Inhibitors

SHP2 degrader-1: highly efficient, induces SHP2 degradation & cell apoptosis, shows promise in SHP2-related disease research.

Thalidomide-C2-amido-C2-COOH is a compound that includes a CRBN ligand for the E3 ubiquitin ligase, as well as a linker.

α-conotoxin GI, a conopeptide isolated from the venom of the cone snail Conus geographus, is a competitive antagonist of the muscle-type nicotinic acetylcholine

Phototherapeutic agent-1: a light-activated, ROS-generating cancer cell killer with aggregation-induced emission.

PROTAC MDM2 Degrader-3 uses PROTAC tech to efficiently break down MDM2 with a potent inhibitor and E3 ligase ligand.

Funobactam is a potent β-lactamase inhibitor.

Antibacterial agent 30 exhibits remarkable in vitro activity against Xoo, as evidenced by its EC50 value of 1.9 μg/mL.

Nutlin carboxylic acid is a Nutlin 3-based MDM2 ligand; used with a linker to create PROTACs.

NT 2 Toxin is a useful organic compound for research related to life sciences. The catalog number is T124258 and the CAS number is 76348-84-0.

Mitoquinone is a TPP-based, mitochondrially targeted antioxidant .

Antibacterial agent 28 targets MRSA with 0.5-2 μg/mL MIC, showing high potential.

AS-604850: PI3Kγ inhibitor, ATP-competitive, IC50=2.5μM, 30x> PI3Kδ/β, 18x> PI3Kα.

Sirtratumab vedotin (ASG15-ME) is an antibody-drug conjugate (ADC) that links a SLITRK6-specific human gamma 2 antibody (Igγ2) to the microtubule disruption agent monomethyl auristatin E (MMAE) through a protease-cleavable linker [1].

Cap-dependent endonuclease-IN-12 (EXP-35) is a potent inhibitor with low toxicity, active against H1N1.

TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。

Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).

(Rac)-IBT6A HCl: racemic Ibrutinib impurity; for IBT6A dimers/adducts; Ibrutinib is a Btk inhibitor (IC50=0.5nM).

TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.

IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.

Anticancer agent 11 suppresses angiogenesis and induces DNA cross-links for broad-spectrum efficacy.

1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.

OVA Peptide (323-339) is an Ovalbumin epitope crucial for hypersensitivity in BALB/c mice.

SIAIS164018, a PROTAC-derived ALK/EGFR degrader from Brigatinib, has IC50s of 2.5 & 6.6 nM; it hinders cancer cell movement and promotes apoptosis.

HJM-561 is a potent and selective EGFR PROTAC with oral bioavailability, capable of overcoming osimertinib-resistant EGFR triple mutations and demonstrating

PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2).

TL4830031 (8i), quinolone derivative, Axl inhibitor, IC50: 26 nM, blocks Axl phosphorylation, cell invasion & migration; for cancer research.

Mitoquinone-cyclodextrin is a mitochondria-targeted, 1:1 mix of Mitoquinone mesylate and cyclodextrin, aiming to combat oxidative damage.

Taragarestrant (D-0502) is an oral SERD with potent activity against ER+ breast cancer.

GEM-5, a gemcitabine conjugate with HIF-1α inhibitor YC-1 (IC50=30 nM), down-regulates HIF-1α, up-regulates p53, and induces A2780 cell apoptosis.

SK-575-NEG is a methylated form of SK-575, binds PARP1 (IC50: 2.64 nM), but doesn't induce PARP1 degradation up to 1 μM in cells.

Elamipretide TFA (RX-31 TFA) is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide[1].