Autofagia

JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).

BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, …

SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).

Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It …

EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is …

Dioscin is a saponin with antitumor activities.

Autogramin-2 potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits …

UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits …

Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of …

VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).

Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor; enhanced cell permeable derivative …

ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. …

Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates …

GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 …

JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, …

SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.

PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki …

ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high …

Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the …

Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 …

ROC-325 is a novel autophagy inhibitor.

GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 …

PF-06454589 is a potent inhibitor of LRRK2.

Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.

Daurisoline is a hERG inhibitor and also an autophagy blocker.

Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors …

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.

LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and …

GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule …

MK-8719 is a highly potent and selective inhibitor of O-GlcNAcase (OGA) (hOGA, Ki=7.9 nM) .

IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for …

SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, …

LIT-927 is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).

Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle …

Hoechst 33342, is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds …

SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced …

Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

Ursolic acid(Bungeolic acid), a natural pentacyclic triterpenoid carboxylic acid, shows anti-tumor effects.

Hesperidin is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive …

Motixafortide is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis …

P62-mediated mitophagy inducer is a regulator of mitophagy .

Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and …

Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.

SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.

Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived …

SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of …

AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) …

AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).

Graveoline is an apoptosis and autophagy inducer in skin melanoma cancer cells

GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

SRT3190 is an antagonist of CXCR2.

AMD 3465 hexahydrobromide is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.

Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including …

MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 …

GSK2578215A is a potent and selective LRRK2 kinase inhibitor.

Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37, …

CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous …

Oxidopamine hydrobromide is a neurotransmitter dopamine antagonist.

Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal …