Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
Mostrar 10 subcategorías más
Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"
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Chlorasquin
CAS:<p>Chlorasquin is a dihydrofolate reductase inhibitor.</p>Fórmula:C20H19ClN6O5Pureza:98%Forma y color:SolidPeso molecular:458.86KIF18A-IN-3
CAS:<p>KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.</p>Fórmula:C28H38N4O5S2Pureza:98.45%Forma y color:SolidPeso molecular:574.76BMS-688521
CAS:<p>BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.</p>Fórmula:C26H19Cl2N5O4Pureza:98.87%Forma y color:SolidPeso molecular:536.37CDK8/19-IN-51
CAS:<p>CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.</p>Fórmula:C23H22N6O2Pureza:98.65% - 99.62%Forma y color:SoildPeso molecular:414.4610-Formyl-5,8-dideazafolic acid
CAS:<p>10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.</p>Fórmula:C22H21N5O7Pureza:96.04%Forma y color:SolidPeso molecular:467.43RSK-IN-1
CAS:<p>RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].</p>Fórmula:C22H17NO2Forma y color:SolidPeso molecular:327.38UR-3216
CAS:<p>UR-3216 is a prodrug, selectively antagonizing GPIIb/IIIa receptors orally, with its active form, UR-2992, binding tightly to platelets.</p>Fórmula:C27H29N7O7Pureza:98%Forma y color:SolidPeso molecular:563.56CDK9-IN-15
CAS:<p>CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.</p>Fórmula:C16H11N3OSPureza:97.24%Forma y color:SolidPeso molecular:293.34CTP Synthetase-IN-1
CAS:<p>CTP Synthetase-IN-1 is a cytidine 5'-triphosphate synthetase (CTPS) inhibitor with antitumor activity for the study of arthritis and rheumatoid arthritis.</p>Fórmula:C20H19F3N6O3S2Pureza:98.11% - 99.18%Forma y color:SolidPeso molecular:512.53SP-471P
CAS:<p>SP-471P inhibits DENV protease; EC50: DENV1-5.9 μM, DENV2-1.4 μM, DENV3-5.1 μM, DENV4-1.7 μM; CC50 >100 μM; lowers viral RNA synthesis.</p>Fórmula:C33H26BrN5O2Forma y color:SolidPeso molecular:604.515(S)-HpETE
CAS:<p>15(S)-HpETE is a product of arachidonic acid formed in the 15-lipoxygenase pathway and inhibits angiogenesis.</p>Fórmula:C20H32O4Forma y color:SolidPeso molecular:336.47Crisnatol
CAS:<p>Crisnatol (BWA770U) is an oral anticancer DNA intercalator, toxic to breast cancer cells, not skin fibroblasts.</p>Fórmula:C23H23NO2Forma y color:SolidPeso molecular:345.43Cdc7-IN-17
CAS:<p>Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].</p>Fórmula:C13H15N5OSForma y color:SolidPeso molecular:289.36CCG-257081
CAS:<p>CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.</p>Fórmula:C24H19ClF3N3O2Pureza:99.76% - 99.94%Forma y color:SolidPeso molecular:473.87GW8510
CAS:<p>GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.</p>Fórmula:C21H15N5O3S2Pureza:99.32%Forma y color:SolidPeso molecular:449.51CBL 0100 free base
CAS:<p>CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.</p>Fórmula:C24H26N2O2Pureza:98.18% - 98.86%Forma y color:SolidPeso molecular:374.483'-Deoxyuridine-5'-triphosphate
CAS:<p>3'-dUTP, a nucleotide analogue, competitively inhibits RNA polymerases I & II, with a Ki of 2.0 µM.</p>Fórmula:C9H15N2O14P3Forma y color:SolidPeso molecular:468.14CDK8-IN-7
CAS:<p>CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.</p>Fórmula:C30H40N2Forma y color:SolidPeso molecular:428.65XVA143
CAS:<p>XVA143, an α/β I-like allosteric antagonist, blocks LFA-1 adhesion and combats P. gingivalis in mice, preventing bone loss.</p>Fórmula:C25H21Cl2N3O8Forma y color:SolidPeso molecular:562.36IDD388
CAS:<p>IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.</p>Fórmula:C16H12BrClFNO4Pureza:99.56%Forma y color:SolidPeso molecular:416.63Laromustine
CAS:<p>Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.</p>Fórmula:C6H14ClN3O5S2Pureza:≥98%Forma y color:SolidPeso molecular:307.78CDK2-IN-13
CAS:<p>CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.</p>Fórmula:C13H12ClN5Forma y color:SoildPeso molecular:273.72HBV-IN-4
CAS:<p>HBV-IN-4, a phthalazinone, inhibits HBV DNA replication orally (IC50: 14 nM), encouraging genome-free capsids with strong anti-HBV effects.</p>Fórmula:C24H19ClFN5O3Forma y color:SolidPeso molecular:479.89APC 366
CAS:<p>APC 366: Mast cell tryptase inhibitor, Ki 7.1 μM. Reduces EAR, LAR, BHR in allergic asthma (sheep model).</p>Fórmula:C22H28N6O4Pureza:99.8%Forma y color:SolidPeso molecular:440.5MLAF50
CAS:<p>MLAF50 is an inhibitor of the REV1 UBM2-Ubiquitin interaction.</p>Fórmula:C15H12I2O4Forma y color:SolidPeso molecular:510.06Cdc7-IN-15
CAS:<p>Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].</p>Fórmula:C12H14N4OSForma y color:SolidPeso molecular:262.33CP681301
CAS:<p>CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.</p>Fórmula:C17H22N4OForma y color:SolidPeso molecular:298.38DNA Gyrase-IN-2
CAS:<p>DNA Gyrase-IN-2 inhibits E. coli (IC50: 3.29-10.49 μM) and M. tuberculosis (IC50: 4.41-5.61 μM) COX, has antibacterial properties.</p>Fórmula:C24H24N8OS2Forma y color:SolidPeso molecular:504.63CDK7-IN-15
CAS:<p>CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.</p>Fórmula:C21H24F4N6OSForma y color:SolidPeso molecular:484.51Beaucage reagent
CAS:<p>Beaucage reagent, which is found to be effective in causing DNA cleavage.</p>Fórmula:C7H4O3S2Pureza:98.50%Forma y color:White To Off-White PowderPeso molecular:200.23WNK1-IN-1
CAS:<p>WNK1-IN-1, a WNK1 inhibitor (IC50: 1.6 μM), also inhibits OSR1 phosphorylation (IC50: 4.3 μM), used in blood pressure and cancer research.</p>Fórmula:C13H15BrCl2N2O4SPureza:98.09%Forma y color:SolidPeso molecular:446.14DHODH-IN-15
CAS:DHODH-IN-15, a hydroxyfuran analogue of A771726, inhibits rat liver DHODH with an IC50 of 11 μM, and is used for rheumatoid arthritis.Fórmula:C15H11N3O3Pureza:99.8%Forma y color:SolidPeso molecular:281.27Valategrast hydrochloride
CAS:<p>Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.</p>Fórmula:C30H33Cl4N3O4Pureza:98%Forma y color:SolidPeso molecular:641.41CH-1504
CAS:<p>CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis.</p>Fórmula:C23H23N5O5Forma y color:SolidPeso molecular:449.46MMV688844
CAS:<p>MMV688844 inhibits M. abscessus DNA cyclooxygenase (IC50: 2μM) and has MIC50 of 12μM on strain bamboo; useful in antimicrobial studies.</p>Fórmula:C23H25ClN4O2Forma y color:SolidPeso molecular:424.92CDK7-IN-10
CAS:<p>CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)</p>Fórmula:C29H35N7O3Forma y color:SolidPeso molecular:529.63CDK7-IN-16
CAS:<p>CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.</p>Fórmula:C19H21F3N6O2SForma y color:SolidPeso molecular:454.47DNA Gyrase-IN-3
CAS:<p>DNA Gyrase-IN-3 inhibits E. coli DNA gyrase B with IC50 5.41-15.64 μM; shows anti-TB and antibacterial properties.</p>Fórmula:C18H20N6OS2Forma y color:SolidPeso molecular:400.52DHX9-IN-1
CAS:<p>DHX9-IN-1 is a potent ATP-dependent RNA helicase A (DHX9) inhibitor, exhibiting an IC50 of 9.45 nM and demonstrating antitumor activity [1].</p>Fórmula:C21H21F2N5O3SForma y color:SolidPeso molecular:461.49Y-33075
CAS:<p>Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.</p>Fórmula:C16H16N4OPureza:98%Forma y color:SolidPeso molecular:280.32Tripolin A
CAS:<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Fórmula:C15H11NO3Pureza:98%Forma y color:SolidPeso molecular:253.255-OHdU
CAS:<p>5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.</p>Fórmula:C9H12N2O6Pureza:99.5%Forma y color:SolidPeso molecular:244.2DENV-IN-4
CAS:<p>DENV-IN-4: Effective DENV inhibitor (EC50=4.79 μM), low toxicity (CC50>100 μM), and strong selectivity (SI>20.9); suppresses DENV2 and RdRp.</p>Fórmula:C28H32N4O4SiForma y color:SolidPeso molecular:516.66CDK9-IN-14
CAS:<p>CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.</p>Fórmula:C21H23F2N3O4Forma y color:SolidPeso molecular:419.42ST7612AA1
CAS:<p>ST7612AA1: potent, oral HDAC inhibitor; reactivates HIV-1 latency; shows antitumor effects; may study malaria.</p>Fórmula:C20H27N3O4SPureza:99.71%Forma y color:SolidPeso molecular:405.518-Azido-ADP disodium
CAS:<p>8-Azido-ADP (disodium) is a covalent inhibitor of ADP/ATP exchange in mitochondria, causing irreversible inhibition in light.</p>Fórmula:C10H13N8NaO10P2Forma y color:SolidPeso molecular:490.197FAK/aurora kinase-IN-1
CAS:<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Fórmula:C23H24ClN7O3Forma y color:SolidPeso molecular:481.93Triaziquone
CAS:<p>Triaziquone is an alkylating agent that can react with DNA to form intrastrand crosslinks.</p>Fórmula:C12H13N3O2Forma y color:SolidPeso molecular:231.25P18IN003
CAS:<p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>Fórmula:C17H16N2O3Pureza:98.77%Forma y color:SolidPeso molecular:296.32tBID
CAS:tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)Fórmula:C11H3Br4N3O2Pureza:98%Forma y color:SolidPeso molecular:528.78
