Quinazoline and Quinoline Derivatives

<p>Please enquire for more information about Tadalafil spiro-urethane impurity (EP impurity F) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

rac-N-Desisopropyl-N-ethyl acebutolol is a synthetic drug product. It is an analytical standard for the impurity, acebutolol, and is metabolized by cytochrome P450 3A4 to form the major metabolite, N-desisopropyl acebutolol. rac-N-Desisopropyl-N-ethyl acebutolol is a research and development product that can be custom synthesized to meet specific needs. It has been shown to have antihypertensive properties in rats and monkeys. This product is not intended for human use.

<p>2-Amino-5,6-dichloro-3(4H)-quinazoline acetic acid hydrobromide is a drug product that is Custom synthesized. It has a high purity and analytical quality. Metabolism studies have been conducted on this compound. Natural and synthetic sources are available for this compound. It is found in the Drug Development section of the pharmacopoeia. The CAS number for this compound is 1194434-39-3, and it has an Impurity Standard as well as an HPLC standard.</p>

<p>N2-Methyl alfuzosin hydrochloride (1:1) is a synthetic compound that is used as an impurity standard for the drug product Alfuzosin. It has been shown to be metabolized by the liver, and its metabolites are excreted through the bile. The N2-methyl group of this compound provides a marker for metabolism studies and it has been shown to inhibit bacterial growth in vitro.</p>

<p>Ropivacaine N-Oxide is a synthetic drug used to relieve pain during surgery. It is metabolized by the liver, with metabolites excreted in the urine. Ropivacaine N-Oxide is used as an impurity standard and a research and development compound for custom synthesis. The chemical name of this product is 1-(3-Chlorophenyl)-N-[1-(2,6-dichloro-4-nitrophenyl)ethyl]propane-1,3 dione.</p>

<p>Gatifloxacin is a fluoroquinolone antibiotic that inhibits the DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. Gatifloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Gatifloxacin has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.<br>4'-[(4'Methyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][</p>

<p>Enalaprilat benzyl ester is a drug product that is custom synthesized according to the customer's specifications. It is a white or off-white crystalline powder and has a purity of 99%. Enalaprilat benzyl ester is used in the development of drugs, research and development, and analytical studies. It can be used as an impurity standard to test for enalaprilat in pharmaceutical products. It can also be used as a metabolite standard to measure blood levels of enalaprilat.</p>

<p>Desdifluoromethoxy hydroxy pantoprazole is a synthetic compound that is used as an impurity standard for the drug product Pantoprazole. It has a purity of ≥98% and is stable under ambient conditions. Desdifluoromethoxy hydroxy pantoprazole is not active on its own, but it is a metabolite of pantoprazole. It can be used to study the metabolism of pantoprazole.</p>

<p>3,4-Dimethoxy-N,N-dimethyl-benzeneethanamine hydrochloride is a drug product that is used as an analytical standard. This drug development chemical is not found in nature and has been synthesized in the laboratory. The chemical's structure closely resembles that of amphetamine and methamphetamine. 3,4-Dimethoxy-N,N-dimethyl-benzeneethanamine hydrochloride is used to develop analytical methods for determining impurities in APIs such as 3,4-dimethoxyamphetamine (DMA). It is also used to help identify metabolites of amphetamines. 3,4-Dimethoxy-N,N-dimethyl-benzeneethanamine hydrochloride has been shown to have a half life of approximately 12 hours and is excreted through the urine.</p>

<p>N-(1-Oxobutyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine (GW1929) is a potent vasodilator that is used for the treatment of hypertension. It is synthesized by condensation of sodium hydroxide with 2-(4′-chlorophenyl)piperazine followed by methyl esterification and chloride acylation. The synthesis of GW1929 has been accomplished in two steps: carbonate cyclization and valsartan hydrolysis. In the first step, the carboxylic acid group of GW1929 was converted to its corresponding chloride compound which was then reacted with methyl bromide to yield the desired product. The second step involved hydrolysis of GW1929 with potassium carbonate, after which it was oxidized with azide to form an ester. Sodium</p>

<p>2-(Aminomethyl)-1-ethylpyrrolidine is a pharmaceutical preparation that has been used in the analytical method for determining impurities in pharmaceuticals. It has also been used as an intermediate for pharmaceutical dosage preparations and as a reagent for chromatographic analysis of various substances. 2-(Aminomethyl)-1-ethylpyrrolidine is produced by acylation of pyrrole with ethyl chloride, followed by hydrolysis with sodium carbonate and hydrochloric acid. The substance can be separated into its two components using chromatography, which is based on the difference in their polarity. 2-(Aminomethyl)-1-ethylpyrrolidine is a dopamine receptor antagonist that blocks uptake of dopamine into cells by inhibiting the dopamine transporter (DAT). This leads to increased levels of extracellular dopamine and subsequent activation of postsynaptic D2 receptors.</p>

<p>Please enquire for more information about 2-[[2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ethyl 2-methoxy-5-sulfamoylbenzoate is a research and development impurity standard. It is a white to off-white crystalline solid that is soluble in water. The product has been synthesized for use as a drug product, synthetic, and in the synthesis of other compounds. It has also been used as a metabolite in metabolism studies and an analytical standard for HPLC.</p>

<p>Risperidone E-oxime impurity is a drug product that has been studied for its metabolism in humans, animals and plants. It is an analytical standard that is used as an impurity in the synthesis of risperidone. Risperidone E-oxime impurity is also a synthetic compound with CAS No. 691007-09-7. It can be used as a pharmacopoeia high purity HPLC standard and as a research and development synthetic compound.</p>

<p>Ingavirin, a novel inhibitor of the influenza virus reproduction, inhubits the formation of the virus specific hemagglutinin.</p>

Vapendavir diphosphate binds enterovirus capsids, inhibiting EV71 replication effectively (EC50: 0.5-1.4 μM).

(R)-Carvedilol is a non-selective blocker of β/α-1. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

PDE4 inhibitor, orally active

Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.

Indenolol is a blocker of beta-adrenergic.

Arasertaconazole, a sterol-14-alpha demethylation inhibitor, is used potentially for the treatment of vulvovaginal candcanidiasis.

<p>Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor.</p>

<p>Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.</p>

Levobetaxolol (AL-1577A/Betaxon) is a beta-blocker for ocular hypertension and glaucoma.

LPA2 antagonist 1 is a potent LPA2 antagonist.

<p>Distigmine Bromide is an acetylcholinesterase inhibitor. It is used for the treatment of underactive neurogenic bladder and myasthenia gravis.</p>

Medroxalol (RMI81968), an oral α- & β-adrenergic blocker, has antihypertensive and vasodilatory effects.

TAK-875 Hemihydrate (Fasiglifam) is a selective GPR40 agonist with EC50 of 14 nM, 400-fold more potent than oleic acid.

BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).

Piperaquine is a bisquinoline antimalarial compound and a companion compound to artemisinin.

Otamixaban (FXV673) is a selective and highly effective Xa inhibitor that inhibits the generation of thrombin and can be used to study acute coronary syndrome.

<p>P2X1 receptor antagonist</p>

Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium.

Mianserin, an H1 receptor reverse agonist, is a psychoactive compound in the tetracyclic antidepressant (TeCA) treatment family.

(R,R)-Glycopyrrolate is an agent of anticholinergic, has the ability to reduce the frequency of drooling in vivo with developmental disabilities.

Vasicinone may act as a hepatoprotective agent.

MMP-1-IN-1 is a highly potent MMP-1 inhibitor with an IC 50 of 0.034 μM .

Tropatepine: oral anticholinergic, treats extrapyramidal symptoms, anti-Parkinson's.

Pipotiazine treats chronic schizophrenia with less sedation, low hypotension risk, but high extrapyramidal side effects.

(R)-Praziquantel is an active enantiomer of praziquantel.

Moricizine is an antiarrhythmia agent which is used primarily for ventricular rhythm disturbances.

<p>Repirinast is a mediator release inhibitor. It is used to treat asthma.</p>

Benproperine is a bioactive molecule with antineoplastic properties.

<p>Clonidine (Kapvay): central alpha-adrenergic agonist, antihypertensive, often combined, not tied to liver issues.</p>

Penbutolol is a nonselective beta-blocker utilized as an antihypertensive and an antianginal.

<p>Zuclopenthixol decanoate is an anti-schizophrenia drug.</p>

NBI-42902 is a potent GnRH receptor antagonist (Ki=0.56 nm, Kd=0.19 nm), suppressing serum LH in macaques without causing histamine release.

Pridinol is an antispasmodic and muscle relaxant.

<p>Quinfamide is a compound with the potential to treat tropical parasitic infections such as Amoebiasis and Helminthiasis.</p>

(S)-Terazosin is an active S-enantiomer of Terazosin.

<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>

Levobunolol is a nonselective beta-blocker. It is used topically to treat glaucoma.

Oxolamine is an agent of a cough suppressant.

Enadoline is a K-opioid agonist with visual and dissociative effects, studied for pain but dropped due to dysphoria.

Clofedanol, also known as chlophedianol or antitussin, is used in the treatment of pediatric pertussis.

<p>Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of</p>

MMP-3 expression inhibitor

ND-336 selectively inhibits MMP-2, MMP-9, MMP-14, boosts diabetic wound healing, reduces inflammation, and promotes angiogenesis and skin repair.

<p>Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways.</p>

Guanfacine is a selective agonist of the α2A receptor.

ABT-770: an orally potent and selective MMP inhibitor, shown to reduce tumor growth in animal models.

Thiorphan disulfide: Racecadotril impurity; antidiarrheal; limits water/electrolyte intestinal absorption.

Fidarestat (SNK 860),Aldose reductase inhibitor (IC50=26 nM). Targets AKR1B10 (33 μM) and V301L AKR1B10 (1.8 μM). Potential diabetes treatment.

Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

<p>Vernakalant (RSD-1235) is a mixed ion channel blocker.</p>

Camylofine (Avacan) is an antimuscarinic, used for relaxing smooth muscle.

Safironil, a novel antifibrotic, competitively inhibits collagen synthesis and modulates fibrosis, impacting type I/III collagen levels.

Isopropamide (R5) is a long-acting anticholinergic for treating peptic ulcers and excessive gastric acid.

<p>Azelastine (Azelastinum) is a phthalazine derivative, and is an histamine antagonist and mast cell stabilizer.</p>

<p>TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.</p>

<p>Deterenol Free Base is a beta-adrenoceptor agonist.</p>

Chlophedianol hydrochloride: a cough suppressant for dry cough with antihistamine and local anesthetic traits; possibly anticholinergic at high doses.

<p>Ivabradine: oral HCN blocker, lowers heart rate without affecting blood pressure, has anticonvulsant and anti-anginal properties.</p>

Esreboxetine( PNU-165442, (S,S) -reboxetine) is a selective inhibitor of norepinephrine reuptake.

Evogliptin (DA-1229) is an oral DPP4 inhibitor effective in reducing blood sugar and liver inflammation.

Hemustine is an inhibitor of human glutathione reductase and widely used as an anti-tumor agent.

TAPI-0 is a matrix metalloprotease (MMP) and TACE inhibitor.

<p>Sarafloxacin (A56620) has antibacterial activities against Gram-positive and Gram-negative bacteria.</p>

Phenindamine (Nu 1504) is an H1-receptor antagonist which is antihistamine[1].

GW-3333 inhibits matrix metalloproteinases and TNF-Converting Enzyme, showing potential as an antiarthritic therapy.

(S)-Propafenone, or (S)-SA-79, is an S-enantiomer with beta-blocking effects and sodium channel blocking class 1 antiarrhythmic properties.

Oxyphenbutazone monohydrate: Phenylbutazone derivative, anti-inflammatory, non-selective COX inhibitor, kills dormant M. tuberculosis.

<p>Oral tyrosine kinase inhibitor Vandetanib Fumarate targets RET, VEGFRs, EGFR in thyroid cancer.</p>

<p>Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.</p>

Thiochrome is a selective enhancer of M4 muscarinic receptor of acetylcholine (ACh) affinity.

Mizolastine dihydrochloride is a histamine H1-receptor antagonist (IC50: 47 nM).

Blonanserin is an antagonist of dopamine-D2 and serotonin-S2.

<p>Famotidine disulfide blocks histamine, reduces acid, treats ulcers and GERD.</p>

(R)-Azelastine, an antihistamine, reduces H1R, M1R, M3R levels and inhibits HNEpC growth.

Bifeprunox: partial dopamine/serotonin agonist for schizophrenia; suppresses VTA neurons via D2; affects rat nicotine-seeking.

Ketotifen: Oral H1 blocker & mast cell stabilizer, inhibits 6-phosphogluconate dehydrogenase, antiviral, for EAE & asthma prevention research.

<p>(S)-Azelastine is an antihistamine reducing receptors H1R, M1R, M3R, and inhibiting HNEpC cell growth.</p>

WAY-151693 is an inhibitor of human collagenase-3 (MMP-13).

Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM).

<p>Rufloxacin HCl (MF-934 HCl): a fluoroquinolone that inhibits topoisomerase and B-cell differentiation.</p>

MMP13-IN-4 (compound 13) is a potent, selective MMP-13 inhibitor with an IC50 of 14.6 μM, implicated in the pathology of osteoarthritis (OA) [1].

(S)-Pomalidomide is an inhibitor of angiogenesis and growth of B-cell neoplasias, which induces complete regressions of Burkitt's lymphoma cell tumors.

Pirbuterol, a short-acting β2 adrenoreceptor agonist, has bronchodilating action used in the treatment of asthma.