Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(70 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"
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SNX7
CAS:<p>SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.</p>Fórmula:C15H14N2OPureza:99.05%Forma y color:SolidPeso molecular:238.28GS-443902 trisodium
CAS:<p>GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.</p>Fórmula:C12H16N5O13P3·xNaForma y color:SolidCatumaxomab
CAS:<p>Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.</p>Pureza:95%Forma y color:LiquidUridine triphosphate 13C9,15N2 sodium
CAS:<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>Fórmula:C9H1415N2NaO15P3Forma y color:SolidPeso molecular:517.0411H-Benzo[a]carbazole
CAS:<p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>Fórmula:C16H11NPureza:99.14%Forma y color:SolidPeso molecular:217.27Nogalamycin
CAS:<p>Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.</p>Fórmula:C39H49NO16Pureza:98%Forma y color:SolidPeso molecular:787.812Erythromycin lactobionate
CAS:<p>Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.</p>Fórmula:C49H89NO25Forma y color:SolidPeso molecular:1092.233SMS 121
CAS:<p>SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.</p>Fórmula:C20H21NO5Pureza:98.29%Forma y color:SoildPeso molecular:355.38CDK12/13-IN-2
<p>CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.</p>Fórmula:C24H22FN7O2Forma y color:SolidPeso molecular:459.48JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Fórmula:C43H45ClFN7O10SForma y color:SolidPeso molecular:906.375TAS-119
CAS:<p>TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95</p>Fórmula:C23H22Cl2FN5O3Pureza:99.65%Forma y color:SolidPeso molecular:506.36Farletuzumab
CAS:<p>Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.</p>Pureza:> 95%Forma y color:LiquidPeso molecular:145.36 kDaCTP Synthetase-IN-1 Ammonium salt
<p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>Fórmula:C20H22F3N7O3S2Pureza:99.97%Forma y color:SolidPeso molecular:529.56pNP-ADPr
CAS:<p>pNP-ADPr: Used in PARG & ARH3 activity assays; aids in PARP enzyme research.</p>Fórmula:C21H26N6O16P2Forma y color:SolidPeso molecular:680.41(1S,3R,5R)-PIM447 dihydrochloride
<p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>Fórmula:C24H25Cl2F3N4OPureza:98%Forma y color:SolidPeso molecular:513.38(E/Z)-THZ1 2HCl
CAS:<p>THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.</p>Fórmula:C31H30Cl3N7O2Pureza:99.51%Forma y color:SolidPeso molecular:638.98Clofarabine-5'-diphosphate
CAS:<p>Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>Fórmula:C10H13ClFN5O9P2Forma y color:SolidPeso molecular:463.64PD-1/PD-L1-IN-50
<p>Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.</p>Forma y color:Odour SolidDSPE-PEG2000-cRGD
<p>DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.</p>Forma y color:Odour SolidNusinersen
CAS:<p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>Pureza:98.62%Forma y color:Solid16,16-dimethyl Prostaglandin A1
CAS:<p>16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.</p>Fórmula:C22H36O4Forma y color:SolidPeso molecular:364.526Torvutatug
CAS:<p>Torvutatug is a human IgG1κ monoclonal antibody that acts against FOLR1.</p>Forma y color:LiquidN7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>Fórmula:C21H35N12O17P3Forma y color:SolidPeso molecular:820.49STX-100
<p>PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.</p>Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:Odour LiquidJH-XVI-178
CAS:<p>JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.</p>Fórmula:C22H22ClN7OForma y color:SolidPeso molecular:435.92DNA Gyrase-IN-12
<p>DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.</p>Forma y color:Odour SolidN3-(2S)-[2-(tert-Butoxycarbonyl)amino-3-(tert-butoxy carbonyl)]propyluridine
<p>N3-(2S)-propyluridine is a uridine analog with potential as an antiepileptic and for antihypertensive agent research.</p>Fórmula:C22H35N3O10Forma y color:SolidPeso molecular:501.53Nocarnickelamides B
<p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>Fórmula:C29H42N6O9Forma y color:Odour SolidPeso molecular:618.68IRE1-IN-2
<p>IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.</p>Fórmula:C16H20O6Forma y color:SolidPeso molecular:308.125995'-O-DMT-Bz-rC
CAS:<p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C37H35N3O8Forma y color:SolidPeso molecular:649.69Clofarabine-5'-diphosphate trisodium
<p>Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>Fórmula:C10H10ClFN5Na3O9P2Forma y color:SolidPeso molecular:529.585'-O-TBDMS-dA
CAS:<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C16H27N5O3SiForma y color:SolidPeso molecular:365.509Anti-c-myc Antibody (9E10)
<p>Anti-c-myc Antibody (9E10) is a chimeric mouse IgG1 antibody targeting human c-myc.</p>Forma y color:Odour LiquidErythromycin thiocyanate
CAS:<p>Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.</p>Fórmula:C38H68N2O13SPureza:98%Forma y color:SolidPeso molecular:793.02Viquidacin
CAS:<p>NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.</p>Fórmula:C25H29FN2O4S2Forma y color:SolidPeso molecular:504.64DSPE-PEG3000-iRGD
<p>DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.</p>Forma y color:Odour Solidα-Methyl-DL-aspartic acid
CAS:<p>α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.</p>Fórmula:C5H9NO4Pureza:99.91%Forma y color:SolidPeso molecular:147.13Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Fórmula:C16H18F3N7Forma y color:SolidPeso molecular:365.364αVβ8-IN-1
CAS:<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Fórmula:C25H32ClN5O4Forma y color:SolidPeso molecular:502.01TC113
<p>TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.</p>Fórmula:C37H50F2N12O13Forma y color:SolidPeso molecular:908.86(+)-Glaucarubinone
<p>(+)-Glaucarubinone is a natural product that can be used as a reference standard.</p>Fórmula:C25H34O10Forma y color:SolidPeso molecular:494.537EC0488
CAS:<p>EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.</p>Fórmula:C65H98N16O34SPureza:98%Forma y color:SolidPeso molecular:1679.63WRN inhibitor 17
CAS:<p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>Fórmula:C33H34F4N4O6SForma y color:SolidPeso molecular:690.71Dihydro-5-azacytidine
CAS:<p>Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.</p>Fórmula:C8H14N4O5Pureza:>99.99%Forma y color:SolidPeso molecular:246.22CDK4/6-IN-5
CAS:<p>CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)</p>Fórmula:C22H28ClFN6O4SForma y color:SolidPeso molecular:527.01DHFR-IN-11
<p>DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.</p>Forma y color:Odour SolidDSPE-PEG2000-iRGD
<p>DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.</p>Forma y color:Odour SolidClofarabine-5'-triphosphate
CAS:<p>Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.</p>Fórmula:C10H14ClFN5O12P3Forma y color:SolidPeso molecular:543.62NUAK1-IN-1
<p>NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.</p>Fórmula:C25H30N6OForma y color:SolidPeso molecular:430.545HDAC-IN-85
<p>HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.</p>Fórmula:C24H27FN4O5Forma y color:SolidPeso molecular:470.49
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