et al.: Polym., 79, 290 (2015);<br></p>

<p>Applications Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo xy peptidase, plasmin, and plasminogen activator.<br>References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),<br></p>

<p>Applications 3-FERROCENOYLPROPIONIC ACID (cas# 1291-72-1) is a useful research chemical.<br></p>

<p>Applications 5-(3-Benzyloxyphenyl)nicotinic acid<br></p>

<p>Applications Androstenediol 17-Acetate is used in synthetic preparation for direct organocatalytic stereoselective transfer hydrogenation of conjugated olefins of steroids. Androstenediol 17-Acetate is also obtained from Dehydro Epiandrosterone (D229585) which is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.<br>References Ebeling, P., et al.: Lancet, 343, 1479 (1994); Morales, A.J., et al.: J. Clin. Endocrinol. Metab., 78, 1360 (1994); Ramachary, D.B., et al.: RSC Advances, 3, 13497-13506 (2013); Yahara, M., et al.: J. Toxicol. Sci., 2, 161 (1977);<br></p>

<p>Applications Methyl 4-Bromophenylacetate (cas# 41841-16-1) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Propylboronic Acid is a chemical reagent used in the synthesis of pharmaceutical agents such as inhibitors of mTOR for use in anti-tumor treatments. Also used to synthesize endothelial lipase inhibitors<br>References Takeuchi, C. et al.: J. Med. Chem., 56, 2218 (2013); O'Connell, D. et al.: Bioorg. Med. Chem. Lett., 22, 1397 (2012);<br></p>

<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>

<p>Applications Ammonium Carbonate Carbamate is used in the study of amino acids and has important implications in biochemical studies.<br>References Nanping, W. et al.: J. Phys. Chem., 99, 359 (1995);<br></p>

<p>Applications N-(4-bromo-2-thienyl)-carbamic Acid 1,1-Dimethylethyl Ester, is an intermediate for the synthesis of bicyclic inhibitors of ROCK protein kinsae.<br>References Hahmann, C. et al.: Cell. Mol. Life Sci., 67, 171 (2010);<br></p>

<p>Applications 3-(N,N-Dimethylamino)phenylboronic Acid (cas# 178752-79-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Oxooctanoic Acid is one of mid-chain oxocarboxylic acids detected in Antarctic aerosols and possible precursors to the production of low molecular weight diacids such as succinic acid.Also, it is derived from 4-Octanolide (O239723), which is one of the fine organic aerosol emitted from meat cooking operations that was examined by high-resolution gas chromatography.<br>References Nishikiori, M., et al.: Chikyu Kagaku, 30, 27-34 (1996); Rogge, W., et al.: Environ. Sci. Technol., 25, 1112 (1992)<br></p>

<p>Applications tert-Butyl carbamate is used to prepare N-Boc-protected anilines. It is also used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.<br>References Bhagwanth, S., et al.: J. Org. Chem., 74, 4634 (2009); Cadierno, V., et al.: J. Heterocycl. Chem., 47, 233 (2010)<br></p>

<p>Applications N-Pentylboronic Acid is used in the synthesis of (-)-Δ8-THC and (-)-Δ9-THC. Also it aids in the synthesis of boronic acid inhibitors of endothelial lipase.<br>References O'Connell, D. et al.: Bioorg. Med. Chem. Lett., 22, 1397 (2012); Cheng, L. et al.: Org. Lett., 15, 764 (2013);<br></p>

<p>Applications 3-(Cyclopropylaminocarbonyl)phenylboronic acid<br></p>

<p>Applications 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid is used for the preparation of Terfenadine ((T114500) analogs.<br>References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),<br></p>

<p>Applications Methyl 2-Acetamido-2-(Dimethoxyphosphoryl)Acetate (cas# 89524-99-2) is a useful research chemical.<br></p>

<p>Applications A caged, photolabile Nitric Oxide donor that is useful for delivering nitric oxide into intracellular compartments in microsecond time scale without any cytotoxic effects.<br>References Namiki, S., et al.: Bioorg. Med. Chem., 7, 1695 (1999),<br></p>

<p>Applications 2-Cyclohexylideneacetic acid (cas# 1552-91-6) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxy-5-(phenylethynyl)benzoic Acid has antiinflammatory activity.<br>References Shen, T.-Y., et al.: U.S. (1972), US 3657430 A<br></p>

<p>Applications (2S,2aR,2aS,8aR)-2a-(2-((Cyclopropylmethyl)(methyl)amino)ethyl)-2,4,8a-trihydroxy-2,2a,8a-tetrahydro-1H-indeno[1,7,6-bcd]benzo-2-carboxylic Acid is an intermediate used in the synthesis of (4R,4aS,6S,6aR,11bS)-6-Carboxy-3-(cyclopropylmethyl)-1,2,3,4,4a,5,6,6a-octahydro-4a,6,8-trihydroxy-3-methyl-4,11-methanobenzofuro[3',2':2,3]cyclopenta[1,2-c]pyridinium, Inner Salt (C176953), which is an impurity/degradation of N-methyl Naltrexone (M320350), a metabolite of Naltrexone (N285750).<br>References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)<br></p>

<p>Applications 3-Acetamidophenyl acetate<br></p>

<p>Applications DL-3-aminoisobutyric acid hydrate is a useful research chemical for organic synthesis and other chemical processes.<br>References Saito, N., et al.: Bunseki Kagaku, 63, 909 (2014)<br></p>

<p>Applications 3-ethyladamantane-1-carboxylic acid (cas# 37845-05-9) is a useful research chemical.<br></p>

<p>Applications Methyl 2-Aminothioazole-4-carboxylate (cas# 118452-04-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Biphenylcarboxylic acid (cas# 92-92-2) is a useful research chemical.<br></p>

<p>Applications 2,5-Furandicarboxylic Acid Diethyl Ester (cas# 53662-83-2) is a compound useful in organic synthesis.<br></p>

<p>Applications [4-(2-hydroxyacetamido)phenyl]arsonic acid (cas# 144-87-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Temperature Sensitive<br>Applications 2-Oxocyclopentanecarboxylic Acid is a reactant that has been used in the synthesis of Piragliatin, a glucokinase activator.<br>References Sarabu, R., et. al.: J. Med. Chem., 55, 7021 (2012)<br></p>

<p>Applications 2,3-Dimethylphenylacetic Acid (cas# 30981-98-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,4'-Dithiobisbenzoic Acid Dimethyl Ester (cas# 35190-68-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.<br>References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)<br></p>

<p>Applications 1,3-Diethylbarbituric Acid can be used as reactant/reagent in green preparation of spiropyran derivatives via three-component cyclization of indantrione with active methylene compounds and cyclic diketones in the presence of compact fluorescent lamp.<br>References Rai, P., et al.: ChemistrySelect, 1, 4450 (2016)<br></p>

<p>Applications 2,5-Dimethylthiophene-3-boronic acid<br></p>

<p>Stability Light Sensitive<br>Applications 3-(3-Hydroxyphenyl)acrylic acid (cas# 588-30-7) is a useful research chemical.<br></p>

<p>Applications exo-2,3-Norbornanedicarboxylic Acid Monoamide is an impurity in the synthesis of Lurasidone (L474920) an antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007), Cole, P., et al.: Drugs of the Fut., 33, 316 (2008),<br></p>

<p>Applications 3-Cyclohexylbutanoic Acid (cas# 4361-38-0) is a useful reagent for the preparation of oxoheterocyclylalkyl hydroxypiperidinylketones as USP19 inhibitors for treating diseases.<br>References Hewitt, P., et al.: PCT Int. Appl. (2018), WO 2018020242 A1<br></p>

<p>Applications Methyl 5-bromofuran-2-carboxylate<br></p>

<p>Please enquire for more information about [1-(2-Methoxyethyl)-1H-indol-3-yl]acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cacodylic acid is a white to brown crystalline powder that is soluble in water. It has been used as an analytical reagent, polymerase chain reaction (PCR) inhibitor, and skin cancer treatment. Cacodylic acid inhibits the activity of the bacterial enzyme activities in humans and other mammals. The mechanism of action of cacodylic acid is not completely understood but it appears that it binds to inorganic iron and blocks its availability for use by bacterial enzymes such as dihydropteroate synthase, which is required for DNA synthesis. This leads to cell death. Cacodylic acid has also been shown to inhibit the growth of human HL-60 cells in vitro, suggesting that it may have carcinogenic potential.</p>

<p>Please enquire for more information about 1-Boc-4-aminopiperidine-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>D(+)-Lactic acid lithium salt is a dipolar molecule with an activation energy of about 44 kJ/mol. It has been studied by NMR techniques and found to have a resonance in the range of 1.8-2.0 ppm, which is characteristic of protons on the oxygen atom. The proton magnetic resonance (PMR) study showed that the d-lactate resonances were very broad and shifted to higher frequencies, whereas the l-lactate resonances were sharp and shifted to lower frequencies. This may be due to the different number of protons on each type of lactate molecule. The magnetic resonance (NMR) study showed that lithium salt was a radical with a spin density distribution around 2.6 ppm in the nmr spectrum.</p>

<p>Please enquire for more information about 8-Ethyl-1,3,4,9-tetrahydro-1-(1-methylethyl)pyrano[3,4-b]indole-1-acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Fmoc-4-hydrazinobenzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Boc-L-aspartic acid a-9-fluorenylmethyl ester is a synthetic compound that mimics the structure of acetylcholine. It has been shown to be an efficient method for generating pseudopeptides and cyclic peptides. This compound may be used as a surrogate for acetylcholine in virus research, since it can bind to the same receptor. Boc-L-aspartic acid a-9-fluorenylmethyl ester has also been used to generate monoclonal antibodies that are neutralizing against foot-and-mouth disease viruses.</p>

<p>2-(Bromomethyl)acrylic acid is a monomer that has been synthesized from bromoacetic acid and acrylic acid. It is an efficient method for the synthesis of 2-bromoethyl acrylate, which can be used as a precursor for polyurethanes and other polymers. The 2-bromoethyl acrylate can be obtained through allylation with ethylene glycol, followed by hydrolysis to produce acrylic acid. This monomer reacts with free hydroxyl groups to form esters and ethers. It also reacts with nitrogen atoms to form amides or nitriles. Cell culture studies have shown that this compound has no toxic effects on human erythrocytes or hepatocytes.</p>

<p>Methyl 4-chloroacetoacetate is a neutral compound that reacts with hydrochloric acid to produce a salt, chloromethyl acetate. The reaction solution is then heated to evaporate the water and produce an organic solution. This reaction produces a molecular model of the compound, which has potent antibacterial activity against gram-positive and gram-negative bacteria.</p>

<p>Please enquire for more information about 2-Bromo-5,6-dihydro-8h-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Methyl 2-pyridylacetate is a reactive compound that can be used as a reagent for trifluoromethylthiolation of terminal alkynes. This compound has been shown to react with anilines and form isomers, including the acid form. The reaction rate of the methyl 2-pyridylacetate with pyridine compounds is slow, but it reacts quickly with thionyl chloride and hydrochloric acid. Methyl 2-pyridylacetate also reacts with nucleophiles such as methyl anthranilate to form the corresponding quinolizine derivatives.</p>

<p>Hydantoin-5-acetic acid is a molecule that has been studied for its potential use in the stabilization of polymers and plastics. It has shown antibacterial activity against certain bacterial strains including Escherichia coli and Staphylococcus aureus. The molecule has the ability to coordinate with metal ions such as copper, zinc, and iron. The protonation state of the molecule is dependent on the pH of the environment. Hydantoin-5-acetic acid can exist in two tautomeric forms: hydantoin or 5-hydantoin. Hydantoin-5-acetic acid can be used to determine the concentration of hydrogen in proteins through chromatographic methods. This molecule also has Langmuir adsorption isotherm properties, which give it potential for use in supramolecular structures.</p>

<p>2,5-Pyridinedicarboxylic acid is a white crystalline solid that is soluble in water and alcohol. It has been shown to be an effective catalyst for the oxidation of hydrocarbons. 2,5-Pyridinedicarboxylic acid also binds with metal hydroxides and forms hydrogen bonding interactions. This compound may be used as a catalyst in the production of nitric acid from ammonia, or in the manufacture of picolinic acid. 2,5-Pyridinedicarboxylic acid has a pK value of 7.4 and an optimum pH of 7. 2,5-Pyridinedicarboxylic acid can also react with sodium salts to form a n-oxide that coordinates with nitrogen atoms to give coordination geometry in which each atom is bonded to four other atoms (e.g., square planar). The molecular formula for this compound is C6H4N2O</p>

<p>Please enquire for more information about 6-(Methoxycarbonyl)spiro[3.3]heptane-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Succinic acid monomethyl ester (SAMME) is an antimicrobial agent that inhibits the enzyme activities of succinate dehydrogenase, producing mitochondrial membrane depolarization and neuronal death. SAMME has been shown to be effective in treating syncytial virus infection and solid tumours, although it has not been studied in depth. The biological sample used for this study was water vapor, which is a substrate molecule for the enzyme succinic acid semialdehyde dehydrogenase (SASD). This enzyme converts SAMME to succinic acid, which can then inhibit phosphofructokinase-1 or pyruvate kinase, leading to cellular necrosis.</p>

<p>4-(4-Hydroxyphenoxy)benzoic acid is a molecule that can be used to treat hypercholesterolemia. It is metabolized in the body to butyric acid, which has been shown to have an anti-inflammatory effect on the bladder and may reduce water permeability of the bladder. 4-(4-Hydroxyphenoxy)benzoic acid can also be used as a choline precursor for acetylcholine synthesis and may have osmotic properties.</p>

<p>Hyodeoxycholic acid sodium salt is a nonsteroidal anti-inflammatory drug that belongs to the class of hyodeoxycholic acids. It is an inhibitor of the enzyme activities that are involved in the synthesis of prostaglandins from arachidonic acid. Hyodeoxycholic acid sodium salt has been shown to inhibit the activity of enzymes such as cyclooxygenase, lipoxygenase, and 5-lipoxigenase. This inhibition leads to decreased production of inflammatory prostaglandins, which are responsible for inflammation and pain. Hyodeoxycholic acid sodium salt also has neurotrophic effects that may be due to its ability to stimulate NGF synthesis by neurons in vitro.</p>

<p>4-Bromo-2,5-difluorobenzoic acid is a potent inhibitor of isoforms CYP2C9 and CYP2D6. It is an acidic drug with a pKa of 3.8, which makes it ionizable in biological fluids. 4-Bromo-2,5-difluorobenzoic acid inhibits the activity of CYP2C9 and CYP2D6 by binding to the pharmacophore region of these enzymes. 4-Bromo-2,5-difluorobenzoic acid also has an isosteric functionality that increases its selectivity for CYP2C9 and CYP2D6 over other cytochrome P450 isoforms. The functional groups on 4-bromo-2,5-difluorobenzoic acid are part of the inhibitor's nature that make it selective for these two cytochrome</p>

<p>2-Methyl butyric acid is a fatty acid that is produced by the fungus Monascus purpureus. 2-Methyl butyric acid has been shown to inhibit the activity of a number of enzymes in gland cells, including proteases, lipases, and amylases. This effect may be due to its ability to inhibit lipid peroxidation. Further research into the metabolic profiles of 2-methyl butyric acid has shown that it inhibits the activity of enzymes involved in fatty acid synthesis and metabolism, such as tiglic acid synthase and ketoacyl CoA reductase. It also shows some potential as a solid catalyst for kinetic studies.</p>

<p>2-Methyl-4-chlorophenoxyacetic acid is a sodium salt of 2-methyl-4-chlorophenoxyacetic acid. It is a herbicide that inhibits photosynthesis by disrupting the electron transport chain in chloroplasts. The hydroxyl group on the phenoxy ring is responsible for its herbicidal activity. 2-Methyl-4-chlorophenoxyacetic acid has been shown to cause significant cell death in tissue culture, which may be due to its ability to inhibit enzymes such as acetylcholinesterase, phosphodiesterase, and carboxypeptidase A2. This chemical also has carcinogenic potential, but no toxicological studies have been conducted in humans or animals.</p>

<p>Please enquire for more information about 3-Methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Diethyl 1-[2-(1H-indol-3-yl)ethyl]-2,5-dimethyl-1H-pyrrole-3,4-dicarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(2,4-Dimethylphenyl)boronic acid is an arylboronic acid that is used in organic synthesis. The boron atom of the 2,4-dimethylphenyl group coordinates with the metal atom in the catalyst to form a stable complex. This allows for a multilayer reaction and fluorescence to occur. The activated fluorine atoms can be used to boost the reaction by adding them to the substrate and increasing the rate of oxidation. Astragalus membranaceus and rapeseed extracts have been shown to increase the rate of oxidation as well as inhibiting the formation of disaccharides. These extracts also have shown anti-inflammatory effects when tested on rats. (2,4-Dimethylphenyl)boronic acid has also been found to interact with dihydroisoquinolines, which are compounds that are structurally similar to morphine and codeine.</p>

<p>Please enquire for more information about Methyl (2S)-2-methylpyrrolidine-2-carboxylate hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about tert-Butyl 4,7-diazaspiro[2.5]octane-7-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Aluminum diacetate hydroxide is a white powder that is soluble in water. It is used as a laser ablation material and can be used to seal chemical reactions. Aluminum diacetate hydroxide also functions as a gas sensor, with its sensitivity to aromatic hydrocarbons and fatty acids. This compound has clinical use in detergent compositions, where it prevents the formation of foam.</p>

<p>Glycerolipid metabolism component</p>

<p>Please enquire for more information about rac-cis despropionyl mefentanyl N-trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 1-tert-Butyl 3-methyl pyrrolidine-1,3-dicarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Tranexamic acid is a non-protein amino acid that is used to reduce the risk of blood loss in surgical procedures. It is an inhibitor of plasmin, which is an enzyme that breaks down clots and fibrin. Tranexamic acid binds to the active site of plasmin and blocks its activity, preventing the breakdown of fibrin clots. Tranexamic acid has been shown to be selective for plasmin, as other enzymes such as urokinase are not blocked by this drug. The picolyl group on tranexamic acid interacts with the benzyl group on plasmin and this interaction may be responsible for the selectivity of tranexamic acid for plasmin over other enzymes.</p>

<p>Lys-Bradykinin is a peptide that is a member of the group of kinins. It has been shown to be effective at inhibiting the activity of kallikrein, which is an enzyme that converts kininogen to bradykinin. This inhibition lowers the levels of bradykinin in the blood and may be used as a diagnostic tool for identifying diseases such as congestive heart failure, pulmonary edema, and acute renal failure. Lys-Bradykinin can also be used as a model system for studying kinins and their biological effects on various systems. For example, it has been shown to have natriuretic properties in humans by increasing levels of erythropoietin and ANP.</p>