Antimicrobials

<p>Aqabamycin B is a novel antibiotic compound, which is derived from marine microorganisms. This secondary metabolite is isolated from a marine sponge-associated bacterium, showcasing the rich potential of oceanic sources for discovering new antimicrobial agents. The mode of action of Aqabamycin B involves inhibition of bacterial cell wall synthesis, disrupting the structural integrity and leading to cell lysis. Its efficacy extends predominantly to combatting multi-drug resistant bacterial strains.</p>

<p>Aqabamycin C is an antibiotic compound, which is derived from marine bacteria, specifically, the actinomycete strain found in marine environments. Its mode of action involves the disruption of bacterial cell wall synthesis, making it particularly effective against certain gram-negative bacteria. This antibiotic selectively inhibits pathogens by interfering with their essential cellular processes.</p>

<p>Clindamycin-2,4-diphosphate is a phosphorylated derivative of the antibiotic clindamycin, which is a semi-synthetic lincosamide antibiotic originally derived from Streptomyces lincolnensis. Its mode of action involves the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing peptide chain elongation during translation. This mechanism effectively disrupts protein production in susceptible bacteria, leading to their growth inhibition or death.</p>

<p>(R)-(+)-Pantoprazole is a proton pump inhibitor (PPI), which is derived from benzimidazole compounds. Its mode of action involves the selective and irreversible inhibition of the H+/K+ ATPase enzyme system, commonly known as the proton pump, located on the gastric parietal cells. By binding covalently to this enzyme, (R)-(+)-Pantoprazole effectively reduces gastric acid secretion, leading to an increase in gastric pH.</p>

<p>6-(2-Chlorophenoxy)-5-fluoro-4(3H)-pyrimidinone is a heterocyclic compound, which is a synthetic derivative developed for biochemical research. This compound is synthesized through a series of organic reactions, involving halogenation and cyclization techniques, typically conducted in a controlled laboratory setting. Its design incorporates specific structural features, such as the chlorophenoxy and fluoro groups, which are strategically positioned to enhance its binding affinity and specificity.</p>

<p>Fenamiphos-sulfoxide d3 (S-methyl d3) is a deuterated, labeled pesticide intermediate, which is often utilized in advanced laboratory settings for precise analytical studies. This compound is synthesized as a stable isotope-labeled analog, enabling researchers to conduct sophisticated mass spectrometric analyses. Its mode of action involves serving as a reference or tracer in studies concerning the metabolism and degradation of fenamiphos, a well-known organophosphate pesticide.</p>

<p>Famciclovir-d4 is a deuterium-labeled antiviral nucleoside analog, which is a synthetic derivative of the guanine analog famciclovir. This compound is sourced through advanced chemical synthesis where deuterium atoms replace specific hydrogen atoms, providing an isotopic label that aids in the tracking and analysis of the pharmaceutical compound within biological systems.</p>

<p>BPH-1358 is a novel synthetic inhibitor, which is derived from a series of advanced chemoinformatics-based design strategies. It functions through the targeted binding to specific cell surface receptors involved in the modulation of immune responses. By blocking these receptors, BPH-1358 effectively alters signaling pathways that are crucial for immune activation and inflammatory responses.</p>

<p>Thiabendazole NH d6 is a deuterated derivative of Thiabendazole, which is an antifungal agent and pesticide. It is derived from synthetic sources, specifically designed by incorporating deuterium atoms into the molecular structure. This subtle isotopic modification enhances its utility in research settings, particularly in studies related to pharmacokinetics and metabolic profiling. The mode of action of Thiabendazole involves the inhibition of the enzyme fumarate reductase, interfering with the energy metabolism of fungal and parasitic organisms. Additionally, it disrupts microtubule formation, preventing cell division and growth.</p>

<p>4'-Ethynyl-2'-deoxyadenosine is a deoxynucleoside analogue, which is synthesized through chemical processes. This compound acts as an antiviral agent, primarily targeting the viral replication machinery. Its mode of action involves the incorporation into viral DNA by mimicking natural nucleosides, which subsequently inhibits the enzymatic activity of reverse transcriptase. This inhibition disrupts the synthesis of viral DNA, effectively curtailing viral replication.</p>

<p>Tebufenozide-1-hydroxyethyl is an insect growth regulator, which is a synthetic chemical derived from a modified benzoic acid structure. Its mode of action involves mimicking the molting hormone ecdysone, which disrupts the normal development process of insects by inducing premature molting. This specific interference targets lepidopteran larvae, leading to incomplete development and eventual death, thereby controlling pest populations effectively without harming non-target organisms.</p>

<p>A macrolide, broad-spectrum antibiotic that targets cytochrome P4503A4 (CYP3A4). Clarithromycin has been used to potentiate the pharmacological effects of some drugs that are metabolised by the cytochrome P450.</p>

<p>Cladospirone bisepoxide is a naturally occurring bioactive compound, classified specifically as a fungal metabolite, which is derived from species within the Cladosporium genus. The compound exhibits a complex bisepoxide structure, contributing to its unique chemical properties. Its mode of action involves disrupting microbial cellular processes, displaying potent antimicrobial activity by interfering with the synthesis and functioning of vital cellular components in targeted microorganisms.</p>

<p>Tioconazole is an antifungal agent, which is a synthetic derivative of imidazole with broad-spectrum activity against fungi. This compound is chemically synthesized through complex organic reactions to enhance its antimycotic efficacy. Tioconazole functions by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. By disrupting the ergosterol biosynthesis pathway, tioconazole destabilizes the fungal cell membrane, leading to increased permeability and eventual cell death.</p>

<p>Tigecycline is an antibiotic specifically tailored for use in culture media, which is derived from glycylcycline, a structural analogue of minocycline. Its mode of action involves binding to the 30S ribosomal subunit, thereby inhibiting protein synthesis in a broad spectrum of Gram-positive and Gram-negative bacteria. This action is distinct and not easily circumvented by common resistance mechanisms, such as efflux or ribosomal protection proteins, making tigecycline an effective agent in controlling bacterial contamination during microbiological studies.</p>

<p>HSV-tk substrate is a nucleotide analogue, which is a synthetic compound derived from the herpes simplex virus thymidine kinase (HSV-tk) gene. This substrate is specifically phosphorylated by the HSV-tk enzyme, a property that provides significant utility in molecular biology and genetic research. The mode of action involves the selective phosphorylation of the substrate by HSV-tk, which is typically absent in mammalian cells but can be introduced via genetic engineering. Once phosphorylated, the substrate becomes toxic to the host cell, allowing researchers to selectively target and eliminate cells expressing the HSV-tk gene.</p>

<p>Entecavir-13C2,15N is an isotopically labeled antiviral agent, which is a synthetic nucleoside analogue derived from natural sources. Its mode of action involves selectively inhibiting the reverse transcription activity of the hepatitis B virus (HBV) polymerase. By mimicking the natural substrates of the viral polymerase, Entecavir-13C2,15N becomes incorporated into viral DNA, ultimately leading to chain termination and suppression of viral replication.</p>

<p>Sitafloxacin is an antibacterial agent belonging to the fluoroquinolone class of antibiotics, which is synthetically derived from chemical processes involving fluorinated quinolones. Its mode of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes crucial for bacterial DNA replication and transcription. By interfering with these enzymes, Sitafloxacin effectively hampers bacterial DNA synthesis, leading to the eventual demise of the bacterial cell.</p>

<p>Bensulide-oxon is a metabolite derived from the organophosphate pesticide bensulide, which is predominantly used in agricultural settings. It forms as a result of environmental or biological processes that involve the oxidation of bensulide. As a potent acetylcholinesterase (AChE) inhibitor, bensulide-oxon disrupts normal neuronal signaling by preventing the breakdown of the neurotransmitter acetylcholine, leading to an accumulation that affects the nervous systems of target organisms.</p>

<p>Butafenacil is a herbicide, which is a chemical formulation sourced from synthetic compounds. It acts by inhibiting protoporphyrinogen oxidase (PPO), an enzyme critical in the biosynthesis of chlorophyll. This inhibition disrupts the photosynthetic process, leading to the accumulation of reactive oxygen species that cause cell membrane damage and ultimately result in plant death.</p>

<p>Please enquire for more information about Chloraniformethan including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Hodgkinsine B is an indole alkaloid, which is a complex organic compound derived from natural sources. It is isolated from the leaves of certain Rubiaceae family plants, including Psychotria colorata. Hodgkinsine B is characterized by its unique trimeric structure that contributes to its pharmacological properties.</p>

<p>Albendazole-2-aminosulfoxide is a metabolite of the benzimidazole class of antiparasitic agents, which is derived from the biotransformation of albendazole in the liver. As a potent bioactive compound, its mode of action primarily involves the selective binding to the β-tubulin of parasitic organisms, disrupting the polymerization of microtubules necessary for their cellular structures. This disruption impedes vital processes such as glucose uptake and cellular division, leading to parasite death.</p>

<p>Inhibitor of protein synthesis; aminoglycoside</p>

<p>Tebufloquin is an insecticide, which is a synthetic compound designed to target specific pests. It is derived from chemical synthesis with a mode of action that interferes with critical biological pathways in insects, rendering them unable to survive or reproduce. Tebufloquin works primarily by targeting the nervous system of insects, leading to paralysis and eventual death.</p>

<p>Malformin C is a cyclic pentapeptide, which is a secondary metabolite derived from certain strains of the fungus Aspergillus. Its mode of action involves disrupting cellular processes by interfering with cell division. Specifically, it is thought to affect mitotic spindle formation, leading to abnormal cell cycle progression.</p>

<p>25-Desacetyl rifapentin is a derivative of rifapentin, an antibiotic belonging to the rifamycin class, sourced from the bacterial species *Amycolatopsis rifamycinica*. This compound functions by inhibiting bacterial DNA-dependent RNA polymerase, which is crucial for transcription in susceptible bacterial strains. By inhibiting this enzyme, 25-Desacetyl rifapentin effectively hampers RNA synthesis, ultimately leading to bacterial cell death.</p>

<p>Please enquire for more information about BO3482 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Dimethenamid-oxalamid is a pre-emergent herbicide, which is a synthetic compound developed for agricultural use. It is derived from research focused on improving crop protection through chemical innovation. The mode of action involves inhibiting the synthesis of very long-chain fatty acids (VLCFAs) in weeds, disrupting their cell division and growth processes, ultimately leading to the prevention of weed emergence.</p>

<p>Tunicamycin V is an antibiotic and nucleoside analog, which is a secondary metabolite derived from various Streptomyces species. It functions predominantly by inhibiting the initial step of N-linked glycosylation, a critical post-translational modification process in eukaryotic cells. This inhibition occurs through the blockage of UDP-N-acetylglucosamine: dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase, thereby preventing the synthesis of dolichol-linked oligosaccharides and ultimately affecting protein folding and quality control mechanisms within the endoplasmic reticulum.</p>

<p>2-(1-Hydroxyethyl)-6-ethylaniline is an organic chemical compound, which is often utilized as an intermediate in the synthesis of dyes, pigments, and other industrial chemicals. This compound is derived from aromatic amines and undergoes specific chemical reactions that enable its functionality in various synthetic processes.</p>

<p>Dihydropenicillin F potassium is a novel antibiotic compound, which is semisynthetic in nature, derived from the penicillin family. It is sourced through the modification of natural penicillins, bringing about enhanced stability and efficacy against certain resistant bacterial strains. The mode of action involves the inhibition of bacterial cell wall synthesis, primarily targeting the penicillin-binding proteins (PBPs). This disruption consequently leads to cell lysis and the eventual bacterial death.</p>

<p>Nocardamine is a siderophore-based antioxidant, which is naturally derived from the soil-dwelling actinobacteria known as Streptomyces. Its primary mode of action involves the chelation of metal ions, effectively sequestering them and preventing metal-catalyzed oxidation reactions. By binding to iron and other transition metals, Nocardamine mitigates oxidative stress at a cellular level, which could otherwise contribute to cellular damage and dysfunction.</p>

<p>Curvularin is a secondary metabolite, which is derived from the fungal genus *Curvularia*. This compound is produced through the natural biosynthetic pathways of filamentous fungi, specifically isolated from strains such as *Curvularia lunata*. Curvularin exerts its biological activity primarily through modulation of microtubule dynamics, making it a significant subject of study in cell biology. It disrupts the polymerization processes, impacting the assembly and stability of microtubules, which are critical components of the cytoskeleton involved in cell division, intracellular transport, and structural integrity.</p>

<p>Azithromycin Dihydrate is a macrolide antibiotic and is used for the treatment of various bacterial infections. It binds to the 23S rRNA of the 50S ribosomal subunit, inhibiting protein synthesis</p>

<p>Polymyxin B1-I is an antimicrobial peptide, which is sourced from the bacterium *Bacillus polymyxa*. It functions by interacting with and disrupting the bacterial cell membranes. The polypeptide inserts into the phospholipid bilayer, causing increased permeability and eventual cell lysis. This mechanism is particularly effective against Gram-negative bacteria due to the structural composition of their outer membranes.</p>

<p>Narasin sodium is an ionophore antibiotic, which is a type of compound that facilitates ion transport across biological membranes. It is derived from the fermentation of the bacterium *Streptomyces aureofaciens*. The mode of action involves the disruption of ion gradients in target organisms, specifically inhibiting the growth of certain pathogenic bacteria and protozoa by altering their cellular ionic balance.</p>

<p>Pefloxacin-d3 is a deuterated fluoroquinolone antibiotic, which is a synthetic derivative of pefloxacin utilized primarily for research purposes. This compound is chemically modified to include deuterium atoms, a stable isotope of hydrogen, thus offering unique properties essential for precise quantitative analysis in pharmacokinetic studies.</p>

<p>Flucloxacillin is a beta-lactam antibiotic, which is derived from the penicillin family. It is synthetically produced through chemical modification to enhance its stability against beta-lactamase enzymes. The mode of action of flucloxacillin involves inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which in turn inhibits the transpeptidation or cross-linking of peptidoglycan chains. This action leads to cell lysis and ultimately, bacterial death.</p>

<p>Nikkomycin Z is an antifungal agent, which is a secondary metabolite isolated from the bacterium Streptomyces tendae. This compound functions as a competitive inhibitor of chitin synthase, an essential enzyme responsible for the synthesis of chitin, a vital component of the fungal cell wall. By inhibiting this enzyme, Nikkomycin Z disrupts the structural integrity of the fungal cell wall, leading to impaired growth and cell lysis in susceptible fungi.</p>

<p>Leptomycin B is a bacterial secondary metabolite, which is derived from the bacterium Streptomyces sp. This compound is a potent nuclear export inhibitor with a mechanism of action that targets and inhibits the export receptor CRM1 (Chromosomal Maintenance 1), also known as Exportin 1. By binding irreversibly to CRM1, Leptomycin B prevents the nuclear export of proteins and RNA, disrupting the nuclear-cytoplasmic transport essential for cell function.</p>

<p>Spiramycin I is a macrolide antibiotic with action on bacterial protein synthesis inhibition and is used for treating toxoplasmosis and bacterial infections.</p>

<p>Polymyxin B nonapeptide TFA is an antimicrobial peptide, which is derived from the bacterium *Bacillus polymyxa*. This peptide is a truncated form of polymyxin B, lacking the fatty acyl tail and N-terminal amino acid, resulting in a nonapeptide structure. Its mode of action involves binding to the lipid A portion of bacterial lipopolysaccharides, thereby disrupting the integrity of the bacterial cell membrane. This interaction increases membrane permeability and leads to cell lysis, particularly in Gram-negative bacteria.</p>

<p>4-Demethyl daunomycinone is an anthracycline derivative, which is a natural or semi-synthetic compound derived from the bacterium *Streptomyces*. It is primarily studied for its potential use in anticancer therapies, given its structural similarity to other well-known anthracyclines like daunorubicin and doxorubicin. These compounds are known to intercalate into DNA, thereby disrupting the function of DNA and RNA synthesis, leading to the inhibition of cell proliferation.</p>

<p>Micafungin is an antifungal drug that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes. It is a cyclic peptide with a lipophilic fatty acid chain that has been modified to allow penetration into cells. Micafungin is active against Candida and Aspergillus species and has shown activity against some strains of Cryptococcus neoformans. The MIC (minimum inhibitory concentration) for this drug ranges from 0.06 to 1 microgram/mL, depending on the bacterial strain being tested. Micafungin FR-179642 impurity (acid) is an impurity in micafungin that can be present as trace amounts in the final product and may contribute to hemolytic activity. This impurity is formed by hydrolysis during the synthesis process.</p>

<p>Sisomicin sulfate is a sulfate salt form of sisomicin with similar action and applications as sisomicin.</p>

<p>Cecropin A is an antimicrobial peptide, which is derived from the immune systems of insects, specifically moths. It displays potent antimicrobial properties through its ability to disrupt bacterial cell membranes, leading to cell lysis and death. This peptide primarily targets Gram-negative bacteria but is also effective against some Gram-positive strains. Cecropin A has garnered significant scientific interest due to its potential applications in developing new antimicrobial agents, particularly in the face of increasing antibiotic resistance. By integrating Cecropin A into therapeutic strategies, researchers aim to broaden the spectrum of antimicrobial options available for use in both clinical and agricultural settings, offering a promising avenue for future drug development.</p>

<p>Oteseconazole is an antifungal medication, which is a synthetic triazole-derived agent. It functions by inhibiting the activity of the fungal enzyme lanosterol 14α-demethylase. This inhibition disrupts the synthesis of ergosterol, a vital component of fungal cell membranes, thereby interfering with cell membrane integrity and function, ultimately leading to fungal cell death.</p>

<p>Cefmenoxime hydrochloride is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating gynecological and obstetric infections.</p>

<p>Cefepime Related Compound E is a chemical impurity, which is typically encountered as a byproduct in the synthesis or degradation of the antibiotic cefepime. This impurity is derived from synthetic processes used in the pharmaceutical industry and can originate from a variety of pathways during the manufacturing or storage of cefepime.</p>

<p>STAADIUMTM PeptiZide L-Pyr is a targeted inhibitor for pyroglutamyl-aminopeptidase-producing bacteria. The antibacterial activity of STAADIUMTM PeptiZide L-Pyr is triggered by the enzyme pyroglutamyl aminopeptidase (a.k.a. pyrase or pyrrolidonyl peptidase) that is present, not only in bacteria, but also in archaea, plants and animals. STAADIUMTM PeptiZide can be used to suppress the growth of Citrobacter freundii on diagnostic agar plates for Salmonella. L-pyrrolidonyl peptidase activity has also been exploited to distinguish Enterococcus species and Streptococcus pyogenes from other Streptococaceae species. More details in the application notes document.</p>

<p>DMDNA31 is a synthetic nucleotide analog, which is a man-made compound designed to mimic the natural building blocks of DNA. It originates from advanced chemical synthesis processes, allowing precise control over its structure to mimic specific nucleotide sequences. DMDNA31 operates by integrating into DNA strands during replication, thereby enabling the study of genetic mutations and the mapping of genomic sequences.</p>

<p>Ceftriaxone sodium is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating severe bacterial infections like meningitis and pneumonia.</p>

<p>Ofloxacin Q acid is a quinolone analog, which is a synthetic derivative known for its significant antibacterial properties. This compound is sourced from the chemical synthesis of fluoroquinolone derivatives, designed to enhance reactivity and efficacy in pharmaceutical applications. Ofloxacin Q acid acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication, transcription, and repair, thereby leading to the cessation of bacterial growth and replication.</p>

<p>Oxibendazole-amine hydrochloride is a synthetic anthelmintic compound, which is a derivative of benzimidazole, known for its broad-spectrum efficacy against various helminths. It primarily acts by disrupting the polymerization of tubulin into microtubules, effectively impairing essential cellular structures and functions within parasitic worms, leading to their death.</p>

<p>Bacampicillin Hydrochloride is an aminopenicillin antibiotic and is used for the treatment of bacterial infections. It is a prodrug that is converted to ampicillin in the body, which then inhibits bacterial cell wall synthesis.</p>

<p>14-Bromodaunorubicin HBr is a synthetic antitumor antibiotic derivative, which is a modified version of daunorubicin, an anthracycline antibiotic originally isolated from Streptomyces peucetius. With the inclusion of a bromine atom at the 14th position, this compound is designed to enhance the antitumor efficacy and alter pharmacokinetic properties compared to its parent molecule.</p>

<p>Erythromycin C is a macrolide antibiotic, which is a type of product derived from the bacterium *Saccharopolyspora erythraea*. It functions by binding to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis through blocking translocation of peptidyl-tRNA. This mode of action effectively prevents bacterial growth and replication, making it a potent bacteriostatic agent.</p>

<p>Sancycline hydrochloride is a tetracycline antibiotic, which is derived from the natural fermentation process of Streptomyces bacteria. The mechanism of action involves the inhibition of protein synthesis by bindin directly to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl-tRNA to the A site of the ribosome. This action effectively halts the growth of bacteria by impeding protein production, making it bacteriostatic rather than bactericidal.</p>

<p>Ceftizoxime is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating respiratory tract infections, urinary tract infections, and gonorrhea.</p>

<p>Cefazolin is a broad-spectrum antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria. It is an effective cephalosporin antibiotic against both aerobic and anaerobic bacteria. Cefazolin is used in clinical isolates to inhibit the growth of methicillin-resistant staphylococcus, resistant microorganisms, and systemic inflammation. Some studies has shown good results to inhibit tumor necrosis factor-α (TNFα) production in cell culture.</p>

<p>Tenofovir alafenamide (free base) is a prodrug of tenofovir with action on viral reverse transcriptase to block replication and is used for treating HIV/AIDS and chronic hepatitis B with improved safety profile.</p>

<p>Laidlomycin is an ionophore compound with a mode of action that disrupts ion gradients in bacterial cells. It is used as a feed additive to improve feed efficiency in cattle.</p>

<p>**Sulbactam pivoxyl** is a prodrug, which is a chemically modified form of sulbactam intended to improve its pharmacokinetic properties. Sulbactam itself is a beta-lactamase inhibitor of synthetic origin, specifically designed to combat antibiotic resistance by inhibiting the beta-lactamase enzymes produced by certain bacteria. These enzymes typically break down beta-lactam antibiotics, rendering them ineffective.</p>

<p>Monensin is a polyether ionophore antibiotic, which is derived from the fermentation of the bacterium *Streptomyces cinnamonensis*. It operates by disrupting ion transport across biological membranes, primarily by facilitating the exchange of sodium and potassium ions. This ionophore action alters the osmotic balance in target cells, leading to their destabilization and death, particularly in Gram-positive bacteria and certain protozoa.</p>

<p>1-(6-Amino-3,5-difluoro-2-pyridinyl)-7-[3-[3-[[1-(6-amino-3,5-difluoro-2-pyridinyl)-3-carboxy-8-chloro-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl]amino]-2-hydroxypropoxy]-1-azetidinyl]-8-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is a fluoroquinolone antibiotic, engineered through synthetic chemistry. It is derived from chemical sources involving complex organic synthesis, highlighting its intricate molecular architecture. Its mode of action is distinctive, as it inhibits bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and transcription. This interference with bacterial DNA processes results in bactericidal effects, effectively eliminating susceptible bacterial strains.</p>

<p>Retrocyclin-1 trifluoroacetate salt is a synthetic antimicrobial peptide, which is derived from humanized sequences based on the theta-defensin family, originally found in certain primates. Retrocyclin-1 is particularly notable for its circular structure which contributes to its stability and biological activity. The peptide is produced through a process of solid-phase peptide synthesis, designed to mimic the native cyclic conformation of natural theta-defensins.</p>

<p>N-Acetal bromopride is a chemical compound that serves as a derivative of bromopride, which is a selective dopamine D2 receptor antagonist. This derivative is synthesized from bromopride, typically through organic chemical processes, and modified to possess an acetal functional group. The presence of this functional group potentially alters its pharmacokinetic or pharmacodynamic properties, although these specific changes may still be under research.</p>

<p>Clindamycin 3-phosphate is an antibiotic prodrug, which is a derivative of clindamycin. It is semisynthetic with a synthetic origin, derived by chemically modifying the natural compound lincomycin obtained from the bacterium *Streptomyces lincolnensis*. The mode of action of Clindamycin 3-phosphate involves the inhibition of bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thereby interfering with the translocation step in protein elongation, ultimately leading to the suppression of bacterial growth.</p>

<p>Lactoferricin B (4-14) (bovine) trifluoroacetate salt is a peptide derivative, which is a fragment derived from bovine lactoferrin. It is obtained by enzymatic digestion of lactoferrin, a glycoprotein with a well-established role in the innate immune system. This specific peptide, Lactoferricin B (4-14), is known for its potent antimicrobial properties, attributed to its amphipathic structure that facilitates the disruption of microbial membranes. Additionally, it can modulate immune responses through interactions with immune cells, thereby influencing inflammatory processes.</p>

<p>Gentamicin C1 pentaacetate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for research and analytical applications.</p>

<p>Lumefantrine is an antimalarial compound with a mode of action that inhibits heme detoxification in Plasmodium parasites. It is used in combination with artemether for treating malaria.</p>

<p>Sulfadimethoxine sodium is a sulfonamide antibiotic with action on bacterial folate synthesis inhibition and is used for treating respiratory and urinary tract infections in veterinary medicine.</p>

<p>Cyclosporin V is an immunosuppressant medication with action on calcineurin inhibition and is used for preventing organ rejection in transplants and treating autoimmune diseases.</p>

<p>Ampicillin-sulbactam is a combination antibiotic, which is a pharmaceutical product derived from the penicillin class of beta-lactam antibiotics. Its source involves semi-synthetic processes, combining ampicillin with sulbactam. The mode of action of this compound is through the inhibition of bacterial cell wall synthesis. Ampicillin specifically binds to penicillin-binding proteins, thereby disrupting the cross-linking process essential for maintaining cell wall structural integrity, leading to bacterial lysis. Sulbactam functions as a beta-lactamase inhibitor, enhancing the efficacy of ampicillin by preventing its degradation by beta-lactamase enzymes produced by certain resistant bacterial strains.</p>

<p>Adenosine analogue with antiviral activity</p>

<p>Sapecin is an antimicrobial peptide, which is derived from the hemolymph of the silk moth (Bombyx mori) with potent bactericidal action. The source of Sapecin is the immune system of the silk moth, where it acts as a natural defense mechanism against microbial infections. Its mode of action involves disrupting bacterial cell membranes, leading to cell lysis and death. The peptide achieves this by inserting itself into the lipid bilayer, creating pores that compromise the structural integrity of the membrane.</p>

<p>Dicresulene Hydrate is an anti-inflammatory compound, which is derived from synthetic sources. It functions primarily by inhibiting specific enzymes involved in the inflammatory response. This inhibition reduces the production of pro-inflammatory mediators, thereby mitigating inflammation and associated symptoms.</p>

<p>Gentamicin C2 sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating severe bacterial infections.</p>

<p>Aripiprazole monohydrate is an atypical antipsychotic medication, which is synthesized through chemical processes involving aryl piperazine derivatives. It acts primarily as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and as an antagonist at 5-HT2A receptors, with additional activity at other neurotransmitter receptors. This unique mechanism of action sets it apart from typical antipsychotics that predominantly function as dopamine antagonists.</p>

<p>Doripenem is a carbapenem antibiotic with action on bacterial cell wall synthesis and is used for treating complicated bacterial infections like intra-abdominal infections and urinary tract infections.</p>

<p>Ceftobiprole medocaril sodium is a broad-spectrum cephalosporin antibiotic, which is a synthetically derived prodrug of ceftobiprole. Upon administration, ceftobiprole medocaril is rapidly converted into its active form, ceftobiprole, by the body's endogenous esterases. The mode of action involves binding to penicillin-binding proteins (PBPs) in the bacterial cell wall, leading to the inhibition of cell wall synthesis and ultimately the death of the bacteria. This action is effective against a wide range of gram-positive and gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae.</p>

<p>Hygromycin A is an antimicrobial compound isolated from the bacterium *Streptomyces hygroscopicus*. It functions by inhibiting protein synthesis within microbial cells. This compound disrupts the elongation phase of translation by binding to the ribosomal subunit, therefore impeding mRNA decoding during protein assembly.</p>