Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65941 products of "Quinazoline and Quinoline Derivatives"
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(±)-2'-Methylpropranolol Hydrochloride
CAS:Controlled Product<p>Applications (±)-2'-Methylpropranolol Hydrochloride, is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Formula:C17H23NO2·ClHColor and Shape:NeatMolecular weight:309.83Leflunomide EP Impurity G
CAS:Controlled ProductFormula:C12H12N2O2Color and Shape:NeatMolecular weight:216.244-(Methylamino)-3-nitrobenzoic Acid
CAS:Controlled Product<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>Formula:C8H8N2O4Color and Shape:NeatMolecular weight:196.16(7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one)
CAS:Controlled Product<p>Impurity Aripiprazole USP Related Compound H<br>Applications (7-(4-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one) is an impurity of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Aripiprazole USP Related Compound H.<br>References Zeidan, T.A., et al.: Crystal. Growth. Design., 13, 2036 (2013); Nagasaka, Y., et al.: Biopharma. Drug. Dispo., 33, 304 (2012); Chen, X., et al.: J. Med. Chem., 55, 7141 (2012);<br></p>Formula:C27H35Cl2N3O3Color and Shape:WhiteMolecular weight:520.49rac N-Desmethyl Mephenytoin-D5 (Major)
CAS:Controlled Product<p>Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),<br></p>Formula:C112H5H7N2O2Color and Shape:NeatMolecular weight:209.262-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol
CAS:Controlled Product<p>Impurity Fluconazole EP Impurity F<br>Stability Hygroscopic<br>Applications 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol (Fluconazole EP Impurity F) is a diol impurity of the antifungal agent Fluconazole (F421000).<br>References Dongre, V.G. et al.: J. Pharmac. Biomed. Anal., 42, 334 (2006):<br></p>Formula:C11H11F2N3O2Color and Shape:Light YellowMolecular weight:255.22N-Hydroxy Pomalidomide
CAS:<p>Applications N-Hydroxy Pomalidomide can be involved in pharmacological activity, biological study, and synthetic preparation and anti-tumor activity of nitrogen-substituted thalidomide analogs.<br>References Shah, J., et al.: PCT Int. Appl., WO 2003014315 A2 20030220 (2003)<br></p>Formula:C13H11N3O5Color and Shape:Light YellowMolecular weight:289.24OPC 14714
CAS:Controlled Product<p>Impurity Aripiprazole Impurity<br>Applications A novel antipsychotic agents with dopamine autoreceptor agonist properties. Aripiprazole Impurity<br>References Simpson, G., et al.: Drugs, 1981, 21, 138 (1981), Banno, K., et al.: Chem. Pharm. Bull., 36, 4377 (1988), Momiyama, T., et al.: Life Sci., 47, 761 (1990), Caprathe, B., et al.: J. Med. Chem., 34, 2736 (1991),<br></p>Formula:C23H28BrN3O2Color and Shape:White To Off-WhiteMolecular weight:458.39α-Phenyl-2-pyridineacetamide
CAS:Controlled Product<p>Applications α-Phenyl-2-pyridineacetamide (cas# 7251-52-7) is a compound useful in organic synthesis.<br></p>Formula:C13H12N2OColor and Shape:NeatMolecular weight:212.25N-(4-Methoxybenzyl)-4-chloro-2-(trifluoroacetyl)aniline
CAS:Controlled ProductFormula:C16H13ClF3NO2Color and Shape:NeatMolecular weight:343.73(4-Methyl-1H-imidazol-5-yl)methanol Hydrochloride
CAS:Controlled Product<p>Applications (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride (cas# 38585-62-5) is a useful research chemical.<br></p>Formula:C5H8N2O·ClHColor and Shape:NeatMolecular weight:148.59rac-Bromo-Descyanobicalutamide
Controlled Product<p>Applications Descyano-Bromo-Bicalutamide is related to Bicalutamide(B382000). A non-steroidal androgen receptor antagonist that binds the androgen receptor and prevents its activation<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990)<br></p>Formula:C17H14BrF4NO4SColor and Shape:NeatMolecular weight:484.26Nilotinib 3-Imidazolyl N-oxide
CAS:Controlled Product<p>Applications 4-Methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl]amino-N-(5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamine is an impurity compound of Nilotinib (N465300), useful in the treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Wei-Sheng H., et al.: Synthesis, 14, 2121 (2007); Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>Formula:C28H22F3N7O2Color and Shape:NeatMolecular weight:545.52Nintedanib 4-Nitrophenyl 2-(4-Nitroso)
Controlled ProductFormula:C13H17N5O4Color and Shape:NeatMolecular weight:307.3054-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl Butyric Acid
CAS:Controlled ProductFormula:C13H15N3O4Color and Shape:Off WhiteMolecular weight:277.28Haloperidol Octanoate
CAS:Controlled ProductFormula:C29H37ClFNO3Color and Shape:NeatMolecular weight:502.06(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate
CAS:Controlled Product<p>Impurity Lansoprazole<br>Applications (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate is an impurity of Lansoprazole (L175000). Lansoprazole is used as a gastric proton pump inhibitor and an antiulcerative. It May limit the severity of tuberculosis.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006); Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Formula:C11H12F3NO3Color and Shape:NeatMolecular weight:263.213Fenbutrazate
CAS:Controlled Product<p>Applications Fenbutrazate is a derivative of Phenmetrazine (P314500). Fenbutrazate is a psychostimulant used as an anorexigen (appetite suppressant).<br>References Betbeder, A. et al.: Bull. Soc. Pharm. Bord., 121, 125 (1982); Hengen, O.: Arzneim.-Forsch., 7, 524 (1957);<br></p>Formula:C23H29NO3Color and Shape:NeatMolecular weight:367.48Dapoxetine N-Oxide (90%)
CAS:Controlled Product<p>Applications The N-oxide impurity of the selective serotonin reuptake inhibitor Dapoxetine (D185700).<br></p>Formula:C21H23NO2Purity:90%Color and Shape:NeatMolecular weight:321.414-Methoxy-3-[3-(morpholin-4-yl)propoxy]benzaldehyde
CAS:Controlled ProductFormula:C15H21NO4Color and Shape:NeatMolecular weight:279.332-(6-Methoxy-2-naphthyl)acetonitrile
CAS:Controlled Product<p>Applications 2-(6-Methoxy-2-naphthyl)acetonitrile (cas# 71056-96-7) is a compound useful in organic synthesis.<br></p>Formula:C13H11NOColor and Shape:NeatMolecular weight:197.237-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin
CAS:<p>Stability Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications A major metabolite of Irinotecan.<br>References Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996), Haaz, M., et al.: Cancer Res., 58, 468 (1998), Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (2000), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2002),<br></p>Formula:C28H30N4O6Color and Shape:NeatMolecular weight:518.564-Fluoro-2-(hydroxymethyl)phenol
CAS:Controlled Product<p>Applications 4-Fluoro-2-(hydroxymethyl)phenol can be used in preparation of naphthyridine derivatives as chemokine receptor antagonists useful in the treatment of pain.<br>References Wang, X., et al.: PCT Int. Appl., WO 2013010453 A1 20130124 (2013)<br></p>Formula:C7H7FO2Color and Shape:NeatMolecular weight:142.128Ibrutinib Addition Adduct with (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)
CAS:Formula:C47H46N12O3Color and Shape:Off-WhiteMolecular weight:826.95Indomethacin 1-Glycerin Ester
CAS:<p>Applications Indometacin 1-Glycerin Ester was synthesized and evaluated for anti-flammatory activity in the rate paw carrageenin edema essay.<br>References Paris, Gerard. , et al.: J. Med. Chem, 23, 9 (1980)<br></p>Formula:C22H22ClNO6Color and Shape:NeatMolecular weight:431.871,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Diethyl Ester
CAS:Controlled ProductFormula:C19H22N2O6Color and Shape:YellowMolecular weight:374.39Haloperidol pyridinium Chloride Impurity
CAS:Controlled Product<p>Applications Haloperidol pyridinium Chloride is a neurotoxic pyridinium metabolite of haloperidol that is formed in the liver and found in the brain. Haloperidol pyridinium Chloride is a substrate for human organic cation transporters.<br>References Kang, H. et. al.: Drug Metab. Dispos., 34, 1145 (2006)<br></p>Formula:C21H18Cl2FNOColor and Shape:NeatMolecular weight:390.282-Chloro Loratadine
CAS:Controlled Product<p>Applications 2-Chloro Loratadine is an impurity of Loratadine (L469575), a nonsedating-type histamine H1-Receptor blocker.<br>References U.S. (1998), US 5719148 A 19980217. PCT Int. Appl. (1995), WO 9510515 A1 19950420.<br></p>Formula:C22H22Cl2N2O2Color and Shape:NeatMolecular weight:417.33Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)
CAS:Formula:C18H16ClFN4O2Color and Shape:NeatMolecular weight:374.8t-Butyl 4-Bromobutanoate
CAS:Controlled Product<p>Applications t-Butyl 4-bromobutanoate is a useful research chemical for organic synthesis and other chemical and pharmaceutical processes.<br>References Brudeli, B., et al.: Bioorg. Med. Chem., 18, 8600 (2010); Colak, S., et al.: Macromolecules, 41, 8436 (2008)<br></p>Formula:C8H15BrO2Color and Shape:NeatMolecular weight:223.11R-Mirtazapine
CAS:Controlled Product<p>Applications R-Mirtazapine is an enantiomer of Mirtazapine (M365000); an antidepressant. R-Mirtazapine showed antinociceptive effects in acute thermal nociception, whereas S-Mirtazapine showed pronociceptive effects.<br>References Muth-Selbach, Uta., et al.: Brain Res. Bull., 79(1), 63-68 (2009); Smith, Donald F., et al.: Psychopharmacology, 200(2), 273-279 (2008); Freynhagen, Rainer., et al.: Brain Res. Bull., 69(2), 168-173 (2006)<br></p>Formula:C17H19N3Color and Shape:NeatMolecular weight:265.35De(2,3-dihydroxy) Nadolol Hydrochloride
CAS:Controlled Product<p>Applications De(2,3-dihydroxy) Nadolol Hydrochloride is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Formula:C17H27NO2·ClHColor and Shape:NeatMolecular weight:313.865-Amino-4-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic Acid
CAS:Controlled ProductFormula:C13H13N3O6Color and Shape:Off-WhiteMolecular weight:307.259Diphenhydramine-d6 N-β-D-Glucuronide
CAS:Controlled Product<p>Applications A labelled glucuronide metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Formula:C23H23D6NO7Color and Shape:NeatMolecular weight:437.52Ofloxacin N-Oxide Hydrochloride
CAS:Controlled ProductFormula:C18H20FN3O5·ClHColor and Shape:Off-WhiteMolecular weight:413.834-Desisopropyl-4-ethyl Nateglinide
CAS:Controlled Product<p>Applications D-phenylanaline derivative and an analog Nateglinide (N379375) with similar hypoglycemic activity.<br>References Shinkai, H. et al.: J. Med. Chem., 32, 1436 (1989);<br></p>Formula:C18H25NO3Color and Shape:NeatMolecular weight:303.405-(4-methylphenyl)imidazolidine-2,4-dione
CAS:Controlled Product<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>Formula:C10H10N2O2Color and Shape:NeatMolecular weight:190.20Desfluoro Bicalutamide
CAS:Controlled Product<p>Impurity Bicalutamide EP Impurity A<br>Applications Desfluoro Bicalutamide (Bicalutamide EP Impurity A) is an impurity of Bicalutamide, a nonsteroidal antiandrogen.<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988),<br></p>Formula:C18H15F3N2O4SColor and Shape:NeatMolecular weight:412.38Oxo-MDV 3100 (Oxo-enzalutamide)
CAS:Controlled Product<p>Applications Oxo-MDV 3100 (Oxo-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);<br></p>Formula:C21H16F4N4O3Color and Shape:NeatMolecular weight:448.375’-Oxo Amisulpride
CAS:Controlled Product<p>Applications 5’-Oxo Amisulpride is an impurity of the dopamine receptor antagonist Amisulpride (A633250).<br></p>Formula:C17H25N3O5SColor and Shape:Off-WhiteMolecular weight:383.463-Bromo-2-methylpropionic Acid
CAS:<p>Impurity Captopril EP Impurity D<br>Stability Hygroscopic<br>Applications 3-Bromo-2-methylpropionic Acid (Captopril EP Impurity D) is used in the preparation of captopril selenium analogs as antioxidants and ACE inhibitors used as antihypertensive drugs.<br>References Bhuyan, B. et al.: Org. Biomol. Chem., 9, 1356 (2011);<br></p>Formula:C4H7BrO2Color and Shape:Colourless LiquidMolecular weight:167.002-Amino-5-cyanobenzotrifluoride
CAS:Controlled Product<p>Applications 2-Amino-5-cyanobenzotrifluoride is used in the design and synthesis of 4-phenylpyrrole derivatives as androgen receptor antagonists which show efficacy against prostate cancer cells.<br>References Yamamoto, S. et al.: Bioorg. Med. Chem. Lett., 20, 422 (2012), Chen, J. et al.: Synth. Met., 160, 1953 (2010);<br></p>Formula:C8H5F3N2Color and Shape:NeatMolecular weight:186.1339N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod
CAS:Controlled Product<p>Applications N-[2(4-(-Octylphenyl))butanoic Acid] Fingolimod, is an impurity of Fingolimod (F805000, HCl salt). Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C37H59NO4Color and Shape:NeatMolecular weight:581.87Ebastine N-Oxide
CAS:<p>Stability -20°C Freezer<br>Applications Ebastine N-Oxide is an impurity of Ebastine (E320000). Ebastine impurity F and G (mixture of cis/trans).<br>References Yardley, J., et al.: J. Med. Chem., 33, 2899 (1990), Johnson, R., et al.: J. Antibiot., 49, 788 (1996), Takekawa, K., et al.: Xenobiotica, 31, 11 (2001), Chen, Z., et al.: Bioorg. Med. Chem. Lett., 14, 5275 (2004),<br></p>Formula:C32H39NO3Color and Shape:NeatMolecular weight:485.66Famotidine Acetaldehyde Adduct Maleate
CAS:Controlled ProductFormula:C10H17N7O2S3·C4H4O4Color and Shape:NeatMolecular weight:479.55(S)-4-Hydroxy Propranolol Hydrobromide
CAS:Controlled Product<p>Applications (S)-4-Hydroxy Propranolol is the main metabolite of (S)-Propranolol (P831795).<br>References Shwed, J., et al.: Xenobiotica, 22, 973 (1992), Fujita, K., et al.: Biol. Pharm. Bull., 22, 446 (1999), Walle, U., et al.: Drug Metab. Dispos., 30, 564 (2002),<br></p>Formula:C16H21NO3·ClHColor and Shape:NeatMolecular weight:311.80Tipelukast
CAS:Controlled Product<p>Applications Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.<br>References Rajasekaran, M., et. al.: BJU Int., 98, 430 (2006)<br></p>Formula:C29H38O7SColor and Shape:NeatMolecular weight:530.676,8-Dioxo Apalutamide
CAS:Controlled Product<p>Applications 6,8-Dioxo Apalutamide is an impurity of Apalutamide (A726120). Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Formula:C21H15F4N5O3Color and Shape:NeatMolecular weight:461.384-Hydroxy-2-methyl- 1,1-dioxide-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide
CAS:Controlled ProductFormula:C8H8N2O4S2Color and Shape:NeatMolecular weight:260.294-(6-Nitro-3-pyridinyl)-1-nitroso-piperazine
CAS:Controlled ProductFormula:C9H11N5O3Color and Shape:NeatMolecular weight:237.215Thioridazine 2-Sulfone
CAS:Controlled Product<p>Impurity Thioridazine EP Impurity E<br>Applications Thioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2).<br>References Niedzwiecki, D., et al.: J. Pharmacol. Exp. Ther., 250, 126 (1989), Eap, C., et al.: Ther. Drug Monit., 13, 356 (1991), Shah, P., et al.: J. Pharm. Sci., 81, 309 (1992), Eap, C., et al.: J. Pharm. Biomed. Anal., 11, 451 (1993), Blake, B., et al.: Xenobiotica, 25, 337 (1995),<br></p>Formula:C21H26N2O2S2Color and Shape:NeatMolecular weight:402.57Gabapentin Ethyl Ester Hydrochloride
CAS:Controlled Product<p>Applications Protected Gabapentin (G117250). Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Formula:C11H21NO2·ClHColor and Shape:NeatMolecular weight:235.75N-Denitroso-N’-nitroso Lomustine-d4
CAS:Controlled ProductFormula:C9D4H12ClN3O2Color and Shape:NeatMolecular weight:237.722-Aminobiphenyl
CAS:<p>Applications Has a mutagenic potency.<br>References Cash, G., et al.: Mutat. Res., 491, 31 (2001), Cash, G., et al.: Environ. Toxicol. Chem., 21, 2095 (2002), Glende, C., et al.: Mutat. Res., 515, 15 (2002),<br></p>Formula:C12H11NColor and Shape:NeatMolecular weight:169.22Cibenzoline
CAS:Controlled Product<p>Applications Cibenzoline acts as a highly active class I antiarrhythmic agent.<br>References Xie, C. et al.: Handbook. Metab. Pathway. Xenobio., 3, 1110 (2014);<br></p>Formula:C18H18N2Color and Shape:NeatMolecular weight:262.355-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid
CAS:Controlled Product<p>Applications Sunitinib intermediate.<br></p>Formula:C16H13FN2O3Color and Shape:NeatMolecular weight:300.28Cilostazol-d4
CAS:Controlled Product<p>Applications Cilostazol-d4 is the labeled analogue of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998); Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999); Tsuchikane, E., et al.: Circulation, 100, 21 (1999)<br></p>Formula:C20H23D4N5O2Color and Shape:NeatMolecular weight:373.492-Acetylbutyrolactone
CAS:Controlled Product<p>Applications An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.<br>References Toche, R.B. et al.: H. Heterocyclic Chem., 45, 1711 (2008); Sabry, S.M., J. Pharm. Biomed. Anal., 40, 1057 (2006);<br></p>Formula:C6H8O3Color and Shape:NeatMolecular weight:128.13α-(2,4-Difluorophenyl)-1H-1,2,4-triazole-1-ethanol
CAS:Controlled ProductFormula:C10H9F2N3OColor and Shape:NeatMolecular weight:225.19N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
CAS:Controlled Product<p>Applications N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide is a metabolite of Amicarbazone (A605040); a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013); Dong, M., et al.: J. Sep. Sci., 38, 2245 (2015)<br></p>Formula:C10H18N4O2Color and Shape:White To Off-WhiteMolecular weight:226.28Ticagrelor Sulfone
CAS:Controlled Product<p>Applications Ticagrelor Sulfone is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O6SColor and Shape:NeatMolecular weight:554.575-Chloro-6-(piperidin-1-yl)pyrimidine-2,4-diamine
CAS:Controlled Product<p>Applications 5-Chloro-6-(piperidin-1-yl)pyrimidine-2,4-diamine is used for biological studies and has potential use in pharmaceutical compositions.<br>References Xiang, F.: Faming Zhuanli Shenqing. 39 pp. (2019)<br></p>Formula:C9H14ClN5Color and Shape:NeatMolecular weight:227.692-(Bromomethyl)-3-nitrobenzoic Acid Methyl Ester
CAS:Controlled Product<p>Applications 2-(Bromomethyl)-3-nitrobenzoic Acid Methyl Ester (cas# 98475-07-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C9H8BrNO4Color and Shape:Off-White To Light YellowMolecular weight:274.073-(Trifluoromethoxy)aniline
CAS:Controlled Product<p>Applications 3-(Trifluoromethoxy)aniline is reactant in the synthesis of pyrazolone-quinazolone hybrids as human hydroxyphenylpyruvate dioxygenase inhibitors which is a potential treatment for type I tyrosinemia.<br>References Xu, Y., et. al.: Bioorg. Med. Chem., 22, 5194 (2014)<br></p>Formula:C7H6F3NOColor and Shape:NeatMolecular weight:177.121-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene
CAS:Controlled Product<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>Formula:C9H10Br2O2Color and Shape:NeatMolecular weight:309.98(alphaR)-α-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine Hydrochloride Salt
CAS:Controlled ProductFormula:C22H22F3N·ClHColor and Shape:NeatMolecular weight:393.87N-trifluoroacetyl Varenicline
CAS:Controlled Product<p>Applications 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is used to prepare varenicline, which is a smoking cessation. It is a Varenicline protected impurity.<br>References Coe, J., et al.: J. Med. Chem., 48, 3474 (2005) ;<br></p>Formula:C15H12F3N3OColor and Shape:NeatMolecular weight:307.2705N-Ethylcarbamic Acid 3-[(1S)-1-(Dimethylamino)ethyl]phenyl Ester
CAS:Controlled ProductFormula:C13H20N2O2Color and Shape:NeatMolecular weight:236.313-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] Balsalazide Sodium Salt (>90%)
CAS:Controlled Product<p>Applications An impurity of the anti-inflammatory drug Balsalazide (B116300).<br></p>Formula:C27H24N6O9xNaPurity:>90%Color and Shape:NeatMolecular weight:576.51(free acid)L-Valinol
CAS:Controlled Product<p>Applications L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.<br>References Chen, N., et al.: Phosphorus Sulfur, 190, 112 (2015); Zhao, Y., et al.: J. Med. Chem., 58, 1038 (2015)<br></p>Formula:C5H13NOColor and Shape:WhiteMolecular weight:103.1631-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)piperidine-4-carboxylic Acid
Controlled ProductFormula:C20H31NO3Color and Shape:NeatMolecular weight:333.4656-Oxo-(S,S)-Palonosetron (~90%)
CAS:Controlled Product<p>Applications 6-Oxo-(S,S)-Palonosetron is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>Formula:C19H22N2O2Purity:~90%Color and Shape:NeatMolecular weight:310.39rac-7-Oxo-pramipexole Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An impurity of Pramipexole production.<br>References Jancic, B., et al.: Acta Chim. Slov., 54, 49 (2007),<br></p>Formula:C10H17Cl2N3OSColor and Shape:NeatMolecular weight:225.31 + 2(36.46)3-Chloro-1,2-propanediol-d5 (10 ug/mL in methanol)
CAS:Controlled ProductFormula:C32H5H2ClO2Color and Shape:ColourlessMolecular weight:115.57N-Despropyl Ropinirole-d3
CAS:Controlled Product<p>Applications An isotopically Labelled metabolite of Ropinirole.<br>References Coldwell, M., et al.: Br. J. Pharmacol., 127, 1135(1999), Ramji, J., et al.: Xenobiotica, 29, 311 (1999)<br></p>Formula:C13H15D3N2OColor and Shape:NeatMolecular weight:221.31Chlor Cyclizine Hydrochloride
CAS:Controlled Product<p>Applications An antihistaminic drug. A drug analog of Cyclizine (C987805).<br>References Leurs, R., et al.: Pharmacol. Ther., 66, 413 (1995), Hu, Q., et al.: J. Biol. Chem., 274, 33995 (1999), Church, M., et al.: Clin. Exp. Allergy, 31, 1341 (2001),<br></p>Formula:C18H21ClN2·ClHColor and Shape:Off-WhiteMolecular weight:337.292-(2,4-Difluorophenyl)-1,2,3-propanetriol
CAS:<p>Applications 2-(2,4-Difluorophenyl)-1,2,3-propanetriol is used as a reagent in the synthesis of glycerol derivatives as intermediates for antifungal phenyltriazolylpropanediol derivatives. Also an impurity of the antifungal agent Fluconazole (F421000).<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985); Yasohara, Y., et al.: PCT Int. Appl. WO 9528374 A1 19951026. Oct 26, 1995<br></p>Formula:C9H10F2O3Color and Shape:NeatMolecular weight:204.17Ezetimibe Hydroxy β-D-Glucuronide
CAS:Controlled Product<p>Applications A metabolite of Ezetimibe. Antilipemic.<br>References Shah, V., et al.: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Patrick, J., et al.: Drug Metab. Dispos., 30, 430 (2002),<br></p>Formula:C30H29F2NO9Color and Shape:NeatMolecular weight:585.55Ethyl 2-Methoxy-5-sulfamoylbenzoate
CAS:Controlled Product<p>Impurity Sulpiride EPimpurity C<br>Applications ethyl 2-methoxy-5-sulfamoylbenzoate (cas# 33045-53-3) is a useful research chemical.<br></p>Formula:C10H13NO5SColor and Shape:NeatMolecular weight:259.28Brivaracetam-d7 (Mixture of Diastereomers)
Controlled Product<p>Applications Brivaracetam-d7 (Mixture of Diastereomers), is a mixture of 2 diastereomers of Brivaracetam-d7 (B677647), and a labeled analogue of Brivaracetam (B677645), 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Formula:C11H13D7N2O2Color and Shape:NeatMolecular weight:219.33cis-Hydroxy Solifenacin (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications Solifenacin (S676700) metabolite.<br>References Naito, R., et al.: J. Med. Chem., 48, 6597 (2005), Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005),<br></p>Formula:C23H26N2O3Color and Shape:NeatMolecular weight:378.462-Thiopheneacetic Acid
CAS:Controlled ProductFormula:C6H6O2SColor and Shape:NeatMolecular weight:142.18Everolimus NHS-carbonate (>85%)
Controlled Product<p>Applications Everolimus NHS-carbonate is a derivative of Everolimus (E945400), a macrolide immunosuppressant.<br></p>Formula:C58H86N2O18Purity:>85%Color and Shape:NeatMolecular weight:1099.3063-Methoxy Favipiravir
CAS:Controlled ProductFormula:C6H6FN3O2Color and Shape:NeatMolecular weight:171.13Desacetyl Diltiazem-d3
CAS:Controlled Product<p>Applications A labelled metabolite of Diltiazem (D460620).<br>References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987), Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990), Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991),<br></p>Formula:C20H21D3N2O3SColor and Shape:NeatMolecular weight:375.5(R)-1-Methyl-3-pyrrolidinol
CAS:Controlled Product<p>Applications (R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.<br>References Isakovic, L., et al.: Bioorg. Med. Chem. Lett., 19, 2742 (2009); Gobbini, M., et al.:J. Med. Chem., 51, 4601 (2008)<br></p>Formula:C5H11NOColor and Shape:NeatMolecular weight:101.15Dehydroxy Terfenadine
CAS:Controlled ProductFormula:C32H41NOColor and Shape:NeatMolecular weight:455.67Ibrutinib Dimer (~90%)
CAS:<p>Applications Ibrutinib Dimer is a dimer impurity of Ibrutinib (I124970), a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>Formula:C50H48N12O4Purity:~90%Color and Shape:NeatMolecular weight:880.99Iso Fluconazole
CAS:Controlled Product<p>Impurity Fluconazole EP Impurity A<br>Applications Iso Fluconazole (Fluconazole EP Impurity A) is an impurity of Fluconazole (F421000). Fluconazole USP impurity A.<br>References Rogers, T., et al.: Antimicrob. Agents Chemother., 30, 418 (1986), Itoh, H., et al.: Chem. Pharmaceut. Bull., 48, 1148 (2000),<br></p>Formula:C13H12F2N6OColor and Shape:Off-WhiteMolecular weight:306.27(S)-4-Phenyl-2-oxazolidinone
CAS:Controlled Product<p>Applications S)-4-Phenyl-2-oxazolidinone is an intermediate for the synthesis and development for cholesterol absorption inhibitor AZD4121.<br>References Soloshonok, V.A., et al.: Tetrahedron. Lett., 46, 1107 (2005); Luo, Y., et al.: Chinese. Chem. Lett., 17, 1551 (2006); Karlsson, S., et al.: Org. Process.Res. Develop., 16, 586 (2012);<br></p>Formula:C9H9NO2Color and Shape:NeatMolecular weight:163.17332-(4-(Methylsulfonamido)phenyl)acetic Acid
CAS:Controlled Product<p>Applications 2-(4-(Methylsulfonamido)phenyl)acetic Acid acts as a reagent for resiniferatoxin analogs preparation as metabolically stable TRPV1 agonists and potential analgesics. Preparation and structure-activity relationships of 2,6-diaryl-4-(phenacylamino)pyrimidines as selective adenosine A2A antagonists.<br>References Choi, H., et al.: Bioorg. Med. Chem. , 17, 690 (2009); Moorjani, M., et al.: Bioorg. Med. Chem. Lett., 18, 1269 (2008)<br></p>Formula:C9H11NO4SColor and Shape:NeatMolecular weight:229.25N-Ethyl-3-buteno-o-toluidide
CAS:Controlled ProductFormula:C13H17NOColor and Shape:NeatMolecular weight:203.28Argatroban
CAS:Controlled Product<p>Applications Synthetic thrombin inhibitor. Antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),<br></p>Formula:C23H36N6O5SColor and Shape:White PowderMolecular weight:508.63N-[3-Methyl-1-(1-phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride
CAS:Controlled Product<p>Applications N-[3-Methyl-1-(phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride is an impurity of Sibutramine Hydrochloride (S422500), a serotonin and noradrenaline reuptake inhibitor.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>Formula:C17H27N·ClHColor and Shape:NeatMolecular weight:281.86Rotigotine Hydrochloride
CAS:<p>Applications It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.<br>References Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989), Edgar, D., et al.: J. Pharmacol. Exp. Ther., 283, 757 (1997), Ferreira, J., et al.: Lancet, 355, 1333 (2000), Arnulf, I., et al.: Neurology, 58, 1019 (2002), Wisor, J., et al.: Neuroscience, 132, 1027 (2005),<br></p>Formula:C19H25NOS·ClHColor and Shape:White To Off-WhiteMolecular weight:351.93N-Methylthiophene-2-carboxamide
CAS:Controlled ProductFormula:C6H7NOSColor and Shape:NeatMolecular weight:141.19(R)-Afatinib
CAS:Controlled Product<p>Applications (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, is an impurity of Afatinib (A355300) an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br></p>Formula:C24H25ClFN5O3Color and Shape:NeatMolecular weight:485.94R-Amisulpride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications R-Amisulpride is an isomer of the antipsychotic Amisulpride (A633250). R-Amisulprideis a potential antidiabetic agent.<br>References Roix, J.J., et. al.: Diabetes Obesity Metab., 14, 329 (2012)<br></p>Formula:C17H27N3O4SColor and Shape:NeatMolecular weight:369.482-Amino Edoxaban Methanesulfonate
CAS:Controlled ProductFormula:C16H22ClN5O3•(CH4O3S)Color and Shape:NeatMolecular weight:463.93Dipyridamole Tripiperidine
CAS:Controlled Product<p>Impurity Dipyridamole EP Impurity A<br>Applications Dipyridamole Tripiperidine (Dipyridamole EP Impurity A) is a Dipyridamole (D492625) impurity.<br>References Bakken, G.A., et al.: J. Med. Chem., 43, 4534 (2000),<br></p>Formula:C25H40N8O2Color and Shape:NeatMolecular weight:484.64Olanzapine Dimer Impurity
Controlled Product<p>Applications An impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Formula:C29H28N6S2Color and Shape:NeatMolecular weight:524.703Ticagrelor TCG Sulfonate
<p>Applications Ticagrelor TCG Sulfonate is an impurity of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O7S2Color and Shape:NeatMolecular weight:602.63(R)-(+)-Verapamil-d6 Hydrochloride
CAS:Controlled ProductFormula:C27H32D6N2O4•HClColor and Shape:Off-WhiteMolecular weight:460.653646Phenylbutazone(diphenyl-d10)
CAS:Controlled Product<p>Applications Phenylbutazone(diphenyl-d10) is the isotope labelled analog of Phenylbutazone (P319570); a non-steroidal anti-inflammatory compound and an inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ali, S.L., Anal. Profiles Drug Subs., 11, 483 (1982); Hughes, M.F., et al.: Mol. Pharmacol., 34, 186 (1988)<br></p>Formula:C192H10H10N2O2Color and Shape:Off White CrystallineMolecular weight:318.44(S)-Carisbamate
CAS:<p>Applications Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.<br>References Novak GP, et al. 2007. Neurotherapeutics. Jan;4(1):106-9Nau C, 2004. J Membr Biol. Sep 1;201(1):1-8Codd EE, 2008. Pain. Feb;134(3):254-62. Epub 2007 May 25<br></p>Formula:C9H10ClNO3Color and Shape:NeatMolecular weight:215.632H-2-Ethyl-d5 Candesartan Cilexetil
CAS:Controlled Product<p>Applications Labelled Candesartan Cilexetil impurity.<br>References Cagigal, E., et al.: J. Chromatogr., 26, 477 (2001), Bakshi, M., et al.: J. Pharm. Biomed. Anal., 28, 1011 (2002),<br></p>Formula:C35H33D5N6O6Color and Shape:WhiteMolecular weight:643.74DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate
CAS:Controlled Product<p>Applications DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate is an isotope labeled compound of DL-threo-Droxidopa (D689950), a synthetic amino acid precursor of Norepinephrine. An Antiparkinson.<br>References Bartholini, J., et al.: J. Pharmacol. Exp. Ther ., 193, 523 (1975), Kato, T., et al.: Biochem. Pharmacol., 36, 3051 (1987), Kawabata, A., et al.: Br J. Pharmacol., 111, 503 (1994)<br></p>Formula:C9H8D3NO5•HCl•x(H2O)Color and Shape:NeatMolecular weight:216.2136461802(Z)-4-(2,4-Difluorobenzoyl)piperidine Oxime
CAS:Controlled Product<p>Applications Intermediate in the preparation of Risperidone (R525000) and it’s derivatives.<br></p>Formula:C12H14F2N2OColor and Shape:NeatMolecular weight:240.2492N1-Methyl-N2-2-pyridinylethanediamide
CAS:Controlled ProductFormula:C8H9N3O2Color and Shape:NeatMolecular weight:179.189-Desmethyl endo-Granisetron Hydrochloride
CAS:Controlled Product<p>Impurity Granisetron USP Related Compound C<br>Stability Hygroscopic<br>Applications 9-Desmethyl endo-Granisetron hydrochloride (Granisetron USP Related Compound C) is an impurity in the synthesis of Granisetron HCl (G780000), a specific serotonin (5HT3) receptor antagonist. Used as an antiemetic.<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),<br></p>Formula:C17H22N4O·ClHColor and Shape:NeatMolecular weight:334.84N-Ethyl-N-nitroso-2-propanamine (100 μg/mL in Methanol)
CAS:Controlled ProductFormula:C5H12N2OColor and Shape:ColourlessMolecular weight:116.16163-[(Methylamino)sulfonyl]-2-thiophenecarboxylic Acid
CAS:Controlled ProductFormula:C6H7NO4S2Color and Shape:Off-WhiteMolecular weight:221.252-(4-Amino-1-oxoisoindolin-2-yl)pentanediamide
CAS:Controlled ProductFormula:C13H16N4O3Color and Shape:Light YellowMolecular weight:276.3N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture)
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>Formula:C31H35NO8Color and Shape:NeatMolecular weight:549.612,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate
CAS:Controlled Product<p>Applications 2,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate is an antibiotic.<br>References Marrero-Ponce, Yovani, et al.: Bioorg. & Med. Chem., 13(8), 2881-2899 (2005)<br></p>Formula:C14H14N2O6Color and Shape:NeatMolecular weight:306.27N-Trityl Candesartan Ethyl Ester
CAS:Controlled Product<p>Applications Candesartan analog as angiotensin II antagonist.<br>References Bakshi, M., et al.: J. Pharm. Biomed. Anal., 28, 1011 (2002),<br></p>Formula:C45H38N6O3Color and Shape:NeatMolecular weight:710.82Desmethoxy Apixaban
CAS:<p>Applications Desmethoxy Apixaban is an impurity of Apixaban; an anticoagulant drug.<br>References Landge, S. B., et al.: Am. J. Anal. Chem., 6, 539 (2015); Arous, B., et al.: Pharm. Chem. J. 52, 573 (2018)<br></p>Formula:C24H23N5O3Color and Shape:NeatMolecular weight:429.471N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Controlled Product<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Formula:C18H18D3N3O3SColor and Shape:NeatMolecular weight:362.462,5-Bis(trifluoromethyl)aniline
CAS:Controlled Product<p>Applications 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).<br>References Liang, Y. et al.: Jil. Dax. Xueb. Lixeub., 45, 1035 (2007);<br></p>Formula:C8H5F6NColor and Shape:ColourlessMolecular weight:229.12N-Methyl Topiramate
CAS:Controlled Product<p>Impurity Topiramate N-methyl impurity<br>Applications N-Methyl Topiramate, is an impurity of Topiramate (T540250); which is an anticonvulsant (antiepilepsy) drug, that has been approved for weight loss by FDA.<br>References Maryanoff, B.E., et al.: J. Med. Chem., 30, 880 (1987), Bialer, M.: Clin. Pharmacokinet., 24, 441 (193),<br></p>Formula:C13H23NO8SColor and Shape:NeatMolecular weight:353.39Homopiperazine
CAS:Controlled Product<p>Applications Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Granese, S. et al.: Corrosion., 44, 322 (1988); Pippel, D. et al.: Org. Proc. Res. Devel., 15, 638 (2011);<br></p>Formula:C5H12N2Color and Shape:NeatMolecular weight:100.16(S)-Propyl Pramipexole
CAS:Controlled Product<p>Applications (S)- Propyl Pramipexole is (S)-Pramipexole (P700750) analogue. (S)-Pramipexole (P700750) is a dopamine-D2-receptor agonist. Antiparkinsonian. Pramipexole (Mirapex, Mirapexin, Sifrol) is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS).[1] It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants.<br>References Mierau, J., et al.: J. Med. Chem., 30, 494 (1987);Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992);Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997);<br></p>Formula:C13H23N3SColor and Shape:NeatMolecular weight:253.412-Nitrodeamino Fingolimod
CAS:Controlled Product<p>Applications An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C19H31NO4Color and Shape:NeatMolecular weight:337.45Triciribine
CAS:Controlled Product<p>Applications Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.<br>References Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011); Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (1998); Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (1978);<br></p>Formula:C13H16N6O4Color and Shape:NeatMolecular weight:320.301H-1-Ethyl Candesartan
CAS:Controlled Product<p>Applications Candesartan (C175575) impurity.<br></p>Formula:C26H24N6O3Color and Shape:WhiteMolecular weight:468.51Ambrisentan-d10
CAS:Controlled Product<p>Applications Ambrisentan-d10, is the labeled analogue of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Formula:C22H12D10N2O4Color and Shape:NeatMolecular weight:388.482-Acetylbenzothiophene
CAS:Controlled Product<p>Applications A novel anti-osteoporosis agent, by enhansing expression of the BMP-2 gene.<br>References Horiguchi, Y., et al.: Chem. Pharm. Bull., 52, 214 (2004), Joshi, E., et al.: Chem. Res. Toxicol., 17, 137 (2004), Liu, Z., et al.: Bioorg. Med. Chem. Lett., 19, 4167 (2009),<br></p>Formula:C10H8OSColor and Shape:NeatMolecular weight:176.234-(Diphenylmethyl)-1-nitrosopiperidine
CAS:Controlled ProductFormula:C18H20N2OColor and Shape:NeatMolecular weight:280.37Deschloro-4’-chloro Clomiphene Hydrochloride
CAS:Controlled Product<p>Applications An impurity of Clomiphene (C587025).<br></p>Formula:C26H29Cl2NOColor and Shape:NeatMolecular weight:442.42N-Triphenylmethyl-5-[4'-methylbiphenyl-2-yl]tetrazole
CAS:Controlled Product<p>Applications An intermediate in the preparation of Candesartan. Also used in the synthesis of novel biphenyltetrazole derivatives.<br>References Chao, S. et al.: J. Chin. Chem. Soc., 52, 539 (235);<br></p>Formula:C33H26N4Color and Shape:NeatMolecular weight:478.59Plerixafor Hydrochloride (1:8)
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Formula:C28H54N8·8ClHColor and Shape:NeatMolecular weight:794.47Quetiapine Carboxylate Impurity
CAS:Controlled Product<p>Applications Quetiapine Carboxylate is an impurity of Quetiapine Hemifumarate (Q510000), an atypical antipsychotic agent used for the treatment of patients with schizophrenia, biopolar disorder and to treat major depressive disorder.<br>References Wetzel, H., et al.: Psychopharmacol., 119, 231 (1995); Bharathi, C., et al.: Pharmazie., 63, 14 (2008);<br></p>Formula:C22H25N3O4SColor and Shape:Light Orange ColourMolecular weight:427.52(S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester
CAS:Controlled Product<p>Impurity Ambrisentan Hydroxyester Impurity<br>Applications (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester is an impurity in the synthesis of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive. (Ambrisentan Hydroxyester Impurity)<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Formula:C17H18O4Color and Shape:NeatMolecular weight:286.32rac N-Nitroso-N-Desmethyl Dapoxetine-D3
Controlled ProductFormula:C20D3H17N2O2Color and Shape:NeatMolecular weight:323.404N’-[2-[2,4-(Dimethylphenyl)thio]phenyl] Vortioxetine
Controlled Product<p>Applications N’-[2-[2,4-Dimethylphenyl)thio]phenyl] Vortioxetine is an impurity of Vortioxetine (V766000, HBr salt) which is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Formula:C32H34N2S2Color and Shape:NeatMolecular weight:510.761H-1-Ethyl-d5 Candesartan
CAS:Controlled Product<p>Applications Labelled Candesartan (C175575) impurity.<br></p>Formula:C26H19D5N6O3Color and Shape:Off-White To Light YellowMolecular weight:473.543-Chlorobenzyl Cyanide
CAS:Controlled Product<p>Applications 3-Chlorobenzyl Cyanide is a useful synthetic intermediate. It was used to design EGFR Tyrosine Kinase Inhibitors. It can also be used to synthesize imidoyl thioureas as non-nucleoside reverse transcriptase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Traxler, P., et al.: J. Med. Chem., 42, 1018 (1999); Ludovici, D., et al.: Bioorg. Med. Chem. Lett., 11, 2225 (2001)<br></p>Formula:C8H6ClNColor and Shape:NeatMolecular weight:151.592,6-Dichloro-7-deazapurine
CAS:Controlled ProductFormula:C6H3Cl2N3Color and Shape:NeatMolecular weight:188.013-Ethynylaniline
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Reagent in the preparation of a metabolite of Erlotinib (E625000).<br></p>Formula:C8H7NColor and Shape:Colourless To Dark RedMolecular weight:117.15cis-Hydroxy Solifenacin N-Oxide(Mixture of Diastereomers)
Controlled Product<p>Applications Solifenacin (S676700) metabolite.<br></p>Formula:C23H26N2O4Color and Shape:NeatMolecular weight:394.46(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
CAS:Controlled Product<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C39H46F2N2O5Si2Color and Shape:NeatMolecular weight:716.961rac Methotrimeprazine Sulfoxide
CAS:Controlled Product<p>Applications A metabolite of Methotrimeprazine (M260785).<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002),<br></p>Formula:C19H24N2O2SColor and Shape:NeatMolecular weight:344.475-Ethenyl-2-pyrrolidinone
CAS:Controlled Product<p>Impurity Vigabatrin USP Related Compound A<br>Applications Vigabatrin (V253000) impurity. Vigabatrin USP Related Compound A.<br>References Durham, S. et al.: Drug Metab. Dispos. 21, 480 (1993).<br></p>Formula:C6H9NOColor and Shape:Colourless To BrownMolecular weight:111.142’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride
CAS:Controlled Product<p>Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride is an impurity of Montelukast (M568000), a selective leukotriene D4-receptor antagonist.<br>References Kumar, I.V. et al.: Asian J. Chem., 23, 4536 (2011)<br></p>Formula:C34H33Cl2NO4SColor and Shape:NeatMolecular weight:622.65-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An intermediate of 5-Fluoro Risperidone (F595925).<br>References Strupczewski, J.T., et al.: J. Med. Chem., 28, 761 (1985),<br></p>Formula:C12H13FN2O·ClHColor and Shape:NeatMolecular weight:256.704-O-Des(difluoromethyl) Roflumilast
CAS:Controlled ProductFormula:C16H14Cl2N2O3Color and Shape:NeatMolecular weight:353.20Decarboxyl Norfloxacin
CAS:Controlled ProductFormula:C15H18FN3OColor and Shape:NeatMolecular weight:275.32(S)-Hydroxy Timolol
CAS:Controlled Product<p>Applications (S)-(-)-Hydroxy Timolol is a metabolite of the non-selective beta-adrenergic receptor blocker, Timolol (T443710).<br>References Volotinen, M. et al.: Basic Clin. Pharmacol. Toxicol., 106, 302 (2010);<br></p>Formula:C13H24N4O4SColor and Shape:NeatMolecular weight:332.42Defluoro-MDV 3100 (Defluoro-enzalutamide)
CAS:Controlled Product<p>Applications Defluoro-MDV 3100 (Defluoro-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);<br></p>Formula:C21H17F3N4O2SColor and Shape:Light YellowMolecular weight:446.454-[4-[(5R)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride (>90%)
CAS:Controlled Product<p>Applications 4-[4-[(5R)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride is an intermediate in the synthesis of ent-Rivaroxaban (R538005), the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent.<br>References Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C14H17N3O4·HClPurity:>90%Color and Shape:White To Off-WhiteMolecular weight:291.31 + (36.46)2-Methyl-5-nitroaniline
CAS:Controlled Product<p>Applications 2-Methyl-5-nitroaniline is used as a reagent in the synthesis of imatinib base derivatives which show antibacterial and antifungal activity. Also used as a reagent in the synthesis of pyrimidinylaminobenzene derivatives which exhibit antiproliferative activity against melanoma. Dyes and metabolites, Environmental Testing. It is a COVID19-related research product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patoliya, M.J., et al.: J. Chem., no vol., no pp. (2013); Kim, H.J., et al.: B. Korean Chem. Soc., 34, 2311 (2013)<br></p>Formula:C7H8N2O2Color and Shape:YellowMolecular weight:152.15α,α'-Diethyl-4,4'-stilbenediol-d4
CAS:Controlled Product<p>Applications α,α'-Diethyl-4,4'-stilbenediol-d4 is an intermediate in the synthesis of d in the synthesis of isotope labelled metabolites of Diethylstibestrol (D445026).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schuller, P.L., et al.: J. Chromatograph., 31, 237 (1967);<br></p>Formula:C18H16D4O2Color and Shape:NeatMolecular weight:272.37O-Desmethylsulpiride
CAS:Controlled ProductFormula:C14H21N3O4SColor and Shape:NeatMolecular weight:327.40Hydroxymethyl Dasatinib
CAS:Controlled Product<p>Applications An oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C22H26ClN7O3SColor and Shape:NeatMolecular weight:504.00Pazufloxacin Mesylate
CAS:Controlled Product<p>Applications A fluorinated quinolone antibiotic. Antibacterial.<br>References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)<br></p>Formula:C16H15FN2O4·CH4O3SColor and Shape:NeatMolecular weight:414.41Nintedanib Acetyl Impurity
CAS:Controlled Product<p>Applications An impurity of Nintedanib, which is an antifibrotic drug.<br>References Holdsworth, G.; et al.: Scientific Reports, 7, 1 (2017)<br></p>Formula:C26H23N3O4Color and Shape:NeatMolecular weight:441.49Ketoconazole N-Oxide
CAS:Controlled Product<p>Applications Ketoconazole N-Oxide is an impure analogue of Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Formula:C26H28Cl2N4O5Color and Shape:Off-WhiteMolecular weight:547.431,3-Dichloroacetone
CAS:Controlled Product<p>Applications 1,3-Dichloroacetone (cas# 534-07-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C3H4Cl2OColor and Shape:NeatMolecular weight:126.97Fenpropimorph
CAS:Controlled Product<p>Applications Systemic fungicide for control of powdery mildew, rust in cereal crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984), Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984),<br></p>Formula:C20H33NOColor and Shape:ColourlessMolecular weight:303.48Diphenhydramine-d6 N-Oxide
CAS:Controlled Product<p>Applications A labelled metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Formula:C17H15D6NO2Color and Shape:NeatMolecular weight:277.39rac trans-2-Phenylcyclopropylamine Hydrochloride
CAS:Controlled Product<p>Applications Non-selective MAO-A/B inhibitor.<br>References Stout, S.C., et al.: J. Pharmacol. Exp. Ther., 300, 1085 (2002),<br></p>Formula:C9H11N·ClHColor and Shape:NeatMolecular weight:169.65(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol
CAS:Controlled Product<p>Applications (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol is a building block used in organic synthesis including bein an intermediate in the synthesis of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel.<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C8H7ClF2OColor and Shape:NeatMolecular weight:192.59Nilvadipine
CAS:Controlled Product<p>Applications Used as an antihypertensive and antianginal.<br>References Gross, G.J., et al.: Gen. Pharmacol., 14, 677 (1983), Molyvdas, P.A. and Sperelakis, N.: J. Cardiovasc. Pharmacol., 8, 449 (1986), Mizuno, K., et al.: Res. Comm. Chem. Pathol. Pharmacol., 52, 3 (1986)<br></p>Formula:C19H19N3O6Color and Shape:NeatMolecular weight:385.375-(Ethoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic Acid
CAS:Controlled ProductFormula:C17H18N2O6Color and Shape:NeatMolecular weight:346.333-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride
CAS:Controlled Product<p>Applications 3-(Dibenzo[b,e]oxepin-11(6H)yl)-N,N-dimethylpropan-1-amine Hydrochloride is an impurity of Doxepin (D550000), which is used clinically to treat anxiety and depression and is classified as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ribbentrop, A., et al.: Arzneim.-Forsch., 15, 863 (1965); Hobbs, D.C., et al.: Biochem. Pharmacol., 18, 1941 (1969); Pinder, R.M., et al.: Drugs, 13, 161 (1977); Shrivastava, R.K., et al.: Clin. Ther., 7, 181 (1985)<br></p>Formula:C19H23NO•(HCl)Color and Shape:NeatMolecular weight:281.3936464-(2-Nitrophenyl)morpholin-3-one
CAS:Controlled Product<p>Applications 4-(2-Nitrophenyl)morpholin-3-one is an intermediate in the synthesis of 4-(2-Aminophenyl)-3-morpholinone (A625985). 4-(2-Aminophenyl)-3-morpholinone is a reagent used in the preparation of various Morpholine based pharmaceuticals.<br>References Mederski, W., et al.: Bioorg. Med. Chem. Lett., 14, 3763 (2004); Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005)<br></p>Formula:C10H10N2O4Color and Shape:NeatMolecular weight:222.2Safinamide-d4
CAS:Controlled Product<p>Applications Safinamide-d4 is a labelled analogue of Safinamide. Safinamide is a potent and selective MAO-B inhibitor, and is used as an add-on treatment to treat Parkinson’s disease.<br>References Finberg, J.P.M., et al.: Front Pharmacol., 7, 340-54 (2016);<br></p>Formula:C17D4H15FN2O2Color and Shape:NeatMolecular weight:306.3681-(2,5-Dimethylphenyl)ethanol
CAS:Controlled Product<p>Applications 1-(2,5-Dimethylphenyl)ethanol can be used as a reagent in reactions or as a aroma compound<br>References Zhou, J., et al.: Yuanyi Xuebao., 37, 1621-1628 (2010)<br></p>Formula:C10H14OColor and Shape:NeatMolecular weight:150.22Risperidone 9-Ethylidenecarboxylate Hydrochloride
Controlled Product<p>Applications Risperidone 9-Ethylidenecarboxylate Hydrochloride, is the derivative of Risperidone (R525000), which is combined serotonin (5-HT2) and dopamine (D2) receptor antagonist, used for the treatment of schizophrenia, bipolar disorder and behavior problems in people with autism.<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>Formula:C25H27FN4O4Color and Shape:NeatMolecular weight:466.503646L-threo-Methylphenidate Hydrochloride
CAS:Controlled Product<p>Applications Controlled substance. CNS stimulant. The less potent threo-enantiomer of Methylphenidate. The threo enantomers have shown that the pharmacological activity residues predominantly in the d-threo enantiomer.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981), Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>Formula:C14H19NO2·ClHColor and Shape:NeatMolecular weight:269.775-Methoxy-1-[4-(difluoromethyl)phenyl]-1-pentanone Oxime
CAS:Controlled Product<p>Applications Defluoro Fluvoxamine intermediate.<br></p>Formula:C13H17F2NO2Color and Shape:NeatMolecular weight:257.28(S)-Rivastigmine
CAS:<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Formula:C14H22N2O2Color and Shape:ColourlessMolecular weight:250.34Thiorphan Disulfide
CAS:Controlled Product<p>Applications Thiorphan Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski<br></p>Formula:C24H28N2O6S2Color and Shape:NeatMolecular weight:504.62N-Benzyl Epinephrine-d3
CAS:Controlled Product<p>Applications Labelled analogue of N-Benzyl Epinephrine, an impurity of Epinephrine (E588580).<br></p>Formula:C16H16D3NO3Color and Shape:NeatMolecular weight:276.35MRX-2843
CAS:Controlled Product<p>Applications MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3.<br>References Minson, K. A. et al.: JCI Insight. 2016 Mar;1(3):e85630.;<br></p>Formula:C29H40N6OColor and Shape:NeatMolecular weight:488.67Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity
CAS:<p>Applications Des(methylpiperazinyl-N-methyl) Imatinib Dimer is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity E. It is a COVID19-related research product.<br></p>Formula:C52H48N12O2Color and Shape:White To Off-WhiteMolecular weight:873.02Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Controlled Product<p>Applications Protected Varenicline metabolite.<br></p>Formula:C15H12F3N3O2Color and Shape:NeatMolecular weight:323.272,2'-Ethylenedianiline
CAS:Controlled Product<p>Applications 2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity.<br>References Asmaa, M., et al.: Pac. J. Cancer Prevent., 15, 475 (2014); Kalis, M. & Huff, N.: Clin. Ther., 23, 680 (2001); Malke, S., et al.: Pharm. Sci., 69, 211 (2007); Schmidt, D. & Elger, C.: Epil. Beh., 5, 627 (2004)<br></p>Formula:C14H16N2Color and Shape:NeatMolecular weight:212.293-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:<p>Applications An intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, T., et al.: J. Med. Chem., 33, 527 (1990), Yapi, A., et al.: Chem. Pharm. Bull., 48, 1886 (2000), Yapi, A., et al.: Arch. Pharm., 339, 201 (2006); Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000);<br></p>Formula:C11H11ClN2OColor and Shape:NeatMolecular weight:222.672-(Trifluoroacetyl)-4-chloroaniline, Hydrochloride Hydrate
CAS:Controlled Product<p>Applications HIV reverse transcriptase inhibitor.<br></p>Formula:C8H5ClF3NO·ClHColor and Shape:NeatMolecular weight:260.042,5-Bis-(3,4-dihydroxyphenyl)piperazine Dihydrochloride
Controlled ProductFormula:C16H18N2O4•2(HCl)Color and Shape:BrownMolecular weight:302.3323646Indomethacin 1-Menthol ester
CAS:Controlled Product<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Formula:C29H34ClNO4Color and Shape:NeatMolecular weight:496.0382-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol
CAS:Controlled Product<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700) derivatives as antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012)<br></p>Formula:C17H27ClN4O4SColor and Shape:NeatMolecular weight:418.943-(tert-Butyldimethylsilyl)morphinone
CAS:Controlled Product<p>Applications Protected Morphinone (M652350), a toxic metabolite of Morphine.<br>References James, R., et al.: J. Pharmacol. Exp. Ther., 221, 708 (1982), Yamano, S., et al.: J. Biol. Chem., 260, 5259(1985), Ishida, T., et al.: Drug Metab. Dispos., 17, 77 (1989), Yamano, S., et al.: Xenobiotica, 27, 645 (1997),<br></p>Formula:C23H31NO3SiColor and Shape:NeatMolecular weight:397.582,2’-Methylene Bis[Ranitidine]
CAS:Controlled Product<p>Impurity Ranitidine EP Impurity I<br>Stability Light Sensitive, Temperature Sensitive<br>Applications 2,2’-Methylene Bis[Ranitidine] (Ranitidine EP Impurity I) is an impurity of histamine H2-receptor antagonist Ranitidine (R120000).<br>References Jones, M.D. et al.: J. Sep. Sci., 29, 2409 (2006); Kelly, M.A. et al.: J. Chrom. A, 798, 297 (1998);<br></p>Formula:C27H44N8O6S2Color and Shape:NeatMolecular weight:640.82(E/Z)-Chlorprothixene-d6 Hydrochloride(Mixture)
CAS:Controlled Product<p>Applications Labelled cis/trans-Chlorprothixene (C424850). Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Formula:C18H13D6Cl2NSColor and Shape:NeatMolecular weight:358.364-Hydroxy Flecainide
CAS:Controlled Product<p>Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>Formula:C17H20F6N2O4Color and Shape:NeatMolecular weight:430.34Vortioxetine Lactose Adduct
Controlled Product<p>Stability Hygroscopic<br>Applications Vortioxetine Lactose Adduct, is an impurity of Vortioxetine (V766000), a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).<br>References Paunovic, A. et al.: ACS Chem. Biol., 12, 132 (2017);<br></p>Formula:C30H42N2O10SColor and Shape:NeatMolecular weight:622.73
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