Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(646 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.022 produtos)
- BACE(37 produtos)
- Beta Amilóide(228 produtos)
- CaMK(73 produtos)
- COX(600 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(373 produtos)
- Gama-secretase(61 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(43 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5584 produtos de "Neurociência"
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Tribendimidine
CAS:Tribendimidine: broad-spectrum oral anthelmintic, nAChR agonist, effective against A. lumbricoides and N. americanus.Fórmula:C28H32N6Pureza:≥98%Cor e Forma:SolidPeso molecular:452.59DSP-0565
CAS:DSP-0565 is a broad-spectrum anti-epileptic with a high safety margin and effectiveness in several convulsant models.Fórmula:C14H12FNOPureza:99.51% - 99.56%Cor e Forma:SolidPeso molecular:229.25Ref: TM-T11106
1mg109,00€2mg163,00€1mL*10mM (DMSO)208,00€5mg241,00€10mg354,00€25mg532,00€50mg745,00€100mg1.018,00€500mg2.035,00€SB228357
CAS:SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively.Fórmula:C22H17F4N3O2Pureza:99.82%Cor e Forma:SolidPeso molecular:431.38CPCCOEt
CAS:CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1bFórmula:C13H13NO4Pureza:99.91%Cor e Forma:SolidPeso molecular:247.255HT6-ligand-1
CAS:5HT6-ligand-1 is an orally active ligand of 5-HT6 receptor (Ki = 1.43 nM).Fórmula:C20H22BrN3O2SPureza:99.24% - 99.93%Cor e Forma:SolidPeso molecular:448.38ASM-024
CAS:ASM-024, a synthetic piperazine, activates nicotinic and β2-adrenergic receptors for potential asthma and bronchitis treatment with anti-inflammatory effects.Fórmula:C15H25N2Pureza:99.74%Cor e Forma:SolidPeso molecular:233.37Cyamemazine
CAS:Cyamemazine is an antipsychotic compound with sedative and anxiolytic activity.Cyamemazine is a 5-HT3, 5-HT2A, and 5-HT2C receptor antagonist.Fórmula:C19H21N3SPureza:97.01%Cor e Forma:SolidPeso molecular:323.46Xanomeline
CAS:Xanomeline: orally active, M1/M4 selective activator for neurological disorders; promising in trials, crosses blood-brain barrier, liver metabolized.Fórmula:C14H23N3OSPureza:99.61%Cor e Forma:SolidPeso molecular:281.422-BFI hydrochloride
CAS:2-BFI hydrochloride: High-affinity I2 agonist; used in researching stroke and immune disease protection.Fórmula:C11H11ClN2OPureza:99.94%Cor e Forma:SolidPeso molecular:222.675-HT2 antagonist 1
CAS:5-HT2 antagonist 1 is a potent 5-HT2 receptor antagonist, has weak α1 adrenoceptor blocking activity.Fórmula:C22H29FN4O2Pureza:99.76%Cor e Forma:SolidPeso molecular:400.49Ref: TM-T12597
1mg642,00€5mg1.288,00€1mL*10mM (DMSO)1.521,00€10mg1.738,00€25mg2.583,00€50mg3.484,00€100mg4.708,00€Valiglurax
CAS:Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.Fórmula:C16H10F3N5Pureza:98.29%Cor e Forma:SolidPeso molecular:329.28SB 258719
CAS:SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.Fórmula:C18H30N2O2SPureza:99.73%Cor e Forma:SolidPeso molecular:338.51Ref: TM-T12855
2mg34,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg85,00€25mg155,00€50mg240,00€100mg355,00€200mg502,00€CAY10649
CAS:1CAY10649, a thiazolinone compound, directly inhibits 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.28 μM and in a soluble fraction of an S100 PMNL cell lysate with an IC50 value of 0.09 μM, following stimulation by calcium and arachidonic acid. This activity highlights its potential in mitigating inflammatory responses by targeting the biosynthesis of leukotrienes, substances implicated in various inflammatory processes such as neutrophil chemotaxis, increased vascular permeability, and smooth muscle contraction.Fórmula:C17H12ClNO2SCor e Forma:SolidPeso molecular:329.8Des-4-fluorobenzyl Mosapride
CAS:Des-4-fluorobenzyl Mosapride, the main metabolite of mosapride, acts as a gastroprokinetic agent improving upper gastrointestinal (GI) motility by stimulating the serotonin receptor 4 (5-HT4; EC50= 74.2 nM, in guinea pig ileal longitudinal muscle myenteric plexus). It has been shown to increase colonic motility in dogs, horses, and guinea pigs in vivo. Mosapride, including this metabolite, is utilized in human and veterinary medicine to mitigate post-surgical and Parkinson's-induced constipation.Fórmula:C14H20ClN3O3Cor e Forma:SolidPeso molecular:313.78CP-122288
CAS:CP-122288: potent, selective 5-HT1B/D/F agonist; inhibits plasma protein extravasation, neurogenic inflammation.Fórmula:C16H23N3O2SPureza:98%Cor e Forma:SolidPeso molecular:321.44BMS 433796
CAS:BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.Fórmula:C21H20F2N4O4Pureza:99.17%Cor e Forma:SolidPeso molecular:430.4Flesinoxan HCl
CAS:Flesinoxan HCl is the salt form of Flesinoxan, which is a selective 5-HT1A receptor agonist.Fórmula:C22H27ClFN3O4Cor e Forma:SolidPeso molecular:451.92GMA-839
CAS:GMA-839 is a selective modulator of gamma-aminobutyric acid(A) receptors.Fórmula:C21H31F3O3Pureza:98%Cor e Forma:SolidPeso molecular:388.462-Methyl-5-HT
CAS:2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Fórmula:C11H14N2OPureza:97.18%Cor e Forma:SolidPeso molecular:190.24Ref: TM-T10075
5mg48,00€1mL*10mM (DMSO)50,00€10mg84,00€25mg177,00€50mg334,00€100mg500,00€500mg1.099,00€PTAC oxalate
CAS:muscarinic receptor ligandFórmula:C14H21N3O4S2Pureza:98%Cor e Forma:SolidPeso molecular:359.465-HT2C agonist-3 free base
CAS:5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-Fórmula:C19H22FNO2Pureza:98%Cor e Forma:SolidPeso molecular:315.38Wf-516
CAS:Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressantFórmula:C25H25Cl2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:502.39AChE-IN-31
CAS:AChE-IN-31 (compound 1), a non-competitive acetylcholinesterase (AChE) inhibitor, exhibits potential for Alzheimer's disease research [1].Fórmula:C27H44Na2O9S2Cor e Forma:SolidPeso molecular:622.74AAK1-IN-4
CAS:AAK1-IN-4 selectively inhibits AAK1 with IC50 of 4.6 nM; penetrates CNS, oral bioactive, potential for studying neuropathic pain.Fórmula:C20H28N4O3Cor e Forma:SolidPeso molecular:372.465-HT2 agonist-1 free base
CAS:Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,Fórmula:C19H22N2O2Pureza:98%Cor e Forma:SolidPeso molecular:310.39QM-FN-SO3
CAS:QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].Fórmula:C29H25N4NaO3S2Cor e Forma:SolidPeso molecular:564.65CGP 64213
CAS:CGP 64213 is a GABAb receptor agonist.Fórmula:C26H36IN2O7PPureza:98%Cor e Forma:SolidPeso molecular:646.45PQM130
CAS:PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.Fórmula:C23H27NO4Pureza:98.73%Cor e Forma:SolidPeso molecular:381.46MDL-74156
CAS:MDL-74156 is an active metabolite of dolasetron and a 5-hydroxy-tryptamine3 (5-HT3) antagonist.Fórmula:C19H22N2O3Cor e Forma:SolidPeso molecular:326.39(1R,4R)-N-desmethyl Sertraline hydrochloride
CAS:"(1R,4R)-N-desmethyl Sertraline, a metabolite of the selective serotonin reuptake inhibitor (SSRI) sertraline, plays a key role in its pharmacological effects."Fórmula:C16H15Cl2NHClCor e Forma:SolidPeso molecular:328.66rTRD01
CAS:rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269.Fórmula:C18H21FN4O2Pureza:99.44%Cor e Forma:SolidPeso molecular:344.383β-Hydroxy-lup-20(29)-en-16-one
CAS:3β-Hydroxy-lup-20(29)-en-16-one (compound 9) serves as a dual inhibitor of both AChE and BChE, displaying a preference for BChE with an IC50 of 28.9 μM [1].Fórmula:C30H48O2Cor e Forma:SolidPeso molecular:440.7Osemozotan Free Base
CAS:Osemozotan Free Base is a 5-HT(1A) receptor agonist.Fórmula:C19H21NO5Cor e Forma:SolidPeso molecular:343.375-HT2 agonist-1
CAS:Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively.Fórmula:C19H23ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:346.85Lanabecestat HCl
CAS:Lanabecestat (AZD3293/LY3314814) is a potent oral BACE1 inhibitor that crosses the BBB and reduces Aβ levels.Fórmula:C26H29ClN4OCor e Forma:SolidPeso molecular:448.995Lanabecestat
CAS:Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Fórmula:C26H28N4OPureza:98.55%Cor e Forma:SolidPeso molecular:412.53FPTQ
CAS:FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].Fórmula:C17H12FN5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:305.31Ref: TM-T5509
500mgA consultar1mg52,00€2mg70,00€5mg105,00€1mL*10mM (DMSO)110,00€10mg152,00€25mg294,00€50mg398,00€100mg527,00€L-822179
CAS:L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.Fórmula:C17H14N8O2Pureza:98.5% - 99.61%Cor e Forma:SolidPeso molecular:362.35Brilaroxazine
CAS:Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.Fórmula:C22H25Cl2N3O3Pureza:99.36%Cor e Forma:SolidPeso molecular:450.36Ref: TM-T14782
1mg100,00€5mg236,00€1mL*10mM (DMSO)268,00€10mg385,00€25mg663,00€50mg954,00€100mg1.305,00€200mg1.738,00€YM348
CAS:YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).Fórmula:C14H17N3OPureza:98%Cor e Forma:SolidPeso molecular:243.3Tiotropium Bromide hydrate
CAS:Tiotropium Bromide hydrate is a potent, long-lasting anticholinergic bronchodilator for COPD, with high affinity for muscarinic receptors M1, M2, and M3.Fórmula:C19H24BrNO5S2Pureza:98.44% - 99.41%Cor e Forma:SolidPeso molecular:490.436,2'-Dihydroxyflavone
CAS:6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.Fórmula:C15H10O4Pureza:99.44% - 99.67%Cor e Forma:SolidPeso molecular:254.24MRK-560
CAS:MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.Fórmula:C19H17ClF5NO4S2Pureza:98.87%Cor e Forma:SolidPeso molecular:517.92Zaldaride (free base)
CAS:Zaldaride (free base) is a calmodulin antagonist.Fórmula:C26H28N4O2Cor e Forma:SolidPeso molecular:428.535-HT2A receptor agonist-3
CAS:5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.Fórmula:C21H26BrNO3Pureza:98%Cor e Forma:SolidPeso molecular:420.34MK-8768
CAS:MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized byFórmula:C21H22F3N5O2Cor e Forma:SolidPeso molecular:433.43(±)-N-desmethyl Venlafaxine hydrochloride
CAS:(±)-N-desmethyl Venlafaxine, a minor active metabolite of venlafaxine, serves as a selective norepinephrine and serotonin reuptake inhibitor (SNRI). Generated through the metabolization by the cytochrome P450 (CYP) isoform CYP3A4, it exhibits reuptake inhibition of norepinephrine and serotonin in rat synaptosome preparations, demonstrated by IC50 values of 4.7 and 1.6 µM, respectively. Clinically, it has been shown to counteract reserpine-induced hypothermia in mice, displaying efficacy at a minimum effective dose (MED) of 10 mg/kg.Fórmula:C16H26ClNO2Cor e Forma:SolidPeso molecular:299.84VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Fórmula:C18H15FN2OPureza:99.56%Cor e Forma:SolidPeso molecular:294.32Gepirone
CAS:Gepirone is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.Fórmula:C19H29N5O2Pureza:99.35% - 99.89%Cor e Forma:SolidPeso molecular:359.47GSM-1
CAS:GSM-1 is a modulator of γ-Secretase.Fórmula:C26H31ClF3NO2Cor e Forma:SolidPeso molecular:481.98
