Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65578 products of "Quinazoline and Quinoline Derivatives"
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2-(4-(3-(2',8-Bis(trifluoromethyl)-10H-[3,10'-biphenothiazin]-10-yl)propyl)piperazin-1-yl)ethanol
Controlled ProductFormula:C35H32F6N4OS2Color and Shape:NeatMolecular weight:702.78N-Cyano-3-(cyanoamino)-N'-methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-imidamide (Cimetidine Impurity)
CAS:Controlled Product<p>Impurity Cimetidine EP Impurity H<br>Applications N-Cyano-3-(cyanoamino)-N'-methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-imidamide (Cimetidine EP Impurity H) is an impurity of Cimetidine (C441650), an H2-receptor antagonist that is used for the treatment and prevention of stress-induced gastroduodenal lesions.<br>References Burland, W., et al.: Brit. J. Clin. Pharm., 2, 481 (1975); Kauffman, G. & Morton, I.: Gastroenterology, 75, 1099 (1978); Peura, D. & Johnson, L.: Ann. Int. Med., 103, 173 (1985)<br></p>Formula:C10H18N8S2Color and Shape:Off-WhiteMolecular weight:314.43(E/Z)-Tamoxifen-d5
CAS:Controlled Product<p>Applications Mixture of labelled Tamoxifen and its (E)-isomer.<br></p>Formula:C26H24D5NOColor and Shape:Off White SolidMolecular weight:376.55Ethyl 2-((1-(furan-2-carboxamido)-2-oxo-2-(p-tolyl)ethyl)amino)-4-phenylthiophene-3-carboxylate
CAS:Purity:98%Molecular weight:488.55999755859375rac-erythro Methylphenidate Hydrochloride
CAS:Controlled Product<p>Applications The erythro isomers have been shown to exhibit very little therapeutic effect and contribute mainly to the toxic hypertensive effects of this drug.Controlled substance.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981), Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>Formula:C14H19NO2·ClHColor and Shape:NeatMolecular weight:269.773-Phenyl-4-thioxo-3,4-dihydrophthalazine-1-carboxylic acid
CAS:Purity:98%Molecular weight:282.32000732421875Diphenylglycoluril
CAS:Controlled Product<p>Applications Diphenylglycoluril is a bicyclic bis-urea derivative. Studies suggest that it has potential anticonvulsant activity.Diphenylglycoluril is also an impurity found in the synthesis of Phenytoin (D491650).<br>References Khlebnikov, A.I. et al.: Pharm. Chem. J., 36, 240 (2002); Babkibayev, A.A. et al.: Pharm. Chem. J., 8, 15 (1994);<br></p>Formula:C16H14N4O2Color and Shape:NeatMolecular weight:294.31Trametinib Impurity-I
CAS:Controlled ProductFormula:C26H23FIN5O5Color and Shape:NeatMolecular weight:631.394(R)-(-)-Chlorpheniramine Maleate
CAS:Formula:C16H19ClN2•C4H4O4Color and Shape:NeatMolecular weight:274.7911607Cyamemazine-d6
CAS:Controlled Product<p>Applications Labelled Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966), Miller, L., et al.: J. Pharmacol. Exp. Ther., 246, 170 (1988), Podhorna, J., et al.: Curr. Pharm. Des., 8, 23 (2002), Hameg, A., et al.: Biochem. Pharmacol., 65, 435 (2003),<br></p>Formula:C19H15D6N3SColor and Shape:NeatMolecular weight:329.49Rivaroxaban Diol
CAS:Controlled Product<p>Applications A metabolite of Rivaroxaban (R538000).<br>References Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005), Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005), Biemond, B., et al.: Thromb. Haemost., 97, 471 (2007), Lang, D., et al.: Drug Metab. Dispos., 37, 1046 (2009),<br></p>Formula:C19H20ClN3O6SColor and Shape:White To Off-WhiteMolecular weight:453.9Darunavir-d9
CAS:Controlled Product<p>Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>Formula:C272H9H28N3O7SColor and Shape:Off-White To Light BeigeMolecular weight:556.724-(thiophen-2-yl)-2,3-dihydro-1H-1,5-benzodiazepine
CAS:Purity:95.0%Molecular weight:228.30999755859375Dihydro-Axitinib
CAS:<p>Applications Dihydro-Axitinib is a useful intermediate for the preparation of axitinib; an antitumor agent.<br>References Chekal, B. P., et al.: Org. Process Res. Dev., 18, 266 (2014)<br></p>Formula:C22H20N4OSColor and Shape:White To Off-WhiteMolecular weight:388.496-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
CAS:Controlled Product<p>Impurity Risperidone EP Impurity M; Paliperidone USP Related Compound B<br>Applications 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride (Risperidone EP Impurity M; Paliperidone USP Related Compound B) is a novel antiproliferative agent.<br>References Benaka P. et al.: Invest. New Drugs., 27, 534 (2009);<br></p>Formula:C12H13FN2O·ClHColor and Shape:NeatMolecular weight:256.70(R)-Lisinopril Sodium Salt
CAS:<p>Applications R,S,S-Isomer of Lisinopril (L468985).<br>References Goa, K.L., et al.: Drugs, 52, 564 (1996), Chaturvedi, N., et al.: Lancet, 351, 28 (1998)<br></p>Formula:C21H31N3NaO5Color and Shape:NeatMolecular weight:428.483-Chloromethyl-5-methylpyridine Hydrochloride
CAS:Controlled Product<p>Applications 3-Chloromethyl-5-methylpyridine is an intermediate in the synthesis of Rupatadine (R701650).<br>References Merlos, M., et al.: Pharmacol. Exp. Therap., 280, 114 (1997), Bell, I., et al.: J. Med. Chem., 41, 2146 (1998),<br></p>Formula:C7H8ClN·ClHColor and Shape:White To BeigeMolecular weight:178.065-Hydroxy Omeprazole Sodium Salt
CAS:<p>Stability Hygroscopic<br>Applications The main metabolite of Omeprazole.<br>References Renberg, L., et al.: Drug Metab. Dispos., 17, 69 (1989), Calabresi, L., et al.: Pharmacol. Res., 49, 493 (2004), Yin, O., et al.: J. Clin. Pharmacol., 44, 582 (2004),<br></p>Formula:C17H18N3NaO4SColor and Shape:White To Light YellowMolecular weight:383.40Teneligliptin Sulfoxide (Mixture of Diastereomers)
Controlled Product<p>Applications Teneligliptin Sulfoxide, is an impurity of Teneligliptin (T018300) which is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. Tenegliptin is eliminated from the via excretion, and has a half-life of 24.2 hours in the human body.<br>References Goda, M. & Kadowaki, T.: Drugs Today, 49, 615 (2013); Kishimoto, M.: Diabetes Metab. Syndr. Obes., 6, 187 (2012)<br></p>Formula:C22H30N6O2SColor and Shape:NeatMolecular weight:442.588-chloro-2-(3-methylphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:297.739990234375Benzidine
CAS:Controlled Product<p>Applications Potentially mutagenic compound. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dairou, J., et al.: Toxicol. App. Pharmacol., 236, 366 (2009), Toropov, A., et al.: Chem. Biol. Drug Design, 73, 482 (2009),<br></p>Formula:C12H12N2Purity:95%Color and Shape:Tan Or Dark Grey To BlackMolecular weight:184.243’-(2-Fluorophenyl) Ezetimibe
CAS:Controlled Product<p>Impurity Ezetimibe o-Fluorobenzene Isomer (USP)<br>Applications 3’-(2-Fluorophenyl) Ezetimibe is an impurity of Ezetimibe (E975005), an antihyperlipoproteinemic and a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C24H21F2NO3Color and Shape:White To Off-WhiteMolecular weight:409.43N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
CAS:Controlled Product<p>Applications N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to increase white blood cell levels in blood and hematopoietic progenitor cells in bone marrow.<br></p>Formula:C19H16N2O5Color and Shape:NeatMolecular weight:352.343-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:Controlled Product<p>Impurity Paliperidone USP Related Compound C<br>Applications Paliperidone USP Related Compound C<br></p>Formula:C11H15ClN2O2Color and Shape:Light Yellow To BrownMolecular weight:242.703-(4-Fluorophenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde
CAS:Purity:95.0%Molecular weight:266.27499389648445-Hydroxypyrazine-2-carboxylic Acid
CAS:<p>Applications A versatile building block for the synthesis of new antituberculous agents. A metabolite of Pyrazinamide (P840600).<br>References Wieser, M. et al.: Appl. Microbiol. Biotech., 48, 174 (1997); Lacroix, C. et al.: Eur. J. Clin. Pharmacol., 36, 395 (1989);<br></p>Formula:C5H4N2O3Color and Shape:Light YellowMolecular weight:140.10N”Nitrosoketamine
CAS:Controlled ProductFormula:C13H15ClN2O2Color and Shape:White To Light YellowMolecular weight:266.723Prochlorperazine Sulfoxide-d3
CAS:Controlled Product<p>Applications A labelled metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>Formula:C202H3H21ClN3OSColor and Shape:Off WhiteMolecular weight:392.96Desbutyl Dronedarone Hydrochloride
CAS:<p>Impurity Dronedarone USP Related Compound A<br>Applications A metabolite of Dronedarone (D679445). Dronedarone impurity D. Dronedarone USP Related Compound A.<br>References Bolderman, R.W. et al.: J Chrom. B:Anal. Tech. Biomed. Life Sci., 887, 1727 (2009); Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009);<br></p>Formula:C27H36N2O5S·ClHColor and Shape:NeatMolecular weight:537.11Boc-3-hydroxy-1-adamantyl-D-glycine
CAS:Controlled Product<p>Applications Boc-3-hydroxy-1-adamantyl-D-glycine is used in the preparation of a Saxagliptin intermediate.<br>References Hanson, R.L., et. al.: Adv. Scyn. Catal., 349, 1369 (2007)<br></p>Formula:C17H27NO5Color and Shape:NeatMolecular weight:325.4Adrafinil
CAS:Controlled ProductFormula:C15H15NO3SColor and Shape:Off-White Light Orange ColourMolecular weight:289.35Tazarotene Sulfone
CAS:Controlled Product<p>Applications Tazarotene Sulfone is a derivative of Tazarotene (T010050) that has been used for treating skin disorders.<br></p>Formula:C21H21NO4SColor and Shape:NeatMolecular weight:383.464-(3-Aminophenyl)-3-morpholinone
CAS:Controlled Product<p>Applications 4-(3-Aminophenyl)-3-morpholinone is an intermediate during the preparation of imidazothiazoles as protein kinase inhibitors for treating cancers.<br>References Bamaung, N., et al.: PCT Int. Appl. (2009), WO 2009070516 A1 20090604.<br></p>Formula:C10H12N2O2Color and Shape:NeatMolecular weight:192.2142-(chloromethyl)-5-(5-methylthiophen-2-yl)-1H,4H-thieno[2,3-d]pyrimidin-4-one
CAS:Purity:95%Molecular weight:296.7900085449219Diethyl Rivastigmine
CAS:Controlled Product<p>Applications An impurity in Rivastigmine (R541000), a cholinesterase inhibitor.<br>References Tse, F., et al.: Pharm. Res., 15, 1614 (1998), Melchiorre, C., et al.: J. Med. Chem., 47, 5945 (2004), Srinivasu, M., et al.: J. Pharm. Biomed. Anal., 37, 57 (2005),<br></p>Formula:C15H24N2O2Color and Shape:NeatMolecular weight:264.3633Fenfluthrin
CAS:Controlled Product<p>Applications Fenfluthrin can be used in agricultural use and as analyte in analytical/biological study of retrospective screening of relevant pesticide metabolites in food using liquid chromatography high resolution mass spectrometry and accurate-mass databases of parent molecules and diagnostic fragment ions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Polgar, L., et al.: J. Chromatogr. A., 1249, 83-91 (2012)<br></p>Formula:C15H11Cl2F5O2Color and Shape:Off-WhiteMolecular weight:389.14(+/-)-4-Hydroxy Mephenytoin
CAS:Controlled Product<p>Applications CYP2C19 metabolite of Mephenytoin.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980)<br></p>Formula:C12H14N2O3Color and Shape:White SolidMolecular weight:234.25N-nitroso Rasagiline
CAS:Controlled ProductFormula:C12H12N2OColor and Shape:NeatMolecular weight:200.237Fingolimod-d4 Hydrochloride
CAS:Controlled Product<p>Applications A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C19H30D4ClNO2Color and Shape:NeatMolecular weight:347.96Salsalate-d8
CAS:Controlled Product<p>Applications Isotope labelled Nonacetylated aspirin analog. Analgesic, anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, L.L., et al.: J. Pharm. Sci., 69, 1268 (1980), Dromgoole, S.M., et al.: J. Pharm. Sci., 73, 1657 (1984),<br></p>Formula:C14H2D8O5Color and Shape:NeatMolecular weight:266.28Mosapride Citric Amide Disodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Disodium salt of Mosapride (M731000) derivative.<br>References Yoshida, N., et al.: Arch. Int. Pharmacodyn. Ther., 300, 51 (1989), Yatera, S., et al.: Japan. Pharmacol. Ther., 21, 21 (1993), Ruth, M., et al.: Aliment Pharmacol. Ther., 12, 35 (1998),<br></p>Formula:C27H29ClFN3Na2O9Color and Shape:NeatMolecular weight:639.962-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)acetohydrazide
CAS:Purity:95.0%Molecular weight:253.610000610351565-Desmethyl-3-methyl Leflunomide
CAS:Controlled Product<p>Impurity Leflunomide EP Impurity E<br>Applications 5-Desmethyl-3-methyl Leflunomide (Leflunomide EP Impurity E) is the 3-methyl-isomer of Leflunomide (L322750), as a poisonous impurity.<br></p>Formula:C12H9F3N2O2Color and Shape:NeatMolecular weight:270.21R-(+)-Norketamine hydrochloride
CAS:Controlled Product<p>Applications R-(+)-Norketamine is the main metabolite of ketamine (K165300) and is also a non-competitive NMDA receptor antagonist found in the rat cortex and spinal cord models.<br>References Ebert, B., et al.: Eur. J. Pharmacol., 333, 99 (1997); Stephen, R., et al.: Life. Sci., 69, 2051 (2001)<br></p>Formula:C12H14ClNO•(HCl)Color and Shape:NeatMolecular weight:260.16Flibanserin Hydrochloride
CAS:Controlled Product<p>Applications Flibanserin is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women (1,2).<br>References 1) Gelez, H., et. al.: (2013) Psychopharmacology 230 :639-52.2) Katz, M., et. al.: (2013) J. Sex. Med. 10, 1807-15<br></p>Formula:C20H21F3N4O·ClHColor and Shape:NeatMolecular weight:426.86Pimozide
CAS:Controlled Product<p>Applications Pimozide is a D2 dopamine receptor antagonist that binds to the cloned 5-HT7 receptor with high affinity (1,2,3,4). Pimozide is also a Ca2+ channel antagonist. Pimozide is used as an antipsychotic.<br>References (1) Nikonenko, I., et al.: Mol. Pharmacol., 68, 84 (2005) (2) Mariot, P., et al.: J. Biol. Chem., 277, 10824 (2002) (3) Liu, J., et al.: Br. J. Pharmacol., 126, 245 (1999) (4) Santi, C., et al.: J. Neurosci., 22, 396 (2002)<br></p>Formula:C28H29F2N3OColor and Shape:Off-WhiteMolecular weight:461.552-(4-(Methylsulfonamido)phenoxy)acetic Acid
CAS:Controlled Product<p>Applications 2-(4-(Methylsulfonamido)phenoxy)acetic Acid is a metabolite of antiarrhythmic drug Dofetilide (D525700), which is a is a potassium channel blocker.<br>References Smith, D., et al.: Xenobiotica, 22, 709 (1992); Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Walker, D., et al.: Drug Metab. Dispos., 24, 447 (1996); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>Formula:C9H11NO5SColor and Shape:NeatMolecular weight:245.255-Chloro-2-methoxypyridin-3-ol
CAS:Formula:C6H6ClNO2Purity:95.0%Color and Shape:SolidMolecular weight:159.574-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol
CAS:Purity:98%Molecular weight:361.489013671875O-Desmethyl Indomethacin
CAS:Controlled Product<p>Applications The major metabolite of Indomethacin.<br>References Lewis, R., et al.: J. Clin. Invest., 53, 1607 (1974), Alvan, G., et al.: Clin. Pharmacol. Ther., 18, 364 (1975), Mungall, D., et al.: J. Pharm. Sci., 73, 1000 (1984), Baldwin, S., et al.: Xenobiotica, 25, 261 (1995),<br></p>Formula:C18H14ClNO4Color and Shape:NeatMolecular weight:343.76rac-Paroxetine-d4 Hydrochloride
CAS:Controlled Product<p>Applications rac-Paroxetine-d4 Hydrochloride is a racemic labeled analogue of Paroxetine Hydrochloride (P205750), a selective serotonin reuptake inhibitor. Used as an antidepressant.<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978); Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982)<br></p>Formula:C19H17D4ClFNO3Color and Shape:White To Light BrownMolecular weight:369.855-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-carbaldehyde
CAS:Purity:97.0%Molecular weight:473.8900146484375Pefloxacin Mesylate
CAS:Controlled Product<p>Applications Pefloxacin is a fluorinated quinolone antibacterial; analog of Norfloxacin.<br>References Barre, J., et al.: J. Pharm. Sci., 73, 1379 (1984), Contrepois, A., et al.: J. Antimicrob. Chemother., 14, 51 (1984),<br></p>Formula:C17H20FN3O3·CH4O3SColor and Shape:Off-WhiteMolecular weight:429.4610,11-Dihydro-10-hydroxy Carbamazepine-D4 (Major)
CAS:Controlled ProductFormula:C152H4H10N2O2Color and Shape:BrownMolecular weight:258.31cis-Hydroxy Perhexiline-d11 (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications A labelled metabolite of Perhexiline.<br>References Shah, R., et al.: Br. Med. J., 284, 295 (1982), Gould, B., et al.: Xenobiotica, 16, 491 (1986), Marquet, P., et al.: Ther. Drug Monit., 24, 255 (2002), Sallustio, B., et al.: Br. J. Clin. Pharmacol., 54, 107 (2002),<br></p>Formula:C19D11H24NOColor and Shape:NeatMolecular weight:304.56Gabapentin Related Compound B
CAS:<p>Impurity Gabapentin EP Impurity B; Gabapentin USP Related Compound B<br>Applications Gabapentin Related Compound B (Gabapentin EP Impurity B; Gabapentin USP Related Compound B) is a Gabapentin analogue for treatment of neurological disorders.<br>References Sit, S., et al.: J. Med. Chem., 33, 2982 (1990), O'Brien, P., et al.: J. Med. Chem., 37, 1810 (1994), Bryans, J., et al.: Med. Res. Rev., 19, 149 (1999),<br></p>Formula:C9H13NO2Color and Shape:NeatMolecular weight:167.206,6’-Methylenebis[(3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one(Ondansetron Impurity B)
CAS:<p>Impurity Ondansetron EP Impurity B<br>Applications Ondansetron EP Impurity B.<br></p>Formula:C37H38N6O2Color and Shape:NeatMolecular weight:598.74Naproxen-d3
CAS:Controlled Product<p>Applications Naproxen-d3 is an isotopic compound of Naproxen (N377520). Naproxen is a a nonsteroidal anti-inflammatory compound with analgesic and antipyretic properties.<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)<br></p>Formula:C14H11D3O3Color and Shape:Off-White To BeigeMolecular weight:233.28Edoxaban-d6
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor.<br>References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)<br></p>Formula:C24H24D6ClN7O4SColor and Shape:Light Beige To Light BrownMolecular weight:554.09Rilpivirine
CAS:Controlled Product<p>Applications A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.<br>References Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001),<br></p>Formula:C22H18N6Color and Shape:YellowMolecular weight:366.42Roflumilast N-Oxide
CAS:Controlled Product<p>Applications Roflumilast-N-oxide is the active metabolite of Roflumilast (R639700).<br>References Chiba, M., et al.: Drug Metab. Dispos., 25, 1022 (1997), Jarvis, B., et al.: Drugs, 59, 891 (2000),<br></p>Formula:C17H14Cl2F2N2O4Color and Shape:NeatMolecular weight:419.216-methyl-2-(2-methylphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:277.322998046875Methyl 4-Acetamido-5-bromo-2-methoxybenzoate
CAS:Controlled Product<p>Applications Methyl 4-Acetamido-5-bromo-2-methoxybenzoate is an impurity of bromopride (B686645), which is an antimetic.<br>References Fontaine, J., et al.: Arch. Int. Pharmacodyn. Ther., 213, 322 (1975), Lucker, P.W., et al.: Arzneim.-Forsch., 33, 453 (1983)<br></p>Formula:C11H12BrNO4Color and Shape:Off-WhiteMolecular weight:302.12(R)-Tamsulosin-d4 Hydrochloride
CAS:Controlled Product<p>Applications (R)-Tamsulosin-d4 Hydrochloride is the labeled analogue of (R)-Tamsulosin Hydrochloride (T006350), a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990); Abrams, P., et al.: Br. J. Urol., 76, 325 (1995); Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004)<br></p>Formula:C20H25D4ClN2O5SColor and Shape:NeatMolecular weight:449.06-Hydroxy-2-naphthaleneacetic Acid
CAS:<p>Applications A metabolite of Nabumetone.<br>References Nobilis, M., et al.: J., Pharm., Biomed., Anal., 32, 641 (2003),<br></p>Formula:C12H10O3Color and Shape:NeatMolecular weight:202.21N1,N3-Bis[2-(3,4-dimethoxyphenyl)ethyl]-N1,N3-dimethyl-1,3-propanediamine Dihydrochloride
CAS:Controlled Product<p>Impurity Verapamil EP Impurity A DIHCL<br>Stability Hygroscopic<br>Applications N1,N3-Bis[2-(3,4-dimethoxyphenyl)ethyl]-N1,N3-dimethyl-1,3-propanediamine Dihydrochloride (Verapamil EP Impurity A DIHCL) is an impurity of Verapamil (V125000), a calcium channel blocker. Antihypertensive; antianginal; antiarrhythmic (class IV).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981), Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)<br></p>Formula:C25H38N2O4·2ClHColor and Shape:NeatMolecular weight:503.51Perampanel
CAS:Controlled Product<p>Applications Perampanel is a novel, noncompetitive AMPA receptor antagonist for the treatment of epilepsy. Also in the treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy. Perampanel is a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist that reduces neuronal excitation (1,2,3,4).<br>References (1) Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013)(2) Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011)(3) Franco, V., et al.: Ther Drug Monit. 38, 744 (2016) (4) Rudzinski, L. A., et al.: J Investig Med. 64, 1087 (2016)<br></p>Formula:C23H15N3OColor and Shape:Light YellowMolecular weight:349.383-Phenyl-1-propanol
CAS:Controlled Product<p>Impurity Alverine EP Impurity B<br>Applications 3-Phenyl-1-propanol is used as a reagent in the synthesis of Dihydrocinnamyl Cilnidipine (D448605) and is a potent aroma biotransformation product.<br>References Bosse, A.K., et al.: Food Chem., 141, 2952 (2013)<br></p>Formula:C9H12OColor and Shape:ColourlessMolecular weight:136.19(R)-Crizotinib-d5 (piperidine-3,3,4,5,5-d5)
CAS:Controlled Product<p>Applications (R)-Crizotinib-d5 (piperidine-3,3,4,5,5-d5) (CAS# 1395950-84-1) is a useful isotopically labeled research compound.<br></p>Formula:C21D5H17Cl2FN5OColor and Shape:NeatMolecular weight:455.36752-Methylpyrazine
CAS:Controlled Product<p>Applications 2-Methyl-pyrazine is an intermediate used to synthesize 5-Methyl-2(1H)-pyrazinone (M324900) which is a derivative of 2-Hydroxypyrazine (H952710). 2-Hydroxypyrazine (H952710) is used in the synthesis of potential antioxidants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shi, J. et al.: J. Phys. Org. Chem., 22, 1038 (2009); Bonde, C. et al.: Ind. J. Hetero. Chem., 10, 271 (2001);<br></p>Formula:C5H6N2Color and Shape:NeatMolecular weight:94.11N-Nitrosometoprolol
CAS:<p>Applications N-Nitrosometoprolol is an N-nitroso derivative of rac Metoprolol(M338815), which is a β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder. N-Nitrosometoprolol can be used to assess human and rat hepatocytes.<br>References McGourty, J.C., et al.: Br. J. Clin. Pharmacol. 20, 555 (1985); Lennard, M.S., et al.: Biochem. Pharmacol., 35, 2757 (1986); Martelli, A., In Vivo, 11, 189-194, (1997);<br></p>Formula:C15H24N2O4Color and Shape:Colourless To Light YellowMolecular weight:296.36Seleno-D,L-ethionine
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Used as a substrate for methionine adenosyltransferase from rat liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lombardini, J.B., et al.: Biochem. Pharmacol., 32(3), 489 (1983), Kajander, E., et al.: Cancer Res., 46 (6), 2866 (1986), Kajander, E., et al.: Biochem. J., 267 (3), 767 (1990)<br></p>Formula:C6H13NO2SeColor and Shape:Off-White To Light BeigeMolecular weight:210.133,5-Dimethyl-2-pyridinemethanol
CAS:Controlled Product<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>Formula:C8H11NOColor and Shape:Colourless To BrownMolecular weight:137.179Boc-(S)-3-Amino-4-(2,4,5-trifluorophenyl)butyric Acid
CAS:Controlled Product<p>Applications Boc-(S)-3-Amino-4-(2,4,5-trifluorophenyl)butyric Acid is a reactant used in the preparation of peptidase IV inhibitors.<br>References Park, W. et al.: Bioorg. Med. Chem. Lett., 21, 1366 (2011);<br></p>Formula:C15H18F3NO4Color and Shape:NeatMolecular weight:333.3Vildagliptin-d3
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Labelled Vildagliptin. It is a new oral anti-hyperglycemic agent of a new dipeptidyl peptidase-IV (DPP-IV) inhibitor class of drugs. Antidiabetic.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formula:C17H22D3N3O2Color and Shape:NeatMolecular weight:306.42N-(2,3-Dichlorophenyl)piperazine Hydrochloride
CAS:Controlled ProductFormula:C10H12Cl2N2·ClHColor and Shape:WhiteMolecular weight:267.58Indocyanine Green (~90%)
CAS:Controlled ProductFormula:C43H47N2O6S2·NaPurity:~90%Color and Shape:NeatMolecular weight:774.967-Despropyl 7-Methyl Vardenafil
Controlled Product<p>Applications 7-Despropyl 7-Methyl Vardenafil is an impurity of Vardenafil (V098001, 2HCl); a selective phosphodiesterase type 5 (PDE5) inhibitor.<br>References Bischoff, E., et al.: J. Urol., 165, 1316 (2001); Kim, N.N., et al.: Life Sci., 69, 2249 (2001); Kendirci, M., et al.: Expert Opin. Pharmacother., 5, 923 (2004)<br></p>Formula:C21H28N6O4SColor and Shape:Off White SolidMolecular weight:460.55Carmustine
CAS:Controlled Product<p>Stability Temperature Sensitive<br>Applications An alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),<br></p>Formula:C5H9Cl2N3O2Color and Shape:Light Yellow To Light Orange ColourMolecular weight:214.05De-4-fluoro 5-Fluoro Chidamide
CAS:<p>Applications De-5-fluoro 4-Fluorochidamide is an analogue of Chidamide (CAS 743420-02-0), a hitsone deacetylase inhibitor (HDACI) that enhances gemcitabine (G305000) cytotoxicity in pancreatic cancer cells.<br>References Qiao, Z., et. al.: Biochem. Bioph. Res. Co., 434, 95 (2013)<br></p>Formula:C22H19FN4O2Color and Shape:Off White PowderMolecular weight:390.41Sulpiride N-oxide
CAS:Controlled Product<p>Applications 5-(Aminosulfonyl)-N-[(1-ethyl-1-oxido-2-pyrrolidinyl)methyl]-2-methoxy-benzamide is a Sulpiride impurity and water pollutant.<br>References Bader, T. et al.: Analytical Chemistry, 89, 13219 (2017);<br></p>Formula:C15H23N3O5SColor and Shape:White To Off-WhiteMolecular weight:357.43Desmethyl Sibutramine
CAS:Controlled Product<p>Applications Desmethyl Sibutramine is a metabolite of Sibutramine (S422500), a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998); Woolard, J., et al.: J. Pharmacol. Exp. Ther., 308, 1102 (2004); Geranton, S., et al.: Neuropharmacol., 46, 511 (2004)<br></p>Formula:C16H24ClNColor and Shape:Colourless To YellowMolecular weight:265.823-(1H-2-INDOLYL)-4-(4-METHOXYPHENYL)-1-METHYL-1H-2-QUINOLINONE
CAS:Purity:97.0%Molecular weight:380.4469909667969(3’R)-Ezetimibe
CAS:Controlled Product<p>Applications Azetidinone Ezetimibe (E975000) analog. A cholesterol absorption inhibitor.<br>References Hauser, H., et al.: Biochemistry, 37, 17843 (1998), Davis, et al.: Metabolism, 50, 1234 (2001), Berger., et al.: Therapeutics, 4, 163 (2002),<br></p>Formula:C24H21F2NO3Color and Shape:Off-WhiteMolecular weight:409.43Desethylcarbamoyl Cabergoline
CAS:Controlled Product<p>Impurity Cabergoline EP Impurity D<br>Applications A metabolite of Cabergoline, having affinity for D1 and D2 dopamine receptors in rat striatum<br>References Battaglia, R., et al.: Xenobiotica, 23, 1377 (1993), Miyagi, M., et al.: Biol. Pharm. Bull., 19, 1210 (1996),<br></p>Formula:C23H32N4OColor and Shape:Beige SolidMolecular weight:380.534-Chlorobenzamide
CAS:Controlled Product<p>Applications 4-chlorobenzamide (cas# 619-56-7) is a useful research chemical.<br></p>Formula:C7H6ClNOColor and Shape:NeatMolecular weight:155.582-(2,6-Dimethylbenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Purity:97.0%Molecular weight:288.3599853515625Pentoxifylline-d6
CAS:Controlled Product<p>Applications A labelled metabolite of Pentifylline. Methylxanthine derivative that improves blood flow by decreasing blood viscosity. Phosphodiesterase inhibitor. Inhibits the synthesis of tumor necrosis factor α (TNF-α).<br>References Ward, A., et al.: Drugs, 34, 50 (1987), Samlaska, C.P., et al.: J. Am. Acad. Dermatol., 30, 603 (1994), Poulakis, et al.: Respir. Med., 93, 52 (1999), Reuter, et al.: Am J. Physiol., 277, 854 (1999),<br></p>Formula:C132H6H12N4O3Color and Shape:NeatMolecular weight:284.34Efavirenz Pent-3-ene-1-yne (cis/trans Mixture)
Controlled Product<p>Applications Efavirenz Pen-3-ene-1-yne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C14H9ClF3NO2Color and Shape:NeatMolecular weight:315.67
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