Carboxylic Acids

<p>Applications Methyl 1-formylcyclopropane-1-carboxylate, is a building block used in the synthesis of chemical compounds.<br></p>

<p>Stability Hygroscopic<br>Applications tert-Butyl (((mesityl)sulfonyl)oxy)carbamate is a useful reagent for the enantioselective aziridination of α,β-unsaturated aldehydes.<br>References Arai, H., et l.: Tetrahedron Lett., 50, 3329(2009)<br></p>

<p>Applications Methyl Phenylacetate is used as a reagent in the synthesis of various organic reactions, one of which is the synthesis of Vulpinic Acid (V850000); a lichen metabolite with anti-inflammatory properties.<br>References Shachak, M., et al.: Science, 236, 1098 (1987); Froberg, L., et al.: Lichenologist, 25, 83 (1993); Hesbacher, S., et al.: J. Chem. Ecology, 21, 233 (1995)<br></p>

<p>Applications 2-(prop-2-ynyloxy)propanoic acid (cas# 134126-59-3) is a useful research chemical.<br></p>

<p>Applications Suberic Acid is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.<br>References Cui, C. et al.: Biomat., 34, 3858 (2013); Kusukawa, T. et al.: Tetra., 68, 9973 (2012);<br></p>

<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>

<p>Applications 3-Formylbenzene-1,2-disulfonoic Acid is derived from 5,6-Difluoro Anthranilic Acid (D445550), which is used in the preparation of 2-[[2-(phenylamino)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzamide derivatives as inhibitors of IGF-1R and IR receptor tyrosine kinase as anticancer agents.<br>References Rubinstein, E., et al.: Chemotherapy, 47, 3 (2001), Grohs, P., et al.: Antimicrob. Agents Chemother., 47, 3542 (2003),<br></p>

<p>Applications 6-Acrylamidohexanoic Acid is a useful research chemical for organic synthesis and other chemical processes.<br>References Yamada, K., et al.: Tetrahedron Lett., 36, 9493 (1995); Park, W. K. C., et al.: Methods Enzymol., 242, 294 (1994); Nishimura, S., et al.: Tetrahedron Lett., 35, 5657 (1994)<br></p>

<p>Applications 4-Carboxymethylphenylboronic acid<br></p>

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Applications 4-Hydroxy-3,5-dimethylbenzoic Acid is used in the synthesis of Mexiletine (M340800) derivatives as orally bioavailable inhibitors. Also, used as a chemical reagent in the preparation of potent transthyretin (TTR) amyloidogenesis inhibitors affecting thyroid hormone.<br>References Frederickson, M. et al.: J. Med. Chem., 51, 183 (2008); Johnson, S. et al.: J. Med. Chem., 51, 260 (2008);<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Applications 5-Amino-2-bromobenzoic acid (cas# 2840-02-0) is a useful research chemical.<br></p>

<p>Applications Methyl 4-Bromophenylacetate (cas# 41841-16-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Acetamidophenyl acetate<br></p>

<p>Applications 3-(2-Hydroxypropan-2-yl)phenylboronic acid<br></p>

<p>Applications 2-Butyl-4,6-dihydroxybenzoic Acid is an intermediate in preparation of compounds for study in primin and miconidin biosynthesis routes in Primula obconica.<br>References Horper, W., et al.: Phytochem., 41, 451 (1996);<br></p>

<p>Applications Methyl 2-Aminothiazole-5-carboxylate (cas# 6633-61-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Cyclopentenecarboxylic Acid can be used for enantioselective 1,3-dipolar cycloadditions of diazoacetates and solid-phase synthesis of substituted indolines. It can also be used to develop antagonists for A1- and A2-adenosine receptors.<br>References Sibi, M. P., et al.: Org Lett. 9, 1553 (2007); Nicolaou, K. C., et al.: J. Am. Chem. Soc. 122, 2966 (2000); Jacobson, K. A., et al.: Biochem. Pharmacol. 37, 3653 (1988)<br></p>

<p>Applications Methyl 5-bromofuran-2-carboxylate<br></p>

<p>Applications methyl 3-chloro-4-hydroxyphenylacetate (cas# 57017-95-5) is a useful research chemical.<br></p>

<p>Applications tert-Butyl (Trimethylsilyl)acetate is used to prepare lithium enolates, and is also a useful synthetic intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rathke, M. &amp; Elghanian, R. tert-Butyl Trimethylsilylacetate In Handbook of Reagents for Organic Synthesis: Reagents for Silicon-Mediated Organic Synthesis; Fuchs, P.; Wiley, 2011; 147-148<br></p>

<p>Applications Oxirane-​2-​carboxylic Acid is used as reactant in the synthesis of glutathione peptidomimetics as components of antiparkinson prodrugs.<br>References More, S., Vince, R.: J. Med. Chem., 51, 4581 (2008);<br></p>

<p>Applications Mevinolinic Acid, Monoammonium Salt can be used as reactant/reagent in process for the preparation of the Simvastatin precursor, 2,2-dimethylbutanoic acid (1S,3R,7S,8S,8aR)-8-[(3R,5R)-7-(cyclopropylamino)-3,5-dihydroxy-7-oxoheptyl]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl ester, via an amidation reaction.<br>References Khanna, J., et al.: Indian, IN 184809 A1 20000930 (2000)<br></p>

<p>Applications Phosphorodichloridic Acid is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.<br>References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)<br></p>

<p>Applications Furan-2-boronic acid<br></p>

<p>Applications 4-(3-aminopropyl)-1,2,5-oxadiazole-3-carboxylic acid 5-oxide (cas# 352647-66-6) is a useful research chemical.<br></p>

<p>Applications Carbamic Acid 2-​Hydroxypropyl Ester is an organic reagent used in the preparation of polyurethane foams.<br>References Mueller, E. et al.: Angew. Makri, Chem., 34, 111 (1973)<br></p>

<p>Applications Methyl Dimethylbenzeneacetate (cas# 57625-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-Butyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate has been used as a reactant in the preparation of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 with potential use in osteoarthritis therapy.<br>References Durham, T.B., et. al.: J. Med. Chem., 57, 10476 (2014)<br></p>

<p>Applications Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Chloronicotinic Acid, is an organic building block used for the synthesis of various biologically active compounds, including inhibitors. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.<br>References Xie, Y., et al.: Bioorg. Med. Chem. Lett., 23, 2306 (2013); Shiroya, U., et al.: Med. Chem. Res., 22, 5227 (2013);<br></p>

<p>Applications 2,4-Diaminobenzenesulfonic acid (cas# 88-63-1) is a useful reagent for improving the chlorine resistance and water permeability of polyamide (PA) membrane in water treatment.<br>References Meng, Q. W., et al.: ACS Applied Mat., 12, 35393 (2020)<br></p>

<p>Applications DL-3-(Benzylthio)lactic Acid is used in the preparation of somatostatin analogs, affecting growth hormones.<br></p>

<p>Applications (2E,​4E)​-2,​4-​Tetradecadienoic acid is used as a reactant in polymerization reactions such as the syntheses of monoacylglycerol and 1,​2-​diacyl-​sn-​glycerol.<br>References Matsumoto, A., et al.: Polym. J., 35, 652-61 (2003); Srisiri, W., et al.: J. Org. Chem. 61, 5911-15 (1996)<br></p>

<p>Applications N-​Methylaniline Trifluoroacetate is regent used in organic synthesis, functioning as an α-methylating agent for ketones and activates internucleodecoupling upon removal.<br>References Nikolaev, V. et al.: E-Eros. Encyc. Reag. Org. Synth, 1, (2001); Wallace, D. et al.: Tetrahedron Lett., 54, 4425 (2013);<br></p>

<p>Applications Methyl 5-Chloro-3-(Chlorosulfonyl)Thiophene-2-Carboxylate (cas# 126910-68-7) is a useful research chemical.<br></p>

<p>Applications Ethyl 4-Oxo-5-hexanoic Acid Ester is used in the synthesis of analogs of 5-aminolevulinic acid (ALA), which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis;Also, it is an intermediate of 4-Oxo-6-(2-oxo-5-vinylpyrrolidin-1-yl)hexanoic Acid (O858780), which is derived from Ethyl Succinoyl Chloride (E818230), which is used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones. Vigabatrin Impurity 2<br>References Appleton, D., et al.: J. Chem. Soc., Perkin Trans., 89-101 (1998); Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012)<br></p>

<p>Applications 3-(2-Oxo-cyclohexyl)-propionic Acid is an intermediate in the synthesis of Hexahydrocoumarin (H293905), a derivative of Coumarin (C755380) that is used as a fragrance ingredient.<br>References Letizia, C. S., et al.: Food and Chemical Toxicology, 38, S115 (2000);<br></p>

<p>Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.<br>References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;<br></p>

<p>Applications Used in the preparation of herbicides.<br></p>

<p>Applications 3-((1-Oxo-1-(3-(trimethylsilyl)propoxy)propan-2-yl)thio)propanoic acid is useful reagent for organic reactions and synthesis.<br></p>

<p>Applications methyl 3-formylcyclohexane-1-carboxylate (cas# 50738-62-0) is a useful research chemical.<br></p>

<p>Applications 3-Amino-3-(3-(p-tolyloxy)phenyl)propanoic Acid is a useful chemical reagent.<br></p>

<p>Applications 3-Aminomethylbenzoic acid<br></p>

<p>Applications 5,6,7,8-tetrahydroquinazoline-6-carboxylic acid (cas# 1369096-46-7) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications 3-(3-Hydroxyphenyl)acrylic acid (cas# 588-30-7) is a useful research chemical.<br></p>

<p>Applications Used in the preparation of (+)-Lysergic acid and α-Ergocryptine (E597500).<br></p>

<p>Applications Methyl (1R,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Ester is used in the discovery of a potent, selective and orally bioavailable dual CCR2 and CCR5 antagonist.<br>References Zheng, C., et al.: Bioorg. Med. Chem. Lett., 21, 1442-1446 (2011)<br></p>

<p>Applications [2-(aminocarbonyl)phenoxy]acetic acid (cas# 25395-22-6) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxy-3-nitrobenzoic acid<br></p>

<p>Applications 2-(5-formylfuran-2-yl)benzoic Acid (cas# 88460-72-4) is a useful research chemical.<br></p>

<p>Applications Periodic Acid is used as a reagent in periodate cleavage reactions which is particularly useful in modifying saccharide rings for determining structure of carbohydrates. Periodic Acid is also used as an oxidising agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jackson, E., et al.: J. Am. Chem. Soc., 59, 994 (1937); Weidman, S., et al.: J. Am. Chem. Soc., 88, 5820 (1966);<br></p>