Enzyme Modulators
Enzyme modulators are compounds that can enhance or inhibit the activity of enzymes, thereby regulating the rate of biochemical reactions. These modulators play a critical role in controlling metabolic pathways, cell signaling, and various physiological processes. Enzyme modulators are widely used in research and drug development to study enzyme functions and to develop therapeutic agents. At CymitQuimica, we offer a comprehensive range of high-quality enzyme modulators to support your research in enzyme regulation and drug discovery.
Subcategories of "Enzyme Modulators"
Found 693 products of "Enzyme Modulators"
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GNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formula:C20H20N4O2Purity:Min. 95%Molecular weight:348.4 g/molPimecrolimus
CAS:Immune suppressant; prevents pro-inflammatory cytokine releaseFormula:C43H68ClNO11Purity:Min. 95%Color and Shape:PowderMolecular weight:810.45 g/molIdelalisib
CAS:Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.Formula:C22H18FN7OPurity:Min. 95%Color and Shape:PowderMolecular weight:415.42 g/molBKM 120
CAS:Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic
Formula:C18H21O2N6F3Purity:Min. 95%Color and Shape:White PowderMolecular weight:410.39 g/molSRT1720 hydrochloride
CAS:SIRT1 activatorFormula:C25H23N7OS·xHClPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:469.56 g/molPimasertib
CAS:A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formula:C15H15FIN3O3Purity:Min. 95%Color and Shape:White To Yellow SolidMolecular weight:431.2 g/molJNJ 10198409
CAS:Selective inhibitor of the platelet derived growth factor receptor PDGFRβ with IC50 value of 4.2 nM. JNJ 10198409 inhibits the PDGFRβ kinase activity and its downstream signalling leading to anti-proliferative and anti-angiogenic effects, which were confirmed in various tumoral cell lines.Formula:C18H16FN3O2Purity:Min. 95%Color and Shape:SolidMolecular weight:325.34 g/molA 939572
CAS:Inhibitor of stearoyl-CoA desaturase SCD1 with IC50 of 6.3 nM, as measured in the SCD1-expressing human microsomes. A 939572 exhibited anticancer activity as it reduced cell proliferation and triggered cell killing in human non-small cell lung carcinoma cells. A 939572 inhibited tumour growth in an in vivo model for gastric carcinoma and reduced the oleic acid:stearic acid ratio in mouse liver and plasma.Formula:C20H22ClN3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:387.86 g/molKU-0063794
CAS:Inhibits mTORC1 and mTORC2 serine/threonine kinasesFormula:C25H31N5O4Purity:Min. 95%Color and Shape:White To Beige To Yellow SolidMolecular weight:465.54 g/mol5-Fluoro-1-(tetrahydro-2-furyl)uracil
CAS:5-Fluoro-1-(tetrahydro-2-furyl)uracil is a chemotherapeutic agent, which is a synthetic derivative of uracil. This compound is developed from modified nucleosides with the aim of enhancing antitumor efficacy. Its mechanism of action involves the inhibition of thymidylate synthase, leading to a disruption in DNA synthesis. By integrating into RNA and DNA, it ultimately impedes tumor cell proliferation due to RNA processing interference and DNA damage.Formula:C8H9FN2O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:200.17 g/molMK 1775
CAS:Wee1 inhibitor with an IC50 of 5.2 nMFormula:C27H32N8O2Purity:Min. 95%Color and Shape:PowderMolecular weight:500.6 g/molPeiminine
CAS:Inhibitor of TGF-α, CTGF, ERK1/2, NF-κB and FasL; anti-inflammatoryFormula:C27H43NO3Purity:Min. 98 Area-%Molecular weight:429.64 g/molSGC AAK1 1
CAS:Dual inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K) with IC50 values of 270 nM and 1 μM, respectively. In a recent study, SGC AAK1 1 stabilised β-catenin, inhibited phosphorylation of the AP2 complex subunit mu protein (AP2M1) and activated Wnt signalling in in vitro experiments._x000D_Formula:C21H25N5O3SPurity:Min. 95%Color and Shape:SolidMolecular weight:427.52 g/molDeracoxib
CAS:Inhibitor of COX-2 and PDE4 enzymes; NSAID of coxib classFormula:C17H14F3N3O3SPurity:Min. 95%Color and Shape:White To Off-White To Brown SolidMolecular weight:397.37 g/molHistone deacetylase inhibitor VIII
CAS:Potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 2.4 nM. Its anti-inflammatory activity was examined in a mouse model for acute colitis. The compound protected from intestinal inflammation by prevention of infiltration of CD19+ B-cells into the lamina propria of colonic epithelium and attenuated neutrophil activation. Its broad anti-inflammatory response involved decrease in 24 inflammatory chemokines and cytokines. Also, it is a potent inhibitor of cell proliferation in pancreatic cancer cell lines.
Formula:C22H30N4O6Purity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:446.21653Hydroxychloroquine sulfate - Bio-X ™
CAS:Hydroxychloroquine is a drug that is used to treat multiple types of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus and discoid lupus. It is a prodrug, which is activated in the liver to hydroxychloroquine. It inhibits the production of inflammatory cytokines and nitric oxide by binding to the toll-like receptor 4 (TLR4) and inhibiting signaling pathways downstream of TLR4 activation. Additionally, Hydroxychloroquine is used to prevent and treat malaria caused by parasitic protozoan from the Plasmodium genus. Furthermore, recent studies revealed that hydroxychloroquine has beneficial effects on COVID-19 patients, as the current evidence shows that hydroxychloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the spike glycoprotein.Formula:C18H28ClN3O5SPurity:Min. 95%Color and Shape:PowderMolecular weight:433.95 g/molEN 6
CAS:Autophagy activator that acts through targeting the ATP6V1A subunit of vATPaseFormula:C19H14F2N4O2Purity:Min. 95%Color and Shape:White To Yellow To Beige SolidMolecular weight:368.34 g/molNilotinib HCl monohydrate - Bio-X ™
CAS:Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Formula:C28H22F3N7O•HCl•H2OPurity:Min. 95%Color and Shape:PowderMolecular weight:583.99 g/molCobicistat
CAS:Cobicistat is an inhibitor of human cytochrome P450 3A enzymes (CYP) with no antiviral activity. Cobicistat is used in the treatment of HIV-1 infection, as an alternative to ritonavir, to increase the half-life of antiviral medications (von Hentig, 2016). Cobicistat acts as a booster by selectively inhibiting the hepatic degradation of the drugs, for example, in the pharmacological regime against HIV-1, which often includes protease inhibitors, such as, darunavir, atazanavir, and lopinavir, or the integrase inhibitor elvitegravir (Deeks, 2014).Formula:C40H53N7O5S2Purity:Min. 95%Color and Shape:PowderMolecular weight:776.03 g/molNVP-BGJ398
CAS:Inhibits FGFR family of kinases; antineoplastic; anti-angiogenicFormula:C26H31Cl2N7O3Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:560.48 g/mol
