Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(647 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.025 produtos)
- BACE(37 produtos)
- Beta Amilóide(230 produtos)
- CaMK(73 produtos)
- COX(602 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(373 produtos)
- Gama-secretase(62 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(43 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5639 produtos de "Neurociência"
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SB 243213 hydrochloride
CAS:SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).ItFórmula:C22H20ClF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:464.87Refisolone
CAS:Refisolone is an antagonist of the GABAA receptor.Fórmula:C18H24O3Cor e Forma:SolidPeso molecular:288.381AAZ-A 154 hydrobromide
CAS:AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.Fórmula:C14H21BrN2OCor e Forma:SolidPeso molecular:313.23AAZ-A 154 benzoate
CAS:AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.Fórmula:C21H26N2O3Cor e Forma:SolidPeso molecular:354.44AChE/BACE1/GSK3β-IN-1
AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β.Fórmula:C26H27FN2O4Cor e Forma:SolidPeso molecular:450.5BChE-IN-38
CAS:BChE-IN-38 (compound 13) is a potent BChE inhibitor, with Ki values of 62.05, 28.78, 14.09, and 1.15 nM for hCAI, hCAII, AChE, and BChE, respectively. BChE-IN-38 also demonstrates cytotoxic activity.Fórmula:C27H20N4Cor e Forma:SolidPeso molecular:400.474YM-31636 free base
CAS:YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.Fórmula:C14H11N3SCor e Forma:SolidPeso molecular:253.32BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Fórmula:C29H29FN6O4SCor e Forma:SolidPeso molecular:576.64F 14679
CAS:F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.Fórmula:C21H25ClF2N4OPureza:99.09%Cor e Forma:SolidPeso molecular:422.9Poskine
CAS:Poskine is an anticholinergic and central nervous system depressant. It is utilized in research related to Parkinson's disease and motion sickness.Fórmula:C20H25NO5Cor e Forma:SolidPeso molecular:359.42THRX-194556
CAS:THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.Fórmula:C28H41N5O5SCor e Forma:SolidPeso molecular:559.721MAO-A/SERT-IN-1
CAS:MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.Fórmula:C19H14N2O5Cor e Forma:SolidPeso molecular:350.32VU6007496
CAS:VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).Fórmula:C25H27N5O2Cor e Forma:SolidPeso molecular:429.511,9-Dideoxyforskolin
CAS:The compound is an inactive analog of forskolin(an adenylyl cyclase activator).Fórmula:C22H34O5Pureza:98%Cor e Forma:SolidPeso molecular:378.5Metoquizine
CAS:Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.Fórmula:C22H27N5OPureza:98%Cor e Forma:SolidPeso molecular:377.48SZ1676
CAS:SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.Fórmula:C37H59BrN2O6Pureza:98%Cor e Forma:SolidPeso molecular:707.78BACE1-IN-4
CAS:BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.Fórmula:C21H23F2N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:511.57AChE/BChE-IN-19
CAS:AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.Fórmula:C26H22N4O3Peso molecular:438.48AChE-IN-47
CAS:AChE-IN-47 (compound g17) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 0.24 μM. It prevents the self-aggregation of β-amyloid peptides and exhibits neuroprotective properties by effectively reducing the accumulation of intracellular reactive oxygen species (ROS).
Fórmula:C20H17F3N4O4SPeso molecular:466.43Dual AChE-MAO B-IN-1
Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.Fórmula:C23H25F2NO4Cor e Forma:SolidPeso molecular:417.45MMB-4
CAS:MMB-4 is an oxime that can reactivate cholinesterases (cholinesterases) which have been inactivated due to exposure to organophosphates such as Sarin or Soman.Fórmula:C13H14Br2N4O2Cor e Forma:SolidPeso molecular:418.084CVN766
CAS:CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].Fórmula:C20H21F3N8OCor e Forma:SolidPeso molecular:446.43AM-6494
CAS:AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Fórmula:C22H21F2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:473.5(S)-Praziquantel
CAS:(S)-Praziquantel is the inactive isomer of R-praziquantel.Fórmula:C19H24N2O2Cor e Forma:SolidPeso molecular:312.406AChE/Aβ-IN-5
CAS:Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].Fórmula:C25H24N4Cor e Forma:SolidPeso molecular:380.48AChE-IN-63
CAS:AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].Fórmula:C18H19N5OCor e Forma:SolidPeso molecular:321.38Monoamine Oxidase B inhibitor 2
MAO-B inhibitor 2: potent, reversible, oral, selective (IC50=1.33 nM), BBB-penetrant, with anti-oxidant and anti-inflammatory effects for Parkinson's study.Fórmula:C19H19FO3Cor e Forma:SolidPeso molecular:314.35Befiradol hydrochloride
CAS:Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.Fórmula:C20H23Cl2F2N3OPureza:99.64%Cor e Forma:SolidPeso molecular:430.32LY 215840
CAS:5-HT2/5-HT7 receptor antagonistFórmula:C24H33N3O2Pureza:98%Cor e Forma:SolidPeso molecular:395.54Dihydro-β-erythroidine
CAS:Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolyticFórmula:C16H21NO3Cor e Forma:SolidPeso molecular:275.34PTCA
CAS:PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.Fórmula:C10H5Cl2NO2SCor e Forma:SolidPeso molecular:274.1235-HT2A/5-HT2C inverse agonist 1
CAS:5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.Fórmula:C24H35N5O2Cor e Forma:SolidPeso molecular:425.57β-Secretase Inhibitor III
β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM.Fórmula:C20H20F2N4O3SCor e Forma:SolidPeso molecular:434.46LOXL2-IN-1 tosylate
LOX-IN-5 tosylate (compound 22) is a selective oral inhibitor of lysyl oxidase-like 2 (LOXL2) with an IC50 of less than 300 nM, and it exhibits anti-fibrotic properties.Fórmula:C28H33FN4O5S2Cor e Forma:SolidPeso molecular:588.714BACE1-IN-8
BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).Fórmula:C29H45N5O7Cor e Forma:SolidPeso molecular:575.7GABA-IN-4
CAS:GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.Fórmula:C17H13ClN2O2Cor e Forma:SolidPeso molecular:312.75MAO-B-IN-6
MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.Cor e Forma:SolidAnti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.Fórmula:C35H49NO4Cor e Forma:SolidPeso molecular:547.77PXS-5153A monohydrochloride
CAS:PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.Fórmula:C20H25Cl2FN4O2SPureza:98%Cor e Forma:Odour SolidPeso molecular:475.41CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Fórmula:C14H11ClO4Cor e Forma:SolidPeso molecular:278.69γ-Secretase modulator 11 hydrochloride
CAS:γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).Fórmula:C28H23ClF2N4O2Cor e Forma:SolidPeso molecular:520.965-HT6/5-HT2AR antagonist-1
Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.Fórmula:C21H26N6SCor e Forma:SolidPeso molecular:394.54Alixorexton
CAS:Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.Fórmula:C21H30N2O5SCor e Forma:SolidPeso molecular:422.538AChE-IN-84
CAS:AChE-IN-84 (compound 21) is an inhibitor of AChE.Fórmula:C6H15Br2NCor e Forma:SolidPeso molecular:260.998LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Fórmula:C24H26F2N4O2SCor e Forma:SolidPeso molecular:472.55LY3020371 hydrochloride
CAS:LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Fórmula:C15H16ClF2NO5SCor e Forma:SolidPeso molecular:395.81(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.Fórmula:C15H38N2O9SCor e Forma:SolidPeso molecular:422.54(S)-YNT-3708
CAS:(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749Terguride
CAS:Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.Fórmula:C20H28N4OCor e Forma:SolidPeso molecular:340.46AAK1-IN-2 TFA
AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.Fórmula:C24H22F6N4O4Cor e Forma:SolidPeso molecular:544.45TP003
CAS:TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.
Fórmula:C23H16F3N3OPureza:99.17%Cor e Forma:SolidPeso molecular:407.39Zanapezil fumarate
CAS:Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons.Fórmula:C29H36N2O5Cor e Forma:SolidPeso molecular:492.61(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.Fórmula:C10H19ClNO1·5SPureza:98%Cor e Forma:SolidPeso molecular:244.78LK-732
CAS:LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.Fórmula:C25H29N5O3SCor e Forma:SolidPeso molecular:479.59MAO-IN-4
CAS:MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].Fórmula:C18H11Cl2N3OSCor e Forma:SolidPeso molecular:388.27(R)-Norfluoxetine
CAS:(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine. It functions as a potent serotonin reuptake inhibitor, with a Ki value of 13 nM. This compound is utilized in the research of depression.Fórmula:C16H16F3NOCor e Forma:SolidPeso molecular:295.299γ-secretase modulator 6
CAS:Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.Fórmula:C25H26N6O2Cor e Forma:SolidPeso molecular:442.513Fletazepam
CAS:Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.Fórmula:C17H13ClF4N2Cor e Forma:SolidPeso molecular:356.74DAPM
CAS:DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Fórmula:C20H20F2N2O4Pureza:99.76%Cor e Forma:SolidPeso molecular:390.38Amyloid-β-IN-3
CAS:Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.Fórmula:C22H21F2N3O2Cor e Forma:SolidPeso molecular:397.42(-)-5-HT2C agonist-3
CAS:Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.Fórmula:C19H23ClFNO2Cor e Forma:SolidPeso molecular:351.84Aβ42 agonist-1
CAS:Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.Fórmula:C15H11NO2Pureza:99.77%Cor e Forma:SolidPeso molecular:237.25AChE-IN-5
AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.Fórmula:C38H45N5OCor e Forma:SolidPeso molecular:587.8LY367385 hydrochloride
CAS:LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.Fórmula:C10H12ClNO4Cor e Forma:SolidPeso molecular:245.66R-96544 hydrochloride
CAS:5-HT2 receptor antagonistFórmula:C22H29NO3Pureza:98%Cor e Forma:SolidPeso molecular:355.47BChE-IN-5
BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.Fórmula:C30H42N4OCor e Forma:SolidPeso molecular:474.685-HT2A receptor agonist-8
CAS:5-HT2A receptor agonist-8 (compound 8) is a potent 5-HT2A receptor agonist with an EC50 of 0.6784 nM. It is suitable for research related to depression and bipolar disorder.Fórmula:C22H27N3OCor e Forma:SolidPeso molecular:349.47LY-2979165
CAS:LY-2979165 is a metabotropic glutamate receptor agonist prodrug.Fórmula:C13H17N5O5SCor e Forma:SolidPeso molecular:355.37R-137696
CAS:R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.Fórmula:C17H23N3O2Cor e Forma:SolidPeso molecular:301.38CL-13
CL-13 is an inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 of 1.15 μM and a selectivity index (SI) of 9.2 for acetylcholinesterase. It demonstrates antioxidative activity in SH-SY5Y cells with a DPPHEC50 of 47.01 μM and has the capacity to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at concentrations up to 50 μM. CL-13 can also reverse scopolamine-induced cognitive impairments without affecting motor abilities in mice.Fórmula:C29H32N4OSCor e Forma:SolidPeso molecular:484.66BRD0418
CAS:BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.Fórmula:C29H32N2O5Pureza:99.57%Cor e Forma:SolidPeso molecular:488.57SGE-516
CAS:SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.Fórmula:C23H35N3O2Pureza:98%Cor e Forma:SolidPeso molecular:385.54Dihydro-β-erythroidine hydrobromide
CAS:Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).Fórmula:C16H22BrNO3Pureza:98%Cor e Forma:White SolidPeso molecular:356.26PF-06442609
CAS:PF-06442609 is an orally active γ-secretase modulator with an IC50 value of 6 nM for Aβ42. It exhibits good CNS permeability.Fórmula:C24H24F4N4O3Peso molecular:492.47AChE-IN-11
AChE-IN-11 aids Alzheimer's research, has neuroprotection/antioxidant properties (ORAC=2.5), and acts on AChE, MAO-B, BACE1 with IC50 values of 7.9-9.9 μM.Fórmula:C18H28N2O4Cor e Forma:SolidPeso molecular:336.43BChE-IN-2
BChE-IN-2, a pyrimidine/pyridine derivative, potently inhibits BChE (Ki 0.099 μM) and shows promise in AD research.Fórmula:C22H31N5Cor e Forma:SolidPeso molecular:365.52CEase-IN-1
CEase-IN-1 (A1H3), potent CEase inhibitor, IC50 0.36μM, for hypercholesterolemia study.Fórmula:C13H15F3N2O2Cor e Forma:SolidPeso molecular:288.27Geissoschizoline
CAS:Geissoschizoline inhibits human AChE/BChE (IC50: 20.40/10.21 µM) and has anti-inflammatory properties.Fórmula:C19H26N2OCor e Forma:SolidPeso molecular:298.42SB 258741 hydrochloride
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].Fórmula:C19H31ClN2O2SCor e Forma:SolidPeso molecular:386.985-HT2A receptor agonist-7
CAS:5-HT2A receptor agonist-7 (517) functions as a modulator of the 5-HT2A receptor, with an EC50 value of less than 100 nM.Fórmula:C12H11F2N3Cor e Forma:SolidPeso molecular:235.233ChE/Aβ1-42-IN-1
ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability.Fórmula:C19H24N2O3Cor e Forma:SolidPeso molecular:328.41YNT-3708
CAS:YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749AChE/BuChE-IN-3
CAS:AChE/BuChE-IN-3 inhibits AChE (IC50: 0.65 μM), BuChE (IC50: 5.77 μM), crosses BBB, and hinders Aβ1-42 aggregation for Alzheimer's research.Fórmula:C30H30F3N3O6Cor e Forma:SolidPeso molecular:585.57K203
K203 is a potent tabun-inhibited AChE reactivator and is an important antidote to organophosphorus poisoning.Fórmula:C16H18Br2N4O2Cor e Forma:SolidPeso molecular:458.15EF1502 free base
CAS:EF1502 is a potent and selective GABA transporter inhibitor.Fórmula:C22H26N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:414.58AChE-IN-8
AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.Fórmula:C20H22N4O2SCor e Forma:SolidPeso molecular:382.48(R)-(-)-Pirlindole mesylate
CAS:(R)-(–)-Pirlindole acts as a monoamine oxidase A (MAO-A) inhibitor with an IC50 value of 0.43 µM, exhibiting selectivity for MAO-A compared to MAO-B. When administered at 50 mg/kg, it reduces immobility time in the forced swim test in mice and, at 25 mg/kg, inhibits reserpine-induced palpebral ptosis in mice.Fórmula:C16H22N2O3SCor e Forma:SolidPeso molecular:322.42AAZ-A 154 hydrochloride
CAS:AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.Fórmula:C14H21ClN2OCor e Forma:SolidPeso molecular:268.78Rodatristat ethyl
CAS:Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.Fórmula:C29H31ClF3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:590.0425C-NBF hydrochloride
CAS:25C-NBF hydrochloride is an agonist of 5-HT receptors, specifically activating 5-HT2A and 5-HT2C receptors, with an EC50 of approximately 0.3 μM.Fórmula:C17H20Cl2FNO2Peso molecular:360.251AChE-IN-22
AChE-IN-22 (10q) selectively inhibits AChE (IC50: 0.88 μM), less on BuChE (IC50: 10 μM), targets CAS and PAS, useful in Alzheimer's research.Fórmula:C21H20N4O5SCor e Forma:SolidPeso molecular:440.47(9R)-RO7185876
CAS:(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.Fórmula:C25H28F3N7Cor e Forma:SolidPeso molecular:483.532LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Fórmula:C16H18N2O6Pureza:98.15%Cor e Forma:SolidPeso molecular:334.32Aβ aggregation-IN-1
CAS:Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.Fórmula:C9H8BF3O2Cor e Forma:SolidPeso molecular:215.965Nafimidone hydrochloride
CAS:Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.Fórmula:C15H13ClN2OCor e Forma:SolidPeso molecular:272.73AChE-IN-10
AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.Fórmula:C23H27F2NO4SCor e Forma:SolidPeso molecular:451.53DSP-1053 benzenesulfonate
CAS:DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Fórmula:C32H38BrNO7SCor e Forma:SolidPeso molecular:660.62Rocavorexant
CAS:Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392AAZ-A 154
CAS:AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.Fórmula:C14H20N2OCor e Forma:SolidPeso molecular:232.32Lu 26-046
CAS:Lu 26-046 is a muscarinic receptor agonist.Fórmula:C10H12N2OSCor e Forma:SolidPeso molecular:208.28
