Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(67 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3486 productos de "Ciclo celular / Checkpoint"
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Palbociclib Isethionate
CAS:<p>Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。</p>Fórmula:C24H29N7O2·C2H6O4SPureza:99.01% - 99.27%Forma y color:SolidPeso molecular:573.66ML264
CAS:<p>ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.</p>Fórmula:C17H21ClN2O4SPureza:99.33% - 99.45%Forma y color:SolidPeso molecular:384.88CCT241736
CAS:<p>CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3</p>Fórmula:C22H23Cl2N7Pureza:96.2% - 99.81%Forma y color:SolidPeso molecular:456.3710058-F4
CAS:<p>10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.</p>Fórmula:C12H11NOS2Pureza:98% - 99.87%Forma y color:SolidPeso molecular:249.35Ara-G
CAS:<p>Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.</p>Fórmula:C10H13N5O5Pureza:98.74%Forma y color:Slightly Off White To White PowderPeso molecular:283.24Didox
CAS:<p>Didox (NSC-324360), a synthetic RR inhibitor, lowers oxidative injury markers in HIV-related dementia.</p>Fórmula:C7H7NO4Pureza:99.83%Forma y color:SolidPeso molecular:169.13T56-LIMKi
CAS:<p>T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.</p>Fórmula:C19H14F3N3O3Pureza:98.39% - 99.57%Forma y color:SolidPeso molecular:389.33Mycro 3
CAS:<p>Mycro 3 is potent and selective for c-Myc in whole cell assays.</p>Fórmula:C24H17ClF2N6O4Pureza:99.51% - 99.61%Forma y color:SolidPeso molecular:526.88TP-353
CAS:<p>TP-353 (EOS-61973) is a CDK7 inhibitor.</p>Fórmula:C35H30FNO3Pureza:99.12%Forma y color:SolidPeso molecular:531.62ENMD-2076
CAS:<p>ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.</p>Fórmula:C21H25N7Pureza:97.63% - ≥95%Forma y color:SolidPeso molecular:375.47BI-1347
CAS:<p>BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.</p>Fórmula:C22H20N4OPureza:96.7% - 99.63%Forma y color:SolidPeso molecular:356.42COH29
CAS:<p>COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.</p>Fórmula:C22H16N2O5SPureza:97.04% - 98.92%Forma y color:SolidPeso molecular:420.44Fialuridine
CAS:<p>Fialuridine (DRG-0098), a DNA polymerase inhibitor, shows strong anti-HBV effects both in vitro and in vivo.</p>Fórmula:C9H10FIN2O5Pureza:99.71% - 99.88%Forma y color:Less Crystals Colourless CrystalsPeso molecular:372.09SRI-29329
CAS:<p>SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).</p>Fórmula:C20H26ClN7Pureza:99.18%Forma y color:SolidPeso molecular:399.92NSC23005
CAS:<p>NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).</p>Fórmula:C13H17NO4SPureza:>99.99%Forma y color:SolidPeso molecular:283.34Lifitegrast
CAS:<p>Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.</p>Fórmula:C29H24Cl2N2O7SPureza:99.39% - 99.66%Forma y color:SolidPeso molecular:615.48TH287 hydrochloride
CAS:<p>TH287 inhibits MTH1 (IC50: 0.8 nM), causing DNA damage in cancer cells through oxidized dNTP incorporation, leading to cytotoxicity in mouse xenografts.</p>Fórmula:C11H11Cl3N4Pureza:>99.99%Forma y color:SolidPeso molecular:305.59ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Fórmula:C10H12N6OPureza:99.69%Forma y color:SolidPeso molecular:232.24Trilaciclib
CAS:<p>Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.</p>Fórmula:C24H30N8OPureza:99.624%Forma y color:SolidPeso molecular:446.55Barasertib-HQPA
CAS:<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Fórmula:C26H30FN7O3Pureza:98.43% - 99.29%Forma y color:SolidPeso molecular:507.56N6,N6-Dimethyladenosine
CAS:<p>N6,N6-Dimethyladenosine is find in mycobacterium bovis Bacille Calmette-Guérin tRNA.</p>Fórmula:C12H17N5O4Pureza:98.79%Forma y color:White PowderPeso molecular:295.29Proguanil
CAS:<p>Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the DHFR enzyme .</p>Fórmula:C11H16ClN5Pureza:99.6%Forma y color:SolidPeso molecular:253.739-(β-D-Xylofuranosyl)adenine
CAS:<p>9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) is an adenine nucleoside analog that is a potential smooth muscle vasodilator.9-(β-D-Xylofuranosyl)adenine has</p>Fórmula:C10H13N5O4Pureza:99.97%Forma y color:SolidPeso molecular:267.24PDD00017273
CAS:<p>PDD00017273 is a radiosensitizing PARG) inhibitor with antitumor or activity for the study of epithelial ovaries.</p>Fórmula:C23H26N6O4S2Pureza:99.14% - 99.21%Forma y color:SolidPeso molecular:514.62Muromonab
CAS:<p>Muromonab (OKT3) is a mouse-derived antibody targeting the CD3 receptor, blocking all cytotoxic T cell functions.</p>Pureza:95% - 97.51% (SEC-HPLC)Forma y color:LiquidP-2'-deoxyribose
CAS:<p>P-2'-deoxyribose (P-Nucleoside) is a deoxyribose that is widely found in organisms.</p>Fórmula:C11H15N3O5Pureza:99.71%Forma y color:SolidPeso molecular:269.25LSN2839567
CAS:<p>LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.</p>Fórmula:C25H28F2N8Pureza:99.14%Forma y color:SolidPeso molecular:478.542'-Deoxy-2-iodoadenosine
CAS:2'-Deoxy-2-iodoadenosine is a purine nucleoside analog with potential antimicrobial, antioxidant and anti-leukemic activities.Fórmula:C10H12IN5O3Pureza:99.37%Forma y color:SolidPeso molecular:377.14BC-1471
CAS:<p>BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.</p>Fórmula:C27H32N4O4SPureza:99.98%Forma y color:SolidPeso molecular:508.635-Bromo-2',3',5'-tri-O-acetyluridine
CAS:<p>5-Bromo-2',3',5'-tri-O-acetyluridine is a purine nucleoside analog that can be used to explore explore improve Parkinson's disease.</p>Fórmula:C15H17BrN2O9Pureza:99%Forma y color:SolidPeso molecular:449.212'-O-Methyl-2-thiouridine
CAS:<p>2'-O-Methyl-2-thiouridine, a purine nucleoside analog present in synthetic thermophilic bacterial tRNAs, is more selective for A than unmodified U.</p>Fórmula:C10H14N2O5SPureza:99.89%Forma y color:SolidPeso molecular:274.29N6-(p-Methoxybenzyl)adenosine
CAS:<p>Nucleoside Derivatives - 6-Modified purine nucleosides; Drugs and Inhibitors; plant growth regulator, plant hormone</p>Fórmula:C18H21N5O5Pureza:99.79%Forma y color:SolidPeso molecular:387.392'-Deoxy-N4-methylcytidine
CAS:<p>2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.</p>Fórmula:C10H15N3O4Pureza:99.61%Forma y color:SolidPeso molecular:241.24O6-Methyldeoxy guanosine
CAS:<p>O6-Methyldeoxy guanosine, a deoxypurine nucleoside, is a weak inhibitor of the removal of O6-methylguanine from methylated DNA by rat liver enzymes in vitro.</p>Fórmula:C11H15N5O4Pureza:99.57%Forma y color:SolidPeso molecular:281.27RO0270608
CAS:<p>RO0270608 is an α4β1/α4β7 integrin antagonist with anti-inflammatory activity for the study of allergic inflammatory responses.</p>Fórmula:C24H19Cl3N2O4Pureza:98.26%Forma y color:SolidPeso molecular:505.78Braco-19
CAS:<p>Braco-19 is a telomerase/telomere inhibitor and an inhibitor of HAdV viral replication with antiviral activity that reduces lipid vacuolization in adipocytes, inhibits proliferation and decreases telomerase activity in human glioblastoma cells.</p>Fórmula:C35H43N7O2Pureza:97.01%Forma y color:SolidPeso molecular:593.76CDK12-IN-5
CAS:<p>CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.</p>Fórmula:C18H15F5N8OPureza:99.37%Forma y color:SolidPeso molecular:454.36AZ5576
CAS:<p>AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].</p>Fórmula:C21H24FN3O3Pureza:99.88%Forma y color:SoildPeso molecular:385.43Bexotegrast
CAS:<p>Bexotegrast (PLN-74809) is an αvβ6 and αvβ1 integrin inhibitor with antifibrotic properties for the study of idiopathic pulmonary fibrosis (IPF).</p>Fórmula:C27H36N6O3Pureza:99.53%Forma y color:SolidPeso molecular:492.61N6-(2-Hydroxyethyl)adenosine
CAS:<p>N6-(2-Hydroxyethyl)adenosine is a sedative, Ca2+ antagonist, and anti-inflammatory, affecting brain and heart blood flow.</p>Fórmula:C12H17N5O5Pureza:99.4%Forma y color:SolidPeso molecular:311.295-Bromouridine
CAS:<p>5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.</p>Fórmula:C9H11BrN2O6Pureza:99.89%Forma y color:White PowderPeso molecular:323.12'-Deoxy-N2-methylguanosine
CAS:<p>2'-Deoxy-N2-methylguanosine is a purine nucleoside analog that can be used as a chemical probe to study DNA-protein interactions.</p>Fórmula:C11H15N5O4Pureza:99.79%Forma y color:SolidPeso molecular:281.27DS44960156
CAS:<p>DS44960156 is an inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) that inhibits both MTHFD2 and MTHFD1 and can be used in cancer research.</p>Fórmula:C20H15NO5Pureza:99.13%Forma y color:SolidPeso molecular:349.34N6-Methyl-2'-O-methyladenosine
CAS:<p>N6-Methyl-2'-O-methyladenosine (N6,2′-O-Dimethyladenosine), a substrate for adiposity and obesity-related genes (FTO), is a reversible modifier compound found</p>Fórmula:C12H17N5O4Pureza:99.97%Forma y color:SolidPeso molecular:295.292'-O-(2-Methoxyethyl)adenosine
CAS:<p>2'-O-(2-Methoxyethyl)adenosine is a nucleoside analog used to improve RNA target affinity and nuclease resistance of therapeutic oligonucleotides in preclin.</p>Fórmula:C13H19N5O5Pureza:99.35%Forma y color:SolidPeso molecular:325.32PolQi2
CAS:<p>PolQi2 is a Polθ inhibitor that suppresses the helicase activity of Polθ, and when combined with AZD7648.</p>Fórmula:C21H16ClN5O3SPureza:99.19%Forma y color:SolidPeso molecular:453.9Z62954982
CAS:<p>Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteries</p>Fórmula:C20H21N3O5SPureza:98.28%Forma y color:SolidPeso molecular:415.462'-C-β-Methylguanosine
CAS:<p>2'-C-beta-Methylguanosine (2'-C-Methylguanosine), with antiviral activity, inhibits dengue virus 2.</p>Fórmula:C11H15N5O5Pureza:99.37%Forma y color:SolidPeso molecular:297.273'-Deoxy-3'-fluoroadenosine
CAS:<p>3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue with a wide range of anti-tumor and anti-viral activity, and has inhibitory effects on tick-borne</p>Fórmula:C10H12FN5O3Pureza:99.84%Forma y color:SolidPeso molecular:269.23Etaracizumab
CAS:<p>Etaracizumab (LM 609) is a humanized monoclonal antibody targeting integrin αvβ3, inhibiting angiogenesis and melanoma growth, used in the study of melanoma.</p>Pureza:96.77% (SEC-HPLC) - 99.32% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.3 (kDa)
