Apoptose

<p>Condurango glycoside A activates p53, induces ROS generation, up-regulates p53 expression, and triggers apoptosis as well as premature senescence associated</p>

<p>Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking</p>

<p>SU11652 is an effective and competitive receptor tyrosine kinase (RTK) inhibitor, including VEGFR, FGFR, PDGFR, and Kit.</p>

<p>N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interaction with potential anticancer activity for cancer research.</p>

<p>TZ9 is a Rad6 inhibitor with anticancer activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.</p>

<p>(S)-Oxiracetam is a positive allosteric the AMPA receptorsmodulator.</p>

<p>5-(N,N-Hexamethylene)-amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM). It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.</p>

<p>GSK-843 (GSK'843) is a RIP3 inhibitor with analgesic activity, inhibits RIP3 expression, and can be used as an adjunctive treatment for inflammation.</p>

<p>EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.</p>

<p>Pexidartinib HCl is a potent, selective CSF1R and c-Kit inhibitor with IC50s of 20 nM and 10 nM, respectively, showing anti-tumor activity.</p>

<p>Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.</p>

<p>Tamoxifen-d5 is a deuterium labeled Tamoxifen.</p>

<p>FMAU (2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine) is a thymine nucleoside analog with insertional activity on replicating DNA.FMAU can be used to label</p>

<p>Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.</p>

<p>2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert</p>

PETCM is a caspase-3 activator and acts as an cytochrome c (cyto c)-dependent manner.

<p>6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase, which induces ROS generation and apoptosis in HL-60 cells.</p>

<p>CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.</p>

<p>Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.</p>

<p>Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity and induces apoptosis.</p>

<p>PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).</p>

<p>(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor with neuroprotective activity that induces apoptosis.</p>

<p>Zardaverine (BY 290) is a PDE3/4 inhibitor with anti-hepatocarcinogenic activity and is used in the study of acute renal failure and chronic airflow obstruction</p>

<p>Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.</p>

<p>N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL), a quorum-sensing signaling molecule synthesized by P. aeruginosa and specific B. cepacia complex strains [1][2], facilitates bacterial gene expression modulation in response to cell density escalation and triggers IL-8 production in 16HBE human bronchial epithelial cells [3].</p>

<p>Rutin trihydrate is a natural flavonoid with antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer benefits, plus heart and brain protection.</p>

<p>Prexasertib dimesylate is a selective CHK1 inhibitor with K i 0.9 nM, blocks CHK2 &amp; RSK1, induces DNA breakage, and has potent anti-tumor effects.</p>

<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>

<p>Compound Fr16683 is a natural product for research related to life sciences. The catalog number is Fr16683 and the CAS number is 699-83-2.</p>

<p>Forodesine inhibits lymphocyte growth and induces apoptosis in leukemic cells; oral purine nucleoside phosphorylase blocker; IC50: 0.48-1.57 nM.</p>

<p>Octreotide (SMS 201-995) is a potent inhibitor of growth hormone, glucagon, and insulin.</p>

<p>3,4,5-Trihydroxycinnamic acid decyl ester is an anti-obesity agent that inhibits lipid absorption and pancreatic lipase (EC50 ≈ 0.9μM).</p>

PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).

<p>Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast.</p>

Tubulin inhibitor 1 blocks tubulin polymerization, with strong anti-tumor effects, induces apoptosis and G2/M mitotic arrest.

<p>PND-1186 hydrochloride (VS-4718 hydrochloride) is a highly specific, reversible and potent inhibitor of FAK (IC50: 1.5 nM), which can selectively induce</p>

<p>PT-262: ROCK inhibitor, causes cytoskeleton change, halts lung cancer cell migration.</p>

<p>PI3Kα-IN-9 is an inhibitor of PI3Kα and PI3Kα with antiproliferative activity, inhibits PI3Kα, PI3Kγ, PI3Kδ, and PI3Kβ, induces apoptosis.</p>

Triclabendazole (Standard) is the standard substance of Triclabendazole, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease.

<p>Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor (IC50s: 13 μM and 370 μM).</p>

<p>Busulfan-d8 (Sulphabutin-d8) is the 2H-labeled Busulfan. Busulfan is an anticancer agent with immunosuppressive and myeloablative chemotherapy activities.</p>

<p>Thalidomide-piperazine-Boc is an intermediate utilized for synthesizing BCL6 PROTAC, which targets B-cell lymphoma 6 protein.</p>

<p>PI-103 Hydrochloride is a dual PI3K/Akt and mTOR inhibitor exhibiting nM-level inhibition of p110α, p110β, p110δ, p110γ, DNA-PK, mTORC1, and mTORC2.</p>

<p>Isovalerylcarnitine (3-methylbutyrylcarnitine) is a selective effective calpain activator that can promote cell apoptosis and is related to isovaleric acidemia.</p>

<p>BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.</p>

<p>NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM.</p>

<p>AZT triphosphate is a Nucleoside Triphosphate.</p>

<p>Iodoacetyl-LC-Biotin (Iaa-Biotin) is a sulfhydryl-responsive probe that forms irreversible thioether bonds at alkaline pH, label protein cysteines.</p>

<p>Hematoporphyrin monomethyl ether is a porphyrin photosensitizer that can be used in studies of port wine stains.</p>

<p>AZD-5991, an antitumor compound, is a highly selective, potent and direct MCL-1 inhibitor, rapid apoptosis by Bak-dependent mitochondrial apoptotic pathway.</p>

<p>Fmoc-D-Cha-OH (FDCO) is an apoptotic DNase γ inhibitor that inhibits the release of HMGB1.</p>

<p>GO-203 is a useful organic compound for research related to life sciences. The catalog number is T35351 and the CAS number is 1222186-26-6.</p>

<p>Diuron is an orally active benzoylurea herbicide. Diuron inhibits the production of ATP and NADH,, ROS and cancer.</p>

<p>PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour .</p>

<p>Methylisothiazolinone is a powerful synthetic biocide and preservative.</p>

<p>Thalidomide-5,6-F, a cereblon ligand for CRBN protein recruitment, forms PROTACs for targeted protein degradation.</p>

<p>(Rac)-Apremilast D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast</p>

<p>AK-778-XXMU is an ID2 antagonist with a KD value of 129 nM.AK-778-XXMU has potential antitumor and anticancer activity and can be used for the study of gliomas.</p>

<p>SLF is a synthetic ligand for FKBP12 and increases Ca2+ efflux and protein synthesis.</p>

Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM.

<p>Thalidomide-piperazine HCl may aid leprosy, multiple myeloma research, and developmental biology studies.</p>

<p>Thalidomide-Piperazine 5-fluoride: a cereblon ligand-linked E3 ligase via PROTAC tech.</p>

<p>SC144 hydrochloride: oral gp130 inhibitor, blocks Stat3 and gene expression, triggers apoptosis in ovarian cancer cells.</p>

<p>MPPa, a PDT photosensitizer derived from chlorophyll a, absorbs at 667/674 nm with no dark cytotoxicity.</p>

<p>TDE is an organochlorine insecticide with slightly irritating to the skin.</p>

<p>ML291 triggers UPR, causing apoptosis in solid cancers by activating PERK/eIF2a/CHOP pathway and reducing leukemia cells.</p>

<p>Mardepodect hydrochloride (Mardepodect HCl) is a PDE10A inhibitor.Mardepodect hydrochloride upregulates genes encoding specific growth factors.</p>

<p>Deferasirox (Fe3+ chelate) is an iron chelator with anticancer activity and can be used to study iron overload.</p>

<p>Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway .</p>

<p>Pyridoclax is an inhibitor of potential Mcl-1.</p>

<p>(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.</p>

<p>RKI 1447 dihydrochloride: selective ROCK inhibitor, inhibits colorectal cancer growth, promotes apoptosis (ROCK1 IC50=14.5 nM, ROCK2 IC50=6.2 nM).</p>

<p>GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.</p>

<p>Methopterin shows the activation and bone resorption function of murine osteoclasts.</p>

<p>Isoscabertopin has anticancer activity.</p>

<p>Celosin K (compound 8), isolated from Semen Celosiae seeds, effectively inhibits t-BHP-induced neuronal injury.</p>

<p>Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis, inhibiting SARS-CoV-2 and COVID-19.</p>

<p>Fenobucarb is a broad-spectrum carbamate insecticide and AChE inhibitor. It exhibits neurotoxicity to zebrafish foetal development and induces muscle spasms</p>

<p>PGV-1, an oral Curcumin analog, induces apoptosis by inhibiting COX-2, VEGF, and NF-κB activation.</p>

<p>Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methyltransferase (Mtase) with an IC50 of 8.4 μM.</p>

<p>Sodium cyclamate is a carbonic anhydrase inhibitor, artificial sweetener, with anticonvulsant properties, and used in cancer research.</p>

<p>Fosfenopril is an ACE inhibitor reducing LPS-induced inflammation via TLR4/NF-κB suppression, used in cardiovascular and anti-inflammatory molecular studies.</p>

<p>Bucladesine calcium: PDE inhibitor, boosts cAMP, activates PKA.</p>

<p>TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.</p>

<p>Gum Arabic, from A. Senegal, is an antioxidant that defends against hepatic, renal, and cardiac toxicities and aids in immunohistochemistry.</p>

Venetoclax-d8 (ABT-199-d8) is a deuterated form of Venetoclax, a potent, selective, and orally active Bcl-2 inhibitor that induces autophagy and apoptosis.

<p>MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.</p>

<p>Radotinib (IY-5511), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of Y, most notably</p>

<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>

<p>Picrocrocin is a natural product</p>

<p>4-Methylbenzylidene camphor: UVB blocker in sunscreens, cosmetics; exhibits estrogenic activity.</p>

<p>VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent.</p>