Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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2-(3-Chloro-thiophen-2-yl)-1H-benzoimidazole-5-carboxylic acid
CAS:Color and Shape:SolidMolecular weight:278.7099914550781Nevirapine-d4 (cyclopropyl-2,2,3,3-d4)
CAS:Controlled Product<p>Applications Nevirapine-d4 (cyclopropyl-2,2,3,3-d4) (CAS# 1051418-95-1) is a useful isotopically labeled research compound. This can be prepared to use as non-nucleoside reverse transcriptase inhibitors.<br>References Gant, T., et.al., PCT Int.Appl., 113,(2008);<br></p>Formula:C15D4H10N4OColor and Shape:NeatMolecular weight:270.337-(1-ethyl-5-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS:Purity:95.0%Molecular weight:271.2799987792969(1S,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
CAS:Controlled Product<p>Applications An intermediate in the synthesis of thephosphodiesterase 5 inhibitor Tadalafil (T004500).<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003),<br></p>Formula:C20H18N2O4Color and Shape:White To YellowMolecular weight:350.37Decoquinate
CAS:Controlled Product<p>Applications Decoquinate is a quinolone coccidiostat used in veterinary medicine, in particular as animal feed for poultry.<br>References Del Cacho, E. et al.: Int. J. Parasitol., 36, 1515 (2006); Guo, F.C. et al.: Vet. Parasitol., 147, 239 (2007); Davis, J.L. et al.: Vet. Pharmacol. Therap., 9, 1145 (2009);<br></p>Formula:C24H35NO5Color and Shape:Off-WhiteMolecular weight:417.544-Hydroxy Omeprazole Sulfide
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications An intermediate in the preparation of Omeprazole metabolites.<br>References Hoffmann, K., et al.: Drug Metab. Disposition, 14, 341 (1986), Andersson, T., et al.: Brit. J. Clin. Pharmacol., 36, 521 (1993),<br></p>Formula:C16H17N3O2SColor and Shape:NeatMolecular weight:315.39Edoxaban Tosylate Monohydrate
CAS:<p>Applications Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.<br>References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)<br></p>Formula:C31H38ClN7O7S2•xH2OColor and Shape:White To Off-WhiteMolecular weight:720.263-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:Controlled Product<p>Impurity Risperidone EP Impurity L<br>Applications 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity L) is an intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Formula:C11H15ClN2OColor and Shape:NeatMolecular weight:226.70Rac Albuterol-d9
CAS:Controlled Product<p>Applications A labelled β2-adrenoceptor agonist. Bronchodilator; tocolytic.<br>References Miyagawa, N., et al.: Biol. Pharm. Bull., 31, 2260 (2008), Gonzalez-Munoz, C., et al.: Eur. J. Pharmacol., 607, 151 (2009), Kern, C., et al.: J. Med. Chem., 52, 1773 (2009),<br></p>Formula:C132H9H12NO3Color and Shape:White To YellowMolecular weight:248.37Dibenzazepine-10,11-dione
CAS:Controlled Product<p>Applications Dibenzazepine-10,11-dione is an impurity of Oxcarbazepine (O869250). Dibenzazepine-10,11-dione is used as a reagent in the preparation of bifunctional dipolar electroluminescent template for optoelectronic applications.<br>References Chen, C.-T. et al.: Chem. Comm., 31, 3980 (2005); Heckendorn, R. et al.: Helv, Chim. Acta, 70, 1955 (1987);<br></p>Formula:C14H9NO2Color and Shape:NeatMolecular weight:223.23Levosimendan Triazene Impurity
CAS:<p>Stability Light Sensitive<br>Applications Levosimendan Triazene is an impurity of Levosimendan (L378000); a positive inotropic agent with vasodilating activity. Also cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C22H23N7O2Color and Shape:NeatMolecular weight:417.466-Hexadecanoylamino-4-methylumbelliferyl β-D-Galactopyranoside
CAS:Formula:C32H49NO9Color and Shape:NeatMolecular weight:591.73(6,7-Dimethyl-3-phenyl-quinoxalin-2-yl)-phenyl-methanone
Purity:95.0%Molecular weight:338.4100036621094S-[5-Chloro-3-(trifluoromethyl)pyrid-2-yl]-S-methylsulfilimine 2,4,6-trimethylbenzenesulfonate
CAS:Formula:C16H18ClF3N2O3S2Purity:95.0%Molecular weight:442.9Pimobendan-d3
CAS:Controlled Product<p>Applications Pimobendan-d3, is the labeled analogue of Pimobendan (P447500), a cardiotonic agent.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Formula:C19H15D3N4O2Color and Shape:White To Light YellowMolecular weight:337.39(±)-Rolipram
CAS:Controlled Product<p>Applications (±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.<br>References Xin, W., et. al.: J. Pharmacol. Exp. Ther., 349, 56 (2014);<br></p>Formula:C16H21NO3Color and Shape:NeatMolecular weight:275.343-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester
CAS:Formula:C13H13NO3SPurity:95.0%Molecular weight:263.312,6-Dimethylaniline-d6
CAS:Controlled Product<p>Applications Labelled Bupivacaine (B689560) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lepage, F., et al.: Eur. J. Med. Chem., 27, 581 (1992), Thummel, K.E., et al.: Drug Metab. Dispos., 21, 350 (1993)<br></p>Formula:C82H6H5NColor and Shape:BrownMolecular weight:127.224-Amino-3,5-dichloropyridine
CAS:<p>Applications 4-Amino-3,5-dichloropyridine is a metabolite of the selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).<br>References Jeffrey, A.D. et al.: Drug Chem. Toxicol., 25, 93 (2002); Cassidy, K.C. et al.: J. Pharmac. Biomed. Anal., 22, 869 (2000);<br></p>Formula:C5H4Cl2N2Color and Shape:NeatMolecular weight:163.0rac N-Propyl-2-cyanimidopyrrolidine-5-acetic Acid
CAS:Controlled Product<p>Applications rac N-Propyl-2-cyanimidopyrrolidine-5-acetic Acid is a potent peptidic renin inhibitor. Pramipexole Related Compound<br></p>Formula:C10H15N3O2Color and Shape:NeatMolecular weight:209.24Cinitapride Tartrate
CAS:<p>Applications Cinitapride Tartrate is the salt analogue of Cinitapride (C441990), a novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.<br>References Alarcon de la Lastra, C. et al.: Pharmacol, 54, 193 (1997); Robert, M. et al.: Drug Metab. Disp., 35, 1149 (2007); Alarcon de la Lastra, C. et al.: Inflam. Res., 47, 131 (1998)<br></p>Formula:C21H30N4O4·C4H6O6Color and Shape:NeatMolecular weight:552.57Selexipag
CAS:Controlled Product<p>Applications Selexipag is an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.<br>References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);<br></p>Formula:C26H32N4O4SColor and Shape:Light YellowMolecular weight:496.62Lansoprazole-d4
CAS:Controlled ProductFormula:C162H4H10F3N3O2SColor and Shape:NeatMolecular weight:373.39Dipyridamole Tri(diethanolamine)
CAS:Controlled Product<p>Impurity Dipyridamole EP Impurity B<br>Applications Dipyridamole Tri(diethanolamine) (Dipyridamole EP Impurity B) Dipyridamole (D492625) impurity.<br>References Gerlach, E., et al.: Arzneim.-Forsch., 15, 558 (1965),<br></p>Formula:C23H40N8O6Color and Shape:NeatMolecular weight:524.613-Desamino-3,4-dehydro Sitagliptin
CAS:<p>Impurity Sitagliptin Tablets EP Impurity FP-C<br>Applications 3-Desamino-3,4-dehydro Sitagliptin is an impurity of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem. 48, 141 (2005); Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005); Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Formula:C16H12F6N4OColor and Shape:White To Off-WhiteMolecular weight:390.282-[3,5-Dichloro-4-(4-chlorobenzoyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
CAS:Controlled Product<p>Applications An anticoccidal triazine used for the treatment of coccidiosis in chickens. An impurity of Diclazuril (D436200).<br>References McFarland, J. et al.: J. Med. Chem., 35, 2543 (1992);<br></p>Formula:C16H8Cl3N3O3Color and Shape:NeatMolecular weight:396.61Sulindac Sulfide
CAS:<p>Stability Hygroscopic<br>Applications An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.<br>References Hermann, C., et al.: Oncogene, 17, 1769 (1998), Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999), Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000),<br></p>Formula:C20H17FO2SColor and Shape:Yellow-OrangeMolecular weight:340.41N,O-Bis(trimethylsilyl)trifluoroacetamide (~90%)
CAS:Controlled Product<p>Applications Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Driscoll, J.S. et al.: J. Med. Chem., 34, 3280 (1991); Pan, L. et al.: J. Pharm. Biomed. Anal., 52, 589 (2010);<br></p>Formula:C8H18F3NOSi2Purity:~90%Color and Shape:Colourless To Light YellowMolecular weight:257.40Bisnortilidine
CAS:Controlled Product<p>Applications A metabolite of Tilidine (T440300(M)), which is a controlled substance (opiate) and a analgesic. Tilidine is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.<br>References Hengy, H., et al.: J. Pharm. Sci., 67, 1765 (1978); Cordonnier, J., et al.: J. Anal. Toxicol., 11, 144 (1987); Hajda, J., et al.: J. Clin. Pharmacol., 42, 1257 (2002); Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970); Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983); Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992)<br></p>Formula:C15H19NO2Color and Shape:NeatMolecular weight:245.32N-Nitrosocarvedilol
CAS:Controlled ProductFormula:C24H25N3O5Color and Shape:NeatMolecular weight:435.472MEK 162
CAS:Controlled Product<p>Applications MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication.<br>References Kopetz,S., et al.: N. Engl., 381, 1632-1643<br></p>Formula:C17H15BrF2N4O3Color and Shape:NeatMolecular weight:441.23Praziquantel
CAS:<p>Applications Anthelmintic, effective against flatworms.<br>References Kuhn, I., et al.: Bioorg. Med. Chem., 18, 7900 (2010), Wang, W., et al.: Parasitol., 137, 1905 (2010),<br></p>Formula:C19H24N2O2Color and Shape:White To Off-WhiteMolecular weight:312.41Dehydro Nifedipine
CAS:Controlled Product<p>Impurity Nifedipine EP Impurity A<br>Applications The main Nifedipine metabolite in human plasma.This compound is a contaminant of emerging concern (CECs).<br>References Guengerich, F., et al.: J. Biol. Chem., 261, 5051 (1986), Bork, R., et al.: J. Biol. Chem., 264, 910 (1989), Kerla, V., et al.: Biochem. Pharmacol., 44, 1745 (1992),<br></p>Formula:C17H16N2O6Color and Shape:Light YellowMolecular weight:344.321-[(1-Oxopentyl)amino]-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-cyclopentanecarboxamide
CAS:Controlled Product<p>Impurity Irbesartan EP Impurity A; Irbesartan USP Related Compound A; Irbesartan Metabolite<br>Applications 1-[(1-Oxopentyl)amino]-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-cyclopentanecarboxamide (Irbesartan EP Impurity A; Irbesartan USP Related Compound A; Irbesartan Metabolite) is a metabolite of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Alexandre, V., et. al.: J. Mol. Catal. B-Enzym., 29, 173 (2004); Rao, D.D., et. al.: J. Liq. Chromatogr. R. T., 35, 1973 (2012)<br></p>Formula:C25H30N6O2Color and Shape:NeatMolecular weight:446.54Prochlorperazine
CAS:Controlled Product<p>Applications Prochlorperazine is antiemetic, antipsychotic; used in treatment of vertigo.<br>References Taylor, W.B., et al.: Br. J. Clin. Pharmacol., 23, 137 (1987), Ward, A.E., Br. J. Clin. Pract., 42, 228 (1988),<br></p>Formula:C20H24ClN3SColor and Shape:YellowMolecular weight:373.94Norfloxacin-d5
CAS:Controlled Product<p>Applications Norfloxacin-d5 is deuterium labeled Norfloxacin (N681000), a synthetic fluoroquinolone and an antibacterial agent. Norfloxacin can be used to treat urinary tract infections.<br>References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980), Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981), Holmes, B., et al.: Drugs, 30, 482 (1985),<br></p>Formula:C162H5H13FN3O3Color and Shape:NeatMolecular weight:324.364-((2R,3S,6S)-6-(4-Fluorophenyl)-3-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)phenol (Ezetimibe Impurity)
<p>Applications 4-((2R,3S,6S)-6-(4-Fluorophenyl)-3-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)phenol, is a diol impurity of Ezetimibe (E975000), a drug that lowers plasma cholesterol levels.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C18H19FO3Color and Shape:NeatMolecular weight:302.34trans-4-Aminocyclohexanol
CAS:<p>Applications trans-4-Aminocyclohexanol, used in the preparation of potential hypertensive agents and other biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chan, K.L. et al.: As. J. Pharmacol. Sci., 1, 91 (1979);<br></p>Formula:C6H13NOColor and Shape:NeatMolecular weight:115.1748-Chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one
CAS:Controlled Product<p>Impurity CLOZAPINE EP IMPURITY A<br>Stability Store in Freezer<br>Applications A useful intermediate for the preparation of pharmaceutical actives and fine chemicals. Antipsychotic drug.<br>References Venkat Rao, S., Arab. J. Chem., 13, 6040 (2020)<br></p>Formula:C13H9ClN2OColor and Shape:NeatMolecular weight:244.68
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