Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(116 productos)
- CDK(548 productos)
- Detención del ciclo celular(5 productos)
- Chk(49 productos)
- DYRK(46 productos)
- Dynamin(27 productos)
- Ferroptosis(233 productos)
- HSP(180 productos)
- Integrin(276 productos)
- Kinesina(87 productos)
- LIM quinasa(21 productos)
- Asociado a microtúbulos(274 productos)
- PKC(128 productos)
- PLK(25 productos)
- ROCK(61 productos)
- Rho(6 productos)
- Wee1(14 productos)
- c-Myc(77 productos)
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Se han encontrado 3937 productos de "Ciclo celular / Checkpoint"
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PKD-IN-1 dihydrochloride (956121-30-5 free base)
CAS:CRT0066101 dihydrochloride is an inhibitor of PKD.Fórmula:C18H21Cl3N4OPureza:99.5%Forma y color:SolidPeso molecular:415.75THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Fórmula:C31H28ClN7O2Pureza:97.42% - 99.27%Forma y color:SolidPeso molecular:566.05SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Forma y color:SolidPeso molecular:376.25Eprociclovir potassium
CAS:Eprociclovir potassium, 15x stronger than acyclovir, inhibits EHV1 and human herpesviruses, also treats herpetic keratitis effectively with eyedrops.Fórmula:C11H15KN5O3Forma y color:SolidPeso molecular:304.37Palbociclib monohydrochloride
CAS:Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinasesFórmula:C24H29N7O2·HClPureza:99.73% - >99.99%Forma y color:SolidPeso molecular:483.99ID-8
CAS:ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.Fórmula:C16H14N2O4Pureza:99.32%Forma y color:SolidPeso molecular:298.29WR99210
CAS:WR99210 (BRL 6231 free base) is a DHFR inhibitor with antiparasitic activity.Fórmula:C14H18Cl3N5O2Pureza:98.8%Forma y color:SolidPeso molecular:394.68Alovudine
CAS:3'-Fluoro-3'-deoxythymidine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis,which is less susceptible to inflammatory changes than FDG.Fórmula:C10H13FN2O4Pureza:99.41%Forma y color:Less Solid Colourless SolidPeso molecular:244.22FEN1-IN-SC13
CAS:FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1)
Fórmula:C24H23N3O3SPureza:98.02%Forma y color:SolidPeso molecular:433.52DMTr-LNA-5MeU-3-CED-phosphoramidite
CAS:DMTr-LNA-5MeU-3-CED-phosphoramidite is a derivative of nucleoside.Fórmula:C41H49N4O9PPureza:98.28%Forma y color:SolidPeso molecular:772.82Senexin B
CAS:Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Fórmula:C27H26N6OPureza:99.67%Forma y color:SolidPeso molecular:450.53Ref: TM-T8430
1mg92,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg260,00€25mg401,00€50mg532,00€100mg708,00€200mg964,00€USP25/28 inhibitor AZ1
CAS:USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Fórmula:C17H16BrF4NO2Pureza:99.79% - 99.86%Forma y color:SolidPeso molecular:422.21Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Fórmula:C16H11N3O2Pureza:99.55%Forma y color:Dark Red SolidPeso molecular:277.28SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26Dasabuvir
CAS:Dasabuvir (ABT-333) blocks HCV replication by inhibiting the essential NS5B RNA polymerase.Fórmula:C26H27N3O5SPureza:99.54% - 99.62%Forma y color:SolidPeso molecular:493.57SEL120-34A HCl
CAS:SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFórmula:C15H19Br2ClN4Pureza:98.13% - 98.47%Forma y color:SolidPeso molecular:450.6Protein kinase inhibitors 1
CAS:Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.Fórmula:C18H17N5O3SPureza:98%Forma y color:SolidPeso molecular:383.42CeMMEC13
CAS:CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).Fórmula:C19H16N2O4Pureza:98.52%Forma y color:SolidPeso molecular:336.34Ref: TM-T6801
1mg34,00€2mg44,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg105,00€25mg230,00€50mg334,00€100mg447,00€Simeprevir sodium
CAS:Simeprevir is a drug for the treatment and cure of hepatitis C.Fórmula:C38H46N5NaO7S2Pureza:98%Forma y color:SolidPeso molecular:771.92L189
CAS:L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).Fórmula:C11H10N4OSPureza:97.37%Forma y color:SolidPeso molecular:246.29Amenamevir
CAS:Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mLFórmula:C24H26N4O5SPureza:99.00% - 99.86%Forma y color:SolidPeso molecular:482.55Ref: TM-T4226
1mg34,00€1mL*10mM (DMSO)52,00€5mg71,00€10mg92,00€25mg152,00€50mg222,00€100mg334,00€200mg494,00€Temozolomide Acid
CAS:TMZA, a TMZ metabolite, shows in vitro anticancer effects. TMZ, an oral alkylator, treats GBM and astrocytomas.Fórmula:C6H5N5O3Pureza:99.28%Forma y color:SolidPeso molecular:195.14LDN-192960
CAS:LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).Fórmula:C18H20N2O2SPureza:99.01% - 99.51%Forma y color:SolidPeso molecular:328.43Ref: TM-TQ0111
1mg49,00€2mg64,00€5mg92,00€1mL*10mM (DMSO)104,00€10mg152,00€25mg295,00€50mg477,00€100mg763,00€200mg1.018,00€NSC 617145
CAS:NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependentFórmula:C13H10Cl4N2O4Pureza:99.78%Forma y color:SolidPeso molecular:400.04Ref: TM-T9168
1mg34,00€2mg49,00€5mg73,00€1mL*10mM (DMSO)80,00€10mg90,00€25mg164,00€50mg227,00€100mg358,00€500mg842,00€TAK-960 dihydrochloride
TAK-960 dihydrochloride: oral PLK1 inhibitor, IC50 0.8 nM; also Hinders PLK2 and PLK3 (IC50s 16.9/50.2 nM); curbs cancer cell growth.Fórmula:C27H36Cl2F3N7O3Forma y color:SolidPeso molecular:634.52Dalpiciclib
CAS:Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.Fórmula:C25H30N6O2Pureza:99.69%Forma y color:SolidPeso molecular:446.54Peldesine dihydrochloride
CAS:Peldesine (BCX 34) dihydrochloride is an inhibitor of PNP in humans, rats, and mice, also hindering T-cell proliferation, used in lymphoma and HIV research.Fórmula:C12H13Cl2N5OForma y color:SolidPeso molecular:314.17CYC-116
CAS:CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFórmula:C18H20N6OSPureza:97.36% - 97.59%Forma y color:SolidPeso molecular:368.46Acelarin
CAS:Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.Fórmula:C25H27F2N4O8PPureza:99.26%Forma y color:SolidPeso molecular:580.47Ref: TM-T4060
200mgA consultar1mg43,00€2mg56,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg137,00€25mg259,00€50mg398,00€100mg555,00€CDK9-IN-30
CAS:CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.Fórmula:C16H20FNO3Pureza:99.75%Forma y color:SolidPeso molecular:293.336-Chloropurine riboside
CAS:6-Chloropurine riboside (6-CPR): purine analog with antitumor, anti-inflammatory, antiviral, antifungal effects, and neuroprotective properties.Fórmula:C10H11ClN4O4Pureza:96.84%Forma y color:SoildPeso molecular:286.6700POL1-IN-1
CAS:POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂，IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。
Fórmula:C21H20N6Pureza:98% - 98.01%Forma y color:SolidPeso molecular:356.42Quarfloxin
CAS:Quarfloxin (CX-3543), a fluoroquinolone, inhibits neuroblastoma with nanomolar IC50, disrupting nucleolin and G-quadruplex DNA.Fórmula:C35H33FN6O3Pureza:99.77%Forma y color:SolidPeso molecular:604.67Ref: TM-T16703
1mg71,00€2mg92,00€5mg152,00€1mL*10mM (DMSO)212,00€10mg236,00€25mg380,00€50mg530,00€100mg708,00€MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Fórmula:C21H19N3O2SPureza:98.80%Forma y color:SolidPeso molecular:377.46Ref: TM-T22106
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg161,00€50mg245,00€100mg363,00€200mg515,00€CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H14Cl3N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:358.67Ref: TM-T19913
1mg73,00€5mg128,00€1mL*10mM (DMSO)140,00€10mg185,00€25mg299,00€50mg405,00€100mg545,00€LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Fórmula:C29H48N12O12S2Pureza:>99.99%Forma y color:SolidPeso molecular:820.891,4-Anthraquinone
CAS:1,4-Anthraquinone: anticancer, hinders nucleoside transport, inhibits synthesis, fragments DNA, curbs L1210 cell growth; aids HPLC analysis of NAC, CAP.Fórmula:C14H8O2Pureza:95.96% - 97.01%Forma y color:Orange Brown SolidPeso molecular:208.21TAK-960 monohydrochloride
CAS:TAK-960 monohydrochloride, an oral compound, inhibits PLK1 (IC50=0.8 nM), PLK2, PLK3, stunts cancer cell growth, and is effective in tumor models.Fórmula:C27H35ClF3N7O3Forma y color:SolidPeso molecular:598.07SRPIN340
CAS:SRPIN340 (SRPK inhibitor), a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).Fórmula:C18H18F3N3OPureza:99.79% - 99.96%Forma y color:SolidPeso molecular:349.35Ref: TM-T1954
2mg44,00€5mg65,00€1mL*10mM (DMSO)71,00€10mg100,00€25mg177,00€50mg324,00€100mg421,00€500mg945,00€Remdesivir
CAS:Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase ofFórmula:C27H35N6O8PPureza:97.62% - 99.98%Forma y color:SolidPeso molecular:602.58Ref: TM-T7766
1mg108,00€5mg205,00€1mL*10mM (DMSO)268,00€10mg326,00€25mg497,00€50mg663,00€100mg1.063,00€Nolatrexed
CAS:Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.Fórmula:C14H12N4OSPureza:97.53%Forma y color:SolidPeso molecular:284.34Ref: TM-T4228
1mg39,00€2mg52,00€5mg86,00€1mL*10mM (DMSO)90,00€10mg140,00€25mg226,00€50mg408,00€100mg600,00€Netarsudil mesylate
CAS:Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.Fórmula:C30H35N3O9S2Pureza:99.7%Forma y color:SolidPeso molecular:645.74Ref: TM-T10358L2
1mg34,00€5mg66,00€1mL*10mM (DMSO)96,00€10mg105,00€25mg236,00€50mg409,00€100mg700,00€BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H12Cl2F2N4OSPureza:99.31% - 99.81%Forma y color:SolidPeso molecular:429.27Tempo
CAS:Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as aFórmula:C9H18NOPureza:98.35%Forma y color:Orange Crystals Or PowderPeso molecular:156.255-Hydroxyuridine
CAS:5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue with potential antitumour activity, showing cytotoxicity against human colon adenocarcinoma cell lines.Fórmula:C9H12N2O7Pureza:98.76%Forma y color:SolidPeso molecular:260.25'-O-DMT-N4-Bz-5-Me-dC
CAS:5'-O-DMT-N4-Bz-5-Me-dC (DMT-NBZ-5-METHYL DC) is a modified nucleoside used in the synthesis of nucleoside phosphoramidites.Fórmula:C38H37N3O7Pureza:98.88%Forma y color:SolidPeso molecular:647.723'-Deoxy-3'-fluoroadenosine
CAS:3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue with a wide range of anti-tumor and anti-viral activity, and has inhibitory effects on tick-borneFórmula:C10H12FN5O3Pureza:99.84%Forma y color:SolidPeso molecular:269.23Arg-Gly-Asp-Ser
CAS:Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found in fibronectin, and the von Willebrand factor.Fórmula:C15H27N7O8Pureza:98.29%Forma y color:SolidPeso molecular:433.42CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Fórmula:C18H15F5N8OPureza:99.37%Forma y color:SolidPeso molecular:454.36Ref: TM-T40290
1mg157,00€5mg378,00€1mL*10mM (DMSO)416,00€10mg612,00€25mg1.251,00€50mg1.972,00€100mg2.673,00€Rabacfosadine
CAS:Rabacfosadine (GS-9219) is a novel prodrug of PMEG, an acyclic nucleotide phosphonate, with antitumor activity for the study of lymphoma.Fórmula:C21H35N8O6PPureza:99.06% - 99.37%Forma y color:SolidPeso molecular:526.53
