Enzyme Modulators
Enzyme modulators are compounds that can enhance or inhibit the activity of enzymes, thereby regulating the rate of biochemical reactions. These modulators play a critical role in controlling metabolic pathways, cell signaling, and various physiological processes. Enzyme modulators are widely used in research and drug development to study enzyme functions and to develop therapeutic agents. At CymitQuimica, we offer a comprehensive range of high-quality enzyme modulators to support your research in enzyme regulation and drug discovery.
Subcategories of "Enzyme Modulators"
Found 693 products of "Enzyme Modulators"
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Bafilomycin A1
CAS:Inhibitor of vacuolar-type proton pumpFormula:C35H58O9Purity:Min. 95 Area-%Color and Shape:White PowderMolecular weight:622.83 g/molToceranib phosphate - Bio-X ™
CAS:Controlled ProductToceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).Formula:C22H25FN4O2·H3O4PPurity:Min. 95%Color and Shape:PowderMolecular weight:494.45 g/molNabumetone - Bio-X ™
CAS:Nabumetone is a non-steroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. This drug is also a cyclooxygenase inhibitor and works by inhibiting this enzyme so that pain and inflammation is reduced.Formula:C15H16O2Purity:Min. 95%Color and Shape:PowderMolecular weight:228.29 g/molCHIR 99021
CAS:Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF-β signalling pathways, which are involved in pluripotency. It also affects the Wnt/β-catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.Formula:C22H18Cl2N8Purity:Min. 95%Color and Shape:PowderMolecular weight:465.34 g/mol(Z)-Mycophenolic acid
CAS:(Z)-Mycophenolic acid is an immunosuppressive agent derived from the fermentation of fungi, primarily from the Penicillium species. It functions by inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for de novo purine synthesis. This selective blockade of IMPDH specifically affects lymphocyte proliferation due to their heavy reliance on this pathway for DNA synthesis, thereby exerting its immunosuppressive effects.Formula:C17H20O6Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:320.34 g/molAfatinib - Bio-X ™
CAS:Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.Formula:C24H25ClFN5O3Purity:Min. 95%Color and Shape:PowderMolecular weight:485.94 g/molBIO
CAS:Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.Formula:C16H10BrN3O2Purity:Min. 95%Color and Shape:Red To Dark Red SolidMolecular weight:356.17 g/molMotesanib
CAS:Inhibitor of VEGFR, PDGR, c-Kit and Ret; inhibitor of angiogenesisFormula:C22H23N5OPurity:Min. 95%Molecular weight:373.45 g/molSB 239063
CAS:Inhibits p38 MAP kinase; anti-inflammatory; neuroprotectiveFormula:C20H21FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:368.4 g/molGDC 0941
CAS:Pan-class I phosphatidylinositide 3-kinase (PI3K) inhibitor (IC50 = 3, 33, 3 and 75 nM at catalytic subunits p110α, p110β, p110δ and p110γ respectively). Inhibits proliferation in several cancer cell lines, such as glioblastoma, breast and prostate cancer cells. Has synergistic anti-cancer effect in combination with MEK/ERK kinase inhibitor GDC-0973 (cobimetinib).
Formula:C23H27N7O3S2Purity:Min. 95%Color and Shape:White PowderMolecular weight:513.64 g/molIrsogladine maleate - Bio-X ™
CAS:Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Formula:C13H11Cl2N5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:372.16 g/molBenazepril HCl - Bio-X ™
CAS:Benazepril is a nonsteroidal anti-inflammatory drug that can be used to treat hypertension, heart failure and renal failure. It is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II. This inhibition prevents the vasoconstrictive effects of this peptide, which are mediated through activation of the renin-angiotensin system.Formula:C24H28N2O5•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:460.95 g/mol(-)-Huperzine A
CAS:Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFormula:C15H18N2OPurity:(%) Min. 98%Color and Shape:PowderMolecular weight:242.32 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formula:C20H20N4O2Purity:Min. 95%Molecular weight:348.4 g/molPD 169316
CAS:Inhibitor of p38 kinase
Formula:C20H13FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:360.34 g/molMethotrexate
CAS:Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.Formula:C20H22N8O5Color and Shape:Yellow PowderMolecular weight:454.44 g/molGC376 sodium
CAS:GC 376 is an inhibitor of the main protease Mpro (3CLpro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC 376 inhibits the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 0.03 μM and EC50 of 3.37 μM.
Formula:C21H30N3NaO8SPurity:Min. 95 Area-%Color and Shape:White PowderMolecular weight:507.53 g/molNilotinib HCl monohydrate - Bio-X ™
CAS:Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Formula:C28H22F3N7O•HCl•H2OPurity:Min. 95%Color and Shape:PowderMolecular weight:583.99 g/molPF 06409577
CAS:Potent agonist of a1β1γ1 5′-adenosine monophosphate-activated protein kinase (AMPK). It binds to the allosteric drug and metabolite (ADaM) site at the α- and β- subunit interface of AMPK. It has potential for the treatment of diabetic nephropathy. PF 06409577 reduces infections caused by flaviviruses, mediated by changes in the metabolism of lipids in host cells.
Formula:C19H16ClNO3Purity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:341.79 g/molLOXO-305
CAS:LOXO-305 is a small molecule inhibitor, which is a synthesized chemical compound designed to selectively target specific enzymes or pathways. Its source is rooted in medicinal chemistry and pharmacological research aimed at elucidating pathways involved in oncogenesis.
Formula:C22H21F4N5O3Purity:Min. 95%Color and Shape:PowderMolecular weight:479.43 g/mol
