Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(636 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.030 produtos)
- BACE(37 produtos)
- Beta Amilóide(226 produtos)
- CaMK(73 produtos)
- COX(601 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(369 produtos)
- Gama-secretase(62 produtos)
- GluR(264 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(42 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(42 produtos)
- Receptor opioide(325 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5488 produtos de "Neurociência"
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[Ala2,8,9,11,19,22,24,25,27,28]-VIP
CAS:[Ala2,8,9,11,19,22,24,25,27,28]-VIP can be used for related research in the field of life sciences. Its product number is T36637 and CAS number is 866552-34-3.Fórmula:C131H219N41O33SCor e Forma:SolidPeso molecular:2928.51E3 ligase Ligand 41
CAS:E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.Fórmula:C13H12ClF3N2O4Cor e Forma:SolidPeso molecular:352.69Merinetug
CAS:Merinetug is a humanized IgG1κ antibody that targets Amyloid Beta (Aβ). Its corresponding isotype control is Human IgG1 kappa, Isotype Control.Cor e Forma:LiquidLafadofensine
CAS:Lafadofensine, a monoamine reuptake inhibitor, exhibits significant effects upon short-term administration.Fórmula:C16H16F2N2Cor e Forma:SolidPeso molecular:274.315GABA-A Receptor Ligand-1
GABA-A Receptor Ligand-1 (Compound 4) is a ligand for the GABA-A receptor with a pKi of 7.27. It alleviates mitochondrial dysfunction, promotes neurite outgrowth and neuronal regeneration, and demonstrates neuroprotective effects in a rat ischemic stroke model.Fórmula:C20H20FN3OCor e Forma:SolidPeso molecular:337.391Dapoxetine
CAS:Dapoxetine (Dapoxetina) is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.Fórmula:C21H23NOPureza:99.73%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:305.42KGP-25
KGP-25 is an inhibitor of the voltage-gated sodium channel 1.8 (Nav1.8), utilized for analgesia by targeting the peripheral nervous system (PNS). Additionally, it targets the γ-aminobutyric acid subtype A receptor (GABAA) in the central nervous system (CNS) for use as a general anesthetic.Cor e Forma:Odour Solid4-Methylamphetamine hydrochloride
CAS:4-Methylamphetamine hydrochloride is a 5-HT1A receptor agonist that induces a decrease in body temperature in rats by binding to the 5-HT1A receptor. Additionally, it increases the extracellular levels of neurotransmitters norepinephrine (NE), dopamine (DA), and serotonin (5-HT) by affecting their transporters. 4-Methylamphetamine hydrochloride is applicable in the study of neurological disorders.Fórmula:C10H16ClNCor e Forma:SolidPeso molecular:185.69Amyloid-β-IN-1
Amyloid-β-IN-1 (compound 13), a synthetic peptide featuring the hydrophobic C-terminal segment "VVIA-NH2" and its reversed sequence "AIVV-NH2" derived from Aβ 42, acts as an Aβ inhibitor. It effectively inhibits Aβ aggregation and exhibits neuroprotective effects.Fórmula:C18H35N5O4Peso molecular:385.5Olanzapine Lactam Impurity
CAS:Olanzapine lactam impurity, found in olanzapine, forms under heat or oxidative stress.Fórmula:C17H20N4O2Cor e Forma:SolidPeso molecular:312.373CC-3240
CAS:CC-3240 (compound 13), a molecular glue degrader of CaMKK2 based on CC-8977, has an IC50 of 9 nM [1].Fórmula:C52H64N6O7SPeso molecular:917.17ACHE Inhibitor 12
CAS:ACHE Inhibitor 12 inhibited acetylcholinesterase with an IC50 value of 0.38 µM.Fórmula:C11H12OPureza:97.07%Cor e Forma:SolidPeso molecular:160.21RI-OR2-TAT
CAS:RI-OR2-TAT is a brain-penetrable inhibitor targeting β-amyloid (β-Amyloid) oligomerization. It is engineered by integrating the HIV protein transduction domain TAT into RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a Kd value of 58-125 nM. It reduces Aβ aggregation and plaque levels, diminishes microglial activation and oxidative damage, and enhances the number of young neurons in the dentate gyrus.Fórmula:C117H201N49O23Cor e Forma:SolidPeso molecular:2662.16GABOB (β-hydroxy-GABA)
CAS:GABOB, an epilepsy treatment, is GABA's analogue and may act as a neurotransmitter.Fórmula:C4H9NO3Cor e Forma:White To Light Yellow Crystal PowderPeso molecular:119.12(S)-AMPA HCl
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.Fórmula:C7H11ClN2O4Pureza:99.18%Cor e Forma:SolidPeso molecular:222.63BChE-IN-35
BChE-IN-35 (Azo-9) is an inhibitor of BChE. This compound exhibits dynamic cis/trans conformational changes, with the cis isomer preferentially binding to BChE. Additionally, BChE-IN-35 can be utilized in research on Alzheimer's disease (AD).Fórmula:C35H39N5O2Cor e Forma:SolidPeso molecular:561.72Guluronic acid
CAS:Guluronic acid (G2013) is in hyaluronic acid; a nonsteroidal anti-inflammatory with benefits.Fórmula:C6H10O7Pureza:98%Cor e Forma:SolidPeso molecular:194.139DAA-1106
CAS:DAA-1106 is a potent and selective ligand for PBR, acting as a potent and selective agonist at the peripheral benzodiazepine receptor.Fórmula:C23H22FNO4Pureza:99.54%Cor e Forma:SolidPeso molecular:395.42Brexpiprazole S-oxide
CAS:Brexpiprazole S-oxide is the main metabolite of Brexpiprazole, a human 5-HT1A and dopamine receptor partial agonist (Ki: 0.12, 0.3 nM).Fórmula:C25H27N3O3SPureza:98%Cor e Forma:SolidPeso molecular:449.57Nemifitide diTFA
CAS:Nemifitide diTFA is a synthetic pentapeptide with antidepressant properties, resembling MIF, that crosses the blood-brain barrier.Fórmula:C37H45F7N10O10Pureza:99.78% - 99.84%Cor e Forma:SolidPeso molecular:922.8Furosemide
CAS:Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.Fórmula:C12H11ClN2O5SPureza:99.32% - 99.89%Cor e Forma:Crystals From Aqueous Ethanol Tasteless (Ntp 1992)Peso molecular:330.744BSB
CAS:BSB is a Congo red-derived fluorescent probe, an amyloid protein imaging agent, interacting with amyloid fibrils formed by Aβ (1-40) peptides in rodents.Fórmula:C24H17BrO6Pureza:95.53%Cor e Forma:SolidPeso molecular:481.29Litoxetine HCl
Litoxetine HCl, an SSRI and 5-HT antagonist, treats urinary incontinence and relaxes rat oesophageal muscles without antimuscarinic effects.Fórmula:C16H20ClNOPureza:98.97% - 99.9%Cor e Forma:SoildPeso molecular:277.79Ref: TM-T67956L
1mg97,00€5mg217,00€10mg325,00€25mg557,00€50mg797,00€100mg1.103,00€1mL*10mM (DMSO)208,00€ZZL-7
CAS:ZZL-7 is a rapid antidepressant targeting nNOS & SERT in DRN, crosses blood-brain barrier, with MDD research potential.Fórmula:C11H20N2O4Pureza:99.64%Cor e Forma:SoildPeso molecular:244.29Lu AF27139
CAS:Lu AF27139: P2X7 receptor antagonist; IC50: 12 nM (human), 2.4 nM (rat); Ki: 22 (mouse), 54 (human), 13 nM (rat); for CNS research.Fórmula:C21H19ClF3N5O2SPureza:99.96%Cor e Forma:SolidPeso molecular:497.92Ref: TM-T9786
1mg87,00€5mg210,00€10mg338,00€25mg562,00€50mg817,00€100mg1.103,00€1mL*10mM (DMSO)233,00€Tiquizium
CAS:Tiquizium has effective Antimuscarinic effect, and causes significant bronchodilation in patients with chronic obstructive pulmonary disease.
Fórmula:C19H24NS2Pureza:99.82%Cor e Forma:SolidPeso molecular:330.53TB-11
CAS:TB-11 is an inhibitor of Cathepsin D with IC50 values of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), and 48.8 nM (BACE1). It is primarily utilized in oncological research.Fórmula:C52H78N8O12Cor e Forma:SolidPeso molecular:1007.22BU 226 hydrochloride
CAS:BU 226 hydrochloride demonstrates affinity for imidazoline (I) receptors, in particular the I2 binding site with a Ki of 1.4 nM.Fórmula:C12H12ClN3Pureza:99.67%Cor e Forma:SolidPeso molecular:233.7(S)-3,4-DCPG HCl
(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.Fórmula:C10H10ClNO6Pureza:99.53% - 99.86%Cor e Forma:SoildPeso molecular:275.64Ref: TM-T23288L
1mg183,00€5mg462,00€10mg660,00€25mg1.035,00€50mg1.415,00€100mg1.872,00€500mg3.763,00€1mL*10mM (DMSO)415,00€LRRK2 inhibitor 1
CAS:LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.Fórmula:C20H23N5O4Pureza:99.98%Cor e Forma:SolidPeso molecular:397.43Ref: TM-T11878
1mg74,00€2mg97,00€5mg160,00€10mg264,00€25mg557,00€50mg944,00€100mg1.491,00€1mL*10mM (DMSO)170,00€Aminoacetone hydrochloride
CAS:Aminoacetone hydrochloride (1-Aminoacetone Hydrochloride) is an oxidative agent that induces loss of ferritin ferrireductase activity and iron uptake.Fórmula:C3H8ClNOPureza:99.76%Cor e Forma:SolidPeso molecular:109.564-Iodoamphetamine hydrochloride
CAS:4-Iodoamphetamine (p-Iodoamphetamine) hydrochloride is a halogenated phenethylamine characterized by the presence of an iodine atom at the para position of the phenyl group. It selectively induces serotonin release and inhibits reuptake in rat brain synaptosomes.Fórmula:C9H13ClINCor e Forma:SolidPeso molecular:297.565-(2-Aminopropyl)indole
CAS:5-(2-Aminopropyl)indole is an orally active psychoactive substance that inhibits monoamine oxidase (MAO) and exhibits long-lasting stimulant effects.Fórmula:C11H14N2Cor e Forma:SolidPeso molecular:174.24Pridinol hydrochloride
CAS:Pridinolhydrochloride is the hydrochloride form of Pridinol. Pridinol hydrochloride is an orally active anticholinergic agent, which can also be used as a muscle relaxant.Fórmula:C20H26ClNOCor e Forma:SolidPeso molecular:331.885-MeO-MET
CAS:5-MeO-MET (5-Methoxy-N-methyl-N-ethyltryptamine) is a compound belonging to the 5-methoxytryptamine class. It acts as an agonist for 5-HT1A and 5-HT2A receptors. In mice, 5-MeO-MET inhibits locomotion and has sedative effects.Fórmula:C14H20N2OCor e Forma:SolidPeso molecular:232.3225N-NBOMe hydrochloride
CAS:25N-NBOMe hydrochloride is a derivative of 2C-N and acts as an agonist for the 5-HT2A and 5-HT2C receptors, with Ki values of 0.144 nM and 1.06 nM, respectively. It has minimal effect on the release of preloaded neurotransmitters from recombinant dopamine, serotonin, and norepinephrine transporters.Fórmula:C18H23ClN2O5Cor e Forma:SolidPeso molecular:382.84Desalkylgidazepam
CAS:Desalkylgidazepam, a benzodiazepine compound, is a metabolite of gidazepam. It is capable of activating both GABA A-type receptors and the translocator protein (TSPO).Fórmula:C15H11BrN2OCor e Forma:SolidPeso molecular:315.174-Bromo-2,5-DMMA
CAS:4-Bromo-2,5-DMMA (Compound 2) demonstrates affinity for the 5-HT2 binding site and has an ED50 of 0.82 mg/kg in rat discrimination experiments.Fórmula:C12H18BrNO2Cor e Forma:SolidPeso molecular:288.18DOPR hydrochloride
CAS:DOPR hydrochloride is a psychoactive substance belonging to the amphetamine class.Fórmula:C14H24ClNO2Cor e Forma:SolidPeso molecular:273.8Cinazepam
CAS:Cinazepam is a GABAA receptor partial agonist and a benzodiazepine derivative with anxiolytic and sedative properties. Cinazepam can be utilized in research related to sleep disorders.Fórmula:C19H14BrClN2O5Cor e Forma:SolidPeso molecular:465.68p-Xylene bis(pyridinium bromide)
CAS:p-Xylene bis(pyridinium bromide) (compound 21) is a cationic quenching agent and acts as a weak bis-quaternary ammonium salt inhibitor for AChE and BChE, with IC50 values of 1540 μM and 529 μM, respectively.Fórmula:C18H18Br2N2Cor e Forma:SolidPeso molecular:422.16TET-13
TET-13 is a positive allosteric modulator of the GABAA receptor with an EC50 of 5.65 μM, which is more potent than Etomidate (EC50: 9.29 μM). It exhibits strong anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg in mice and 0.69 mg/kg in rats.Fórmula:C15H16N2O3SCor e Forma:SolidPeso molecular:304.36MAO-B-IN-25
MAO-B-IN-25 (compound 92) is a selective inhibitor of monoamine oxidase B (MAO-B), exhibiting inhibitory half-maximal inhibitory concentrations (IC50) of 240 nMFórmula:C16H13BrO3Pureza:98%Cor e Forma:SolidPeso molecular:333.18MRS7925
MRS7925 (Compound 43) serves as a potent antagonist of the 5-HT2B receptor, with an inhibition constant (Ki) of 17 nM, and is utilized in the study of fibrosisFórmula:C20H26IN5O3Pureza:98%Cor e Forma:SolidPeso molecular:511.365-HT6 agonist 1
Compound 19, a 5-HT6 agonist with an affinity (K i : 5 nM), exhibits antidepressant-like effects and enhances cognitive function while also inhibiting plateletFórmula:C17H22Cl2N6SPureza:98%Cor e Forma:SolidPeso molecular:413.37MAO-B-IN-18
MAO-B-IN-18 is a potent, selective inhibitor of MAO B, demonstrating IC50 values of 52 nM for hMAO B and 14 μM for hMAO A.Fórmula:C25H22N4O5Pureza:98%Cor e Forma:SolidPeso molecular:458.47MAO-B-IN-3
MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki
Fórmula:C24H25N3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.47GABA receptor Antagonist 1
GABA receptor Antagonist 1 (compound 7w) effectively inhibits the Px RDL1 GABAR at an IC50 of 7.08 nmol/L and demonstrates insecticidal efficacy against P.Pureza:98%Cor e Forma:Odour SolidMAOA-IN-1
MAOA-IN-1 (compound 15) is an orally-active inhibitor of monoamine oxidase A (MAOA) that exhibits cytotoxic effects on prostate cancer cells.Fórmula:C13H16Cl2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:303.18IHC3
IHC3 is a competitive and reversible monoamine oxidase B (MAO-B) inhibitor with an IC50 of 1.672 μM, which targets Cys172 within the enzyme's active site.Fórmula:C17H12FN3OPureza:98%Cor e Forma:SolidPeso molecular:293.3GAD65(247-266) epitope TFA
GAD65(247-266) epitope TFA, a T cell epitope derived from islet antigens, exhibits competitive binding to the type I diabetes-associated molecule I-A g7, albeitFórmula:C111H174F3N27O29S4Pureza:98%Cor e Forma:SolidPeso molecular:2535.99CaMKIIα-PHOTAC
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα).Fórmula:C54H58Cl2N10O11Pureza:98%Cor e Forma:SolidPeso molecular:1094MmTx1 toxin
Micrurotoxin 1 (MmTx1 toxin) acts as an allosteric modulator of GABA A receptors, enhancing the receptor's sensitivity to its agonist [1].Fórmula:C295H455N95O97S10Pureza:98%Cor e Forma:SolidPeso molecular:7205Guvacine hydrobromide
CAS:Guvacine hydrobromide, an alkaloid derived from the Areca catechu nut, serves as a potent inhibitor of GABA (GABA uptakp) uptake.
Fórmula:C6H10BrNO2Pureza:98%Cor e Forma:SolidPeso molecular:208.05Methyllycaconitine citrate
CAS:Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.Fórmula:C43H58N2O17Pureza:98.03% - 98.91%Cor e Forma:SolidPeso molecular:874.92(S)-Vamicamide
CAS:(S)-Vamicamide is an anti-anticholinergic compound.Fórmula:C18H23N3OPureza:99.48% - 99.65%Cor e Forma:SoildPeso molecular:297.39Adatanserin hydrochloride
CAS:Adatanserin hydrochloride (WY50324 hydrochloride) is a 5-HT(1A)/5-HT(2) receptor ligand that is neuroprotective and may be used in the study of depression.Fórmula:C21H32ClN5OPureza:99.64%Cor e Forma:SolidPeso molecular:405.96AChE-IN-45
AChE-IN-45 (Compound 14) is an acetylcholinesterase (AChE) inhibitor exhibiting an IC50 value of 11.57±0.45 nM, and it demonstrates both antioxidant andCor e Forma:Odour Solid2-Methyl-N,N-dimethyltryptamine
CAS:2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) exhibits binding affinity for the serotonin (5-HT) receptor, with a pA2 value of 6.04. It plays a significant role in neurological disease research.Fórmula:C13H18N2Cor e Forma:SolidPeso molecular:202.3BChE-IN-21
BChE-IN-21, a potent inhibitor of butyrylcholinesterase (BChE), exhibits an inhibition constant (IC50) of 0.14 ± 0.02 μM, indicating promise for research inCor e Forma:Odour Solidisomer-Cilansetron
CAS:isomer-Cilansetron is an isomer of Cilansetron.Fórmula:C20H21N3OPureza:99.92% - 99.96%Cor e Forma:SoildPeso molecular:319.4PZ-1922
PZ-1922 (Compound 16), able to cross the blood-brain barrier, is a dual antagonist for 5-HT6R and 5-HT3R with K i values of 17 nM and 0.45 nM, respectively.Pureza:98%Cor e Forma:Odour SolidCannabidiolic acid methyl ester
CAS:Cannabidiolic acid methyl ester (HU-580) is an orally active analogue of cannabidiolic acid. It enhances the activation of 5-HT1A receptors and increases the expression of c-Fos and NeuN in specific hypothalamic nuclei in rats. Cannabidiolic acid methyl ester exhibits anti-nausea, anxiolytic, and anti-nociceptive effects.Fórmula:C23H32O4Cor e Forma:SolidPeso molecular:372.5(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
CAS:(Rac)-5-Hydroxymethyl Tolterodine HCl, or (Rac)-Desfesoterodine HCl, is a potent mAChR blocker researched for overactive bladder.
Fórmula:C22H32ClNO2Cor e Forma:SolidPeso molecular:377.95MAO-B-IN-24
MAO-B-IN-24 (compound 11h) is a selective, reversible, competitive inhibitor of MAO-B with an IC50 value of 1.60 μM.Fórmula:C20H18N2OPureza:98%Cor e Forma:SolidPeso molecular:302.37Sodium Channel Targeted Library
A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;Cor e Forma:Odour SolidRef: TM-L7400
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarhAChE-IN-3
hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM,Fórmula:C30H24ClN3O5Pureza:98%Cor e Forma:SolidPeso molecular:541.98AChE-IN-29
AChE-IN-29, a 3-OH pyrrolidine derivative, acts as a cholinesterase (ChE) inhibitor with potent activity against human acetylcholinesterase (hAChE), electricFórmula:C18H19BrN2O2Cor e Forma:SolidPeso molecular:375.26Fasciculic acid C
CAS:Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Fórmula:C38H63NO11Pureza:98%Cor e Forma:SolidPeso molecular:709.915-HT2A receptor agonist-5
CAS:5-HT2A receptor agonist-5 (compound I-3) is a potent 5-HT2A agonist with a Ki value of 0.017 µM and exhibits antidepressant activity.Fórmula:C23H29N3OCor e Forma:SolidPeso molecular:363.5Anti-inflammatory agent 53
Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrestFórmula:C24H22N2O4SPureza:98%Cor e Forma:SolidPeso molecular:434.51Paynantheine
CAS:Paynantheine is an alkaloid with antinociceptive properties, found in Mitragyna speciosa. It also acts as an agonist at 5-HT1AR and 5-HT2BR receptors, inducing lower lip contraction and providing antinociception in rats.Fórmula:C23H28N2O4Cor e Forma:SolidPeso molecular:396.48JPC0323
JPC0323 is a dual positive allosteric modulator of the 5-HT2C and 5-HT2A receptors, featuring on-target properties, acceptable plasma exposure, and adequateFórmula:C22H43NO4Pureza:98%Cor e Forma:SolidPeso molecular:385.58Tranylcypromine
CAS:Tranylcypromine (SKF 385), a potent monoamine oxidase (MAO) inhibitor [1], is used in medicinal applications.Fórmula:C9H11NPureza:98%Cor e Forma:SolidPeso molecular:133.19Neuronal Signaling Compound Library
A unique collection of xnum compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;Cor e Forma:Odour SolidRef: TM-L2600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultar3-Aminopropylphosphonic Acid
CAS:3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding
Fórmula:C3H10NO3PPureza:99.84%Cor e Forma:Light Yellow LiquidPeso molecular:139.09COX-2-IN-35
COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].Fórmula:C22H19NO2S2Pureza:98%Cor e Forma:SolidPeso molecular:393.52Aducanumab
CAS:Aducanumab (BIIB037) is an IgG1 antibody targeting amyloid beta to treat Alzheimer's; it's brain-permeable.
Pureza:95% - 97.10%Cor e Forma:LiquidPeso molecular:145.93 kDa1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
CAS:1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986.
Fórmula:C10H12N2O2SPureza:99.96%Cor e Forma:SoildPeso molecular:224.285-HT1AR agonist 2
5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice.Fórmula:C31H31N5O3Cor e Forma:SolidPeso molecular:521.61Tiflucarbine
CAS:Tiflucarbine is a potential non-selective 5-HT agonist with antidepressant activity.Tiflucarbine dose-dependently increased the specific activity of solubleFórmula:C16H17FN2SPureza:97.71%Cor e Forma:SolidPeso molecular:288.38GABAA receptor modulator-4
GABAA receptor modulator-4 (Compound 4) acts as a negative allosteric modulator of the GABAA receptor. It inhibits the peak and steady-state currents mediated by the α1β3γ2 GABAA receptors, with an IC50 of 10 μM for both.Fórmula:C15H17BrO4SCor e Forma:SolidPeso molecular:373.26(+)-OSU 6162
CAS:(+)-OSU 6162 (Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, (3R)-) is an agonist of 5-HT Receptor with anti-Alzheimer and antidepressant activities.Fórmula:C15H23NO2SPureza:98.19%Cor e Forma:SoildPeso molecular:281.41Ref: TM-T60027
1mg77,00€5mg155,00€10mg220,00€25mg338,00€50mg472,00€100mg632,00€200mg853,00€1mL*10mM (DMSO)163,00€Apoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Cor e Forma:Odour SolidRef: TM-L9000
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarMinesapride
CAS:Minesapride: novel 5-HT4 partial agonist, may treat constipation-predominant IBS.
Fórmula:C21H31ClN4O5Pureza:99.85% - 99.88%Cor e Forma:SolidPeso molecular:454.95DD205-291
CAS:DD205-291 is an orally active PROTAC HPK1 degrader with a DC50 of 5.3 nM. It inhibits SLP-76 phosphorylation and induces IL-2 and IFN-γ.Fórmula:C38H38ClF3N10O3Cor e Forma:SolidPeso molecular:775.22β-Amyloid (22-35)
CAS:β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells.Fórmula:C59H102N16O21SPureza:98%Cor e Forma:SolidPeso molecular:1403.62γ-Acetylenic GABA hydrochloride
CAS:γ-Acetylenic GABA hydrochloride is a GABA transaminase inhibitor.Fórmula:C6H10ClNO2Pureza:97.83% - 99.44%Cor e Forma:SolidPeso molecular:163.6Neural Regeneration Compound Library
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
Cor e Forma:Odour SolidLupanine hydrochloride
CAS:Lupanine hydrochloride, a Sparteine derivative, binds to nAChR with a Ki of 500 nM and has ganglioplegic properties.Fórmula:C15H25ClN2OCor e Forma:SolidPeso molecular:284.83Lesogaberan napadisylate
CAS:Lesogaberan (AZD-3355) is a selective GABAB agonist with EC50 of 8.6 nM, Ki of 5.1 nM in rats, and acts peripherally on the esophageal sphincter.Fórmula:C13H17FNO5PSCor e Forma:SolidPeso molecular:349.31Nitrazolam
CAS:Nitrazolam is a benzodiazepine compound that may exhibit central nervous system depressant properties similar to traditional benzodiazepine drugs by acting on the GABA receptors (GABA receptor). These effects include sedation, hypnosis, anxiolytic, and anticonvulsant activities.Fórmula:C17H13N5O2Cor e Forma:SolidPeso molecular:319.32CNS-Penetrant Compound Library
A unique collection of 509 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
Cor e Forma:Odour Solidβ-Amyloid (22-40)
CAS:This synthetic peptide consists of amino acids 22 to 40 of beta amyloid protein.Fórmula:C78H135N21O26SPureza:98%Cor e Forma:SolidPeso molecular:1815.15-HT1AR/5-HT6R ligand-1
5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.Fórmula:C25H29ClN4O2SCor e Forma:SolidPeso molecular:485.04CUR-IPA
CUR-IPA is a cholinesterase inhibitor with IC50 values of 5.99 μM for eAChE (electric eel), 59.30 μM for hAChE (human), and 60.66 μM for hBChE (human). It has free radical scavenging and antioxidant activity and is useful for researching cognitive dysfunction.
Fórmula:C43H38N2O8Cor e Forma:SolidPeso molecular:710.77Mesoridazine Besylate
CAS:Mesoridazine Besylate (Serentil), a piperidine antipsychotic and phenothiazine, treats schizophrenia; it's a thioridazine metabolite.Fórmula:C27H32N2O4S3Pureza:98.87%Cor e Forma:SolidPeso molecular:544.75Calcium Channel Compound Library
A unique collection of 140 calcium channel blockers and agonists for high throughput and high content screening;Cor e Forma:Odour SolidRef: TM-L7200
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarIon Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;
Cor e Forma:Odour SolidAnticonvulsant agent 9
Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.Fórmula:C22H24N4O2Cor e Forma:SolidPeso molecular:376.45
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