Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(940 produtos)
- ACK(1 produtos)
- AChR(574 produtos)
- ATP Citrato Liase(16 produtos)
- Receptor adrenérgico(2.939 produtos)
- BACE(36 produtos)
- Beta Amilóide(204 produtos)
- CaMK(68 produtos)
- COX(562 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor GABA(336 produtos)
- Gama-secretase(59 produtos)
- GluR(255 produtos)
- GlyT(24 produtos)
- Receptor de Histamina(358 produtos)
- LRRK2(33 produtos)
- Receptor de Melatonina(24 produtos)
- NMDAR(28 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(296 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5400 produtos de "Neurociência"
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LY 53857
CAS:<p>LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.</p>Fórmula:C27H36N2O7Cor e Forma:SolidPeso molecular:500.5925-HT3-In-1
CAS:<p>5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.</p>Fórmula:C16H21ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:352.82Facinicline hydrochloride
CAS:<p>Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).</p>Fórmula:C15H19ClN4OPureza:98.70%Cor e Forma:SolidPeso molecular:306.79PHP 501 trifluoroacetate
CAS:<p>GABAA antagonist</p>Fórmula:C20H21N3OPureza:98%Cor e Forma:SolidPeso molecular:319.4Biphenylindanone A
CAS:<p>Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.</p>Fórmula:C30H30O4Pureza:98%Cor e Forma:SolidPeso molecular:454.56MAO-B-IN-13
CAS:<p>MAO-B-IN-13: a potent, reversible MAO-B inhibitor with BBB penetration, neuroprotective effects; used in Parkinson’s research (IC50=10nM).</p>Fórmula:C18H19NO3Cor e Forma:SolidPeso molecular:297.35GYKI-46903 HCl
CAS:<p>GYKI-46903 is a noncompetitive 5-HT3 receptor antagonist.</p>Fórmula:C17H21ClFNO2Cor e Forma:SolidPeso molecular:325.81NCS-382 sodium
CAS:<p>NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease</p>Fórmula:C13H13NaO3Pureza:98%Cor e Forma:SolidPeso molecular:240.23Zamifenacin fumarate
CAS:<p>Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.</p>Fórmula:C31H33NO7Pureza:99.88%Cor e Forma:SolidPeso molecular:531.6Dothiepin
CAS:<p>Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing</p>Fórmula:C19H21NSPureza:98%Cor e Forma:SolidPeso molecular:295.44PNU109291
CAS:<p>PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation.</p>Fórmula:C24H31N3O3Pureza:98%Cor e Forma:SolidPeso molecular:409.52L-772,405
CAS:<p>L-772,405 is a highly selective agonists of h5-HT(1D) receptor.</p>Fórmula:C26H31FN6OPureza:98%Cor e Forma:SolidPeso molecular:462.56FGIN-1-27
CAS:<p>FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM).</p>Fórmula:C28H37FN2OPureza:99.86%Cor e Forma:SolidPeso molecular:436.6BMS-933043
CAS:<p>BMS-933043: α7 nAChR partial agonist, binds rat (Ki=3.3 nM) & human (Ki=8.1 nM), agonist with EC50=23.4 nM (calcium assay), 0.14-0.29 μM (electrophysiology).</p>Fórmula:C16H19N7OPureza:98%Cor e Forma:SolidPeso molecular:325.37LY108742
CAS:<p>LY108742 is an antagonist of 5-HT2.</p>Fórmula:C21H28N2O3Pureza:98%Cor e Forma:SolidPeso molecular:356.46Octahydroaminoacridine succinate
CAS:<p>Octahydroaminoacridine succinate, an acetylcholinesterase inhibitor, is used potentially for the treatment of Alzheimer's disease.</p>Fórmula:C17H24N2O4Pureza:99.91%Cor e Forma:SolidPeso molecular:320.38KBR 2822
CAS:<p>KBR 2822 is an inhibitor of esterase.</p>Fórmula:C9H15ClF3O3PSPureza:98%Cor e Forma:SolidPeso molecular:326.7LG 50643
CAS:<p>LG 50643 is a muscarinic antagonist.</p>Fórmula:C24H34INO2Pureza:98%Cor e Forma:SolidPeso molecular:495.44MAO-B-IN-27
CAS:<p>MAO-B-IN-27 (Compound 12c), a monoamine oxidase B (MAO-B) inhibitor, exhibits a potent and selective inhibitory effect on hMAO-B, with an IC50 value of 8.9 nM,</p>Fórmula:C16H17ClF3NOPureza:98%Cor e Forma:SolidPeso molecular:331.76AAK1-IN-2
CAS:<p>AAK1-IN-2, a potent (IC50=5.8 nM) AAK1 inhibitor, selective & brain-penetrant, is used for neuropathic pain studies.</p>Fórmula:C20H20N4Cor e Forma:SolidPeso molecular:316.4BMS 433796
CAS:<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Fórmula:C21H20F2N4O4Pureza:99.17%Cor e Forma:SolidPeso molecular:430.43β-Hydroxy-lup-20(29)-en-16-one
CAS:<p>3β-Hydroxy-lup-20(29)-en-16-one (compound 9) serves as a dual inhibitor of both AChE and BChE, displaying a preference for BChE with an IC50 of 28.9 μM [1].</p>Fórmula:C30H48O2Cor e Forma:SolidPeso molecular:440.7CAY10649
CAS:<p>1CAY10649, a thiazolinone compound, directly inhibits 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.28 μM and in a soluble fraction of an S100 PMNL cell lysate with an IC50 value of 0.09 μM, following stimulation by calcium and arachidonic acid. This activity highlights its potential in mitigating inflammatory responses by targeting the biosynthesis of leukotrienes, substances implicated in various inflammatory processes such as neutrophil chemotaxis, increased vascular permeability, and smooth muscle contraction.</p>Fórmula:C17H12ClNO2SCor e Forma:SolidPeso molecular:329.8GMA-839
CAS:<p>GMA-839 is a selective modulator of gamma-aminobutyric acid(A) receptors.</p>Fórmula:C21H31F3O3Pureza:98%Cor e Forma:SolidPeso molecular:388.46Lanabecestat camsylate
CAS:<p>Lanabecestat camsylate is used as a BACE1 Inhibitor.</p>Fórmula:C36H44N4O5SPureza:98%Cor e Forma:SolidPeso molecular:644.83P11149
CAS:<p>P11149: oral AChE inhibitor, crosses BBB, IC50 1.3 μM, based on Galanthamine, aims Alzheimer's research.</p>Fórmula:C27H34ClNO4Cor e Forma:SolidPeso molecular:472.02VU 0255035
CAS:<p>VU 0255035 is a highly selective, competitive and brain penetrant muscarinic M1 receptor antagonist with an IC50 of 130 nM.</p>Fórmula:C18H20N6O3S2Pureza:98.09% - 98.1%Cor e Forma:SolidPeso molecular:432.52rel-HDMP 28 hydrochloride
CAS:<p>Rel-HDMP-28 hydrochloride (Compound 2g) is an analogue of methylphenidate, exhibiting selective affinity for the serotonin transporter (SERT) with a binding constant (Ki) of 105 nM [1].</p>Fórmula:C18H22ClNO2Cor e Forma:SolidPeso molecular:319.83Brasofensine Maleate
CAS:<p>Brasofensine Maleate inhibits the monoamine re-uptake.</p>Fórmula:C20H24Cl2N2O5Cor e Forma:SolidPeso molecular:443.32VU0360172
CAS:<p>VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).</p>Fórmula:C18H15FN2OPureza:99.56%Cor e Forma:SolidPeso molecular:294.32CP-122288
CAS:<p>CP-122288: potent, selective 5-HT1B/D/F agonist; inhibits plasma protein extravasation, neurogenic inflammation.</p>Fórmula:C16H23N3O2SPureza:98%Cor e Forma:SolidPeso molecular:321.445-HT2A antagonist 1
CAS:<p>5-HT2A antagonist 1, from US5728835A & JP 1007727, may treat gastrointestinal and circulatory issues.</p>Fórmula:C26H28N4O2Pureza:98%Cor e Forma:SolidPeso molecular:428.53Eslicarbazepine
CAS:<p>Eslicarbazepine (Stedesa) can be used for adjunctive therapy for adults with partial-onset seizures.</p>Fórmula:C15H14N2O2Pureza:99.97%Cor e Forma:Off-White SolidPeso molecular:254.28FPTQ
CAS:<p>FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].</p>Fórmula:C17H12FN5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:305.31PTAC oxalate
CAS:<p>muscarinic receptor ligand</p>Fórmula:C14H21N3O4S2Pureza:98%Cor e Forma:SolidPeso molecular:359.46ADX71441
CAS:<p>ADX71441, a GABAB PAM, lengthens urinary latencies, lessens events & volume, and may aid in alcoholism and bladder pain.</p>Fórmula:C19H15ClF2N4O4Cor e Forma:SolidPeso molecular:436.8Adipiplon
CAS:<p>Adipiplon(NG2-73, NG273) is a novel selective gamma-aminobutyric acid (GABA) partial agonist.</p>Fórmula:C18H18FN7Cor e Forma:SolidPeso molecular:351.38U 89843A
CAS:<p>U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.</p>Fórmula:C16H23N5Pureza:99.62%Cor e Forma:SolidPeso molecular:285.39AMG-8718
CAS:<p>AMG-8718, an oral BACE1 blocker (IC50: 0.0007 μM), also inhibits BACE2 (IC50: 0.005 μM), lowering CSF and Aβ40 brain levels.</p>Fórmula:C25H19FN4O3Cor e Forma:SolidPeso molecular:442.44UNC9994
CAS:<p>UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.</p>Fórmula:C21H22Cl2N2OSCor e Forma:SolidPeso molecular:421.38NAS-181
CAS:<p>NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM).NAS-181 enhances the accumulation of 5-HTP in rat brain regions.</p>Fórmula:C20H30N2O7SCor e Forma:SolidPeso molecular:442.53L 663581
CAS:<p>L 663581 is the benzodiazepine receptor partial agonist.</p>Fórmula:C17H16ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:357.79LY3202626
CAS:<p>LY3202626, an amyloid precursor protein secretase (BACE protein) inhibitor, is used for the treatment of Alzheimer's disease.</p>Fórmula:C22H20F2N8O2SPureza:98%Cor e Forma:SolidPeso molecular:498.51BACE1-IN-13
CAS:<p>BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (</p>Fórmula:C20H17FN8O2Pureza:98%Cor e Forma:SolidPeso molecular:420.4Robalzotan
CAS:<p>Robalzotan is a selective 5-HT1A receptor antagonist.</p>Fórmula:C18H23FN2O2Pureza:98%Cor e Forma:SolidPeso molecular:318.39N-Demethyl MK-6884
CAS:<p>N-Demethyl MK-6884 (compound 34) is an M4 mAChR modulator for Alzheimer's and related disease research.</p>Fórmula:C24H23N5OCor e Forma:SolidPeso molecular:397.475-HT2A&5-HT2C agonist-1
CAS:<p>5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.</p>Fórmula:C14H20N2OPureza:98%Cor e Forma:SolidPeso molecular:232.32AMPA receptor modulator-5
CAS:<p>AMPA Receptor Modulator-5 (Example 217) serves as an AMPA receptor modulator, utilized in neurological disease research [1].</p>Fórmula:C20H12F4N6Pureza:98%Cor e Forma:SolidPeso molecular:412.345-HT2A receptor agonist-3
CAS:<p>5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.</p>Fórmula:C21H26BrNO3Pureza:98%Cor e Forma:SolidPeso molecular:420.34FPPQ
CAS:<p>FPPQ blocks 5-HT3 and 5-HT6 receptors (Ki: 0.9 & 3 nM) and may improve psychosis and cognition.</p>Fórmula:C21H19FN4O2SCor e Forma:SolidPeso molecular:410.46γ-Secretase-IN-1
CAS:<p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>Fórmula:C27H24F2N4O3Pureza:99.56%Cor e Forma:SolidPeso molecular:490.5CGP 78608 hydrochloride
CAS:<p>CGP 78608 hydrochloride: NMDA receptor antagonist (IC50=6 nM), anticonvulsant, enhances GluN1/GluN3A currents (EC50=26.3 nM).</p>Fórmula:C11H14BrClN3O5PPureza:99.85%Cor e Forma:SolidPeso molecular:414.58JNJ-42253432
CAS:<p>JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels</p>Fórmula:C28H38N4OPureza:99.98%Cor e Forma:SolidPeso molecular:446.63AMPA receptor modulator-1
CAS:<p>AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.</p>Fórmula:C16H11ClF3NO2Pureza:99.93%Cor e Forma:SolidPeso molecular:341.71Atabecestat
CAS:<p>Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.</p>Fórmula:C18H14FN5OSPureza:99.21% - 99.77%Cor e Forma:SolidPeso molecular:367.4Tematropium
CAS:<p>Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.</p>Fórmula:C21H31NO8SPureza:99.89%Cor e Forma:SolidPeso molecular:457.54Didesmethyl cariprazine
CAS:<p>Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.</p>Fórmula:C19H28Cl2N4OPureza:99.52%Cor e Forma:SolidPeso molecular:399.36Rislenemdaz
CAS:<p>Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).</p>Fórmula:C19H23FN4O2Pureza:98.18%Cor e Forma:SolidPeso molecular:358.41R-(+)-EU-1180-453
CAS:<p>R-(+)-EU-1180-453 is a novel GluN2C/D selective NMDAR-positive modulator for the study of neurological disorders.</p>Fórmula:C22H21FN2O3Pureza:99.63%Cor e Forma:SolidPeso molecular:380.41SB 216641 hydrochloride
CAS:<p>SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.</p>Fórmula:C28H31ClN4O4Pureza:98.06% - 99.23%Cor e Forma:SolidPeso molecular:523.02Philanthotoxin 74 dihydrochloride
CAS:<p>Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.</p>Fórmula:C24H44Cl2N4O3Pureza:99.75%Cor e Forma:SolidPeso molecular:507.54VU6004909
CAS:<p>VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.</p>Fórmula:C21H15FN2O4Pureza:96.68% - 98.44%Cor e Forma:SolidPeso molecular:378.35WAY-607695
CAS:<p>WAY-607695 is a potential 5-HT1A receptor agonist.</p>Fórmula:C13H12FNO2Pureza:99.82%Cor e Forma:SolidPeso molecular:233.24Gossypolone
CAS:<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Fórmula:C30H26O10Pureza:96.66%Cor e Forma:SolidPeso molecular:546.52Osemozotan HCl
CAS:<p>Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.</p>Fórmula:C19H22ClNO5Pureza:98.87% - 99.63%Cor e Forma:SolidPeso molecular:379.84Dalzanemdor
CAS:<p>Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive</p>Fórmula:C27H43F3O2Pureza:98.2% - >99.99%Cor e Forma:SolidPeso molecular:456.62BuChE-IN-TM-10
CAS:<p>TM-10: Potent BuChE inhibitor, IC50 8.9 nM, disaggregates Aβ, antioxidant, BBB penetrant, may treat Alzheimer's.</p>Fórmula:C32H38N2O3Pureza:99.54%Cor e Forma:SolidPeso molecular:498.66TZ3O
CAS:<p>TZ3O is an anticholinergic compound with neuroprotective activity.TZ3O ameliorates memory impairment in Scopolamine-induced Alzheimer's type model in rats.</p>Fórmula:C18H13NO4SPureza:99.84%Cor e Forma:SolidPeso molecular:339.37AMPA receptor antagonist-3
CAS:<p>AMPA receptor antagonist-3 is an AMPA receptor antagonist.</p>Fórmula:C20H19N5O2SPureza:99.79%Cor e Forma:SolidPeso molecular:393.46Lumateperone
CAS:<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Fórmula:C24H28FN3OPureza:99.68% - 99.91%Cor e Forma:SolidPeso molecular:393.5BMS-986176
CAS:<p>AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).</p>Fórmula:C19H23F4N3OPureza:98.58% - 98.7%Cor e Forma:SolidPeso molecular:385.4PXS-5120A
CAS:<p>PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity.</p>Fórmula:C22H25ClFN3O4SPureza:97.02%Cor e Forma:SolidPeso molecular:481.97MDR-1339
CAS:<p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>Fórmula:C20H22O4Pureza:98.57%Cor e Forma:SolidPeso molecular:326.39PXS-5153A
CAS:<p>PXS-5153A rapidly inhibits lysyl oxidase 2/3 enzymes, blocks activity in 15 mins, and reduces fibrosis.</p>Fórmula:C20H25Cl2FN4O2SPureza:99.58%Cor e Forma:SolidPeso molecular:475.41SB-616234-A
CAS:<p>SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.</p>Fórmula:C32H36ClN5O3Pureza:99.72%Cor e Forma:SolidPeso molecular:574.11U92016A hydrochloride
CAS:<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Fórmula:C19H26ClN3Cor e Forma:SolidPeso molecular:331.89AChE-IN-63
CAS:<p>AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].</p>Fórmula:C18H19N5OCor e Forma:SolidPeso molecular:321.38PF-06648671
CAS:<p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>Fórmula:C25H23ClF4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:538.92AChE/Aβ-IN-5
CAS:<p>Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].</p>Fórmula:C25H24N4Cor e Forma:SolidPeso molecular:380.48Monoamine Oxidase B inhibitor 1
<p>Potent, selective MAO-B inhibitor; reversible; oral; crosses BBB; IC50=0.02 nM; potential for Parkinson's research.</p>Fórmula:C18H15FO3Cor e Forma:SolidPeso molecular:298.31γ-Secretase modulator 11 hydrochloride
CAS:<p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>Fórmula:C28H23ClF2N4O2Cor e Forma:SolidPeso molecular:520.96γ-secretase modulator 6
CAS:<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Fórmula:C25H26N6O2Cor e Forma:SolidPeso molecular:442.513BACE-1 inhibitor 2
CAS:<p>BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].</p>Fórmula:C21H21F4N5O3Cor e Forma:SolidPeso molecular:467.42MAO-B-IN-10
<p>MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.</p>Fórmula:C23H26N2O4Cor e Forma:SolidPeso molecular:394.46Amyloid-β-IN-2
CAS:<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Fórmula:C22H21F2N3O2Cor e Forma:SolidPeso molecular:397.42MAO-B-IN-5
CAS:<p>MAO-B-IN-5: potent, selective oral MAO-B inhibitor, IC50=0.204μM, potential for Parkinson's research.</p>Fórmula:C19H21FN2O2Pureza:97.68%Cor e Forma:SolidPeso molecular:328.38Aβ aggregation-IN-1
CAS:<p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>Fórmula:C9H8BF3O2Cor e Forma:SolidPeso molecular:215.965Carlina oxide
CAS:<p>Carlina oxide is both an AChE inhibitor and an antioxidant, effective in eliminating mosquito larvae (LC50=1.39 μg/mL). Furthermore, Carlina oxide exhibits cytotoxicity in vertebrate cells, human dermis, and HCT116 and MDA-MB231 cell lines.</p>Fórmula:C13H10OCor e Forma:SolidPeso molecular:182.222,6-Dimethoxybenzylamine hydrochloride
CAS:<p>2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.</p>Fórmula:C9H14ClNO2Cor e Forma:SolidPeso molecular:203.6662002-G12
CAS:<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Fórmula:C20H16N6Cor e Forma:SolidPeso molecular:340.381Dihydro-β-erythroidine
CAS:<p>Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolytic</p>Fórmula:C16H21NO3Cor e Forma:SolidPeso molecular:275.34MAO-A inhibitor 3
CAS:<p>MAO-A inhibitor3 (Compound 360) is an MAO-A inhibitor with an IC50 greater than 100 μM. It is utilized in the investigation of neurological disorders.</p>Fórmula:C11H8O5Cor e Forma:SolidPeso molecular:220.178MAO-B-IN-42
CAS:<p>MAO-B-IN-42 (Compound 4f) is a selective and reversible monoamine oxidase-B (MAO-B) inhibitor, with an IC50 value of 0.184 μM. By blocking the oxidative deamination of monoamines catalyzed by MAO-B, it helps maintain neurotransmitter levels. MAO-B-IN-42 shows potential for research into Parkinson's disease.</p>Fórmula:C19H12FNO2Cor e Forma:SolidPeso molecular:305.302YNT-3708
CAS:<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749SB 258741 hydrochloride
<p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>Fórmula:C19H31ClN2O2SCor e Forma:SolidPeso molecular:386.98AChE-IN-11
<p>AChE-IN-11 aids Alzheimer's research, has neuroprotection/antioxidant properties (ORAC=2.5), and acts on AChE, MAO-B, BACE1 with IC50 values of 7.9-9.9 μM.</p>Fórmula:C18H28N2O4Cor e Forma:SolidPeso molecular:336.43hAChE-IN-10
CAS:<p>hAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. This compound is capable of scavenging free radicals and exhibits antioxidant activity. Additionally, hAChE-IN-10 demonstrates metal-chelating properties, inhibiting Cu2+-induced Aβ1-42 aggregation, reducing amyloid plaque formation, and offering neuroprotective effects. It also ameliorates cognitive impairment in mice induced by Scopolamine.</p>Fórmula:C25H24ClFN6O2Cor e Forma:SolidPeso molecular:494.948GABA-IN-4
CAS:<p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>Fórmula:C17H13ClN2O2Cor e Forma:SolidPeso molecular:312.75K203
<p>K203 is a potent tabun-inhibited AChE reactivator and is an important antidote to organophosphorus poisoning.</p>Fórmula:C16H18Br2N4O2Cor e Forma:SolidPeso molecular:458.15(+)-Sparteine sulfate pentahydrate
<p>(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.</p>Fórmula:C15H38N2O9SCor e Forma:SolidPeso molecular:422.54AChE-IN-8
<p>AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.</p>Fórmula:C20H22N4O2SCor e Forma:SolidPeso molecular:382.48MAO-B-IN-40
CAS:<p>MAO-B-IN-40 (3a) is an inhibitor of MAOB, exhibiting an IC50 value of 0.493 μM against hMAOB, and demonstrates significant neuroprotective and antioxidant effects. MAO-B-IN-40 (3a) is applicable in Parkinson's disease research.</p>Fórmula:C17H15N3O3Cor e Forma:SolidPeso molecular:309.319CEase-IN-1
<p>CEase-IN-1 (A1H3), potent CEase inhibitor, IC50 0.36μM, for hypercholesterolemia study.</p>Fórmula:C13H15F3N2O2Cor e Forma:SolidPeso molecular:288.27Geissoschizoline
CAS:<p>Geissoschizoline inhibits human AChE/BChE (IC50: 20.40/10.21 µM) and has anti-inflammatory properties.</p>Fórmula:C19H26N2OCor e Forma:SolidPeso molecular:298.42AChE/BChE/MAO-B-IN-5
CAS:<p>AChE/BChE/MAO-B-IN-5 is a multi-target inhibitor capable of crossing the blood-brain barrier, targeting cholinesterases (AChE and BChE) and monoamine oxidase MAO-B. It exhibits IC50 values of 0.24 µM for AChE, 6.29 µM for BChE, and 0.11 µM for MAO-B. AChE/BChE/MAO-B-IN-5 holds potential for research in neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C22H14F3NO2Cor e Forma:SolidPeso molecular:381.347ChE/Aβ1-42-IN-1
<p>ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability.</p>Fórmula:C19H24N2O3Cor e Forma:SolidPeso molecular:328.41Dual AChE-MAO B-IN-1
<p>Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.</p>Fórmula:C23H25F2NO4Cor e Forma:SolidPeso molecular:417.45AChE-IN-84
CAS:<p>AChE-IN-84 (compound 21) is an inhibitor of AChE.</p>Fórmula:C6H15Br2NCor e Forma:SolidPeso molecular:260.998AZD 2066 hydrate
<p>AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].</p>Fórmula:C19H18ClN5O3Cor e Forma:SolidPeso molecular:386.33LP 12 hydrochloride hydrate
<p>LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.</p>Fórmula:C32H39N3O·HCl·xH2OCor e Forma:SolidCaMKK2-IN-1
CAS:<p>CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.</p>Fórmula:C22H22N2O3Peso molecular:362.42HW161023
CAS:<p>HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.</p>Fórmula:C20H24F2N4OCor e Forma:SolidPeso molecular:374.428BPN-15606 besylate
<p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>Fórmula:C29H29FN6O4SCor e Forma:SolidPeso molecular:576.64MAO-B-IN-6
<p>MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.</p>Cor e Forma:SolidDSP-1053 benzenesulfonate
CAS:<p>DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.</p>Fórmula:C32H38BrNO7SCor e Forma:SolidPeso molecular:660.62AChE/BChE-IN-1
<p>AChE/BChE-IN-1: dual AChE/BChE inhibitor, IC50 of 1.06 nM/7.3 nM, crosses blood-brain barrier, with antioxidant properties for Alzheimer's research.</p>Fórmula:C32H35ClN6O3Cor e Forma:SolidPeso molecular:587.11PTCA
CAS:<p>PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.</p>Fórmula:C10H5Cl2NO2SCor e Forma:SolidPeso molecular:274.123Revexepride
CAS:<p>Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.</p>Fórmula:C21H32ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:425.95Mesulergine hydrochloride
CAS:<p>5-HT2A and 2C receptor antagonist</p>Fórmula:C18H27ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:398.95AChE-IN-22
<p>AChE-IN-22 (10q) selectively inhibits AChE (IC50: 0.88 μM), less on BuChE (IC50: 10 μM), targets CAS and PAS, useful in Alzheimer's research.</p>Fórmula:C21H20N4O5SCor e Forma:SolidPeso molecular:440.47AChE-IN-5
<p>AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.</p>Fórmula:C38H45N5OCor e Forma:SolidPeso molecular:587.8PXS-5153A monohydrochloride
CAS:<p>PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.</p>Fórmula:C20H25Cl2FN4O2SPureza:98%Cor e Forma:Odour SolidPeso molecular:475.41(RS)-AMPA hydrochloride
CAS:<p>(RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and serves as an efficient selective agonist for the excitatory neurotransmitter L-glutamic acid (L-glutamic acid). It does not interfere with the binding sites of alginate or NMDA receptors.</p>Fórmula:C7H11ClN2O4Cor e Forma:SolidPeso molecular:222.63(-)-5-HT2C agonist-3
CAS:<p>Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.</p>Fórmula:C19H23ClFNO2Cor e Forma:SolidPeso molecular:351.84(S)-Praziquantel
CAS:<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Fórmula:C19H24N2O2Cor e Forma:SolidPeso molecular:312.406BACE1-IN-8
<p>BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).</p>Fórmula:C29H45N5O7Cor e Forma:SolidPeso molecular:575.7AM-6494
CAS:<p>AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).</p>Fórmula:C22H21F2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:473.5PXS-4787 hydrochloride
CAS:<p>PXS-4787 hydrochloride is a specific and potent pan-lysyl oxidase inhibitor that effectively eliminates the activity of lysyl oxidase. It exhibits varying IC50 values against different forms of the enzyme, including 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). In addition, PXS-4787 hydrochloride reduces the deposition and cross-linking of collagen I secreted by human fibroblasts.</p>Fórmula:C10H13ClFNO2SCor e Forma:SolidPeso molecular:265.73DL-AP5 lithium
CAS:<p>DL-AP5 (2-APV) lithium is a competitive antagonist of the NMDA (N-Methyl-D-aspartate) receptor. It exhibits notable analgesic activity and specifically blocks channels in the rabbit retina.</p>Fórmula:C5H11LiNO5PCor e Forma:SolidPeso molecular:203.06Elzasonan hydrochloride
CAS:<p>Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.</p>Fórmula:C22H24Cl3N3OSCor e Forma:SolidPeso molecular:484.87hMAO-B-IN-10
<p>hMAO-B-IN-10 (compound 7) is an inhibitor of MAO-A/B with IC50 values of 424.1 nM and 177.9 nM, respectively. It has demonstrated neuroprotective effects in the MPTP-induced mouse model of Parkinson's Disease (PD).</p>Fórmula:C16H12N4O4Cor e Forma:SolidPeso molecular:324.29AChE-IN-79
<p>AChE-IN-79 (compound 3i) is an acetylcholinesterase inhibitor with an IC50 of 2.7 µM, suitable for studies related to Alzheimer's disease.</p>Fórmula:C29H27NO6SCor e Forma:SolidPeso molecular:517.59Tuclazepam
CAS:<p>Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.</p>Fórmula:C17H16Cl2N2OCor e Forma:SolidPeso molecular:335.23Remlifanserin
CAS:<p>Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).</p>Fórmula:C24H29F2N3O2Cor e Forma:SolidPeso molecular:429.50Nedemelteon
CAS:<p>Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).</p>Fórmula:C15H18N2O2Cor e Forma:SolidPeso molecular:258.32BGT1-IN-1
CAS:<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Fórmula:C6H9NO2Cor e Forma:SolidPeso molecular:127.14DL-Thyroxine
CAS:<p>DL-Thyroxine is a thyroid hormone that acts as a monoamine oxidase (monoamine oxidase) inhibitor.</p>Fórmula:C15H11I4NO4Cor e Forma:SolidPeso molecular:776.87PF-06751979
CAS:<p>PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).</p>Fórmula:C18H19F2N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:455.5P2X7 receptor antagonist-5
CAS:<p>P2X7 receptor antagonist-5 (compound 13a) is a potent, orally active, and long-lasting antagonist of the P2X7 receptor.</p>Fórmula:C21H17F3N6O3S2Cor e Forma:SolidPeso molecular:522.52Rodatristat ethyl
CAS:<p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.</p>Fórmula:C29H31ClF3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:590.04Cyproflanilide
CAS:<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Fórmula:C28H17BrF12N2O2Cor e Forma:SolidPeso molecular:721.33Relicpixant
CAS:<p>Relicpixant is a potent purine receptor (P2X) antagonist.</p>Fórmula:C20H19ClF2N4O5SCor e Forma:SolidPeso molecular:500.9Flucopride
CAS:<p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>Fórmula:C22H33FN2O2Cor e Forma:SolidPeso molecular:376.51LRRK2-IN-16
CAS:<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Fórmula:C18H19N5OSCor e Forma:SolidPeso molecular:353.441Serotonin maleate
CAS:<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Fórmula:C14H16N2O5Cor e Forma:SolidPeso molecular:292.287SB 243213 hydrochloride
CAS:<p>SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It</p>Fórmula:C22H20ClF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:464.87Glutaminyl Cyclase Inhibitor 3
CAS:<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Fórmula:C24H32N6O2SPureza:98%Cor e Forma:SolidPeso molecular:468.61(E)-CHBO4
CAS:<p>(E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.</p>Fórmula:C15H10BrFOCor e Forma:SolidPeso molecular:305.142P2X4 antagonist-1
CAS:<p>P2X4 antagonist-1 is a potent P2X4 receptor antagonist used in the study of neurological, cardiovascular, and immune system diseases.</p>Fórmula:C20H15Cl3N2O4SPureza:99.9%Cor e Forma:SolidPeso molecular:485.77LY2794193
CAS:<p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>Fórmula:C16H18N2O6Pureza:98.15%Cor e Forma:SolidPeso molecular:334.32BRD0418
CAS:<p>BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.</p>Fórmula:C29H32N2O5Pureza:99.57%Cor e Forma:SolidPeso molecular:488.57RO-1-5237
CAS:<p>RO-1-5237, a cholinergic compound and a metabolic product of Pyridostigmine Bromide, is utilized in research for myasthenia gravis.</p>Fórmula:C6H8BrNOCor e Forma:SolidPeso molecular:190.04VU6016235
CAS:<p>VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.</p>Fórmula:C21H22N4OSCor e Forma:SolidPeso molecular:378.49Poskine
CAS:<p>Poskine is an anticholinergic and central nervous system depressant. It is utilized in research related to Parkinson's disease and motion sickness.</p>Fórmula:C20H25NO5Cor e Forma:SolidPeso molecular:359.428 Hydroxy PIPAT oxalate
CAS:<p>8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.</p>Fórmula:C18H24INO5Cor e Forma:SolidPeso molecular:461.29MAO-B-IN-34
CAS:<p>MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.</p>Fórmula:C15H9Cl2NO3Cor e Forma:SolidPeso molecular:322.14Fletazepam
CAS:<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Fórmula:C17H13ClF4N2Cor e Forma:SolidPeso molecular:356.74PF470
CAS:<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Fórmula:C18H16N6OCor e Forma:SolidPeso molecular:332.36UB 165
CAS:<p>Subtype-selective nicotinic agonist</p>Fórmula:C13H15ClN2Pureza:98%Cor e Forma:SolidPeso molecular:234.72Azotomycin
CAS:<p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>Fórmula:C17H23N7O8Pureza:98%Cor e Forma:SolidPeso molecular:453.41VU6007496
CAS:<p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>Fórmula:C25H27N5O2Cor e Forma:SolidPeso molecular:429.51ZK 93426 hydrochloride
CAS:<p>benzodiazepine receptor antagonist,competitive</p>Fórmula:C18H21ClN2O3Pureza:98%Cor e Forma:SolidPeso molecular:348.82LY593093
CAS:<p>LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.</p>Fórmula:C32H30FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:507.61,9-Dideoxyforskolin
CAS:<p>The compound is an inactive analog of forskolin(an adenylyl cyclase activator).</p>Fórmula:C22H34O5Pureza:98%Cor e Forma:SolidPeso molecular:378.5EF1502 free base
CAS:<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Fórmula:C22H26N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:414.58Metoquizine
CAS:<p>Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.</p>Fórmula:C22H27N5OPureza:98%Cor e Forma:SolidPeso molecular:377.48Pareptide monohydrochloride
CAS:<p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>Fórmula:C14H27ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:334.84Beloxepin
CAS:<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Fórmula:C19H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:295.38YM 202074
CAS:<p>metabotropic glutamate receptor type 1 (mGlu1) antagonist</p>Fórmula:C56H72N8O16S2Pureza:98%Cor e Forma:SolidPeso molecular:1177.34SZ1676
CAS:<p>SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.</p>Fórmula:C37H59BrN2O6Pureza:98%Cor e Forma:SolidPeso molecular:707.78AChE/BChE-IN-19
CAS:<p>AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.</p>Fórmula:C26H22N4O3Peso molecular:438.48MAO-B-IN-28
CAS:<p>MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research.</p>Fórmula:C19H10F3NO4SPeso molecular:405.35QP5020
CAS:<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Fórmula:C20H19FN6Peso molecular:362.40AChE-IN-47
CAS:<p>AChE-IN-47 (compound g17) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 0.24 μM. It prevents the self-aggregation of β-amyloid peptides and exhibits neuroprotective properties by effectively reducing the accumulation of intracellular reactive oxygen species (ROS).</p>Fórmula:C20H17F3N4O4SPeso molecular:466.43MAO-A inhibitor 1
CAS:<p>MAO-A Inhibitor 1 (compound VIII) acts as a MAO-A inhibitor and exhibits an IC50 value of 100 μM [1].</p>Fórmula:C14H12O4Cor e Forma:SolidPeso molecular:244.24SNRI-IN-1
CAS:<p>SNRI-IN-1 (Compound 7a) acts as a dual inhibitor of serotonin and noradrenaline monoamine reuptake, with a P-glycoprotein Efflux Ratio of 20 [1].</p>Fórmula:C16H20Cl2N2O2Cor e Forma:SolidPeso molecular:343.25ChEs/MAOs-IN-2
CAS:<p>ChEs/MAOs-IN-2 (compound a11) serves as an inhibitor for both cholinesterases and monoamine oxidases, exhibiting IC 50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for AChE, and 0.40 µM for BChE. This compound shows promise for Alzheimer's disease research [1].</p>Fórmula:C15H12N2O3SCor e Forma:SolidPeso molecular:300.33Buntanetap L-Tartrate
CAS:<p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>Fórmula:C24H29N3O8Cor e Forma:SolidPeso molecular:487.50CVN766
CAS:<p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>Fórmula:C20H21F3N8OCor e Forma:SolidPeso molecular:446.43MAO-IN-4
CAS:<p>MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].</p>Fórmula:C18H11Cl2N3OSCor e Forma:SolidPeso molecular:388.27AAZ-A 154 mesylate
CAS:<p>AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.</p>Fórmula:C15H24N2O4SCor e Forma:SolidPeso molecular:328.43Amyloid-β-IN-3
CAS:<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Fórmula:C22H21F2N3O2Cor e Forma:SolidPeso molecular:397.42AAZ-A 154 hydrochloride
CAS:<p>AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.</p>Fórmula:C14H21ClN2OCor e Forma:SolidPeso molecular:268.78AAZ-A 154 benzoate
CAS:<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Fórmula:C21H26N2O3Cor e Forma:SolidPeso molecular:354.44AAZ-A 154 hydrobromide
CAS:<p>AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.</p>Fórmula:C14H21BrN2OCor e Forma:SolidPeso molecular:313.23CB2R/5-HT1AR agonist 1
CAS:<p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>Fórmula:C24H33NO3Cor e Forma:SolidPeso molecular:383.52Tebideutorexant
CAS:<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Fórmula:C23H16D2F4N4O2Pureza:98.89%Cor e Forma:SolidPeso molecular:460.42CPPG
CAS:<p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>Fórmula:C11H14NO5PCor e Forma:SolidPeso molecular:271.21FP0429
CAS:<p>FP0429 is an agonist of mGlu4.</p>Fórmula:C10H12N2O7Pureza:98%Cor e Forma:SolidPeso molecular:272.21AAZ-A 154
CAS:<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Fórmula:C14H20N2OCor e Forma:SolidPeso molecular:232.32Lu 26-046
CAS:<p>Lu 26-046 is a muscarinic receptor agonist.</p>Fórmula:C10H12N2OSCor e Forma:SolidPeso molecular:208.28Monoamine Oxidase B inhibitor 2
<p>MAO-B inhibitor 2: potent, reversible, oral, selective (IC50=1.33 nM), BBB-penetrant, with anti-oxidant and anti-inflammatory effects for Parkinson's study.</p>Fórmula:C19H19FO3Cor e Forma:SolidPeso molecular:314.35LY367385 hydrochloride
CAS:<p>LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.</p>Fórmula:C10H12ClNO4Cor e Forma:SolidPeso molecular:245.66Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Fórmula:C35H49NO4Cor e Forma:SolidPeso molecular:547.77Befiradol hydrochloride
CAS:<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Fórmula:C20H23Cl2F2N3OPureza:99.1%Cor e Forma:SolidPeso molecular:430.32(R)-Norfluoxetine
CAS:<p>(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine. It functions as a potent serotonin reuptake inhibitor, with a Ki value of 13 nM. This compound is utilized in the research of depression.</p>Fórmula:C16H16F3NOCor e Forma:SolidPeso molecular:295.2995-HT6R/MAO-B modulator 1
<p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>Fórmula:C33H38N4O3SCor e Forma:SolidPeso molecular:570.74cSPM
<p>cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.</p>Fórmula:C27H57N7Cor e Forma:SolidPeso molecular:479.79AChE-IN-24
<p>AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.</p>Fórmula:C22H30N2O4S2Cor e Forma:SolidPeso molecular:450.61SGE-516
CAS:<p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>Fórmula:C23H35N3O2Pureza:98%Cor e Forma:SolidPeso molecular:385.54
