Carboxylic Acids

<p>Applications Benzo[b]thien-3-ylboronic acid is used in the synthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar/glycoprotein sensing.<br>References Akay, S., et al.: Chem. Biol. Drug Des., 70, 279 (2007)<br></p>

<p>Applications 2-Hydroxyphenylboronic acid<br></p>

<p>Applications 3-(4-Biphenyl)propionic Acid is a reactant in the preparation of 1,3,4-oxadiazole containing histone deacetylase inhibitors with anticancer activity.<br>References Valente, S., et. al.: J. Med. Chem., 57, 6259 (2014)<br></p>

<p>Applications Methyl 4-Oxocyclohexanecarboxylate is an intermediate for preparation of imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for treatment of sleep disorders.<br>References Monti, J., et al.: CNS Drugs, 13, 87 (2000), Tashiro, M., et al.: Life Sci., 72, 409 (2002), Popa, D., et al.: J. Neurosci., 25, 11231 (2005),<br></p>

<p>Applications 3-(2-Aminoethoxy)propionic Acid (cas# 144942-89-2) is a compound useful in organic synthesis.<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Stability Air Sensitive<br>Applications methyl 2-(2-formylphenyl)acetate (cas# 63969-83-5) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxy-3,5-dimethylbenzoic Acid is used in the synthesis of Mexiletine (M340800) derivatives as orally bioavailable inhibitors. Also, used as a chemical reagent in the preparation of potent transthyretin (TTR) amyloidogenesis inhibitors affecting thyroid hormone.<br>References Frederickson, M. et al.: J. Med. Chem., 51, 183 (2008); Johnson, S. et al.: J. Med. Chem., 51, 260 (2008);<br></p>

<p>Applications rel-N-[(1R,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]carbamic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of the HIV reverse transcriptase inhibitor ziagen.<br>References Grumann, A., et al.: Tetrahedron. Lett., 36, 7767 (1995);<br></p>

<p>Applications 3,4-Dimethyl-3-cyclopentene-1-carboxylic Acid is a useful intermediate for organic synthesis.<br>References Otake, K., et al.: Chem. Pharm. Bull., 63, 998 (2015); Bartlett, P. D., et al.: J. Am. Chem. Soc., 87, 1297 (1965)<br></p>

<p>Applications (2-Ethynylphenyl)boronic acid<br></p>

<p>Applications 4-​Chloro-​3-​sulfobenzoic acid is a useful chemical for the preparation of pyridinylbiphenylcarboxamide derivatives for the use as nervous system agents.<br>References Wei, Z.L., et al.: PCT Int. Appl. 199pp. Patent 2009 CODEN:PIXXD2;<br></p>

<p>Applications Ethyl 2-(2,6-Dichlorophenyl)acetate (cas# 90793-64-9) is a useful research chemical.<br></p>

<p>Stability Epimerize in solution<br>Applications 5-Hydroxy-1,3-oxathiolane-2-carboxylic Acid is used in the synthesis of potent antiviral agent (-)-2’-Deoxy-3’-thiacytidine and its enantiomer.<br>References Jin, H.L., et al.: J. Org. Chem., 60, 2621 (1995);<br></p>

<p>Applications tert-Butyl 2-(diethylphosphono)acetate is a chemical reagent used in the synthesis of pharmaceuticals such as Clopidogrel (C587250), s prodrug anticoagulant.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015);<br></p>

<p>Applications 4-Oxo-3,4-dihydroquinazoline-7-carboxylic acid (cas# 202197-73-7) is a useful research chemical for organic synthesis and other chemical processes.<br>References Bogert, M. T., et al.: J. Am. Chem. Soc., 29, 82 (1907); Baker, B. R., et al.: J. Org. Chem., 17, 141 (1952)<br></p>

<p>Applications 2-Carboxyfuran-5-boronic acid, pinacol ester<br></p>

<p>Applications 9-Hydroxydecanoic Acid is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.<br>References Weber, A. E., et al.: J. Med. Chem., 35, 3755 (1992);<br></p>

<p>Stability Temperature Sensitive<br>Applications 2-Oxocyclopentanecarboxylic Acid is a reactant that has been used in the synthesis of Piragliatin, a glucokinase activator.<br>References Sarabu, R., et. al.: J. Med. Chem., 55, 7021 (2012)<br></p>

<p>Applications 2,5-Furandicarboxylic Acid Diethyl Ester (cas# 53662-83-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Fluoronicotinic acid<br></p>

<p>Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.<br>References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)<br></p>

<p>Applications tert-butyl 2-ethynylmorpholine-4-carboxylate (cas# 1416229-07-6) is a useful research chemical.<br></p>

<p>Applications 4,5-dimethylthiophene-3-carboxylic acid (cas# 19156-52-6) is a useful research chemical.<br></p>

<p>Applications 2,3-Dimethylphenylacetic Acid (cas# 30981-98-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-N-OCTYLOXYBENZOIC ACID (cas# 2493-84-7) is a useful research chemical.<br></p>

<p>Stability Store FROZEN<br>Applications Material that was assayed to be approximately 80% pure was diluted to 5% in benzene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications tert-Butyl Methylcarbamate is an substituent in the synthetic preparation of PF-06463922, a macrocyclic inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).<br>References Johnson, T. W., et al.: J. Med. Chem., 57, 4720 (2014);<br></p>

<p>Applications DITHIOCARBONIC ACID S,S'-DIETHYL ESTER (cas# 623-80-3) is a useful research chemical.<br></p>

<p>Applications 4-CYANO-4-[(ETHYLSULFANYLTHIOCARBONYL)SULFANYL]PENTANOIC ACID (cas# 1137725-46-2) is a useful research chemical.<br></p>

<p>Impurity Fluorouracil EP Impurity B; Fluorouracil USP Related Compound B<br>Applications A 5-hydroxy derivative of the nucleobase Uracil (U801000) and an isomer of Barbituric Acid (B118650). Studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been used as oxidative DNA damage biomarker in tissue engineered skin. Fluorouracil EP Impurity B. Fluorouracil USP Related Compound B<br>References Varatharasa T. et al.: Chem. Comm., 3, 400 (2005); Jaruga, P. et al.: Nucleic Acid Res., 24, 1389 (1996); Rodriguez, H. et al.: Adv. Exp. Med. Biol., 534, 129 (2003);<br></p>

<p>Applications L-Menthyl 2,2-Dihydroxyacetate is used as a reagent in the synthesis of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977); Goodyear, M.D., et al.: Tetrahedron Lett., 46, 8535 (2005); Kametani, T., et al.: Heterocycles, 25, 241 (1987)<br></p>

<p>Applications (9H-Purin-6-ylamino)-acetic acid (cas# 10082-93-6) is a useful research chemical.<br></p>

<p>Applications 3-[(2-Hydroxyethyl)Amino]Propanoic Acid (cas# 5458-99-1) is a useful research chemical.<br></p>

<p>Applications 2,5-Dihydroxybenzoic Acid Butylamine Salt [Matrix for MALDI-TOF/MS] (cas# 666174-80-7) is a useful research chemical.<br></p>

<p>Applications Cyclopentylacetic acid is a reagent the synthesis of Cyclopentamine (C988355), which is a vasoconstrictor that acts as a releasing agent of the neurotransmitters norepinephrine, epinephrine and dopamine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, J.L. et al.: J. Pharmacol. Exp. Ther., 145, 83 (1964); Iversen, L.L.: J. Pharm. Pharmacol., 16, 435 (1964);<br></p>

<p>Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients<br>References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9<br></p>

<p>Applications GAMMA-CHLOROCROTONIC ACID (cas# 26340-58-9) is a useful research chemical.<br></p>

<p>Applications 1H,1aH,6H,6aH-cyclopropa[a]indene-1-carboxylic acid (cas# 501418-06-0) is a useful research chemical.<br></p>

<p>Applications 2-(methylamino)octanoic acid (cas# 101080-67-5) is a useful research chemical.<br></p>

<p>Applications 3-Hydroxy-2-nitrobenzoic Acid (cas# 602-00-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Amino-1,3-benzenedisulfonic Acid is used as a reagent in the synthesis of arylazopyridoxal phosphate and phosphonate derivatives as P2 receptor antagonists.<br>References Kim, Y., et al.: Drug Develop. Res., 45, 52 (1998)<br></p>

<p>Applications Ethyl 5-amino-1-benzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy.<br>References Chezal, J.M., et al.: J. Medn. Chem., 51, 3133 (2008); Heinrich, T., et al.: J. Medn. Chem., 47, 4684 (2004);<br></p>

<p>Applications 3-ethyladamantane-1-carboxylic acid (cas# 37845-05-9) is a useful research chemical.<br></p>

<p>Applications Methyl Dimethylbenzeneacetate (cas# 57625-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Propylthio)nicotinic acid (cas# 175135-22-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrophthalic acid is a useful building block in organic synthesis.<br></p>

<p>Applications N-Phenylanthranilic acid is used in biological studies for inhibitors of aldo-keto reductase 1C3 based on N-phenyl-aminobenzoates.<br>References Adeniji, A. O., et al.: J. Med. Chem., 55, 2311 (2012);<br></p>

<p>Applications Tetronic Acid (cas# 4971-56-6) is a useful research chemical.<br></p>

<p>Applications Glycolic Anhydride Diacetate, is the product of reaction involving Lead tetraacetate as an oxidizing agent It is also an intermediate in the synthesis of Chrysogine, a metabolite of Penicillium chrysogenum and some related 2-substituted 4-(3H)-quinazolinones.<br>References Dimroth, O., et al: Berichte der Deutschen, 56B, 1375 (1923); Bergman, J., et al.: Tetrahedron, 46, 1295 (1990);<br></p>

<p>Stability Store Under Argon; Air Sensitive<br>Applications 4-Mercaptobenzoic Acid (cas# 1074-36-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References J. Org. Chem., 2835 (1962)<br></p>

<p>Applications Methyl (3α,5β,6α)-3-(Acetyloxy)-6-bromo-7-oxo-cholan-24-oic Acid Ester is an intermediate used in the synthesis of ω-Muricholic Acid (M732760), which is used in the regulation of weight gain and lipid metabolism by bacterial bile acid modification in gut for the control of obesity and hypercholesterolemia.<br>References Joyce, Susan A., et al.: Proc. Natl. Acad. Sci. USA, 111, 7421 (2014)<br></p>

<p>Applications Bromosuccinic acid is prepared from Succinic acid (S688765), an important precursor in many chemicals used in the food, chemical and pharmaceutical fields. Bromosuccinic acid is also used as a reagent to prepare L-Hydrazinosuccinic acid.<br>References Gutowsky, H., et al.: J. Chem. Phys., 31, 1278 (2004); Song, H. &amp; Lee, S.: Enzyme Microb. Tech., 39, 352 (2006); Yamada, R., et al.: BBA-Prot. Struc. Mol. Enzym., 831, 82 (1985)<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrofuran-2,5-dicarboxylic Acid (cas# 2240-81-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-anilinobutanoic acid (cas# 67832-70-6) is a useful research chemical.<br></p>

<p>Applications (2,5-Dimethylphenyl)boronic Acid is a useful synthetic intermediate. It can be used to prepare fluorenones/indenofluorenediones.<br>References Liu, T., et al.: Org. Lett., 13, 2452 (2011)<br></p>