Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(115 productos)
- CDK(547 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(47 productos)
- Dynamin(27 productos)
- Ferroptosis(227 productos)
- HSP(180 productos)
- Integrin(269 productos)
- Kinesina(87 productos)
- LIM quinasa(20 productos)
- Asociado a microtúbulos(273 productos)
- PKC(126 productos)
- PLK(25 productos)
- ROCK(62 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(76 productos)
Mostrar 10 subcategorías más
Se han encontrado 3909 productos de "Ciclo celular / Checkpoint"
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Pritelivir
CAS:Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).Fórmula:C18H18N4O3S2Pureza:97.96% - 99.42%Forma y color:SolidPeso molecular:402.49Y16 acetate(429653-73-6 free base)
Y16 acetate(429653-73-6 free base) is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoAFórmula:C51H74N14O13Pureza:98%Forma y color:SolidPeso molecular:1091.24A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Fórmula:C15H12N2OS2Pureza:98.07% - 98.52%Forma y color:SolidPeso molecular:300.4Ref: TM-T2254
2mg42,00€5mg50,00€1mL*10mM (DMSO)67,00€10mg77,00€25mg152,00€50mg258,00€100mg505,00€500mg1.108,00€Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Fórmula:C21H18F3N5OPureza:98.91%Forma y color:SolidPeso molecular:413.4Ref: TM-T5524
1mg66,00€2mg89,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg401,00€50mg580,00€100mg797,00€200mg1.099,00€TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Fórmula:C24H21Cl2NO5Pureza:98.98%Forma y color:SolidPeso molecular:474.33Ref: TM-T5310
1mg50,00€5mg99,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg245,00€50mg353,00€100mg492,00€200mg700,00€LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.
Fórmula:C23H29ClN8OPureza:100%Forma y color:SolidPeso molecular:469.022′-Deoxy-2′-fluoroguanosine
CAS:2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Fórmula:C10H12FN5O4Pureza:99.89%Forma y color:SolidPeso molecular:285.23BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H14Cl2F2N4OSPureza:98.01% - 99.88%Forma y color:SolidPeso molecular:431.29Ref: TM-T4598
1mg40,00€2mg52,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg116,00€25mg188,00€50mg281,00€100mg420,00€Fosifloxuridine nafalbenamide
CAS:Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.
Fórmula:C29H29FN3O9PPureza:95.87%Forma y color:SolidPeso molecular:613.53Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Fórmula:C18H18FN5O2SPureza:98.8%Forma y color:SolidPeso molecular:387.43Ref: TM-T10464L
1mg84,00€2mg114,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg313,00€25mg580,00€50mg773,00€100mg1.063,00€Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Fórmula:C27H40N8O7Pureza:98% - 99.8%Forma y color:SolidPeso molecular:588.66Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Fórmula:C26H30N6O3Pureza:97.88% - 98.79%Forma y color:White PowderPeso molecular:474.55KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.69%Forma y color:SolidPeso molecular:332.4Silver sulfadiazine
CAS:Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.Fórmula:C10H9AgN4O2SPureza:99.04% - 99.58%Forma y color:SolidPeso molecular:357.14Arginine-glycine-aspartic acid
CAS:RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Fórmula:C12H22N6O6Pureza:99.11%Forma y color:SolidPeso molecular:346.34YKL-5-124
CAS:YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFórmula:C28H33N7O3Pureza:99.36%Forma y color:SolidPeso molecular:515.61Ref: TM-T22461
1mg82,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg222,00€25mg385,00€50mg560,00€100mg790,00€PTC-209 hydrobromide
CAS:PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in
Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Forma y color:SolidPeso molecular:576.1Ref: TM-T6178
1mg37,00€5mg78,00€1mL*10mM (DMSO)89,00€10mg124,00€25mg265,00€50mg465,00€100mg753,00€200mg1.035,00€Bredinin aglycone
CAS:Bredinin aglycone (SM-108) is a purine nucleotide analog.Fórmula:C4H5N3O2Pureza:99.06%Forma y color:SolidPeso molecular:127.1WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Fórmula:C28H31N7O2Pureza:98.33%Forma y color:SolidPeso molecular:497.59Ref: TM-T8916
1mg66,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg225,00€25mg398,00€50mg532,00€100mg767,00€200mg1.018,00€HALOFUGINONE LACTATE
CAS:HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.Fórmula:C19H23BrClN3O6Pureza:99.70% - 99.96%Forma y color:SolidPeso molecular:504.8Ref: TM-T8785
2mg39,00€5mg56,00€1mL*10mM (DMSO)63,00€10mg89,00€25mg123,00€50mg197,00€100mg294,00€200mg437,00€dGTP
CAS:dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFórmula:C10H16N5O13P3Pureza:99.64%Forma y color:SolidPeso molecular:507.182'-Fluoro-2'-Deoxyadenosine
CAS:2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Fórmula:C10H12FN5O3Pureza:99.95%Forma y color:SolidPeso molecular:269.23Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Fórmula:C28H26Cl2N4O5Pureza:99.26% - 99.72%Forma y color:SolidPeso molecular:569.44Levomefolate calcium
CAS:Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.Fórmula:C20H23CaN7O6Pureza:97.35%Forma y color:Off-White To Pale Yellow SolidPeso molecular:497.52AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Forma y color:SolidPeso molecular:362.42Ref: TM-T6093
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg90,00€25mg167,00€50mg265,00€100mg424,00€CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Fórmula:C21H17ClF6N2O2Pureza:99.58%Forma y color:SolidPeso molecular:478.82Ref: TM-T22062
5mg35,00€1mL*10mM (DMSO)40,00€10mg54,00€25mg108,00€50mg178,00€100mg286,00€200mg425,00€Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Fórmula:C27H32F2N8Pureza:99.43% - 99.87%Forma y color:SolidPeso molecular:506.59NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFórmula:C38H43N3O6Pureza:99.16% - 99.27%Forma y color:SolidPeso molecular:637.76NSC23005 Sodium
CAS:NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Fórmula:C13H16NNaO4SPureza:99.64%Forma y color:SolidPeso molecular:305.32BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Fórmula:C22H32N6·HClPureza:99.21%Forma y color:SolidPeso molecular:416.99Ref: TM-T6162
200mgA consultar1mg37,00€2mg52,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg116,00€25mg250,00€50mg416,00€100mg645,00€Triazavirin
CAS:Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Fórmula:C5H7N6NaO5SPureza:99.55%Forma y color:SolidPeso molecular:286.2NSC 617145
CAS:NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependentFórmula:C13H10Cl4N2O4Pureza:99.78%Forma y color:SolidPeso molecular:400.04Ref: TM-T9168
1mg34,00€2mg49,00€5mg73,00€1mL*10mM (DMSO)80,00€10mg90,00€25mg164,00€50mg227,00€100mg358,00€500mg842,00€Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Pureza:97.15% (SDS-PAGE); 97.2% (SEC-HPLC) - 98.00%Forma y color:LiquidPeso molecular:146.19 kDaJNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Fórmula:C15H12F2N6O3SPureza:99.1% - 99.85%Forma y color:SolidPeso molecular:394.36Ref: TM-T6126
1mg48,00€1mL*10mM (DMSO)94,00€5mg100,00€10mg155,00€25mg268,00€50mg432,00€100mg595,00€200mg833,00€6-Bromo-2-hydroxy-3-methoxybenzaldehyde
CAS:6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α (IC50 : 0.08 μM).Fórmula:C8H7BrO3Pureza:99.82%Forma y color:SolidPeso molecular:231.04Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Fórmula:C29H26FN5O4SPureza:97.45% - 99.4%Forma y color:SolidPeso molecular:559.61Ref: TM-T8487
1mg86,00€5mg173,00€1mL*10mM (DMSO)231,00€10mg261,00€25mg425,00€50mg583,00€100mg803,00€200mg1.063,00€4μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Fórmula:C11H8O4Pureza:97.48% - 98.45%Forma y color:SolidPeso molecular:204.18Isoindigotin
CAS:Isoindigotin is used in the therapy of Y.
Fórmula:C16H10N2O2Pureza:98.14% - ≥95%Forma y color:SolidPeso molecular:262.26Pyridostatin Trihydrochloride
CAS:Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Fórmula:C31H35Cl3N8O5Pureza:99.69%Forma y color:SolidPeso molecular:706.026-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Fórmula:C10H12N4O4SPureza:97.74%Forma y color:SolidPeso molecular:284.29CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Fórmula:C23H21ClN2O3Pureza:98.82% - 99.50%Forma y color:SolidPeso molecular:408.88RI-1
CAS:RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).Fórmula:C14H11Cl3N2O3Pureza:99.3% - 99.62%Forma y color:SolidPeso molecular:361.61TMPyP4 tosylate
CAS:TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Fórmula:C72H66N8O12S4Pureza:98.61% - 99.85%Forma y color:SolidPeso molecular:1363.6Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFórmula:C31H32N8O5Pureza:98%Forma y color:SolidPeso molecular:596.64Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Fórmula:C27H32N8O2Pureza:98.65% - 99.86%Forma y color:SolidPeso molecular:500.6Ref: TM-T2077
5mg46,00€1mL*10mM (DMSO)49,00€10mg66,00€25mg81,00€50mg96,00€100mg110,00€200mg161,00€500mg260,00€CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Fórmula:C14H12N6O2SPureza:99.54%Forma y color:SolidPeso molecular:328.35Ref: TM-T9615
1mg50,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg356,00€50mg557,00€100mg858,00€200mg1.153,00€Indisulam
CAS:Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Fórmula:C14H12ClN3O4S2Pureza:98.68% - 99.77%Forma y color:SolidPeso molecular:385.85Ref: TM-T4321
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg88,00€25mg130,00€50mg198,00€100mg298,00€Risdiplam
CAS:Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Fórmula:C22H23N7OPureza:98.68% - 99.64%Forma y color:SolidPeso molecular:401.46Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Fórmula:C27H35F2N7O3Pureza:97.1% - >99.99%Forma y color:SolidPeso molecular:543.61HAMNO
CAS:HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Fórmula:C17H13NO2Pureza:99.96%Forma y color:SolidPeso molecular:263.29
