Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(95 productos)
- CDK(501 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(262 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(69 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
Mostrar 10 subcategorías más
Se han encontrado 3485 productos de "Ciclo celular / Checkpoint"
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Zelpolib
CAS:<p>Zelpolib is a specific inhibitor of DNA polymerase δ (Pol δ), inhibiting DNA replication. antiproliferative.</p>Fórmula:C22H21N3O5S2Pureza:98.79%Forma y color:SolidPeso molecular:471.55Cdc7-IN-3
CAS:<p>Cdc7-IN-3 is a potent inhibitor of Cdc7 kinase.</p>Fórmula:C20H22N4O5Pureza:98%Forma y color:SolidPeso molecular:398.41Flurocitabine
CAS:<p>Flurocitabine is a therapeutic agent with antineoplastic activity.</p>Fórmula:C9H10FN3O4Pureza:98%Forma y color:SolidPeso molecular:243.19FN-1501-propionic acid
CAS:<p>FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.</p>Fórmula:C25H27N9O4Pureza:98%Forma y color:SolidPeso molecular:517.5410-Methyl-10-deazaaminopterin
CAS:<p>10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity.</p>Fórmula:C21H23N7O5Pureza:98%Forma y color:SolidPeso molecular:453.45LCAHA
CAS:<p>LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.</p>Fórmula:C24H41NO3Forma y color:SolidPeso molecular:391.59N2-Ethylguanosine
CAS:<p>N2-Ethylguanosine is a Nucleoside Derivative - 2-Modified purine nucleoside.</p>Fórmula:C12H17N5O5Forma y color:SolidPeso molecular:311.29Y-9738
CAS:<p>Y-9738 is an agent of hypolipidemic.</p>Fórmula:C15H16ClNO4Pureza:98%Forma y color:SolidPeso molecular:309.74NSC 693868
CAS:<p>CDKs and GSK-3 inhibitor</p>Fórmula:C9H7N5Pureza:98%Forma y color:SolidPeso molecular:185.19Zaurategrast ethyl ester sulfate
CAS:<p>Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.</p>Fórmula:C56H60Br2N8O10SPureza:98%Forma y color:SolidPeso molecular:1197.01DHFR-IN-5
CAS:<p>DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.</p>Fórmula:C18H24N4O4Forma y color:SolidPeso molecular:360.41NSC666715
CAS:<p>NSC666715 is the strand-displacement activity of DNA polymerase inhibitor.</p>Fórmula:C15H13Cl2N5O2S2Pureza:98%Forma y color:SolidPeso molecular:430.33Aurora A/PKC-IN-1
CAS:<p>Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.</p>Fórmula:C16H14N6OSe2Forma y color:SolidPeso molecular:464.24HBV-IN-22
CAS:<p>HBV-IN-22 (Compound LC5f) is an HBV DNA replication inhibitor that acts on both wild-type HBV (IC50: 0.71 μM) and drug-resistant HBV (IC50: 0.84 μM).</p>Fórmula:C26H29N3O2S2Forma y color:SolidPeso molecular:479.66DHODH-IN-1
CAS:<p>DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.</p>Fórmula:C21H20F3N3O2Pureza:99.76%Forma y color:SolidPeso molecular:403.4ROCK2-IN-5
<p>ROCK2-IN-5, a compound blending fasudil, caffeic, and ferulic acids, shows promise for ALS research involving SOD1 mutations.</p>Fórmula:C23H25N3O5SForma y color:SolidPeso molecular:455.53S-(N-PhenethylthiocarbaMoyl)-L-cysteine
CAS:<p>PEITC-Cys: anticarcinogenic, antileukemic, inhibits DNA synthesis in HL60, P450 inhibitor.</p>Fórmula:C12H16N2O2S2Forma y color:SolidPeso molecular:284.4KIRA-7
CAS:<p>KIRA-7: imidazopyrazine, anti-fibrotic, inhibits IRE1α RNase (IC50: 110 nM) allosterically.</p>Fórmula:C27H23FN6OForma y color:SolidPeso molecular:466.51BRD9185
CAS:<p>BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.</p>Fórmula:C23H21F6N3O2Pureza:98%Forma y color:SolidPeso molecular:485.42Zaurategrast ethyl ester
CAS:<p>Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.</p>Fórmula:C28H29BrN4O3Pureza:98%Forma y color:SolidPeso molecular:549.46Atuveciclib S-Enantiomer
CAS:<p>Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.</p>Fórmula:C18H18FN5O2SPureza:98%Forma y color:SolidPeso molecular:387.438-Deazahomofolic acid
CAS:<p>8-Deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.</p>Fórmula:C21H22N6O6Pureza:98%Forma y color:SolidPeso molecular:454.44(E/Z)-BIO-acetoxime
CAS:<p>(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.</p>Fórmula:C18H12BrN3O3Forma y color:SolidPeso molecular:398.21Direct Black 38 free acid
CAS:<p>Ferristatin II (Direct Black 38 free acid) is a polysulphonated dye and promotes the degradation of transferrin receptor-1 in vitro and in vivo.</p>Fórmula:C34H27N9O7S2Pureza:98%Forma y color:SolidPeso molecular:737.77Capzimin
CAS:<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Fórmula:C30H24N6O2S4Pureza:98.31% - 99.32%Forma y color:SolidPeso molecular:628.81A 65281
CAS:<p>A 65281: antibacterial isothiazoloquinolone, inhibits P4-unknotting, induces DNA breakage via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Forma y color:SolidPeso molecular:378.4MFH290
CAS:<p>MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.</p>Fórmula:C26H31N5O3S2Forma y color:SolidPeso molecular:525.69RHI002-Me
CAS:<p>RHI002-Me is a methylated derivative of RHI002, a selective inhibitor of human RNaseH2.</p>Fórmula:C18H19N3O2S2Pureza:98%Forma y color:SolidPeso molecular:373.49DHFR-IN-2
CAS:<p>DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.</p>Fórmula:C14H13NO2Forma y color:SolidPeso molecular:227.26ROCK-IN-D2
CAS:<p>ROCK-IN-D2 is an effective and selective inhibitor of ROCK.</p>Fórmula:C22H28N6OPureza:98%Forma y color:SolidPeso molecular:392.5DHODH-IN-24
CAS:<p>DHODH-IN-24 (compound 16) serves as a powerful inhibitor of human dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value of 91 nM [1].</p>Fórmula:C26H26N4Forma y color:SolidPeso molecular:394.51Apricitabine
CAS:<p>Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-</p>Fórmula:C8H11N3O3SPureza:99.45%Forma y color:SolidPeso molecular:229.26PD 130883
CAS:<p>PD 130883 is a potent lipophilic quinazoline antifolate.</p>Fórmula:C18H15N5O3Pureza:98%Forma y color:SolidPeso molecular:349.34RP-106
CAS:<p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>Fórmula:C17H19N3OPureza:98%Forma y color:SolidPeso molecular:281.35A 65282
CAS:<p>A 65282: antibacterial isothiazoloquinolone, inhibits P4-unknotting, causes DNA breaks via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Forma y color:SolidPeso molecular:378.4CDK8-IN-10
CAS:<p>CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.</p>Fórmula:C25H15ClF3N5O3Forma y color:SolidPeso molecular:525.87RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Fórmula:C28H28N6O4SForma y color:SolidPeso molecular:544.62(R)-Filanesib
CAS:<p>(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).</p>Fórmula:C20H22F2N4O2SForma y color:SolidPeso molecular:420.48CRT5
CAS:<p>CRT5, a selective PKD inhibitor, blocks VEGF effects on histone deacetylase 5, CREB, HSP27, and endothelial functions. IC50s: 1-2 nM for PKD1-3.</p>Fórmula:C28H30N4O2Forma y color:SolidPeso molecular:454.56CDK4/6-IN-8
CAS:<p>CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).</p>Fórmula:C18H18N6O5Forma y color:SolidPeso molecular:398.37IMB-10
CAS:<p>IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.</p>Fórmula:C19H15NOS2Forma y color:SolidPeso molecular:337.46AnnH31
CAS:<p>AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the</p>Fórmula:C15H13N3OPureza:99.88%Forma y color:SolidPeso molecular:251.28Clociguanil
CAS:<p>Clociguanil has antimalarial activity.</p>Fórmula:C12H15Cl2N5OForma y color:SolidPeso molecular:316.19hDHODH-IN-4
CAS:<p>hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.</p>Fórmula:C21H24N4O2Pureza:99.87%Forma y color:SolidPeso molecular:364.44SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Fórmula:C15H13N5O2Pureza:98%Forma y color:SolidPeso molecular:295.3Kira8 Hydrochloride
CAS:<p>Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.</p>Fórmula:C31H30Cl2N6O3SPureza:98%Forma y color:SolidPeso molecular:637.58CDK4/6-IN-12
CAS:<p>CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.</p>Fórmula:C12H10N6Forma y color:SolidPeso molecular:238.25Levofloxacin sodium
CAS:<p>Levofloxacin sodium: synthetic antibacterial, stops DNA replication by inhibiting bacterial DNA gyrase.</p>Fórmula:C18H20FN3NaO4Pureza:98%Forma y color:SolidPeso molecular:384.363Tenofovir exalidex
CAS:<p>Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant</p>Fórmula:C28H52N5O5PPureza:99.83%Forma y color:SolidPeso molecular:569.72BPIC
CAS:<p>BPIC is an agent of anti-tumor that acts by inhibiting inflammation and scavenging free radicals.</p>Fórmula:C27H20N2O5Forma y color:SolidPeso molecular:452.46
