Endocrinología / Hormonas
Los inhibidores de endocrinología/hormonas son compuestos que bloquean la acción de las hormonas o interfieren con las vías de señalización hormonal. Estos inhibidores son esenciales para estudiar la regulación de los sistemas endocrinos y para desarrollar tratamientos para enfermedades relacionadas con las hormonas, como la diabetes, los trastornos tiroideos y los cánceres dependientes de hormonas. Al modular la actividad hormonal, estos inhibidores pueden ayudar a dilucidar las complejas interacciones dentro del sistema endocrino. En CymitQuimica, ofrecemos una amplia gama de inhibidores de endocrinología/hormonas de alta calidad para apoyar su investigación en endocrinología, farmacología y ciencias médicas.
Subcategorías de "Endocrinología / Hormonas"
- Receptor de andrógenos(229 productos)
- Anexina A(16 productos)
- Aromatasa(23 productos)
- Receptor de estrógeno / progestágeno(66 productos)
- GPR(1 productos)
- Receptor de glucocorticoides(164 productos)
- LHRH(2 productos)
- Receptor de opioides(327 productos)
- Receptor de prostaglandinas(122 productos)
- RAAS(89 productos)
- Reductasa(51 productos)
- Somatostatina(57 productos)
- Receptor de la hormona tiroidea (THR)(34 productos)
- Receptor de vasopresina(48 productos)
Mostrar 6 subcategorías más
Se han encontrado 3419 productos de "Endocrinología / Hormonas"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
KOR agonist 5
KOR agonist 5 (Compound 10a) is both a KOR/MOR modulator, exhibiting agonistic effects on KOR and antagonistic effects on MOR. It effectively blocks morphine-induced antinociception and gastrointestinal motility inhibition. KOR agonist 5 is applicable in research related to substance use disorder (SUD).Fórmula:C38H38N2O5Forma y color:SolidPeso molecular:602.72ERα degrader 12
ERα degrader12 (Compound RA3) is an estrogen receptor alpha (ERα) degrader with antitumor properties. It significantly suppresses tumor growth in a xenograft mouse model of breast cancer.Fórmula:C39H41NO9SForma y color:SolidPeso molecular:699.81Nurr1 agonist 5
Compound 5o, a Nurr1 agonist, exhibits neuroprotective properties as a transcription factor Nurr1 agonist, possessing a dissociation constant (Kd) of 0.5 μM andForma y color:Odour SolidLO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Forma y color:Odour SolidUrotensin II (114-124), human TFA
Urotensin II (114-124), human TFA, is an 11-amino acid peptide and potent vasoconstrictor, acting as GPR14 agonist.Fórmula:C66H86F3N13O20S2Pureza:98%Forma y color:SolidPeso molecular:1502.59Zavacorilant
CAS:Zavacorilant is capable of modulating glucocorticoid receptor (GR).Fórmula:C25H26FN7O3S2Forma y color:SolidPeso molecular:555.65PROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.Fórmula:C45H68F3N3O11Forma y color:SolidPeso molecular:884.03KOR agonist 4
KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.Fórmula:C21H25N3Forma y color:SolidPeso molecular:319.44HINT1-IN-1
HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).Fórmula:C23H24N8O5Forma y color:SolidPeso molecular:492.49PROTAC AR-V7 degrader-1
CAS:Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.Fórmula:C41H52N6O6S2Forma y color:SolidPeso molecular:789.02BI 653048 phosphate
CAS:BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).Fórmula:C23H28F4N3O8PSPureza:98%Forma y color:SolidPeso molecular:613.52Enclomiphene-d4
Enclomiphene-d4 is the deuterium-labeled analog of Enclomiphene. Enclomiphene functions as a potent and orally active estrogen receptor antagonist, exhibiting antiestrogenic properties.Forma y color:Odour SolidCgp 29287
CAS:Cgp 29287 is a primate-specific renin inhibitor. It also has a prolonged duration of action.Fórmula:C72H110N20O15Forma y color:SolidPeso molecular:1495.77RLA-4842
RLA-4842: iron-based anti-androgen; inhibits mCRPC cell proliferation.Fórmula:C42H46F3N5O8SForma y color:SolidPeso molecular:837.94A7C-301
4A7C-301, a Nurr1 agonist, exhibits potent neuroprotective effects in vitro and markedly mitigates neuropathological abnormalities while enhancing motor andForma y color:Odour SolidARCC-4
CAS:ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.Fórmula:C53H56F3N7O7S2Pureza:98%Forma y color:SolidPeso molecular:1024.18Parathyroid hormone (1-34) (rat)
CAS:Parathyroid hormone (PTH) receptor agonist. Increases serum PTH levels and bone mass in rats.Fórmula:C180H291N55O48S2Pureza:98%Forma y color:SolidPeso molecular:4057.74Biphalin TFA
CAS:Biphalin TFA is an opioid peptide analog that penetrates the blood-brain barrier (BBB) and encompasses two active enkephalin pharmacophores.Fórmula:C46H56N10O10·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:909.00 (free base)Betamethasone acibutate
CAS:Betamethasone acibutate, a glucocorticoid, is derived from Betamethasone.Fórmula:C28H37FO7Pureza:98%Forma y color:SolidPeso molecular:504.59Remikiren
CAS:Remikiren is a highly specific renin inhibitor with oral activity for the treatment of hypertensio.Fórmula:C33H50N4O6SForma y color:SolidPeso molecular:630.84
