Inhibitors

Lupinine hydrochloride is a bioactive chemical.

Apoptosis Inducer 4 (Compound 12b) is a compound that induces apoptosis and exhibits anticancer properties [1].

Ppack HCl is a peptide that binds thrombin, inhibiting platelet activation (Ki: 0.24 nM). Used as an anticoagulant and to research clotting and inflammation.

PROTAC VEGFR-2 degrader-2 has minimal VEGFR-2 inhibition (IC50 > 1μM) and low anti-proliferative effect on EA.hy926 cells (IC50 > 100μM).

HDAC3/6-IN-2 inhibits HDAC6/3 with IC50s 0.368/0.635 μM; promotes cancer cell apoptosis and histone acetylation.

Mitoquinone-cyclodextrin is a mitochondria-targeted, 1:1 mix of Mitoquinone mesylate and cyclodextrin, aiming to combat oxidative damage.

Antibacterial agent 30 exhibits remarkable in vitro activity against Xoo, as evidenced by its EC50 value of 1.9 μg/mL.

eGFP circRNA, originally isolated from the jellyfish Aequorea victoria, is a reporter widely utilized for direct detection in mammalian cell culture due to its

Antitumor agent-109 (compound 6) is a dual-function inhibitor that targets hyaluronic acid and CD44, which are involved in tumor progression and invasion.

MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis.

SK-575-NEG is a methylated form of SK-575, binds PARP1 (IC50: 2.64 nM), but doesn't induce PARP1 degradation up to 1 μM in cells.

PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2).

m-PEG11-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Thalidomide-O-amido-PEG3-C2-NH2 TFA, a cereblon ligand-PEG linker for PROTAC, is synthesized.

Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.

Compound 17h is a potent antibacterial against VRE and MRSA, reduces MRSA biofilms, and is stable in liver microsomes.

HJM-561 is a potent and selective EGFR PROTAC with oral bioavailability, capable of overcoming osimertinib-resistant EGFR triple mutations and demonstrating

PROTAC eEF2K degrader-1 (11l) targets eEF2K, induces apoptosis in MDA-MB-231 cells, and degrades eEF2K.

Oroxin A, a partial PPARγ agonist, activates PPARγ, inhibits α-glucosidase, and has antioxidant properties.

Microcystin-LY, from Microcystis aeruginosa, is a heptapeptide toxin that triggers oxidative stress by activating the Nrf2 pathway, most effective at 3μM.

BRD73842 is an inhibitor of Plasmodium PI4K .

Antiviral agent 8, surpassing lead compounds crocin-1 and crocin-2, has been identified as a potent and promising candidate with enhanced antiviral activities.

CAY10736: Anticancer agent, blocks cell growth & migration in various cancers, effective in mouse models.

ER degrader 3 targets estrogen receptor, key in cell regulation, potential for cancer research.

Compound 13i is a potent PROTAC BRD4 degrader with IC50s: 29.54 nM (BD1), 3.82 nM (BD2), impedes G2/M progression, and induces apoptosis in MV-4-11 cells.

Glabralide A is a natural product from plants

TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.

Chol-N3 is a bioorthogonal chol probe capable of integrating with super-resolution fluorescence microscopy (SRM) to enable direct nanoscale imaging of lipid

Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.

Fungicide5 is a fungicide candidate targeting succinate dehydrogenase ( K i = 0.095 μM).

AT-1002 TFA, a 6-mer synthetic peptide, functions as a tight junction regulator and absorption enhancer.

M-PEG1-acid, a soluble PEG derivative, has a terminal carboxylic acid for forming amide bonds with primary amines using activators like EDC, DCC.

SIAIS164018, a PROTAC-derived ALK/EGFR degrader from Brigatinib, has IC50s of 2.5 & 6.6 nM; it hinders cancer cell movement and promotes apoptosis.

Stephalonine L is a natural product for research related to life sciences. The catalog number is TN6290 and the CAS number is 2379277-60-6.

Yimitasvir, an oral NS5A inhibitor, treats chronic hepatitis C. Used for research.

PROTAC MDM2 Degrader-3 uses PROTAC tech to efficiently break down MDM2 with a potent inhibitor and E3 ligase ligand.

Yimitasvir (Emitasvir) diphosphate，一种针对丙型肝炎病毒(HCV)非结构蛋白5A (NS5A)的口服活性抑制剂，适用于慢性丙型肝炎病毒感染的研究。

Aflatoxin M1, a toxic metabolite of Aflatoxin B1, is produced by Aspergillus fungi, with a toxicity order: B1 > M1 > G1 > B2 > M2 > G2.

(5R)-Platyphyllone has a wide range of applications in life science related research.

PD-1/PD-L1 binder, Kd 0.51 μM; blocks interaction in flow cytometry at 1 mg/mL; inhibits tumors, extends mouse survival.

Gd-NMC-3, a bimodal imaging probe, exhibits high resolution and sensitivity for tumor imaging with favorable biocompatibility, demonstrating significant

IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.

Questiomycin A derivatives 12 is a Questiomycin A derivative.

ERK1/2 inhibitor 5 targets MAPK pathway, potentially aiding cancer and inflammation research.

Cereblon Ligand-Linker 22: A pomalidomide-based E3 ligase conjugate with a PEG3 linker for PROTACs.

Mitoquinone is a TPP-based, mitochondrially targeted antioxidant .

Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).

Darobactin is an antibiotic effective against critical Gram-negative pathogens, demonstrating activity both in vitro and in animal infection models [1].

Microcystin-LF, a phenylalanine variant of Microcystin-LR, is a bacterial metabolite that exhibits cellular toxicity in Caco-2 cells [1] [2].

TL4830031 (8i), quinolone derivative, Axl inhibitor, IC50: 26 nM, blocks Axl phosphorylation, cell invasion & migration; for cancer research.

Diacetoxyscirpenol: a fungal mycotoxin causing blood disorders in humans/animals.

9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent.

(Rac)-IBT6A HCl: racemic Ibrutinib impurity; for IBT6A dimers/adducts; Ibrutinib is a Btk inhibitor (IC50=0.5nM).

Gynosaponin V is a useful organic compound for research related to life sciences. The catalog number is T126218 and the CAS number is 1207861-73-1.

Moxetumomab pasudotox (CAT 8015), an anti-CD22 immunotoxin for researching hairy cell leukemia.

Nutlin carboxylic acid is a Nutlin 3-based MDM2 ligand; used with a linker to create PROTACs.

Elamipretide acetate (MTP 131), a small tetrapeptide, targets mitochondria to reduce toxic species and stabilize cardiolipin.

Anticancer agent 11 suppresses angiogenesis and induces DNA cross-links for broad-spectrum efficacy.

α-conotoxin GI, a conopeptide isolated from the venom of the cone snail Conus geographus, is a competitive antagonist of the muscle-type nicotinic acetylcholine

Immuno-Oncology Screening Library with 90+ cancer/immunology compounds in 96-well format, 10 mM DMSO solutions, including various target modulators.

PD-1/PD-L1-IN 5 is an inhibitor of PD-1/PD-L1 protein/protein interaction (IC50 of ≤100 nM).