Amino Acids (AA)

<p>Applications 3-Methoxyphenylacetone is a substituted phenylacetone used in the preparation of optically active cyanohydrins. 3-Methoxyphenylacetone is also used in the preparation of CNS active compounds.<br>References Roberge, C. et al.: Tetrahed. Asymm., 18, 208 (2007); Hutchison, G.I. et al.: Aus. J. Chem., 33, 2699 (1980);<br></p>

<p>Applications 3-Bromo-4-methylphenol is a component of the marine alga polysophornia Sphaerocarpa. It is also a useful raw material for organic synthesis and pharmaceuticals.<br>References Flodin, C., et al.: Phytochemistry, 53, 77 (2000); Munday, S. D., et al.: ChemCatChem, 9, 2512 (2017)<br></p>

<p>Applications L-Aspartic Acid (13c4, 99%; 15n, 99%) (cas# 202468-27-7) is a useful research chemical.<br></p>

<p>Applications N-Dodecanoyl-DL-homoserine Lactone is used in biofilm formation and in biomineralization of 1,2,4-trichlorobenzene in culture. Also used in acyl homoserine lactone-based quorum sensing in a methanogenic archaeon.<br>References Sheng, H., et al.: Sci.Total Environ., 605, 1031 (2017); Alves de A., et al.: Arch. Microbiol., 199, 475 (2017); Zhang, G., et al.: ISME J., 6, 1336 (2012); Davis, B. M., et al.: Biophys. J., 101, 245 (2011)<br></p>

<p>Applications N,N-Dimethylaniline-d3 (N-methyl-d3) (CAS# 88889-00-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications (3-(furan-2-yl)-1-methyl-1H-pyrazol-5-yl)methanamine (cas# 1365938-03-9) is a useful research chemical.<br></p>

<p>Applications 4-(4-Acetoxy-3-iodobenzal)-2-methyl-5-oxazolone (cas# 91719-58-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-ylboronic acid, pinacol ester (cas# 1220696-32-1) is a useful research chemical.<br></p>

<p>Applications (E)-1,3-Bis(4-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)-3-methoxyphenyl)prop-2-en-1-one is a useful synthetic intermediate.<br></p>

<p>Applications A pyridine derivative used in the preparation of anti-ulcerative agents and other pharmaceutical compounds.<br>References Kuehler, T.C. et al.: J. Med. Chem., 38, 4906 (1995);<br></p>

<p>Applications 5-Amino-1-tert-butyl-3-(3-methylbenzyl)-4-cyanopyrazole (cas# 1185162-28-0) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Alanine tert-butyl ester is a protected form of L-Alanine (A481500). L-Alanine used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. L-Alanine is a non-essential amino acid for human development and is one of the 20 amino acids encoded by the genetic code.<br>References Bier, D.M. et al.: Diabetes, 26, 1005 (1977); Capaldo, B. et al.: J. Clin. Endocrinol. Metab., 71, 1220 (1990); Giacca, A. et al.: Diabetes, 47, 1763 (1998)<br></p>

<p>Applications Used in the preparation of medicinal and herbicidal agents.<br>References Cronin, J., et al.: Science, 275, 951 (1997), Podlech, J., et al.: Cell Mol. Life. Sci., 58, 44 (2001), Lee, S., et al.: J. Biol. Chem., 278, 46649 (2003),<br></p>

<p>Applications A useful reactant used in the preparation of 4-purinylpyrrolidine nucleosides, kinase inhibitors and antibacterial agents.<br>References Abraham, S. et al.: Bioorg. Med. Chem. Lett., 21, 5296 (2011); Huang, X. et al.: Bioorg. Med. Chem. Lett., 19, 4130 (2009); Peterson, M. &amp; Vince, R.: J. Med. Chem., 34, 2787 (1991)<br></p>

<p>Applications S)-β-Phenylalanine is a key building block used as an intermediate in the synthesis of pharmaceuticals.<br>References Hisashi, K., et al.: Biosci, Biotechnol,Biochem, 70, 99 (2006);<br></p>

<p>Applications N-Carbobenzoxyglycine-13C2,15N is the isotope labelled analog of N-Carbobenzoxyglycine (C175995); a compound used in dipeptide synthesis.<br>References Hans, D., et al.: Med. Chem., 2, 627 (2006); Guzman, F., et al.: J. Biotechnol., 10, 279 (2007); Vlieghe, P., et al.: Drug Discov. Today, 15, 40 (2010)<br></p>

<p>Applications 2-(2-Aminoethyl)-1-methylpyrrolidine is used as an electrochemiluminescence probe within microfluidic chip for ECL detection. 2-(2-Aminoethyl)-1-methylpyrrolidine is also used in chemical microarrays to identify ligands that bind pathogenic cells.<br>References Yin, X._B. et al.: J. Chrom. A, 1091, 158 (2005); Barrett, O.J. et al.: ChemBioChem, 7, 1882 (2006);<br></p>

<p>Stability Hygroscopic<br>Applications L-homopropargylglycine (cas# 98891-36-2) is a useful research chemical.<br></p>

<p>Applications 6-Methoxy-m-cresol is a useful chemical reagent. It has been found as one of the chemical constituent of phytoncides and has antioxidative activity.<br>References Abe T., et al., Aroma Res., 7, 56-62 (2006)<br></p>

<p>Applications Gamma-methyl-L-leucine<br></p>

<p>Applications N-Fmoc-D-methionine is an N-Fmoc-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).<br>References Campbell, K., et al.: Hear. Res., 92, 103 (2007); Cloven, N., et al.: Antican. Res., 20.6B, 4205 (1999); Vuyyuri, S., et al.: Clin. Cancer Res., 14, 2161 (2008)<br></p>

<p>Applications β-Alanine Tert-butyl Ester Hydrochloride is a blocked carboxyl-terminus derivative of β-Alanine amino acid. It is used as reactant or reagent in many syntheses such as synthesis of rhodamines from fluoresceins using Pd-catalyzed C-N cross-coupling.<br>References Grimm, J., Lavis, L.: Org. Lett., 13, 6354 (2011)<br></p>

<p>Applications 4-Fluoro-3-Methylbenzoyl Chloride (cas# 455-84-5) is a useful research chemical.<br></p>

<p>Applications (±)-3-Methyloctane-d20 (CAS# 345909-08-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications The active metabolite of Racecadotril (R070600).<br>References Roques, B.P., et al.: Nature, 288, 286 (1980), Tiraboschi, G., et al.: Protein Engineering, 12, 2, 141 (1999)<br></p>

<p>Applications H-Lys(Boc)OMe HCl<br></p>

<p>Applications 2-Bromo-4-methylthiazole<br></p>

<p>Applications (S)-adamantylglycine is used to prepare saxagliptin (BMS-477118) as highly potent and long-acting and orally active dipeptidyl peptidase IV inhibitor for treatment of type 2 diabetes.<br>References Augeri, D., et al.: J. Med. Chem., 48, 5025 (2005)<br></p>

<p>Applications 2-(4-Benzyloxy-2-methoxyphenoxy)ethylamine (cas# 887353-05-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromo-5-methylphenol is a useful raw material for organic synthesis and pharmaceuticals.<br>References Golinski, M., et al.: Eicosanoids, 5, 87 (1992); Baldwin, J. E., et al.: Tetrahedron, 47, 5603 (1991); Ren, Z., et al.: Org. Lett., 18, 4958 (2016)<br></p>

<p>Applications D-Cysteine Methyl Ester is a protected form of D-Cysteine (C995020) which is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine (C995000), and is not involved in protein or glutathione synthesis.<br>References Glazenburg, E., et al.: Biochem. Pharm., 33, 625 (1984); Klassen, C. &amp; Boles, J.: FASEB J., 11, 404 (1997); Soutourina, J., et al.: J. Biol. Chem., 276, 40864 (2001)<br></p>

<p>Applications Intermediate in the preparation of labelled Trimebutine metabolites.<br></p>

<p>Applications 2-(1-Methylpiperidin-3-yl)ethan-1-ol (cas# 101257-32-3) is a useful reagent for preparing 3-(ω-hydroxyalkyl)-substituted N-methylpiperdines and N-methyl-2-piperidones.<br>References Schneider, W., et al.: Archiv der Pharmazie., 300, 540 (1967)<br></p>

<p>Applications 2-Docosahexaenoyl-d5-sn-glycero-3-phosphocholine is the labeled analogue of 2-Docosahexaenoyl-sn-glycero-3-phosphocholine (D494435), a poly unsaturated fatty acid derivative.<br></p>

<p>Applications DL-3-Bromophenylalanine is used in the synthetic preparation of hydroxyethylene sulfones as scaffolds for design, synthesis, and structural characterization of aspartic proteinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Specker, E.; et al.: J. Med. Chem, 48, 6607 (2005)<br></p>

<p>Applications Building block in peptide synthesis.<br>References Pansare, S. V.; Org. Synth. 70, 10(1992)<br></p>

<p>Applications N-(Diphenylmethylene)glycine Methyl Ester (cas# 81167-39-7) is a compound useful in organic synthesis.<br></p>

<p>Applications An effective antibacterial agent.<br>References Manning, J.M. et al.: Proceed. Nat. Acad. Sci. U.S.A., 71, 471 (1974);<br></p>

<p>Stability Hygroscopic<br>Applications L-Cysteine-D-penicillamine Disulfide is the major urinary metabolite of D-Penicillamine (P223000). L-Cysteine-D-penicillamine Disulfide exposure induces vacuolation in cultured fibroblasts from individuals with cystinosis.<br>References Perrett, D.: Proc. Royal Soc. Med., 70, 61 (1977); Waring, R.H. et al.: Xenobiotica, 18, 235 (1988); Schulman, J.D. et al.: Science, 169, 595 (1970);<br></p>

<p>Applications Proteolysis Targeting Chimera (PROTAC) is a novel approach to modern drug development programs that utilizes small compounds to target proteins for ubiquitination and degradation by proteasome. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile is a PROTAC compound, which has the potential to target oncogenic BCR-ABL for degradation. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile has also been employed in ligand-based pharmacophore modelling to identify c-Src inhibitors.<br>References Lai, A. C., et al., Angew. Chem. Int. Ed. 55, 807 (2016); Sakkiah, S., et al., J. Enzyme Inhib. Med. Chem. 29, 69 (2014)<br></p>

<p>Applications Isotope labelled D-Proline (P755990), which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.<br>References Gawley, R., et al.: Org. Biomol. Chem., 4, 4285 (2006),<br></p>

<p>Stability Moisture Sensitive - Store Under Inert Atmosphere<br>Applications 3-Methyl-8-quinolinesulfonyl Chloride (cas# 74863-82-4) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Cbz-L-tyrosine is an N-Cbz-protected form of L-Tyrosine (T899975). L-Tyrosine is an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines (e.g. Norepinephrine HCl [N674500]) in human keratinocytes, and also for the synthesis of proteins and thyroid hormones.<br>References Gülçin, ?.: Amino Acids, 32, 431 (2007); Langen, K., et al.: Nuc. Med. Biol., 29, 625 (2002); Schallreuter, K., et al.: J. Invest. Derm., 104, 953 (1995); Zhang, W., et al.: Neuropharmacology, 47, 438 (2004)<br></p>

<p>Applications Boc-D-serine is D-serine (S270975) with amine protected from eletrophiles by tert-butyloxycarbonyl group in organic synthesis. Boc-D-serine can be used to synthesize acetamido-methoxypropionamides such as Desacetyl Desmethyl Lacosamide (D288325) which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013)<br></p>

<p>Applications L-Aspartic Acid salcium salt is used in three high-dose oral calcium salts model (CaCO3, CaCl2, Ca-aspartate-hydrochloride) which has effects on acid-base metabolism, plasma electrolytes and urine parameters in rats.<br>References Classen, H.G., et al.: Experim. Clin. Pharmacol., 17, 437 (1995),<br></p>

<p>Applications 6-Chloro-7-methyl-5-nitroquinoline (cas# 86984-28-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(N-Boc-amino)cyclohexanone is an intermediate in the synthesis of tert-Butyl 1,7-diazaspiro[3.5]nonane-1-carboxylate (B692795). tert-Butyl 1,7-diazaspiro[3.5]nonane-1-carboxylate is a reagent in the preparation of -[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as a potent poly(ADP-ribose) polymerase-1 inhibitors active in BRCA deficient cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferrigno, F., et al.: Bioorg. Med. Chem. Lett., 20, 1100 (2010);<br></p>

<p>Applications 3-(Benzyloxy)-4-methoxyphenol is a reactant used in the synthesis of lamellarin α sulfate analogues as anti-HIV-1 agents.<br>References Kamiyama, H., et. al.: Bioorg. Med. Chem., 19, 7541 (2011)<br></p>

<p>Applications Toxicity is similar to salicylic acid. Used in manufacturing of dyes.<br></p>

<p>Applications N-[(1,1-Dimethylethoxy)carbonyl]glycine Methyl Ester is a amino acid glycine (G615990) derivative, used widely in various synthetic preparations of pharmaceutical goods and antioxidants. N-[(1,1-Dimethylethoxy)carbonyl]glycine Methyl Ester can be used in the preparation of Pregabalin (P704800), a GABA analogue used as an anticonvulsant.<br>References Ko, E.H., et al.: J. Am. Chem. Soc., 133, 462 (2011); Heller, S.T., et al.: Org. Lett., 12, 4572 (2010); Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>

<p>Applications L-Alanine Ethyl Ester Hydrochloride is used in the synthesis of nucleoside phosphoramidates as antiviral agents for human immunodeficiency and hepatitis B viruses. Also used in synthesis of enantiomerically pure amino acid ester isocyanates.<br>References Bondada, L. et al.: ACS, Med. Chem. Lett., 4, 747 (2013); Nowick, J. et al.: J. Org. Chem., 57, 7364 (1992);<br></p>

<p>Applications Cisatracurium-20-methyl Dibenzenesulfonate is an impurity of Cisatracurium (C496700), an enantiomer of Atracurium Besylate (A794500), a neuromuscular blocking agent. It could be used in liver transplant patient with safety.<br>References Hughes, R., et al.: Br. J. Anaesth., 53, 31 (1981); Basta, S.J., et al.: Anesth. Analog., 61, 723 (1982); Neill, E.A., et al.: Xenobiotica, 12, 203 (1982); Bangsbo, J., et al.: J. Physiol., 422, 539 (1990)<br></p>

<p>Applications 5-(t-Boc-amino)-1-pentyl-p-toluenesulfonate (cas# 118811-34-0) is a compound useful in organic synthesis.<br></p>

<p>Applications A Glycine ester, a non-essential amino acid for human development.<br>References Tamura, M., et al.: Peptide Chem., 26, 35 (1989),<br></p>

<p>Applications Intermediate in the production of DMEQ-TAD<br>References Shimizu, M., et al.: Anal. Biochem., 194, 77 (1991),<br></p>

<p>Applications 2-amino-N-methylpyridine-3-carboxamide (cas# 870997-87-8) is a useful research chemical.<br></p>

<p>Applications DL-Homocystine is used in the synthesis of potential antitumor agents through inhibition of L-asparagine. There is growing clinical evidence that elevated homocysteine levels are associated with an increased risk of venous and arterial thrombosis.<br>References Brynes, S. et al.: J. Pharm. Sci., 67, 1550 (1978); Lauricella, A. et al.: Thromb. Res., 107, 75 (2002);<br></p>

<p>Applications N-Butyrylglycine-2,2-d2 (CAS# 1219799-10-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Boc-p-nitro-L-phenylalanine is the N-Boc protected form of p-Nitro-L-phenylalanine (N502725, Hydrate) and is a useful synthetic intermediate in the synthesis of Hydroxymelphalan (H939850); an analog of Melphalan (M216900) which is an antineoplastic.<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980)<br></p>

<p>Applications 2-Bromo-1-chloro-4-methyl-benzene is a useful synthetic intermediate. It can be used to synthesize N-heterocycle-fused phenanthridines via palladium-catalyzed tandem N-H/C-H arylation of aryl-N-heteroarenes with dihaloarenes. It can also be used to synthesize substituted fluorenes.<br>References Yan, L., et al.: Org. Biomol. Chem., 11, 7966 (2013); Dong, C., et al.: 64, 2537 (2008)<br></p>

<p>Applications 1-TERT-BUTYL 3-METHYL 3-HYDROXYPYRROLIDINE-1,3-DICARBOXYLATE (cas# 942190-61-6) is a useful research chemical.<br></p>

<p>Impurity Captopril EP Impurity D<br>Stability Hygroscopic<br>Applications 3-Bromo-2-methylpropionic Acid (Captopril EP Impurity D) is used in the preparation of captopril selenium analogs as antioxidants and ACE inhibitors used as antihypertensive drugs.<br>References Bhuyan, B. et al.: Org. Biomol. Chem., 9, 1356 (2011);<br></p>

<p>Applications N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is a reactant in the synthesis of phosphoramidate imidazo[2,1-f][1,2,4]triazine-4-amine adenosine prodrugs that can increase anti-HCV activity.<br>References Tyndall, E.M., et. al.: Bio. Med. Chem. Lett., 25, 869 (2015)<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications Trilithium UDP-glucuronic Acid-3C1, 5N2 is an isotope labelled analog of Trisodium UDP-glucuronic Acid (T886285). Trisodium UDP-glucuronic Acid is a reactant used in the enzymatic preparation of β-glucuronides.<br>References Stevenson, D.E., et. al.: Collect Czech. Chem. C., 65, 117 (2000); Robotham, S.A., Brodbelt, J.S.: Biochem. Pharmacol., 82, 1764 (2011); Kren, V., et. al.: Drug Metab. Dispos., 28, 1513 (2000)<br></p>

<p>Applications Fmoc-Cop is used in the synthesis of disubstituted pyrimidines as Lck inhibitors.<br>References Hunt, J., et al.: Bioorg. Med. Chem. Lett., 19, 5440 (2009)<br></p>