Amino Acids (AA)

<p>Applications 2-(3,4-Diethoxyphenyl)ethanamine is a useful intermediate in the preparation of Drotaverine hydrochloride, an antispasmodic drug arising from papaverine class of biologically active compounds.<br>References Turks, M., et al.: Rigas Tehniskas Universitates Zinatniskie Raksti, Serija 1: Materialzinatne un Lietiska Kimija, 23, 107 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications L-Formiminoglutamic acid is a useful research chemical. It is used medically in the diagnosis of Cobalt deficiencies in Cattle and sheep.<br>References Marsh, K. B., et al.: New Zeal. J. Agric. Res., 31, 273 (1988); Quirk, M. F., et al.: J. Agric. Sci., 110, 465 (1988); Quirk, M. F., et al.: Aust. J. Agric. Res., 38, 1071 (1987)<br></p>

<p>Applications 3,5-Diiodo-DL-tyrosine is used for diagnosis of hypothyroidism caused by DEHAL1 gene defects.<br>References Encinas, S., et al.: Chem. Res. Toxicol., 11, 946 (1998), Daneshvar, A., et al.: Chemosphere, 80, 301 (2010), Eriksson, J., et al.: Photochem. Photobiol., 86, 528 (2010),<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Stability Hygroscopic<br>Applications Used in peptide N-terminal amino acid determination.<br>References Prota, G., et al.: Biochimie, 53, 51 (1971),<br></p>

<p>Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.<br>References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)<br></p>

<p>Applications Carbamoyl-guanidine Amidino Urea Salt, Hydrochloride salt (cas# 926-72-7) is a compound useful in organic synthesis.<br></p>

<p>Applications S-Methyl-L-cysteine is a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA). It has been studied as a theurapeutic for neurodegenerative diseases including Parkinson′s.<br>References Wassef, R., et al.: J. Neurosci., 21, 12808 (2007)<br></p>

<p>Applications N-Epsilon-acetyl-l-lysine is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.<br>References Sanchez-Lopez, E., et al.: J. Pharm. Biomed. Anal., 140, 313 (2017)<br></p>

<p>Applications 1-methoxypropan-2-amine hydrochloride (cas# 677743-83-8) is a useful research chemical.<br></p>

<p>Applications 5-Methoxyindole-3-acetic Acid is a chemical reagent used in the analysis of the physiological properties of auxins.<br>References Ferro, N. et al.: J. Clin.Info. Model., 46, 1751 (2006);<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Applications Nα-Boc-L-histidine is an N-Boc-protected form of L-Histidine (H456010). L-Histidine is an essential amino acid that plays an important role in mitochondrial glutamine transport and has potential of abolishing oxidative stress caused by brain edema.L-Histidine promotes zinc uptake in human erythrocyes and also has potential as an antioxidant therapy for acute mammary inflammation in cattle.<br>References Chaiyotwittayakun, A., et al.: J. Dairy Sci., 85, 60 (2002); Horn, N., et al.: J. Phys., 489, 73 (1995); Rama Rao, K., et al.: Am. J. Path., 176, 1400 (2010);<br></p>

<p>Applications 5-Carboxy-2-methylphenylboronic Acid acts as a reagent in the synthesis of pyrazolopyridinone-based p38 MAP kinase inhibitor<br>References Milburn, R. R., et al.: Org. Process Res. Dev., 15, 31 (2011); Achmatowicz, M., et al.: J. Org. Chem., 74, 795 (2009)<br></p>

<p>Applications 8-Chloro-4-hydroxy-2-methylquinoline (cas# 5236-87-3) is a useful research chemical.<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Applications D-Aspartic Acid Dimethyl Ester Hydrochloride is a useful synthetic intermediate in the synthesis of MK-7246 (M425045); a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.<br>References Molinaro, C., et al.: J. Org. Chem., 77, 2299 (2012); Gervais, F.G., et al.: Mol. Pharmacol., 79, 69 (2011); Gallant, M, et al.: Bioorg. Med. Chem. Lett., 21, 288 (2011)<br></p>

<p>Applications 2-Bromo-4-methylphenol is a useful synthetic intermediate. It was used in the synthesis of furan-2-ylmethylene thiazolidinediones as potent, and selective inhibitors of phosphoinositide 3-kinase γ. It was also a reactant used to prepare phosphoramidate and phosphorothioamidate analogs of amiprophos Me as potential antimalarial agents.<br>References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Mara, C., et al.: Bioorg. Med. Chem. Lett., 21, 6180 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications 4-(4-Methylpiperazinomethyl)benzoic Acid, Dihydrochloride (cas# 106261-49-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)<br>References Walsh, R., et al.: J. Inherit. Metab. Dis., 22, 251 (1999); Gonzalez, I., et al.: Am J Med Genet A., 134, 409 (2005); MacKenzie, J., et al.: Biochim Biophys Acta., 1772, 509 (2007)<br></p>

<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>

<p>Applications N-Methyl-2-(4-nitrophenyl)ethanamine Hydrochloride is used as a reactant in the preparation of small molecule CDC25 phosphatases inhibitors.<br>References Contour-Galcera, Marie-Odile, et al.: Bioorg. &amp; Med. Chem. Let., 14(23), 5809-5812 (2004)<br></p>

<p>Applications (4-Hydroxyphenyl)glycine, is a key intermediate for the synthesis Cefpiramide (C243400), used as a β-lactam antibiotic.<br>References Xiao, R. Q., et al.: Guangzhou Huagong, 41, 111 (2013);<br></p>

<p>Applications 2-Chloro-L-phenylalanine<br></p>

<p>Applications 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer.<br>References Surh, Y., et al.: Mutat. Res., 480, 243 (2001), Balkwill, F., et al.: Lancet, 357, 539 (2001), Kawanishi, S., et al.: Biol. Chem., 387, 365 (2006), Hoki, Y., et al.: Cancer Sci., 98, 163 (2007),<br></p>

<p>Applications N-Methyl-d3-formamide (CAS# 87955-92-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2S,4R)-4-Hydroxy-L-glutamic Acid is a metabolite of Glutamic acid (G596960).<br>References Hampson, D., et al.: J. Biol. Chem., 274, 33488 (1999), Jensen, A., et al.: Eur. J. Pharmacol., 397, 247 (2000),<br></p>

<p>Applications N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Cinnamylglycine is a derivative of ferulic acid (F308900), a widely distributed compound in plants that is used as an antioxidant and food preservative.<br>References Jellum,E., et al.: J. Pharma. Biomed. Anal., 9, 663 (1991); Kayahara, H., et al.: Anticancer. Res., 19, 3763 (1999); Bollina, V., et al.: Plant. Molec. Biol., 77, 355 (2011);<br></p>

<p>Applications An acylglycine present in urniary excretion that can be analyzed and be used as diagnostic tool for metabolic disorders, complementary to organic acids and acylcarnitine profiles.<br>References Bonafe, L. et al.: Mol. Genetics Metab., 69, 302 (2000);<br></p>

<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>

<p>Applications D-Homotyrosine hydrobromide<br></p>

<p>Applications N-Methyl-N-nitroso-ethenamine is used as research reagent for base induced fragmentation to give aldehydes or ketones and smaller alkylnitrosamine<br>References Leoppky, R.N., et al.: J Org. Chem, 23, 135(1982)<br></p>

<p>Applications 4-Chloro-2-methoxyphenol is used as a reagent in the synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists which may be used in development of treatment against autoimmue diseases and viral infections. Also used in the synthesis of novel inhibtors of P. falciparum enoyl-ACP-reductase which may be used in treatment of malaria.<br>References Guerrero, M., et al.: Bioorg. Med. Chem. Lett., 22, 537 (2012); Belluti, F., et al.: J. Med. Chem., 56, 7516 (2013);<br></p>

<p>Applications 3-Methyl-1,3-butanediol is a useful compound in carbon oxygen coupling reactions.<br></p>

<p>Applications δ-Valerolactam-d4 is a labeled analog of δ-Valerolactam (V091440), which is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.<br>References Potts, K., et al. J. Org. Chem., 58, 5040 (1993); Klibanov, O., et al.: Curr. Opinion Invest. Drugs, 11, 940 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications 1-(2-Methoxyphenyl)piperazine Hydrobromide is a useful reagent for improving the synthesis of Eapidil.<br>References Wang, H., et al.: Anhui Huagong, 37, 23 (2011)<br></p>

<p>Applications 3-Acetyl-2-methylquinoxaline is an intermediate in the synthesis of Desoxyquinocetone which is a metabolite of the veterinay drug Quinocetone.<br>References Li, Y. et al.: J. AOAC Int., 91, 1494 (2008); Liu, Z.-Y. et al.: Anal. Bioanal. Chem., 396, 1259 (1271);<br></p>

<p>Impurity Iohexol EP Impurity K<br>Applications 5-Amino-2,4,6-triiodoisophthalic Acid (Iohexol EP Impurity K) is an intermediate for nonionic iodinated X-ray contrast agents.<br></p>

<p>Stability Air Sensitive<br>Applications L-Homocysteine is the hydrolysis product of adenosine (A280400), a purine nucleoside. Metabolic fate of L-Homocysteine is converted back to L-Methionine( M260440) via tetrahydrofolate.<br>References Liu, X.D., et al.: Org. BIomolec. Chem., 11, 4258 (2013); Chen, C.S., et al.: Nueroendocrinol., 97, 232 (2013);<br></p>

<p>Stability Very Hygroscopic<br>Applications 6-N-Trimethyl L-Lysine-d9, is the labeled analogue of Nε,Nε,Nε-Trimethyllysine, a metabolite and cofactor on the metabolic pathways.<br>References Rebouche C.J., et. al, J. Nutrition, 116(5), 751-759 (1986); Vaz, F.M et. al, J. Bio. Chem., 276(36), 33512-33517 (2001);<br></p>

<p>Applications L-Serine-13C3 is the isotope labelled analog of L-Serine (S270995); a compound used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012)<br></p>

<p>Applications Labelled analogue of L-Vailne. L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.<br>References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);<br></p>

<p>Applications Methylpropylnitrosamine is used in biological studies as human liver microsomal cytochrome P-450 enzymes which are involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.<br>References Shimada, T., et al.: Cancer Res., 48, 3218 (1989);<br></p>

<p>Applications An essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.<br>References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);<br></p>

<p>Applications 3-Methoxypropanoic acid<br></p>

<p>Applications 4-Bromo-6-methyl-3H-1,3-benzodiazole<br></p>

<p>Applications DL-Homocysteine-d4 is used in the detection of the biosynthetic pathway for the formation of volatile aroma compound 2-methyltetrahydrothiophen-3-one by the bacterium Chitinophaga.<br>References Nawrath, T., et al.: ChemBioChem., 11, 1914-1919 (2010)<br></p>

<p>Applications N-Methyltaurine can be used as a counter ion in the formation of soaps.<br>References Miyahara, Reiji, et al.: J. of Oleo Sci., 50(10), 823-830 (2001)<br></p>

<p>Applications Dl-valine<br></p>

<p>Applications 2-Methoxyphenylsulfate is used in the analysis of alkylsulfatases and their kinetics.<br>References Bateman, T. et al.: Biochem. J., 236, 401 (1986);<br></p>

<p>Applications 2,6-Di-(tert-butyl-d9)-4-methylphenol-3,5-d2,OD (CAS# 64502-99-4) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications 2-Chloro-2-Methylpentane (cas# 4325-48-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine Acetate is an impurity of Granisetron HCl (G780000), a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),<br></p>

<p>Applications 4-Hydroxy-4-methylhepta-1,6-diene is a compound useful in organic synthesis.<br>References Ji, X., et al.: Xiangliao Xiangjing Huazhuangpin, 4, 6 (2011)<br></p>

<p>Applications 3-Methyl-1,3,5-pentanetriol is used in the synthesis of Mevalonolactone (M339040), in the synthesis of vitamins and isoprenoids such as steroids.<br>References Yamashita, H. et al.: Frag. J., 28, 62 (2000); Huang, F. et al.: J. Am. Chem. Soc., 97, 4144 (1975);<br></p>

<p>Applications L-Lysine-3,3,4,4,5,5,6,6-d8 Dihydrochloride, is the labelled L-Lysine, a naturally occurring amino acid which is used in the labelling of human bone marrow mesenchymal stem cells for analysis.<br>References Rocha, B. et al.: J. Prot. Res., 11, 5350 (2012); Kumar, D. et al.: Polym. J., 45, 160 (2013);<br></p>

<p>Applications Used in the methods of detecting nitrotyrosine and aminotyrosine residues of peptides and proteins. Also used in the studies on the separation and photometric determination of antiepileptics.<br>References Quednow, B., et al.: Pharmazie, 34, 724 (1979),<br></p>

<p>Applications D-LEUCYL-L-TYROSINE (cas# 3303-29-5) is a useful research chemical.<br></p>

<p>Applications Pteroyltri-γ-L-glutamic acid is a folate derivative found in various foods such as yeast, spinach, beef liver, beef fillet and peas.<br>References Tamura, T., et al.: Br. J. Haematol., 25, 513 (1973); Ndaw, S., et al.: J. Chromatogr. A, 928, 77 (2001)<br></p>

<p>Applications 4-Methyl-d3-catechol (CAS# 83719-41-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Methylbutyl Acetate-d3 (CAS# 1219804-75-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes.<br>References Naveed S. et al.: Diab., 53, 11 (2004); Barlind, J. et al.: Bioorg. Med. Chem. Lett., 23, 2721 (2013);<br></p>

<p>Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.<br>References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications Labelled 2-Methylfuran (M305440). 2-Methylfuran is a volatile organic compound (VOCs) used as a potential non-intrusive tool for screening of lung cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McWilliams, et al.: Curr. Oncol. Rep., 4, 487 (2002), Buszewski, B., et al.: Biomed. Chromatogr., 21, 553 (2007), Ligor, T., et al.: J. Breath. Res., 1, 1 (2007),<br></p>