Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(940 produtos)
- ACK(1 produtos)
- AChR(574 produtos)
- ATP Citrato Liase(16 produtos)
- Receptor adrenérgico(2.942 produtos)
- BACE(36 produtos)
- Beta Amilóide(204 produtos)
- CaMK(68 produtos)
- COX(562 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor GABA(336 produtos)
- Gama-secretase(59 produtos)
- GluR(255 produtos)
- GlyT(24 produtos)
- Receptor de Histamina(358 produtos)
- LRRK2(33 produtos)
- Receptor de Melatonina(24 produtos)
- NMDAR(28 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(296 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5400 produtos de "Neurociência"
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Osemozotan Free Base
CAS:<p>Osemozotan Free Base is a 5-HT(1A) receptor agonist.</p>Fórmula:C19H21NO5Cor e Forma:SolidPeso molecular:343.37AMG-8718
CAS:<p>AMG-8718, an oral BACE1 blocker (IC50: 0.0007 μM), also inhibits BACE2 (IC50: 0.005 μM), lowering CSF and Aβ40 brain levels.</p>Fórmula:C25H19FN4O3Cor e Forma:SolidPeso molecular:442.44UNC9994
CAS:<p>UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.</p>Fórmula:C21H22Cl2N2OSCor e Forma:SolidPeso molecular:421.38NAS-181
CAS:<p>NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM).NAS-181 enhances the accumulation of 5-HTP in rat brain regions.</p>Fórmula:C20H30N2O7SCor e Forma:SolidPeso molecular:442.53Naspm trihydrochloride
CAS:<p>Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA</p>Fórmula:C22H37Cl3N4OPureza:99.75%Cor e Forma:SolidPeso molecular:479.91mGAT-IN-1
CAS:<p>mGAT-IN-1 is a potent, non-selective GAT inhibitor that inhibits mGAT3 activity well (IC50: 2.5 μM, pIC50: 5.61).</p>Fórmula:C28H34ClN3O2S2Cor e Forma:SolidPeso molecular:544.17CGP 55845 hydrochloride
CAS:<p>CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC 50 of 6 nM which can be used in neurological research [1] [2].</p>Fórmula:C18H23Cl3NO3PCor e Forma:SolidPeso molecular:438.71Anti-amyloid agent-1
CAS:<p>Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].</p>Fórmula:C21H17F3N2O3Cor e Forma:SolidPeso molecular:402.37LY3202626
CAS:<p>LY3202626, an amyloid precursor protein secretase (BACE protein) inhibitor, is used for the treatment of Alzheimer's disease.</p>Fórmula:C22H20F2N8O2SPureza:98%Cor e Forma:SolidPeso molecular:498.51VU6012962
CAS:<p>VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).</p>Fórmula:C21H19F3N4O4Pureza:99.61% - 99.74%Cor e Forma:SolidPeso molecular:448.4YM348
CAS:<p>YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).</p>Fórmula:C14H17N3OPureza:98%Cor e Forma:SolidPeso molecular:243.3Diproqualone
CAS:<p>Diproqualone, analogous to methaqualone, exhibits sedative, anxiolytic, anti-inflammatory, and analgesic properties [1].</p>Fórmula:C12H14N2O3Cor e Forma:SolidPeso molecular:234.255Pomaglumetad methionil hydrochloride
CAS:<p>LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.</p>Fórmula:C12H19ClN2O7S2Pureza:98.57%Cor e Forma:SolidPeso molecular:402.87QM-FN-SO3
CAS:<p>QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].</p>Fórmula:C29H25N4NaO3S2Cor e Forma:SolidPeso molecular:564.65mGAT3/4-IN-2
CAS:<p>mGAT3/4-IN-2 are potent inhibitors of mGAT3/mGAT4 with their pIC50 values of 5.44 and 5.25, respectively.</p>Fórmula:C26H32ClN3OS2Cor e Forma:SolidPeso molecular:502.13Indeloxazine hydrochloride
CAS:<p>Indeloxazine HCl: Serotonin releaser, NE reuptake inhibitor, NMDA antagonist; antidepressant that boosts acetylcholine in rats.</p>Fórmula:C14H18ClNO2Pureza:98%Cor e Forma:SolidPeso molecular:267.75LY2033298
CAS:<p>LY2033298 enhances oximoline's effect on hamster circadian rhythms, aiding neurosystem disorders.</p>Fórmula:C13H14ClN3O2SPureza:99.06%Cor e Forma:SolidPeso molecular:311.796,2'-Dihydroxyflavone
CAS:<p>6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.</p>Fórmula:C15H10O4Pureza:99.44% - 99.67%Cor e Forma:SolidPeso molecular:254.245-HT2A receptor agonist-3
CAS:<p>5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.</p>Fórmula:C21H26BrNO3Pureza:98%Cor e Forma:SolidPeso molecular:420.34CP-122288
CAS:<p>CP-122288: potent, selective 5-HT1B/D/F agonist; inhibits plasma protein extravasation, neurogenic inflammation.</p>Fórmula:C16H23N3O2SPureza:98%Cor e Forma:SolidPeso molecular:321.44Timepidium bromide
CAS:<p>Timepidium bromide is an agent of anticholinergic.</p>Fórmula:C17H22BrNOS2Pureza:98%Cor e Forma:SolidPeso molecular:400.4BACE1-IN-10
CAS:<p>BACE1-IN-10 is a potent inhibitor of BACE1, demonstrating sub-micromolar activity against recombinant BACE1 (rBACE1) [1].</p>Fórmula:C33H49N5O8SPureza:98%Cor e Forma:SolidPeso molecular:675.84Lanabecestat camsylate
CAS:<p>Lanabecestat camsylate is used as a BACE1 Inhibitor.</p>Fórmula:C36H44N4O5SPureza:98%Cor e Forma:SolidPeso molecular:644.83VU0360172
CAS:<p>VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).</p>Fórmula:C18H15FN2OPureza:99.56%Cor e Forma:SolidPeso molecular:294.32(-)-Bicuculline methochloride
CAS:<p>(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.</p>Fórmula:C21H20ClNO6Pureza:98%Cor e Forma:SolidPeso molecular:417.84GR-127935
CAS:<p>GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist.</p>Fórmula:C29H31N5O3Cor e Forma:SolidPeso molecular:497.59L 687306
CAS:<p>L 687306 is a partial agonist of muscarinic M1 receptors. It is also a highly competitive antagonist at cardiac M2 receptors and ileal M3 muscarinic receptors.</p>Fórmula:C11H15N3OCor e Forma:SolidPeso molecular:205.265-HT2C agonist-3 free base
CAS:<p>5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-</p>Fórmula:C19H22FNO2Pureza:98%Cor e Forma:SolidPeso molecular:315.385-HT2 agonist-1 free base
CAS:<p>Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,</p>Fórmula:C19H22N2O2Pureza:98%Cor e Forma:SolidPeso molecular:310.39MAO-IN-3
CAS:<p>MAO-IN-3 (Compound 5), a reversible and competitive monoamine oxidase (MAO) inhibitor with inhibition constants (K i) of 0.6 μM for MAO A and 0.2 μM for MAO B,</p>Fórmula:C42H54N4O4Pureza:98%Cor e Forma:SolidPeso molecular:678.9ADX71441
CAS:<p>ADX71441, a GABAB PAM, lengthens urinary latencies, lessens events & volume, and may aid in alcoholism and bladder pain.</p>Fórmula:C19H15ClF2N4O4Cor e Forma:SolidPeso molecular:436.8P11149
CAS:<p>P11149: oral AChE inhibitor, crosses BBB, IC50 1.3 μM, based on Galanthamine, aims Alzheimer's research.</p>Fórmula:C27H34ClNO4Cor e Forma:SolidPeso molecular:472.02Flesinoxan
CAS:<p>Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).</p>Fórmula:C22H26FN3O4Cor e Forma:SolidPeso molecular:415.46Gepirone
CAS:<p>Gepirone is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.</p>Fórmula:C19H29N5O2Pureza:99.35% - 99.89%Cor e Forma:SolidPeso molecular:359.47DQP-26
CAS:<p>DQP-26, a potent negative allosteric modulator of NMDA receptors (NMDARs), exhibits IC50 values of 0.77 μM for GluN2C and 0.44 μM for GluN2D subunits,</p>Fórmula:C28H21Cl2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:534.39PTAC oxalate
CAS:<p>muscarinic receptor ligand</p>Fórmula:C14H21N3O4S2Pureza:98%Cor e Forma:SolidPeso molecular:359.46AAK1-IN-2
CAS:<p>AAK1-IN-2, a potent (IC50=5.8 nM) AAK1 inhibitor, selective & brain-penetrant, is used for neuropathic pain studies.</p>Fórmula:C20H20N4Cor e Forma:SolidPeso molecular:316.4MAO-B-IN-19
CAS:<p>MAO-B-IN-19, a selective MAO-B inhibitor, exhibits neuroprotective and anti-inflammatory properties and demonstrates an IC50 value of 0.67 μM [1].</p>Fórmula:C15H11FO2Pureza:98%Cor e Forma:SolidPeso molecular:242.25Abaperidone
CAS:<p>Abaperidone is an atypical antipsychotic, antagonizes 5-HT2A (IC50=6.2 nM) and D2 receptors (IC50=17 nM), reduces hsp70 mRNA in rat brains.</p>Fórmula:C25H25FN2O5Pureza:98.22%Cor e Forma:SolidPeso molecular:452.47VU6005649
CAS:<p>VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).</p>Fórmula:C16H12F5N3OPureza:99.87%Cor e Forma:SolidPeso molecular:357.28COR659
CAS:<p>COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.</p>Fórmula:C16H16ClNO3SPureza:99.75%Cor e Forma:SolidPeso molecular:337.82BMS-933043
CAS:<p>BMS-933043: α7 nAChR partial agonist, binds rat (Ki=3.3 nM) & human (Ki=8.1 nM), agonist with EC50=23.4 nM (calcium assay), 0.14-0.29 μM (electrophysiology).</p>Fórmula:C16H19N7OPureza:98%Cor e Forma:SolidPeso molecular:325.375-HT2 agonist-1
CAS:<p>Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively.</p>Fórmula:C19H23ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:346.85(±)-Fabesetron hydrochloride
CAS:<p>FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.</p>Fórmula:C18H20ClN3OPureza:98%Cor e Forma:SolidPeso molecular:329.82Thioflosulide
CAS:<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Fórmula:C16H13F2NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:369.41FGIN-1-27
CAS:<p>FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM).</p>Fórmula:C28H37FN2OPureza:99.86%Cor e Forma:SolidPeso molecular:436.6LY320954
CAS:<p>LY320954 is an antagonist of 5-HT2A receptor.</p>Fórmula:C21H26N4O3Pureza:98%Cor e Forma:SolidPeso molecular:382.46SB 258719
CAS:<p>SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.</p>Fórmula:C18H30N2O2SPureza:99.73%Cor e Forma:SolidPeso molecular:338.515-HT2A&5-HT2C agonist-1
CAS:<p>5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.</p>Fórmula:C14H20N2OPureza:98%Cor e Forma:SolidPeso molecular:232.325-HT3-In-1
CAS:<p>5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.</p>Fórmula:C16H21ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:352.82
