Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(939 produtos)
- ACK(1 produtos)
- AChR(574 produtos)
- ATP Citrato Liase(16 produtos)
- Receptor adrenérgico(2.943 produtos)
- BACE(36 produtos)
- Beta Amilóide(204 produtos)
- CaMK(68 produtos)
- COX(561 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor GABA(336 produtos)
- Gama-secretase(59 produtos)
- GluR(255 produtos)
- GlyT(24 produtos)
- Receptor de Histamina(358 produtos)
- LRRK2(33 produtos)
- Receptor de Melatonina(24 produtos)
- NMDAR(28 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5397 produtos de "Neurociência"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
CGP 54626 hydrochloride
CAS:<p>CGP 54626 hydrochloride is a GABAB receptor antagonist.</p>Fórmula:C18H29Cl3NO3PPureza:98%Cor e Forma:SolidPeso molecular:444.76Wf-516
CAS:<p>Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant</p>Fórmula:C25H25Cl2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:502.395-HT3 antagonist 1
CAS:<p>5-HT3 antagonist 1 is a potent and selective antagonist of 5-HT3 receptor.</p>Fórmula:C22H27N5OPureza:98%Cor e Forma:SolidPeso molecular:377.48Bisnorcymserine
CAS:<p>Bisnorcymserine reversibly inhibits butyrylcholinesterase, binding Ser(200) and His(440) non-covalently and stacking with Trp(84).</p>Fórmula:C21H25N3O2Pureza:98%Cor e Forma:SolidPeso molecular:351.44R-96544
CAS:<p>R-96544 is an orally active antagonist of the 5-HT2A receptor that has demonstrated the ability to inhibit platelet aggregation in vitro [1].</p>Fórmula:C22H30ClNO3Cor e Forma:SolidPeso molecular:391.93AChE-IN-30
CAS:<p>AChE-IN-30 is an acetylcholinesterase (AChE) inhibitor exhibiting neuroprotective effects with an inhibitory concentration (IC 50) of 4.4 μM.</p>Fórmula:C22H24N4O2Cor e Forma:SolidPeso molecular:376.45mGluR5 antagonist-1
CAS:<p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>Fórmula:C23H18N4O2Cor e Forma:SolidPeso molecular:382.41AAK1-IN-2
CAS:<p>AAK1-IN-2, a potent (IC50=5.8 nM) AAK1 inhibitor, selective & brain-penetrant, is used for neuropathic pain studies.</p>Fórmula:C20H20N4Cor e Forma:SolidPeso molecular:316.4Brasofensine
CAS:<p>Brasofensine, a benztoalkane MA reuptake inhibitor, shows promise for Parkinson's and Alzheimer's.</p>Fórmula:C16H20Cl2N2OCor e Forma:SolidPeso molecular:327.25ELND007
CAS:<p>ELND007 is a Gamma secretase inhibitor.</p>Fórmula:C19H14F4N4O2SCor e Forma:SolidPeso molecular:438.4GSM-1
CAS:<p>GSM-1 is a modulator of γ-Secretase.</p>Fórmula:C26H31ClF3NO2Cor e Forma:SolidPeso molecular:481.98BACE-1 inhibitor 1
CAS:<p>BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM).</p>Fórmula:C17H14BrF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:443.22Piperidine-4-sulfonic acid
CAS:<p>Piperidine-4-sulfonic acid is a potent GABA agonist, demonstrating an IC50 value of 0.034 μM for the inhibition of H-GABA binding [1].</p>Fórmula:C5H11NO3SPureza:98%Cor e Forma:SolidPeso molecular:165.21Biphenylindanone A
CAS:<p>Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.</p>Fórmula:C30H30O4Pureza:98%Cor e Forma:SolidPeso molecular:454.56GR 125487 sulfamate
CAS:<p>GR 125487 sulfamate is a 5-HT4 receptor antagonist.</p>Fórmula:C19H29FN4O8S2Pureza:98%Cor e Forma:SolidPeso molecular:524.58BMS-932481
CAS:<p>BMS-932481 is a γ-secretase modulator.</p>Fórmula:C24H24FN7OCor e Forma:SolidPeso molecular:445.493β-Hydroxy-lup-20(29)-en-16-one
CAS:<p>3β-Hydroxy-lup-20(29)-en-16-one (compound 9) serves as a dual inhibitor of both AChE and BChE, displaying a preference for BChE with an IC50 of 28.9 μM [1].</p>Fórmula:C30H48O2Cor e Forma:SolidPeso molecular:440.7Anti-amyloid agent-1
CAS:<p>Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].</p>Fórmula:C21H17F3N2O3Cor e Forma:SolidPeso molecular:402.37Pomaglumetad methionil hydrochloride
CAS:<p>LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.</p>Fórmula:C12H19ClN2O7S2Pureza:98.57%Cor e Forma:SolidPeso molecular:402.87MFZ 10-7
CAS:<p>MFZ 10-7 is anegative allosteric modulator of the mGluR5.</p>Fórmula:C15H9FN2Pureza:99.80%Cor e Forma:SolidPeso molecular:236.24Diproqualone
CAS:<p>Diproqualone, analogous to methaqualone, exhibits sedative, anxiolytic, anti-inflammatory, and analgesic properties [1].</p>Fórmula:C12H14N2O3Cor e Forma:SolidPeso molecular:234.255CP-409092
CAS:<p>CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.</p>Fórmula:C17H19N3O2Pureza:98%Cor e Forma:SolidPeso molecular:297.35CAY10649
CAS:<p>1CAY10649, a thiazolinone compound, directly inhibits 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.28 μM and in a soluble fraction of an S100 PMNL cell lysate with an IC50 value of 0.09 μM, following stimulation by calcium and arachidonic acid. This activity highlights its potential in mitigating inflammatory responses by targeting the biosynthesis of leukotrienes, substances implicated in various inflammatory processes such as neutrophil chemotaxis, increased vascular permeability, and smooth muscle contraction.</p>Fórmula:C17H12ClNO2SCor e Forma:SolidPeso molecular:329.8PNU109291
CAS:<p>PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation.</p>Fórmula:C24H31N3O3Pureza:98%Cor e Forma:SolidPeso molecular:409.52Fosthiazate
CAS:<p>Fosthiazate is a broad-spectrum nematicide that combats a range of plant parasitic nematodes such as Meloidogyne spp., Globodera spp., and Pratylenchus spp., by</p>Fórmula:C9H18NO3PS2Pureza:97.78%Cor e Forma:SolidPeso molecular:283.35cis-PDA
CAS:<p>cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.</p>Fórmula:C7H11NO4Pureza:98.71%Cor e Forma:White SolidPeso molecular:173.175-HT2A antagonist 1
CAS:<p>5-HT2A antagonist 1, from US5728835A & JP 1007727, may treat gastrointestinal and circulatory issues.</p>Fórmula:C26H28N4O2Pureza:98%Cor e Forma:SolidPeso molecular:428.53FPTQ
CAS:<p>FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].</p>Fórmula:C17H12FN5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:305.31L-AP4
CAS:<p>L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).</p>Fórmula:C4H10NO5PPureza:98%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:183.1TPA 023
CAS:<p>TPA 023 is a selective agonist of GABAA α2/α3 subtype (Kis = 0.19 - 0.41 nM).</p>Fórmula:C20H22FN7OPureza:99.75%Cor e Forma:SolidPeso molecular:395.435-HT3-In-1
CAS:<p>5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.</p>Fórmula:C16H21ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:352.82Zamifenacin fumarate
CAS:<p>Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.</p>Fórmula:C31H33NO7Pureza:99.88%Cor e Forma:SolidPeso molecular:531.6Octahydroaminoacridine succinate
CAS:<p>Octahydroaminoacridine succinate, an acetylcholinesterase inhibitor, is used potentially for the treatment of Alzheimer's disease.</p>Fórmula:C17H24N2O4Pureza:99.91%Cor e Forma:SolidPeso molecular:320.38BMS 433796
CAS:<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Fórmula:C21H20F2N4O4Pureza:99.17%Cor e Forma:SolidPeso molecular:430.4PQM130
CAS:<p>PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.</p>Fórmula:C23H27NO4Pureza:98.73%Cor e Forma:SolidPeso molecular:381.46BACE1-IN-1
CAS:<p>BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).</p>Fórmula:C18H14F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:389.33Velusetrag
CAS:<p>Velusetrag(TD-5108), a potent 5-HT4 agonist, is in development for gastroparesis, constipation, and IBS.</p>Fórmula:C25H36N4O5SCor e Forma:SolidPeso molecular:504.64C3
CAS:<p>C3 functions as a selective inhibitor of monoamine oxidase B (MAO-B; IC50= 0.021 µM), demonstrating preference over monoamine oxidase A (MAO-A; IC50= 26.8 µM). This compound, at dosages of 0.1, 1, and 3 mg/kg, effectively counters MPTP-induced reductions in dopamine levels within the mouse brain.</p>Fórmula:C18H19FN2O2Cor e Forma:SolidPeso molecular:314.35Cyanopindolol fumarate
CAS:<p>Cyanopindolol fumarate is a 5-HT receptor antagonist [1].</p>Fórmula:C16H21N3O2C4H4O4Cor e Forma:SolidPeso molecular:345.4Osemozotan Free Base
CAS:<p>Osemozotan Free Base is a 5-HT(1A) receptor agonist.</p>Fórmula:C19H21NO5Cor e Forma:SolidPeso molecular:343.37Frovatriptan
CAS:<p>Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.</p>Fórmula:C14H17N3OCor e Forma:SolidPeso molecular:243.3P11149
CAS:<p>P11149: oral AChE inhibitor, crosses BBB, IC50 1.3 μM, based on Galanthamine, aims Alzheimer's research.</p>Fórmula:C27H34ClNO4Cor e Forma:SolidPeso molecular:472.02Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Fórmula:C31H23Cl7N2OPureza:98.53%Cor e Forma:SolidPeso molecular:687.7A-424274
CAS:<p>A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.</p>Fórmula:C14H15N3Pureza:98%Cor e Forma:SolidPeso molecular:225.29Facinicline hydrochloride
CAS:<p>Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).</p>Fórmula:C15H19ClN4OPureza:98.70%Cor e Forma:SolidPeso molecular:306.79NO-711ME
CAS:<p>NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.</p>Fórmula:C22H24N2O3Pureza:99.54%Cor e Forma:SolidPeso molecular:364.44L 687306
CAS:<p>L 687306 is a partial agonist of muscarinic M1 receptors. It is also a highly competitive antagonist at cardiac M2 receptors and ileal M3 muscarinic receptors.</p>Fórmula:C11H15N3OCor e Forma:SolidPeso molecular:205.26Capeserod HCl
CAS:<p>Capeserod HCl, a 5-hydroxytriptamine 4 (5-HT4) receptor agonist, is used potentially for the treatment of Alzheimer's disease.</p>Fórmula:C23H26Cl2N4O4Pureza:98%Cor e Forma:SolidPeso molecular:493.38FPPQ
CAS:<p>FPPQ blocks 5-HT3 and 5-HT6 receptors (Ki: 0.9 & 3 nM) and may improve psychosis and cognition.</p>Fórmula:C21H19FN4O2SCor e Forma:SolidPeso molecular:410.46LY 53857
CAS:<p>LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.</p>Fórmula:C27H36N2O7Cor e Forma:SolidPeso molecular:500.592
