6-membered Rings

<p>Applications Methyl 2-(2-Hydroxyphenyl)acetate is used as a reactant in the preparation of caffeic acid phenylethyl esters as  antiproliferative agents.<br>References Xie, Jin, et al.: Bioorg. &amp; Med. Chem. Let., 27(2), 131-134 (2017)<br></p>

<p>Stability Air Sensitive<br>Applications methyl 2-(2-formylphenyl)acetate (cas# 63969-83-5) is a useful research chemical.<br></p>

<p>Applications Methyl (2S)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoate<br></p>

<p>Applications N,5-diphenyl-1,3,4-thiadiazol-2-amine (cas# 1437-57-6) is a useful research chemical.<br></p>

<p>Applications (E)-5-(3,5-Bis(benzyloxy)phenyl)pent-4-en-2-ol is an intermediate used in the synthesis of 4''-Hydroxycannabidiol (H824830), which is a metabolite of Canabidiol (C175300), a major constituents in marijuana. 4''-Hydroxycannabidiol be used to investigate canabidiol metabolism and human liver microsomes that metabolize Canabidiol into 6α-Hydroxycannabidiol.<br>References Jiang, R., et al.: Life Sci. 89, 165 (2011); Lander, N., et al.: Science 169, 611 (1970)<br></p>

<p>Applications (1S,2S)-1,2-Diphenyl-1,2-ethanediamine (cas# 29841-69-8) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-butyl 2-(4-(bromomethyl)phenyl)acetate (cas# 77292-91-2) is a useful research chemical.<br></p>

<p>Applications 2-(Phenylamino)nicotinic Acid (cas# 16344-24-4) is a useful research chemical.<br></p>

<p>Applications 5-(4-aminophenyl)-1,3,4-oxadiazole-2-thiol (cas# 32058-82-5) is a useful research chemical.<br></p>

<p>Applications (S)-(+)-Z-4-Amino-2-hydroxybutyric Acid is used in the synthesis of aminoglycoside antibiotics.<br>References Rai, R. et al.: Org. Lett., 8, 887 (2006); Li, Jie. et al.: J. org. Chem., 72, 4055 (2007);<br></p>

<p>Applications 4-(tert-Butoxycarbonyloxy)benzylalcohol (cas# 156281-11-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-O-tert-Butyldimethylsilyl-cholest-5-ene-3-ol 24-(2-hydroxyisopropyl) 24-Phenyl Sulfinate is an intermediate in the preparation of Campesterol (C155360).<br></p>

<p>Applications 4-(2,4,4-trimethylpentan-2-yl)benzene-1,2-diol (cas# 1139-46-4) is a useful research chemical.<br></p>

<p>Applications Methyl 3,5-dibromo-4-hydroxybenzoate (cas# 41727-47-3) is a useful research chemical.<br></p>

<p>Applications BENZYL CYANOMETHYLCARBAMATE (cas# 3589-41-1) is a useful research chemical.<br></p>

<p>Applications 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-Dioxide is used in the structure-based design of protein tyrosine phosphatase-1B inhibitors.<br>References Black, E. et al.: Bioorg. Med. Chem. Lett., 15, 2503 (2005);<br></p>

<p>Applications α-(Aminomethyl)-2-(trifluoromethoxy)benzenemethanol is an analog of α-(Aminomethyl)-3-(trifluoromethoxy)benzenemethanol (A630745); a compound that is used as a reagent in the synthesis of potent and selective ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase. It is also used as a reagent in the synthesis of 1-aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.<br>References Jarvest, R.L., et al.: Bioorg. Med. Chem. Lett., 15, 2305 (2005); Keith, J.M., et al.: Bioorg. Med. Chem. Lett., 24, 1280 (2014)<br></p>

<p>Applications 7-Benzyloxy-10,11-dihydrodibenzo[b,f[[1,4]thiazepin-11-one (cas# 329217-07-4) is a compound useful in organic synthesis.<br></p>

<p>Applications [2-(4-Fluorophenyl)cyclopropyl]amine hydrochloride is a synthetic intermediate in the preparation of thiazolinone 4-monosubstituted quinolines as CDK1-Cyclin B inhibitors for use as anti-cancer agents.<br>References Tsai, T.Y., et al.: Bioorg. Med. Chem., 17, 2388 (2009); Vallgaarda, J., et al.: J. Med. Chem., 39, 1485 (1996);<br></p>

<p>Applications N-[1-[3-(2-Ethoxyphenyl)-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl]acetamide is an intermediate in the synthesis of Vardenafil (V098001) related compounds.<br>References Olszewska, T., et al.: Tetahedron., 69, 474 (2013);<br></p>

<p>Applications (1R,2R,4R)-rel-1,2,4-Trimethylcyclohexane is present in jet fuel-derived liquids light fractions.<br>References Xie, G. et al.: Env. Sci. Tech., 37, 4751 (2003); Gentner, D. et al.: Env. Sci. Tech., 47, 11837 (2013);<br></p>

<p>Applications 1-(2,4-Bis(benzyloxy)phenyl)ethanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Chen, D., et al.: Eur. J. Med. Chem., 87, 765 (2014); Malik, N., et al.: Tetrahedron Lett., 54, 4121 (2013)<br></p>

<p>Applications 2,2-Dimethyl-3-(4-mercaptophenyl)propionic Acid (cas# 887354-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications [(Methoxy)methyl]triphenylphosphonium Chloride is used in the synthesis of Cephalotaxine (C261050), an antiviral and antitumor agent. Also used in the synthesis of Taxol A fragment.<br>References Sells, M., et al.: J. Virol., 62, 2836 (1988), Kaneko, S., et al.: J. Clin. Microbiol., 27, 1930 (1989), Baba, Y., et al.: Bioorg. Med. Chem., 13, 5164 (2005), Romero, M., et al.: Antiviral Res., 68, 75 (2005); Hirai, S. et al.: Tetrahedron Lett., 54, 1888 (2013); Xing, P. et al.: Synth., 45, 596 (2013);<br></p>

<p>Applications N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications 4-Benzyloxyphenylacetonitrile is an intermediate in the preparation of Desmethylvenlafaxine, an antidepressant and also in the preparation of RAGE antagonist for the treatment of Alzheimer's disease.<br>References Zhao, J., et al.: Zhongguo Yiyao Gongye Zazhi, 45, 601 (2014); Lee, Y. S., et al.: Bioorg. Med. Chem. Lett., 22, 7555 (2012)<br></p>

<p>Applications 4-Hydroxy-3-nitrobenzoic acid<br></p>

<p>Applications 1-(3,5-Bis(benzyloxy)phenyl)pentan-2-ol is an intermediate for the synthesis of 2''-Hydroxycannabidiol (H824820), which is a metabolite of Canabidiol (C175300), a major constituents in marijuana. 2''-Hydroxycannabidiol can be used to investigate canabidiol metabolism and human liver microsomes that metabolize Canabidiol into 6α-Hydroxycannabidiol.<br>References Jiang, R., et al.: Life Sci. 89, 165 (2011); Lander, N., et al.: Science 169, 611 (1970)<br></p>

<p>Applications (4-Ethynylphenyl)trimethylsilane (cas# 16116-92-0) is a useful research chemical.<br></p>

<p>Applications 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide is used in the preparation of antihypertensive agents.<br>References Topliss, J. G., et al.: Journal of Medicinal Chemistry, 6, 122 (1963);<br></p>

<p>Applications O-(2-Bromo-6-chlorophenyl) O-Ethyl S-Propyl Phosphorothioate is a useful intermediate.<br></p>

<p>Applications Methoxy4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-benzenemethanol, is prepared synthetically from vanillin (V097500) with an intermediate of methoxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-benzaldehyde (M269710).<br>References Gowravarm, S. et al.: Adv. Synth. Catal., 343, 169 (2001)<br></p>

<p>Applications 5-(Benzyloxy)-2-Hydroxybenzoic Acid (cas# 16094-44-3) is a useful research chemical.<br></p>

<p>Applications Substituted cinnamic and dihydrocinnamic acids show anti-inflammatory and analgesic activity, with cinnamic acids being more biologically active.<br>References Runwal, L. et al.: Eastern Pharmacist 38, 141 (1995)<br></p>

<p>Applications 2-Cyclohexylideneacetic acid (cas# 1552-91-6) is a useful research chemical.<br></p>

<p>Applications (Methyl)triphenylphosphonium Iodide is the precursor to a wittig reagent.<br></p>

<p>Applications Methyl 2-cyanobenzoate<br></p>

<p>Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.<br>References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)<br></p>

<p>Applications 5-Hydroxy-3-phenylbenzoic Acid can be used in biological study of preparation and identification of hydroxybenzoic acids as lactate receptor agonists and antilipolytics. It can also be used in discovery of new series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.<br>References Duffy, B. C., et al.: Bioorg Med Chem Lett, 25, 2818 (2015), Dvorak, C. A., et al.: ACS Med Chem Lett, 3, 637 (2012)<br></p>

<p>Applications Bis(2,4,5-tribromophenyl)iodonium Hydrogen Sulfate is an intermediate in the synthesis of 2,2',4,4',5,6'-Hexabromodiphenyl ether (H290745), which is a hepatotoxic polybrominated diphenyl ester (PBDE) that is commonly used as a flame retardant. 2,2',4,4',5,6'-Hexabromodiphenyl ether is also sometimes found in food and meats as well, posing a significant risk to humans (especially during pregnancy) and/or animals that consume it. One of the new POPs under the Stockholm Convention<br>References Johnson, P., et al.: Sci. Total Environ., No vol. given, 445 (2013); Scott, L., et al.: Organo. Comp., 74, 1109 (2012); Zhao, Y., et al.: Env. Sci. Tech., 47, 5939 (2013)<br></p>

<p>Applications 2-Aminobenzeneboronic acid pinacol ester is a reagent used to synthesize regiospecific quinolines. It can also be used to synthesize (±)-Epimeloscine and (±)-Meloscine.<br>References Zhang, H., et al.: J. Am. Chem. Soc. 133, 10376 (2011); Horn, J., et al.: Org. Lett 10, 4117 (2008)<br></p>

<p>Applications 3,4-Bis(phenylmethoxy)benzeneethanamine is an intermediate used in the synthesis of S-(-)-Tretoquinol Hydrochloride (T798100), which belongs to the class of adrenergic inhalants, selective β-2-adrenoreceptor agonists. S-(-)-Tretoquinol is used in the treatment of obstructive airway diseases. S-(-)-Tretoquinol is a bronchodilator.<br>References Meshi, et al.: Biochem. Pharmacol., 19, 2937 (1970), Satoh, et al.: Chem. Pharm. Bull., 19, 667 (1971),<br></p>

<p>Applications (2S,3R,4E)-3-Benzoyl-2-tert-butyloxycarbonylamino-4-octadecen-1,3-diol (cas# 299172-59-1) is a compound useful in organic synthesis.<br>References Kinjo, Y., et al.: Chem. Biol., 15, 654 (2008),<br></p>

<p>Applications Glycidyl 4-Toluenesulfonate is used in the development and validation of a chiral HPLC method for rapid screening of allylic alcohol asymmetric epoxidation processes. Glycidyl 4-Toluenesulfonate is a reagent for organic displacement, additional and ring-opening reactions.<br>References Morante-Zarcero S., et al.: Analytica chimica acta, 618, 102 (2008); Bittman, R., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis; 1, (2001)<br></p>

<p>Stability Light Sensitive<br>Applications 1,3-Cyclohexadiene (cas# 592-57-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Impurity Ketoprofen EP Impurity G<br>Applications 3-​(2-Hydroxyethyl)​benzoic Acid (Ketoprofen EP Impurity G) is an impurity in the synthesis of Ketoprofen (K200800), anti-inflammatory (1,2); analgesic.<br>References 1. Ueno, K. et al.: J Med Chem. 1976 Jul;19(7):941-6. 2. Jamali, F. et al.: Clin Pharmacokinet. 1990 Sep;19(3):197-217.<br></p>

<p>Applications (R)-2-(Tetrahydropyranyloxy)propionic Acid can be employed to synthesize lactic acid oligomers, depsides, and depsipeptides on solid phase.<br>References Kuisle, O., et al.: Tetrahedron Lett. 40, 1203 (1999); Kim, S. et al. tetrahedron asymmetry 22, 1499 (2011)<br></p>

<p>Applications Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate, is a building block used in various chemicla synthesis. It can be used for the preparation of six stereoisomers of diaminocyclohexane carboxamide as key intermediates for synthesis of factor Xa inhibitors.<br>References Wang, X. et al.: Tetrahedron, Vol.73, Iss.11, P1381-1388 (2017);<br></p>

<p>Applications 3,4-Dimethoxytoluene is a volatile flavor compound found is many substances such as boiled buckwheat flour, wild rice grain and tar of hickory wood smoke.<br>References Yajima, I., et. al.: Agr. Bio. Chem. 47, 729 (1983); Withycombe, D.A., et. al.: J. Agr. Food Chem., 26, 816 (1978); Hruza, D.E., et. al.: J. Agr. Food chem., 22, 123 (1974)<br></p>

<p>Applications b-Phenylethyl Furoate (cas# 7149-32-8) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethoxybenzyl Alcohol can be used as a self-indicating standard for the determination of organolithium reagents<br>References Winkle, M.R. et al.: J. Chem. Soc. Chem. Comm., 3, 1980 (1980):<br></p>

<p>Applications (S)​-​(-​)​-​1-​Phenyl-​1-​propanol is a building block used in the synthesis of inhibitors of steroid 11-β hydroxylation in the adrenal cortex related to androgen production in the fetus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zolle, I. et al.: J. med. Chem., 51, 2244 (2008);<br></p>

<p>Applications 2-((tert-bButoxycarbonyl)amino)-2-(hydroxymethyl)-4-(4-octylphenyl)butyl Acetate is the intermediate in the synthesis of Mono-O-acetyl Fingolimod TFA (F524600), which is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001). Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002). Mtaloubian, M., et al.: Nature, 427, 355 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications N-Benzyl-bis(2-chloroethyl)amine hydrochloride (cas# 10429-82-0) is a useful research chemical.<br></p>

<p>Applications 2-(Tetrahydro-2H-pyran-3-yl)ethanol (cas# 1050493-77-0) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications 3-(3-Hydroxyphenyl)acrylic acid (cas# 588-30-7) is a useful research chemical.<br></p>

<p>Applications 4,5-Dimethoxy-2-nitrobenzoic Acid (cas# 4998-07-6) is a compound useful in organic synthesis.<br></p>