Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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Nitrendipine Propyl Ester
CAS:Controlled Product<p>Applications Nitrendipine Propyl Ester is an analogue of the antihypertensive drug Nitrendipine (N490150). Also, Nitrendipine Propyl Ester is an impurity of antihypertensive Lercanidipine (L179000). Lercanidipine impurity A.<br>References Ashimori, A., et al.: Chem. Pharm. Bull., 39, 108 (1991), Baindur, N., et al.: J. Med. Chem., 36, 3743 (1993), Zhang, B., et al.: Bioorg. Med. Chem. Lett., 20, 805 (2010),<br></p>Formula:C19H22N2O6Color and Shape:NeatMolecular weight:374.39Prothipendyl-d6 Hydrochloride
CAS:Controlled Product<p>Applications A labelled Phenothiazine (P318040) analog. Antipsychotic.<br>References Sartorelli, A.C., et al.: Experientia, 21, 457 ( 1965),<br></p>Formula:C16H13D6N3S•HClColor and Shape:NeatMolecular weight:291.4436466-Bromo-2-phenylquinoline-4-carboxylic acid
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:328.16500854492194-Methyl-7-morpholino-2H-pyrano[2,3-b]pyridin-2-one
CAS:Purity:98% GC,TMolecular weight:246.26600646972656(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS:Controlled Product<p>Applications (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012); Sakashita, H., et al.: Bioorg. Med. Chem., 15, 641 (2007)<br></p>Formula:C13H20N2O4SColor and Shape:NeatMolecular weight:300.37Des [3-(1-Dimethylamino)ethyl] 3-Acetyl Rivastigmine
CAS:Controlled Product<p>Impurity Rivastigmine EP Impurity C; USP Related Compound D<br>Applications Des [3-(1-dimethylamino)ethyl] 3-acetyl Rivastigmine (Rivastigmine EP Impurity C) is a derivative of Rivastigmine (Tartrate: R541000), and acetylcholinesterase inhibitor that is commonly used to treat dementia associated with Parkinson’s disease and Alzheimer’s disease.<br>References Emre, M., et al.: New. Engl. J. Med., 351, 2509 (2004); Polinsky, R.: Clin. Ther., 20, 634 (1998); Wilkinson, D., et al.: Int. J. Clin. Pract., 56, 441 (2001)<br></p>Formula:C12H15NO3Color and Shape:Off-WhiteMolecular weight:221.25Tolvaptan-d7
CAS:Controlled Product<p>Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Formula:C26H18D7ClN2O3Color and Shape:NeatMolecular weight:455.982-([1,1'-Biphenyl]-4-yl)-6-fluoroquinoline-4-carboxylic acid
CAS:Purity:98%Molecular weight:343.356994628906256-Amino-1,3-dimethyluracil
CAS:Controlled Product<p>Applications 6-Amino-1,3-dimethyluracil is used as a reagent in the synthesis of new pyrimidine and caffeine derivatives that display highly potential antitumor activity. It is also used as a starting material in the synthesis of fused pyrido-pyrimidines.<br>References Abu-Hashem, A., et al.: Lett. Drug. Des. Discov., 12, 471 (2015); Azev, Y., et al.: Mendeleev Commun., 25, 310 (2015)<br></p>Formula:C6H9N3O2Color and Shape:Light YellowMolecular weight:155.1510H-Phenothiazine 5-Oxide
CAS:<p>Applications 10H-Phenothiazine 5-Oxide is a by-product in the synthesis of Phenothiazine S,S-Dioxide (P297600). Phenothiazine S,S-Dioxide is a derivative of Phenothiazine (P318040), a key component of antipsychotic and antihistaminic drugs.<br>References Bansode, T., et al.: Eur. J. Med. Chem., 44, 5094 (2009); Baell, J., et al.: J. Med. Chem., 53, 2719 (2010); Howard, P., et al.: Environ. Sci. Technol., 44, 2277 (2010); Koren, J., et al.: J. Biol. Chem., 285, 2498 (2010); Amobi, N., et al.: Eur. J. Pharmacol., 627, 285 (2010)<br></p>Formula:C12H9NOSColor and Shape:Light Beige To Light BrownMolecular weight:215.272-[5-(Trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
CAS:Purity:97.0%Molecular weight:263.19000244140625Nitrendipine Dipropyl Ester
CAS:<p>Applications Nitrendipine Dipropyl Ester is an analogue of the antihypertensive drug Nitrendipine (N490150). Also, Nitrendipine Dipropyl Ester is an impurity of antihypertensive Lercanidipine (L179000). Lercanidipine impurity B.<br>References Meyer, H., et al.: Arzneim.-Forsch., 31, 407 (1981),<br></p>Formula:C21H24N2O6Color and Shape:NeatMolecular weight:400.42(R)-3-Aminopiperidine Dihydrochloride
CAS:Controlled Product<p>Applications (R)-3-Aminopiperidine Dihydrochloride has been used as a reactant for the preparation of dipeptidyl peptidase IV inhibitors derived from Alogliptin.<br>References Xie, Hui., et. al.: Eur. J. Med. Chem., 68, 312 (2013)<br></p>Formula:C5H14Cl2N2Color and Shape:NeatMolecular weight:173.084,5-dimethyl-N-(pyridin-4-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Purity:95.0%Molecular weight:269.36999511718758-chloro-2-pyridin-2-ylquinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:284.70001220703125N-(3-Chloro-4-fluorophenyl)-N-(7-methoxy-6-nitroquinazolin-4-yl)acetamide
CAS:Purity:97.0%Molecular weight:390.760009765625Sodium Azide
CAS:<p>Applications Sodium azide is commonly used as a preservative in aqueous laboratory reagents and biological samples. Sodium azide’s toxicity can be attributed to its role as a reversible inhibitor of mitochondrial respiration and insulin secretion in human pancreatic cells. Acts as a catalyst for: Oxidative decarboxylation & Michael addition reactions.Used as a reagent for synthesis of Blue fluorescent copolymers; Metal phosphonates & Arenes via aminations. Actively involved in regioselective synthesis of prianosin B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, S. & Lamm, S.: Int. J. Toxicol., 22, 175 (2003); Misler, S., et al.: Pflügers Archiv., 421, 289 (1992)<br></p>Formula:N3·NaColor and Shape:White To Off-WhiteMolecular weight:65.012-Ethoxy-5-[(morpholine-4-carbonyl)-amino]-benzenesulfonyl chloride
CAS:Formula:C13H17ClN2O5SPurity:98%Color and Shape:SolidMolecular weight:348.82',6'-Picolinoxylidide
CAS:Controlled ProductFormula:C14H14N2OColor and Shape:NeatMolecular weight:226.27Riluzole
CAS:<p>Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.</p>Formula:C8H5F3N2OSPurity:99.71% - 99.88%Color and Shape:PowderMolecular weight:234.23-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid
CAS:Purity:95.0%Molecular weight:280.28298950195316-(Tetrahydro-2H-pyran-4-yloxy)pyridine-2-carboxylic acid
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:223.227996826171883-(1,3-benzothiazol-2-yl)pyrazine-2-carboxylic acid
CAS:Purity:95.0%Molecular weight:257.26998901367192-(3-pyridinyl)-5,6-dihydro-1,3-benzothiazol-7(4H)-one
CAS:Purity:95.0%Molecular weight:230.28999328613285-(4-Fluorophenyl)-2-methyl-4-(4-pyridyl)-1h-pyrimidin-6-one
CAS:Purity:98%Molecular weight:281.29000854492194-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
CAS:Purity:95.0%Color and Shape:Liquid, No data available.Molecular weight:361.7600097656252-PYRAZINECARBOXAMIDE, 5-[2-METHOXY-4-[[[2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHYL]AMINO]METHYL]PHENOXY]-
CAS:Purity:95.0%Molecular weight:386.4519958496094Etoricoxib N1’-Oxide
CAS:Controlled Product<p>Applications Etoricoxib N1’-Oxide is an impurity of Etoricoxib (E934100).<br>References Friesen, R., et al.: Bioorg. Med. Lett., 8, 2777 (1998), Botting, J., et al.: Drugs of Today, 35, 225 (19990, Talley, J., et al.: J. Med. Chem., 43, 775 (2000),<br></p>Formula:C18H15ClN2O3SColor and Shape:NeatMolecular weight:374.84Donafenib
CAS:<p>Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,</p>Formula:C21H13ClD3F3N4O3Purity:99.88%Color and Shape:SolidMolecular weight:467.841-(2-Cyanoethyl)-5-(trifluoromethyl)pyrid-2-(1H)-one
CAS:Purity:95.0%Molecular weight:216.16299438476562Ethyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate
CAS:Purity:95.0%Molecular weight:335.377990722656251-[3'-(Trifluoromethyl)phenyl]-3-[5''-(5'''-(trifluoromethypyridin-2'''-yl)-[1",2",4"]oxadiazol-3''-ylmethyl]urea
CAS:Purity:95.0%Molecular weight:431.298Lansoprazole
CAS:<p>Applications Used as a gastric proton pump inhibitor. An antiulcerative. May limit the severity of tuberculosis (see Chem. and Eng. News. p. 28 July 20 (2018)).<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006), Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Formula:C16H14F3N3O2SColor and Shape:White To Light BeigeMolecular weight:369.362-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:379.4630126953125Ref: 10-F462203
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire250mgTo inquire4-[6-(3-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Purity:95.0%Molecular weight:278.31500244140625Ethyl 2-(4-fluorobenzamido)-4-(p-tolyl)thiophene-3-carboxylate
CAS:Purity:98%Molecular weight:383.44000244140625Methyl 3-(4-bromophenyl)-1-(m-tolyl)-1H-pyrazole-5-carboxylate
CAS:Molecular weight:371.2340087890625Nitisinone
CAS:<p>Applications Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.<br>References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),<br></p>Formula:C14H10F3NO5Color and Shape:NeatMolecular weight:329.233-QUINOLINECARBOXYLIC ACID, 7-[(2-AMINOETHYL)AMINO]-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-4-OXO-
CAS:Purity:97.0%Molecular weight:335.33499145507814,4',4''-(1H-Imidazole-2,4,5-triyl)tripyridine
CAS:Purity:97%Color and Shape:SolidMolecular weight:299.3370056152344Robenacoxib
CAS:<p>Applications A novel COX-2 selective inhibitor, as a nonsteroidal analgesic, anti-inflammatory and antipyretic agent.<br>References McCormack, K., et al.: Drugs, 41, 533 (1991), Giraudel, J., et al.: Br. J. Pharmacol., 146, 642 (2005), Brune, K., et al.: Rheumatology, 46, 911 (2007),<br></p>Formula:C16H13F4NO2Color and Shape:Off-WhiteMolecular weight:327.27[2-(4-Methyl-2-phenylpiperazin-1-yl)phenyl]methanol
CAS:Controlled Product<p>Applications [2-(4-Methyl-2-phenylpiperazin-1-yl)phenyl]methanol is used in the preparation of azepine.<br>References Lypacewicz, Maria K. et al., Pol.(1998);<br></p>Formula:C18H22N2OColor and Shape:White To Light BeigeMolecular weight:282.382,5-Diamino-3-fluoro-4-(trifluoromethyl)pyridine
CAS:Formula:C6H5F4N3Purity:95.0%Color and Shape:SolidMolecular weight:195.1212-(4-aminophenyl)-3-pyridinol dihydrochloride
CAS:Formula:C11H12Cl2N2OPurity:95.0%Color and Shape:SolidMolecular weight:259.132-[5-(2-Fluorobenzoyl)-2-thienyl]acetonitrile
CAS:Formula:C13H8FNOSColor and Shape:SolidMolecular weight:245.27Tert-Butyl 4-(8-amino-5-isoquinolinyl)-1-piperazinecarboxylate
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:328.4159851074219N-Methyl β-Hydroxyl Phentermine
CAS:<p>Applications N-Methyl β-Hydroxyl Phentermine is derived from 2-Nitropropane (N519600), which is an oxidative stress-inducing agent and also a carcinogen. It is used in the induction of DNA polymerase β-dependent base excision repair in response to oxidative stress in the liver.<br>References Cabelof, D.C., et al.: Carcinogenesis,23, 1419 (2002); Kreis, P., et al.: Carcinogenesis, 21, 295 (2000)<br></p>Formula:C11H17NOColor and Shape:Off-WhiteMolecular weight:179.264-(2-Keto-1-benzimidazolinyl)piperidine
CAS:Controlled Product<p>Applications 4-(2-Keto-1-benzimidazolinyl)piperidine is an impurity of Pimozide (P447800). Pimozide impurity A.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andersson, L., et al.: J. Lipid Res., 36, 1392 (1995), Andersson, M., et al.: J. Biol. Chem., 2005, 280, 27578 (2005),<br></p>Formula:C12H15N3OColor and Shape:WhiteMolecular weight:217.275-(4-(2-(5-Ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione
CAS:Purity:97.0%Molecular weight:370.4200134277344Ref: 10-F540283
1gTo inquire2mg79.00€5mg128.00€10mg94.00€25mg120.00€50mg227.00€100mg412.00€250mgTo inquire4-(4-Bromophenyl)pyrazole
CAS:Formula:C9H7BrN2Purity:95.0%Color and Shape:SolidMolecular weight:223.0733-AMINO-5-(TRIFLUOROMETHYL)PYRAZOLE HYDROCHLORIDE
CAS:Formula:C4H5ClF3N3Purity:≥95%Color and Shape:SolidMolecular weight:187.552-[1-Methyl-5-(trifluoromethyl)pyrazol-3-yl]-thiophene-5-carboxaldehyde
CAS:Formula:C10H7F3N2OSColor and Shape:SolidMolecular weight:260.237-chloro-4-methyl-N-(pyridin-4-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Purity:95.0%Molecular weight:289.7799987792969Dexpramipexole
CAS:<p>Dexpramipexole ((R)-Pramipexole) is a mitochondrial protective agent that maintains mitochondrial function and energy production.</p>Formula:C10H17N3SPurity:99.78%Color and Shape:SolidMolecular weight:211.33(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS:<p>Applications (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an intermediate used to prepare pyrazolo-pyrimidine compounds as inhibitors of Bruton's tyrosine kinase. It is also an intermediate for Ibrutinib (I124970) derivatives.<br>References Chen, W., et al.: PCT Int. Appl. (2011), WO 2011046964 A2 20110421<br></p>Formula:C22H22N6OColor and Shape:White To Light YellowMolecular weight:386.451-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonylethylamine (~10% inorganics)
CAS:Controlled Product<p>Impurity Apremilast EP Impurity H<br>Applications 1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonylethylamine is used in the enantioselective synthesis of Apremilast (A729700) aminosulfone using catalytic asymetric hydrogenation. Apremilast EP Impurity H<br>References Ruchelman, A., et al.: Tetrahedron Asymmetr., 26, 553-559 (2015);<br></p>Formula:C12H19NO4SColor and Shape:NeatMolecular weight:273.353-Methyl-1H-indene-2-carboxylic acid
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:174.199005126953124-(2H-1,3-benzodioxol-5-yl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS:Purity:95.0%Molecular weight:297.32998657226564-(2,4-Difluorobenzoyl)piperidine Hydrochloride
CAS:Controlled Product<p>Applications Risperidone intermediate.<br></p>Formula:C12H13F2NO·ClHColor and Shape:NeatMolecular weight:261.69553-(3,5-Dimethyl-pyrazol-1-yl)-benzoic acid
CAS:Formula:C12H12N2O2Purity:95.0%Color and Shape:SolidMolecular weight:216.248(9)-Methoxy-1,3-dimethyl-12-thioxopyrido[1’,2’:3,4]imidazo[1,2-a]benzimidazol-2-(12H)-one (Mixture of Regioisomers)
CAS:Controlled Product<p>Impurity Omeprazole EP Impurity F+Omeprazole EP Impurity G<br>Stability Sample unstable under MS condition<br>Applications 8(9)-Methoxy-1,3-dimethyl-12-thioxopyrido[1’,2’:3,4]imidazo[1,2-a]benzimidazol-2-(12H)-one(Mixture of Regioisomers) (Omeprazole EP Impurity F+Omeprazole EP Impurity G) is a mixture of regioisomers of Omeprazole Impurity.<br>References Rackur, G., et al.: Biochem. Biophys. Res. Commmun., 128, 477 (1985),<br></p>Formula:C16H13N3O2SColor and Shape:NeatMolecular weight:311.366-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione
CAS:Purity:98%Molecular weight:230.14599609375Retigabine
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A new experimental anticonvulsant drug. Anxiolytic.<br>References Dailey, J.W.; et al.: Neuroscience Lett., 195, 77 (1995), Korsgaard, M.P.G., et al.: J. Pharmacol. Exp. Ther., 314, 1, 282 (2005),<br></p>Formula:C16H18FN3O2Color and Shape:NeatMolecular weight:303.333-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:303.3179931640625Ethyl (3-cyano-4,6-dimethylpyridin-2-ylamino)acetate
CAS:Formula:C12H15N3O2Purity:95.0%Color and Shape:SolidMolecular weight:233.2711-(tert-Butoxycarbonyl)-4-(1H-pyrazol-1-yl)piperidine-4-carboxylic acid
CAS:Purity:95%Molecular weight:295.33898925781252-(CHLOROMETHYL)-3,5-DIMETHYL-4-METHOXYPYRIDINE
CAS:Purity:97.0%Color and Shape:Liquid, No data available.Molecular weight:185.64999389648438
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