Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(67 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
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Se han encontrado 3486 productos de "Ciclo celular / Checkpoint"
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Mps1-IN-1
CAS:<p>Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )</p>Fórmula:C28H33N5O4SPureza:98.33%Forma y color:SolidPeso molecular:535.66XL413
CAS:<p>XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.</p>Fórmula:C14H12ClN3O2Pureza:98.40% - >99.99%Forma y color:SolidPeso molecular:289.72L-Guanosine
CAS:<p>L-Guanosine is the L-configuration of Guanosine. Guanosine is a purine nucleoside that has anti-herpesvirus activity [1] [2].</p>Fórmula:C10H13N5O5Forma y color:SolidPeso molecular:283.24Tenofovir exalidex
CAS:<p>Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant</p>Fórmula:C28H52N5O5PPureza:99.83%Forma y color:SolidPeso molecular:569.72UIAA-II-232
CAS:<p>UIAA-II-232 (compound 19b) is a potent inhibitor of DNA gyrase catalytic (IC 50= 3.5 μM).</p>Fórmula:C20H24FN5O3Forma y color:SolidPeso molecular:401.43BPIC
CAS:<p>BPIC is an agent of anti-tumor that acts by inhibiting inflammation and scavenging free radicals.</p>Fórmula:C27H20N2O5Forma y color:SolidPeso molecular:452.46BOP sodium
CAS:<p>BOP sodium salt is an inhibitor of alpha9beta1 and alpha4beta1 integrin.</p>Fórmula:C25H29N3NaO7SForma y color:SolidPeso molecular:538.57CLK1-IN-2
<p>CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.</p>Fórmula:C16H12Cl2N2O2SForma y color:SolidPeso molecular:367.25TDRL-X80
CAS:<p>TDRL-X80 inhibits XPA DNA binding; effective on single, double, and cisplatin-damaged DNA; IC50: 18-29 μM (FP), 21-39 μM (ELISA).</p>Fórmula:C23H15ClN2O6Forma y color:SolidPeso molecular:450.83Protein kinase D inhibitor 1
CAS:<p>Protein kinase D inhibitor 1 (17m) is a potent pan-PKD suppressant with IC50 of 17-35 nM, targeting cortactin phosphorylation.</p>Fórmula:C19H21N7Forma y color:SolidPeso molecular:347.42GSK317354A
CAS:<p>GSK317354A is a GRK2 inhibitor.</p>Fórmula:C25H18F4N6OForma y color:SolidPeso molecular:494.44CH-1504
CAS:<p>CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis.</p>Fórmula:C23H23N5O5Forma y color:SolidPeso molecular:449.46BPKDi
CAS:<p>BPKDi is a potent and selective inhibitor of PKD (protein kinase D).</p>Fórmula:C21H28N6OPureza:98%Forma y color:SolidPeso molecular:380.49Poloxipan
CAS:<p>Poloxipan inhibits PLK1 (IC50: 3.2µM), PLK2 (1.7µM), PLK3 (3µM); minimal effect on Chk2, STAT1, STAT5b, Lck.</p>Fórmula:C14H10BrN3O3SForma y color:SolidPeso molecular:380.22MMV688844
CAS:<p>MMV688844 inhibits M. abscessus DNA cyclooxygenase (IC50: 2μM) and has MIC50 of 12μM on strain bamboo; useful in antimicrobial studies.</p>Fórmula:C23H25ClN4O2Forma y color:SolidPeso molecular:424.92Aloisine A
CAS:<p>Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.</p>Fórmula:C16H17N3OPureza:98%Forma y color:SolidPeso molecular:267.33MMV688845
CAS:<p>MMV688845: NTM RNA polymerase inhibitor, kills Mycobacterium abscessus, and fights TB.</p>Fórmula:C24H25N3O3SForma y color:SolidPeso molecular:435.54TP1287
CAS:<p>TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.</p>Fórmula:C21H21ClNO8PForma y color:SolidPeso molecular:481.82Levofloxacin sodium
CAS:<p>Levofloxacin sodium: synthetic antibacterial, stops DNA replication by inhibiting bacterial DNA gyrase.</p>Fórmula:C18H20FN3NaO4Pureza:98%Forma y color:SolidPeso molecular:384.363SRPIN-803
CAS:<p>SRPIN-803 is a selective dual SRPK1 and CK2 inhibitor.</p>Fórmula:C14H9F3N4O3SPureza:98%Forma y color:SolidPeso molecular:370.31Braco-19 trihydrochloride
CAS:<p>BRACO19 3HCl inhibits telomerase, blocking its capping function, and prevents HAdV viral replication.</p>Fórmula:C35H46Cl3N7O2Pureza:98.74%Forma y color:SolidPeso molecular:703.14MK-0668
CAS:<p>MK-0668 is a very potent and orally active very late antigen-4 antagonist.</p>Fórmula:C31H30Cl2N6O6SForma y color:SolidPeso molecular:685.58CDK7-IN-10
CAS:<p>CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)</p>Fórmula:C29H35N7O3Forma y color:SolidPeso molecular:529.63BI-831266
CAS:<p>BI-831266 is a potent and selective Aurora kinase B inhibitor.</p>Fórmula:C27H38ClN7O2Forma y color:SolidPeso molecular:528.09CDK7-IN-16
CAS:<p>CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.</p>Fórmula:C19H21F3N6O2SForma y color:SolidPeso molecular:454.47BMVC
CAS:<p>BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities.</p>Fórmula:C28H25I2N3Forma y color:SolidPeso molecular:657.33DHX9-IN-1
CAS:<p>DHX9-IN-1 is a potent ATP-dependent RNA helicase A (DHX9) inhibitor, exhibiting an IC50 of 9.45 nM and demonstrating antitumor activity [1].</p>Fórmula:C21H21F2N5O3SForma y color:SolidPeso molecular:461.49DDD100097
CAS:<p>DDD100097 is a N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.</p>Fórmula:C22H30Cl2F2N4O2SPureza:98.89%Forma y color:SolidPeso molecular:523.47CDK4/6-IN-12
CAS:<p>CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.</p>Fórmula:C12H10N6Forma y color:SolidPeso molecular:238.25hDHODH-IN-3
CAS:<p>hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.</p>Fórmula:C18H19BrN4O2Pureza:99.871%Forma y color:SolidPeso molecular:403.27Synucleozid
CAS:<p>Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.</p>Fórmula:C22H20N6Pureza:98%Forma y color:SolidPeso molecular:368.43(R)-DRF053 dihydrochloride
CAS:<p>cdk/CK1 inhibitor,potent and ATP-competitive</p>Fórmula:C23H29Cl2N7OPureza:98%Forma y color:SolidPeso molecular:490.43HBV-IN-14
CAS:<p>HBV-IN-14: a pyridinopyrimidinone, potent cccDNA inhibitor for HBV study (patent WO2021190502A1, comp 5).</p>Fórmula:C22H21ClN2O5Forma y color:SolidPeso molecular:428.87PF-4950834
CAS:<p>PF-4950834, a ATP-competitive, selective Rho kinase inhibitor, provides therapeutic benefits in chronic inflammatory diseases.</p>Fórmula:C21H19N3O2Pureza:98%Forma y color:SolidPeso molecular:345.39PV-1115
CAS:<p>PV-1115 is an effective and highly selective inhibitor of the Chk2.</p>Fórmula:C20H19N7O3Pureza:98%Forma y color:SolidPeso molecular:405.41Aurora Kinases-IN-3
CAS:<p>Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.</p>Fórmula:C20H16F3N3O4Forma y color:SolidPeso molecular:419.35Kira8 Hydrochloride
CAS:<p>Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.</p>Fórmula:C31H30Cl2N6O3SPureza:98%Forma y color:SolidPeso molecular:637.58HIV-1 inhibitor-43
CAS:<p>HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.</p>Fórmula:C24H21ClN2O4SForma y color:SolidPeso molecular:468.95Aurora kinase inhibitor-9
CAS:<p>Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.</p>Fórmula:C19H17Cl2N3O4SForma y color:SolidPeso molecular:454.33Bofumustine
CAS:<p>Bofumustine is a chloroethyl nitrosourea with anti tumor properties.</p>Fórmula:C18H21ClN4O9Forma y color:SolidPeso molecular:472.83PV-1019
CAS:<p>PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.</p>Fórmula:C18H17N7O3Forma y color:SolidPeso molecular:379.37DENV-IN-4
CAS:<p>DENV-IN-4: Effective DENV inhibitor (EC50=4.79 μM), low toxicity (CC50>100 μM), and strong selectivity (SI>20.9); suppresses DENV2 and RdRp.</p>Fórmula:C28H32N4O4SiForma y color:SolidPeso molecular:516.66JTK-101
CAS:<p>JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.</p>Fórmula:C25H23N3O3Forma y color:SolidPeso molecular:413.47(Rac)-Managlinat dialanetil
CAS:<p>Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.</p>Fórmula:C21H33N4O6PSPureza:98.52%Forma y color:SolidPeso molecular:500.55DHODH-IN-12
CAS:<p>DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.</p>Fórmula:C10H9N3O2Pureza:99.53%Forma y color:SolidPeso molecular:203.2CGP 53353
CAS:<p>CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.</p>Fórmula:C20H13F2N3O2Pureza:98.11%Forma y color:SolidPeso molecular:365.33LDN-209929 dihydrochloride
CAS:<p>LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.</p>Fórmula:C17H19Cl3N2OSForma y color:SolidPeso molecular:405.77DHODH-IN-3
CAS:<p>DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.</p>Fórmula:C17H13ClN2O2Pureza:98%Forma y color:SolidPeso molecular:312.75JFN05510
CAS:<p>Compound: 3'-O-tert-BDMS-5'-O-DMT-N2-IBG 2'-CE phosphoramidite; has anticancer properties and activates enzymes.</p>Fórmula:C50H68N7O9PSiForma y color:SolidPeso molecular:970.18CDK9-IN-14
CAS:<p>CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.</p>Fórmula:C21H23F2N3O4Forma y color:SolidPeso molecular:419.42
