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Neurociência

Neurociência

Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.

Subcategorias de "Neurociência"

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Foram encontrados 5390 produtos de "Neurociência"

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  • β-Amyloid (18-28)
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    β-Amyloid (18-28)

    CAS:
    <p>Intracerebroventricular administration of synthetic peptides Beta-amyloid (12-20), (12-28), and (18-28) causes amnesia in mice.</p>
    Fórmula:C55H81N13O18
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1212.31

    Ref: TM-TP1633

  • Asenapine citrate
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    Asenapine citrate

    CAS:
    <p>Asenapine citrate: atypical antipsychotic for schizophrenia, bipolar disorder; targets serotonin, adrenoceptors, dopamine, histamine (pKi: 8.2-10.5).</p>
    Fórmula:C23H24ClNO8
    Cor e Forma:Solid
    Peso molecular:477.89

    Ref: TM-T63129

  • Logotipo do CymitQuimica
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    COX-1-IN-2

    <p>COX-1-IN-2 (compound 5h) serves as a potent anti-inflammatory and analgesic agent. This compound demonstrates a significant inhibitory effect on COX-1, with an IC 50 value of 38.76 nM.</p>
    Fórmula:C29H22FN3OS
    Cor e Forma:Solid
    Peso molecular:479.57

    Ref: TM-T200220

  • α-Conotoxin EI
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    α-Conotoxin EI

    CAS:
    <p>Selective antagonist of neuromuscular nicotinic receptors α1β1γδ</p>
    Fórmula:C83H125N27O27S5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:2093.37

    Ref: TM-TP2218

  • Logotipo do CymitQuimica
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    MAO-IN-6

    <p>MAO-IN-6 (Compound 3f) is a reversible MAO-B inhibitor that can cross the blood-brain barrier, with an IC50 value of 0.09 μM. It also shows inhibitory activity against AChE and BChE, with IC50 values of 4.48 μM and 17.03 μM, respectively. MAO-IN-6 exhibits low cytotoxicity and is applicable in Alzheimer's disease research.</p>
    Fórmula:C22H14F3NO2
    Cor e Forma:Solid
    Peso molecular:381.35

    Ref: TM-T205280

  • Logotipo do CymitQuimica
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    Orexin A (human, rat, mouse) (TFA)

    Endogenous orexin receptor agonist with Ki of 20 nM (OX1) and 38 nM (OX2), promotes feeding, may regulate sleep-wake cycle.
    Fórmula:C154H244N47F3O46S4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:3675.12

    Ref: TM-TP1550

  • nAChR modulator-2
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    nAChR modulator-2

    CAS:
    <p>nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] .</p>
    Fórmula:C12H8ClN3O2
    Cor e Forma:Solid
    Peso molecular:261.66

    Ref: TM-T74397

  • β-Amyloid (29-40)
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    β-Amyloid (29-40)

    CAS:
    <p>β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties</p>
    Fórmula:C49H88N12O13S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1085.36

    Ref: TM-TP1231

  • Moxonidine hydrochloride
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    Moxonidine hydrochloride

    CAS:
    <p>Moxonidine Hydrochloride: selective I1 imidazoline receptor agonist, stronger than α2-AR; lowers blood pressure; central action.</p>
    Fórmula:C9H13Cl2N5O
    Cor e Forma:Solid
    Peso molecular:278.14

    Ref: TM-T40869

  • β-Amyloid (10-35), amide
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    β-Amyloid (10-35), amide

    CAS:
    β-Amyloid (10-35), amide, is a chemical compound consisting of 26 amino acids, specifically residues 10-35 of the Aβ peptide.
    Fórmula:C133H205N35O36S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:2902.33

    Ref: TM-TP1729

  • hAChE/hBuChE-IN-1
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    hAChE/hBuChE-IN-1

    <p>hAChE/hBuChE-IN-1 (compound C2) acts as a dual inhibitor of cholinesterases, exhibiting IC50 values of 514 nM for hAChE and 358 nM for hBuChE. It is orally active and capable of enhancing cognitive function and spatial memory.</p>
    Fórmula:C30H31FN2O3
    Cor e Forma:Solid
    Peso molecular:486.577

    Ref: TM-T204587

  • (1S,3R)-3-Aminocyclopentane carboxylic acid
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    (1S,3R)-3-Aminocyclopentane carboxylic acid

    CAS:
    <p>(1S,3R)-3-Aminocyclopentane carboxylic acid exhibits activity on GABAA receptors.</p>
    Fórmula:C6H11NO2
    Cor e Forma:Solid
    Peso molecular:129.16

    Ref: TM-T203289

  • Logotipo do CymitQuimica
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    Dual AChE-MAO B-IN-3

    <p>Compound C10 is a potent dual AChE/MAO-B inhibitor with IC50s of 0.58μM (AChE) and 0.41μM (MAO-B), useful in Alzheimer's research.</p>
    Fórmula:C30H26F3NO3
    Cor e Forma:Solid
    Peso molecular:505.53

    Ref: TM-T74991

  • AChE/BuChE-IN-6
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    AChE/BuChE-IN-6

    <p>AChE/BuChE-IN-6 (Compound 11f) is an inhibitor of AChE and BuChE, with IC50 values of 1.24 and 1.85 μg/mL, respectively. It exhibits strong DPPH radical scavenging activity (IC50 = 3.15 μg/mL). In vivo toxicity studies demonstrate that AChE/BuChE-IN-6 is safe, showing no significant differences in blood and biochemical parameters compared to controls, and no abnormalities in liver and kidney tissues. This compound shows potential for Alzheimer's disease research.</p>
    Fórmula:C24H20ClN3O3
    Cor e Forma:Solid
    Peso molecular:433.887

    Ref: TM-T204119

  • AC 253
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    AC 253

    CAS:
    <p>Amylin (AMY3) receptor antagonist; blocks cAMP, Ca2+, PKA, MAPK, Akt, and cFOS activity; prevents Aβ-induced neuronal death. Cyclic AC 253 variant exists.</p>
    Fórmula:C122H196N40O39
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:2847.11

    Ref: TM-TP2078

  • OXA(17-33)
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    OXA(17-33)

    CAS:
    Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.
    Fórmula:C79H125N23O22
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1749

    Ref: TM-TP1973

  • Logotipo do CymitQuimica
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    NMDA receptor antagonist 8

    <p>Compound (R)-10a, an NMDA receptor antagonist, exhibits selectivity for the GluN2B subunit, possessing a Ki of 265 nM and an IC50 of 62 nM.</p>
    Fórmula:C22H27N3O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:349.47

    Ref: TM-T79375

  • Logotipo do CymitQuimica
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    RA306

    <p>RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.</p>
    Cor e Forma:Odour Solid

    Ref: TM-T206515

  • Logotipo do CymitQuimica
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    COX-1/2-IN-4

    <p>COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2.</p>
    Fórmula:C22H24N2O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:380.5

    Ref: TM-T79592

  • (-)-Coclaurine hydrochloride
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    (-)-Coclaurine hydrochloride

    CAS:
    <p>(-)-Coclaurine hydrochloride is an antagonist of nAChRs isolated from Sarcopetalum harveyanum.</p>
    Fórmula:C17H20ClNO3
    Pureza:99.07%
    Cor e Forma:Soild
    Peso molecular:321.8

    Ref: TM-TN1519L