Inhibitors

gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.

AT-1002 TFA, a 6-mer synthetic peptide, functions as a tight junction regulator and absorption enhancer.

Activates Notch pathway, boosts NSC self-renewal and neurogenesis, enhances mice memory.

1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.

ER degrader 2: Potent estrogen receptor disruptor; key for cancer research.

Antibacterial agent 30 exhibits remarkable in vitro activity against Xoo, as evidenced by its EC50 value of 1.9 μg/mL.

Kbz probe 1, an adaptable probe utilized for examining histone benzoylation and interactions within living cells, showcases extensive versatility.

NT 2 Toxin is a useful organic compound for research related to life sciences. The catalog number is T124258 and the CAS number is 76348-84-0.

Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.

ERK1/2 inhibitor 5 targets MAPK pathway, potentially aiding cancer and inflammation research.

PROTAC eEF2K degrader-1 (11l) targets eEF2K, induces apoptosis in MDA-MB-231 cells, and degrades eEF2K.

Podoblastin A (D-mannitol) is a useful organic compound for research related to life sciences and the catalog number is TSP-41077145.

VH032-PEG3-acetylene: a VHL ligand-linker for PROTACs, combines VH032 with PEG3-acetylene.

mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases

9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent.

FGFR-IN-1 targets FGFR1-3 with IC50 <100 nM. (US20130338134A1, ex 219)

HJM-561 is a potent and selective EGFR PROTAC with oral bioavailability, capable of overcoming osimertinib-resistant EGFR triple mutations and demonstrating

Gynosaponin V is a useful organic compound for research related to life sciences. The catalog number is T126218 and the CAS number is 1207861-73-1.

Glabralide A is a natural product from plants

Nutlin carboxylic acid is a Nutlin 3-based MDM2 ligand; used with a linker to create PROTACs.

Phototherapeutic agent-1: a light-activated, ROS-generating cancer cell killer with aggregation-induced emission.

Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants ( IC 50 = 0.2-0.7 nM).

SHP2 degrader-1: highly efficient, induces SHP2 degradation & cell apoptosis, shows promise in SHP2-related disease research.

Thalidomide-O-amido-PEG3-C2-NH2 TFA, a cereblon ligand-PEG linker for PROTAC, is synthesized.

MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis.

eGFP circRNA, originally isolated from the jellyfish Aequorea victoria, is a reporter widely utilized for direct detection in mammalian cell culture due to its

PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.

PROTAC PARP/EGFR ligand 1 enables dual PARP EGFR degrader synthesis via PROTAC.

(Rac)-IBT6A HCl: racemic Ibrutinib impurity; for IBT6A dimers/adducts; Ibrutinib is a Btk inhibitor (IC50=0.5nM).

PROTAC VEGFR-2 degrader-2 has minimal VEGFR-2 inhibition (IC50 > 1μM) and low anti-proliferative effect on EA.hy926 cells (IC50 > 100μM).

Microcystin-LF, a phenylalanine variant of Microcystin-LR, is a bacterial metabolite that exhibits cellular toxicity in Caco-2 cells [1] [2].

Mca-Ala-Pro-Lys(Dnp)-OH, a specific quenched fluorogenic substrate for ACE2, enables the detection of ACE2 activity in various tissues including urinary, heart

Chol-N3 is a bioorthogonal chol probe capable of integrating with super-resolution fluorescence microscopy (SRM) to enable direct nanoscale imaging of lipid

3'-O-Angeloylhamaudol is a useful organic compound for research related to life sciences and the catalog number is T124112.

Diacetoxyscirpenol: a fungal mycotoxin causing blood disorders in humans/animals.

Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).

Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.

CAY10736: Anticancer agent, blocks cell growth & migration in various cancers, effective in mouse models.

STING agonist-22 (CF501) boosts vaccines by activating STING, inducing IFN-I and cytokines, aiding in SARS-CoV-2 research.

Ephedrine levulinate: alkaloid, stimulates alpha/beta-adrenergic receptors, boosts norepinephrine release.

RdRP-IN-3, a potential anti-influenza drug candidate, functions by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).

Azido-PEG12-t-butyl ester, a soluble PEG with azide/reactive t-butyl, forms triazoles via Click Chemistry; deprotectable in acid.

TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。

Questiomycin A derivatives 13 is a Questiomycin A derivative.

Darobactin is an antibiotic effective against critical Gram-negative pathogens, demonstrating activity both in vitro and in animal infection models [1].

Cap-dependent endonuclease-IN-12 (EXP-35) is a potent inhibitor with low toxicity, active against H1N1.

Ppack HCl is a peptide that binds thrombin, inhibiting platelet activation (Ki: 0.24 nM). Used as an anticoagulant and to research clotting and inflammation.

PROTAC MDM2 Degrader-3 uses PROTAC tech to efficiently break down MDM2 with a potent inhibitor and E3 ligase ligand.

Mouse IgG3 kappa Isotype Control is a monoclonal antibody serving as an isotype control specifically for mouse IgG3κ antibodies.

OVA Peptide (323-339) is an Ovalbumin epitope crucial for hypersensitivity in BALB/c mice.

Cereblon Ligand-Linker 22: A pomalidomide-based E3 ligase conjugate with a PEG3 linker for PROTACs.

Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.

Thalidomide-NH-PEG4-Ms: cereblon ligand + linker, for PROTAC BCL-XL degrader XZ739.

Oroxin A, a partial PPARγ agonist, activates PPARγ, inhibits α-glucosidase, and has antioxidant properties.

α-conotoxin GI, a conopeptide isolated from the venom of the cone snail Conus geographus, is a competitive antagonist of the muscle-type nicotinic acetylcholine

PD-1/PD-L1 binder, Kd 0.51 μM; blocks interaction in flow cytometry at 1 mg/mL; inhibits tumors, extends mouse survival.

PD-1/PD-L1-IN 5 is an inhibitor of PD-1/PD-L1 protein/protein interaction (IC50 of ≤100 nM).

CAY10735: Anticancer agent; inhibits growth/migration in various cancer cells; reduces tumor in mouse models. IC50=0.674-11.56μM.

Lupinine hydrochloride is a bioactive chemical.

Yimitasvir (Emitasvir) diphosphate，一种针对丙型肝炎病毒(HCV)非结构蛋白5A (NS5A)的口服活性抑制剂，适用于慢性丙型肝炎病毒感染的研究。

Taragarestrant (D-0502) is an oral SERD with potent activity against ER+ breast cancer.

Aflatoxin M1, a toxic metabolite of Aflatoxin B1, is produced by Aspergillus fungi, with a toxicity order: B1 > M1 > G1 > B2 > M2 > G2.