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Neurociência

Neurociência

Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.

Subcategorias de "Neurociência"

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Foram encontrados 5390 produtos de "Neurociência"

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  • 5-HT7R antagonist 3
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    5-HT7R antagonist 3

    CAS:
    <p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>
    Fórmula:C30H33FN4O3
    Cor e Forma:Solid
    Peso molecular:516.61

    Ref: TM-T201849

  • MAO-A inhibitor 1
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    MAO-A inhibitor 1

    CAS:
    <p>MAO-A Inhibitor 1 (compound VIII) acts as a MAO-A inhibitor and exhibits an IC50 value of 100 μM [1].</p>
    Fórmula:C14H12O4
    Cor e Forma:Solid
    Peso molecular:244.24

    Ref: TM-T86857

  • Logotipo do CymitQuimica
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    nAChR antagonist 1

    CAS:
    <p>Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.</p>
    Fórmula:C19H22N4O2
    Cor e Forma:Solid
    Peso molecular:338.4

    Ref: TM-T61064

  • Logotipo do CymitQuimica
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    SB 258741 hydrochloride

    <p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>
    Fórmula:C19H31ClN2O2S
    Cor e Forma:Solid
    Peso molecular:386.98

    Ref: TM-T61724

  • LY367385 hydrochloride
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    LY367385 hydrochloride

    CAS:
    <p>LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.</p>
    Fórmula:C10H12ClNO4
    Cor e Forma:Solid
    Peso molecular:245.66

    Ref: TM-T60355

  • AChE/BChE/MAO-B-IN-5
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    AChE/BChE/MAO-B-IN-5

    CAS:
    <p>AChE/BChE/MAO-B-IN-5 is a multi-target inhibitor capable of crossing the blood-brain barrier, targeting cholinesterases (AChE and BChE) and monoamine oxidase MAO-B. It exhibits IC50 values of 0.24 µM for AChE, 6.29 µM for BChE, and 0.11 µM for MAO-B. AChE/BChE/MAO-B-IN-5 holds potential for research in neurodegenerative diseases such as Alzheimer's disease.</p>
    Fórmula:C22H14F3NO2
    Cor e Forma:Solid
    Peso molecular:381.347

    Ref: TM-T206229

  • Pareptide monohydrochloride
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    Pareptide monohydrochloride

    CAS:
    <p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>
    Fórmula:C14H27ClN4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:334.84

    Ref: TM-T13707

  • EF1502 free base
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    EF1502 free base

    CAS:
    <p>EF1502 is a potent and selective GABA transporter inhibitor.</p>
    Fórmula:C22H26N2O2S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:414.58

    Ref: TM-T27241

  • LY3020371 hydrochloride
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    LY3020371 hydrochloride

    CAS:
    LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.
    Fórmula:C15H16ClF2NO5S
    Cor e Forma:Solid
    Peso molecular:395.81

    Ref: TM-T11911

  • VU6007496
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    VU6007496

    CAS:
    <p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>
    Fórmula:C25H27N5O2
    Cor e Forma:Solid
    Peso molecular:429.51

    Ref: TM-T200762

  • Logotipo do CymitQuimica
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    AChE/BChE-IN-1

    <p>AChE/BChE-IN-1: dual AChE/BChE inhibitor, IC50 of 1.06 nM/7.3 nM, crosses blood-brain barrier, with antioxidant properties for Alzheimer's research.</p>
    Fórmula:C32H35ClN6O3
    Cor e Forma:Solid
    Peso molecular:587.11

    Ref: TM-T64156

  • SZ1676
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    SZ1676

    CAS:
    <p>SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.</p>
    Fórmula:C37H59BrN2O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:707.78

    Ref: TM-T13908

  • Azotomycin
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    Azotomycin

    CAS:
    Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.
    Fórmula:C17H23N7O8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:453.41

    Ref: TM-T26729

  • MAO-B-IN-34
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    MAO-B-IN-34

    CAS:
    <p>MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.</p>
    Fórmula:C15H9Cl2NO3
    Cor e Forma:Solid
    Peso molecular:322.14

    Ref: TM-T200499

  • 8 Hydroxy PIPAT oxalate
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    8 Hydroxy PIPAT oxalate

    CAS:
    8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.
    Fórmula:C18H24INO5
    Cor e Forma:Solid
    Peso molecular:461.29

    Ref: TM-T201052

  • RO-1-5237
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    RO-1-5237

    CAS:
    <p>RO-1-5237, a cholinergic compound and a metabolic product of Pyridostigmine Bromide, is utilized in research for myasthenia gravis.</p>
    Fórmula:C6H8BrNO
    Cor e Forma:Solid
    Peso molecular:190.04

    Ref: TM-T200816

  • Aβ aggregation-IN-1
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    Aβ aggregation-IN-1

    CAS:
    <p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>
    Fórmula:C9H8BF3O2
    Cor e Forma:Solid
    Peso molecular:215.965

    Ref: TM-T204182

  • Logotipo do CymitQuimica
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    CaMKK2-IN-1

    CAS:
    <p>CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.</p>
    Fórmula:C22H22N2O3
    Peso molecular:362.42

    Ref: TM-T208827

  • Logotipo do CymitQuimica
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    QP5020

    CAS:
    QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.
    Fórmula:C20H19FN6
    Peso molecular:362.40

    Ref: TM-T208804

  • Logotipo do CymitQuimica
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    AChE-IN-47

    CAS:
    <p>AChE-IN-47 (compound g17) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 0.24 μM. It prevents the self-aggregation of β-amyloid peptides and exhibits neuroprotective properties by effectively reducing the accumulation of intracellular reactive oxygen species (ROS).</p>
    Fórmula:C20H17F3N4O4S
    Peso molecular:466.43

    Ref: TM-T208738