Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(547 productos)
- Detención del ciclo celular(5 productos)
- Chk(48 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(276 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(273 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3935 productos de "Ciclo celular / Checkpoint"
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NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Fórmula:C16H19ClN6OPureza:98% - 99.34%Forma y color:SolidPeso molecular:346.817BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Fórmula:C16H10BrN3O2Pureza:99.67%Forma y color:SolidPeso molecular:356.17GS-441524 HCl
CAS:GS-441524: Inhibits FIP virus, EC50 at 0.78 μM, precursor to active triphosphate, non-toxic up to 100 μM, works at ≥1 μM, metabolite of Remdesivir.Fórmula:C12H14ClN5O4Forma y color:SolidPeso molecular:327.72FDI-6
CAS:FDI-6 is an effective and selective inhibitor of FOXM1 that blocks DNA binding. FDI-6 binds to the FOXM1 protein and downregulates FOXM1-activated genes.Fórmula:C19H11F4N3OS2Pureza:98.92% - >99.99%Forma y color:SolidPeso molecular:437.43Ref: TM-T4005
1mg34,00€5mg74,00€1mL*10mM (DMSO)84,00€10mg114,00€25mg192,00€50mg274,00€100mg408,00€200mg597,00€Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Fórmula:C18H24N6OPureza:99.09% - 99.53%Forma y color:SolidPeso molecular:340.42Nemorubicin HCL
CAS:Nemorubicin HCL, a PNU152243A salt, acts on resistant tumors via topoisomerase I inhibition and targets NER pathway upregulated cells.Fórmula:C32H38ClNO13Forma y color:SolidPeso molecular:680.1ML-7 hydrochloride
CAS:ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM);Fórmula:C15H18ClIN2O2SPureza:99% - 99.26%Forma y color:White PowderPeso molecular:452.74Ref: TM-T3050
2mg34,00€5mg47,00€1mL*10mM (DMSO)52,00€10mg71,00€25mg141,00€50mg230,00€100mg334,00€200mg434,00€Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Fórmula:C23H28N8OSPureza:99.99%Forma y color:SolidPeso molecular:464.59Ganciclovir sodium
CAS:Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.Fórmula:C9H13N5NaO4Pureza:99.93%Forma y color:SolidPeso molecular:278.22CID-797718
CAS:CID-797718 is a protein kinase D1 (PKD1) inhibitor.Fórmula:C12H11NO3Pureza:98.91% - 99.21%Forma y color:SolidPeso molecular:217.22Ref: TM-T1858
1mg62,00€5mg138,00€1mL*10mM (DMSO)152,00€10mg200,00€25mg339,00€50mg482,00€100mg665,00€200mg893,00€MNS
CAS:MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.Fórmula:C9H7NO4Pureza:98.53%Forma y color:Yellow PowderPeso molecular:193.16MTOB
CAS:MTOB, a CtBP substrate, inhibits CtBP-linked cancer activity in cells/mice and regulates TCF-4, affecting CSC proliferation.Fórmula:C5H7NaO3SPureza:98.23%Forma y color:SolidPeso molecular:170.16SBC-115337
CAS:SBC-115337 is a PCSK9 inhibitor.Fórmula:C29H19N3O4Pureza:99.41%Forma y color:SolidPeso molecular:473.48URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Fórmula:C27H27N5Pureza:99.32% - 99.98%Forma y color:SolidPeso molecular:421.54APY29
CAS:APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Fórmula:C17H16N8Pureza:96.51% - 98.46%Forma y color:SolidPeso molecular:332.36Ref: TM-T3654
2mg40,00€5mg62,00€1mL*10mM (DMSO)67,00€10mg90,00€25mg167,00€50mg285,00€100mg515,00€500mg1.071,00€TP-353
CAS:TP-353 (EOS-61973) is a CDK7 inhibitor.Fórmula:C35H30FNO3Pureza:99.12%Forma y color:SolidPeso molecular:531.62Ref: TM-T22440
1mg43,00€5mg80,00€1mL*10mM (DMSO)105,00€10mg129,00€25mg225,00€50mg314,00€100mg432,00€200mg597,00€THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Fórmula:C31H29Cl2N7O2Forma y color:SolidPeso molecular:602.51Simeprevir
CAS:Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.Fórmula:C38H47N5O7S2Pureza:99.45% - 99.92%Forma y color:SolidPeso molecular:749.94M2N12
CAS:M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.Fórmula:C20H16ClN5O2Pureza:98.01%Forma y color:SolidPeso molecular:393.83Ref: TM-T11929
1mg84,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg447,00€50mg670,00€100mg982,00€MLN8054 sodium
CAS:MLN8054 sodium is an Aurora A inhibitor.Fórmula:C25H14ClF2N4NaO2Forma y color:SolidPeso molecular:498.84Metoprine
CAS:Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.Fórmula:C11H10Cl2N4Pureza:98.42%Forma y color:SolidPeso molecular:269.13WR99210 hydrochloride(47326-86-3 free base)
CAS:WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.Fórmula:C14H19Cl4N5O2Pureza:97.77% - 99.8%Forma y color:SolidPeso molecular:431.14Ref: TM-T17257L
1mg62,00€5mg132,00€1mL*10mM (DMSO)157,00€10mg200,00€25mg338,00€50mg497,00€100mg708,00€200mg954,00€WNK-IN-11
CAS:WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)Fórmula:C21H21Cl2N5OSPureza:98.32%Forma y color:SolidPeso molecular:462.4Ref: TM-T5456
1mg87,00€5mg172,00€1mL*10mM (DMSO)188,00€10mg280,00€25mg474,00€50mg683,00€100mg964,00€500mg1.918,00€Aplidine
CAS:Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM).Fórmula:C57H87N7O15Pureza:99.86%Forma y color:SolidPeso molecular:1110.34Ref: TM-T9715
1mg235,00€5mg588,00€10mg787,00€1mL*10mM (DMSO)938,00€25mg1.216,00€50mg1.568,00€100mg2.527,00€Clevudine
CAS:Clevudine (Levovir) fights HBV, blocks viral DNA synthesis, and has a long half-life reducing relapse risk after treatment.Fórmula:C10H13FN2O5Pureza:99.88% - 99.97%Forma y color:SolidPeso molecular:260.22Lurbinectedin
CAS:Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.Fórmula:C41H44N4O10SPureza:98.11%Forma y color:SolidPeso molecular:784.873'-Deoxyguanosine
CAS:3'-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors.Fórmula:C10H13N5O4Pureza:98.85% - 98.96%Forma y color:SolidPeso molecular:267.24Carotegrast methyl HCl
CAS:Carotegrast methyl (AJM300/PTC-100) is an oral α4 integrin blocker reducing inflammation and experimental colitis.Fórmula:C25H20Cl3N3O5Forma y color:SolidPeso molecular:548.801CID755673
CAS:CID755673 inhibits PKD (IC50: 182 nM), with selectivity over PLK1, AKT, CAMKIIα, CAK, PKC.Fórmula:C12H11NO3Pureza:97.68% - 99.84%Forma y color:SolidPeso molecular:217.22AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Fórmula:C18H18Cl2F3N5O4Forma y color:SolidPeso molecular:496.27Favipiravir
CAS:Favipiravir is a potent and selective RNA-dependent RNA polymerase inhibitor for the treatment of influenza virus infections.Cost-effective and quality-assured.Fórmula:C5H4FN3O2Pureza:97.32% - 99.90%Forma y color:SolidPeso molecular:157.1SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Fórmula:C18H15ClN6OS2·CH4O3SPureza:99.44% - 99.92%Forma y color:SolidPeso molecular:527.04Levofloxacin hydrochloride
CAS:Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Fórmula:C18H21ClFN3O4Pureza:99.78% - 99.98%Forma y color:SolidPeso molecular:397.8Phosphonoformic acid trisodium salt hexa
CAS:Phosphonoformic acid trisodium salt hexa (Sodium phosphonatoformate hexahydrate) is an antiviral drug for the treatment of CMV retinitis.Fórmula:CH12Na3O11PPureza:98%Forma y color:SolidPeso molecular:300.03NU2058
CAS:NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Fórmula:C12H17N5OPureza:99.34% - 99.92%Forma y color:SolidPeso molecular:247.3Ref: TM-T3186
10mg42,00€1mL*10mM (DMSO)47,00€25mg78,00€50mg106,00€100mg160,00€200mg230,00€500mg378,00€LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Fórmula:C16H12FN5OForma y color:SolidPeso molecular:309.3Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Fórmula:C31H43F6N9O12Pureza:95.28% - ≥95%Forma y color:SolidPeso molecular:847.72ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Fórmula:C21H25N7Pureza:97.63% - ≥95%Forma y color:SolidPeso molecular:375.47SAR-020106
CAS:SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Fórmula:C19H19ClN6OPureza:97.78%Forma y color:SolidPeso molecular:382.85PfDHODH-IN-1
CAS:PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for DNA and RNA biosynthesis.Fórmula:C14H11F3N2O2Pureza:99.87%Forma y color:SolidPeso molecular:296.24Ref: TM-T12438
1mg52,00€1mL*10mM (DMSO)92,00€5mg101,00€10mg152,00€25mg295,00€50mg447,00€100mg658,00€200mg888,00€GAK inhibitor 49 hydrochloride
Potent GAK inhibitor 49 hydrochloride: ATP-competitive, highly selective, Ki=0.54 nM, IC50=56 nM, binds to RIPK2.Fórmula:C20H23ClN2O5Forma y color:SolidPeso molecular:406.86Tirapazamine
CAS:Tirapazamine (Win59075) triggers apoptosis in hypoxic cells by damaging DNA and enhances effects of radiation and cisplatin.Fórmula:C7H6N4O2Pureza:96.65% - 99.87%Forma y color:Orange-Red Crystalline PowderPeso molecular:178.152'-Fluoro-2'-Deoxyadenosine
CAS:2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Fórmula:C10H12FN5O3Pureza:99.95%Forma y color:SolidPeso molecular:269.23DHFR-IN-3
CAS:DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.Fórmula:C8H7BrN4Pureza:99.521% - 99.65%Forma y color:SolidPeso molecular:239.07EN4
CAS:EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Fórmula:C25H24N2O4Pureza:98.51%Forma y color:SolidPeso molecular:416.47Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.Fórmula:C93H134N22O25Pureza:99.92%Forma y color:SolidPeso molecular:1960.19BSJ-03-123
CAS:BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.Fórmula:C47H56N10O11Pureza:97.78% - 99.38%Forma y color:SolidPeso molecular:937.01Ref: TM-T5395
1mg87,00€2mg113,00€5mg177,00€10mg259,00€25mg409,00€50mg560,00€100mg800,00€500mg1.611,00€NSAH
CAS:NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Fórmula:C18H14N2O3Pureza:99.27%Forma y color:SolidPeso molecular:306.32BI-1347
CAS:BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.Fórmula:C22H20N4OPureza:96.7% - 99.63%Forma y color:SolidPeso molecular:356.42Ref: TM-T5405
1mg40,00€1mL*10mM (DMSO)87,00€5mg88,00€10mg126,00€25mg240,00€50mg439,00€100mg647,00€500mg1.359,00€LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Fórmula:C18H22Cl2N2O2SPureza:98%Forma y color:SolidPeso molecular:401.35
