Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(939 produtos)
- ACK(1 produtos)
- AChR(575 produtos)
- ATP Citrato Liase(16 produtos)
- Receptor adrenérgico(2.945 produtos)
- BACE(36 produtos)
- Beta Amilóide(205 produtos)
- CaMK(69 produtos)
- COX(561 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor GABA(336 produtos)
- Gama-secretase(59 produtos)
- GluR(255 produtos)
- GlyT(24 produtos)
- Receptor de Histamina(358 produtos)
- LRRK2(33 produtos)
- Receptor de Melatonina(24 produtos)
- NMDAR(28 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5398 produtos de "Neurociência"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Fletazepam
CAS:<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Fórmula:C17H13ClF4N2Cor e Forma:SolidPeso molecular:356.74Nedemelteon
CAS:<p>Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).</p>Fórmula:C15H18N2O2Cor e Forma:SolidPeso molecular:258.32BGT1-IN-1
CAS:<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Fórmula:C6H9NO2Cor e Forma:SolidPeso molecular:127.14AChE-IN-8
<p>AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.</p>Fórmula:C20H22N4O2SCor e Forma:SolidPeso molecular:382.48AChE-IN-24
<p>AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.</p>Fórmula:C22H30N2O4S2Cor e Forma:SolidPeso molecular:450.61P2X7 receptor antagonist-5
CAS:<p>P2X7 receptor antagonist-5 (compound 13a) is a potent, orally active, and long-lasting antagonist of the P2X7 receptor.</p>Fórmula:C21H17F3N6O3S2Cor e Forma:SolidPeso molecular:522.52Neral
CAS:<p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>Fórmula:C10H16OCor e Forma:SolidPeso molecular:152.23ROS151
<p>ROS151 is an AChE inhibitor with IC50 values of 14 nM (hAChE), 1.68 μM (eqBChE), and 8.17 μM (hFAAH). Additionally, it acts as a chelating agent for Fe3+ and Cu2+. ROS151 is utilized in research related to Alzheimer's disease.</p>Fórmula:C18H18FN3O6Cor e Forma:SolidPeso molecular:391.35AChE-IN-79
<p>AChE-IN-79 (compound 3i) is an acetylcholinesterase inhibitor with an IC50 of 2.7 µM, suitable for studies related to Alzheimer's disease.</p>Fórmula:C29H27NO6SCor e Forma:SolidPeso molecular:517.59YNT-3708
CAS:<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749Aβ42 agonist-1
CAS:<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Fórmula:C15H11NO2Pureza:99.77%Cor e Forma:SolidPeso molecular:237.25γ-secretase modulator 6
CAS:<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Fórmula:C25H26N6O2Cor e Forma:SolidPeso molecular:442.513LRRK2-IN-16
CAS:<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Fórmula:C18H19N5OSCor e Forma:SolidPeso molecular:353.441AChE-IN-25
<p>AChE-IN-25: selective, potent AChE inhibitor, non-competitive, IC50 = 2.95 μM, for Alzheimer's research.</p>Fórmula:C20H15ClN4O4SCor e Forma:SolidPeso molecular:442.882002-G12
CAS:<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Fórmula:C20H16N6Cor e Forma:SolidPeso molecular:340.381AChE-IN-5
<p>AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.</p>Fórmula:C38H45N5OCor e Forma:SolidPeso molecular:587.8F 14679
CAS:<p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>Fórmula:C21H25ClF2N4OPureza:99.09%Cor e Forma:SolidPeso molecular:422.9Terguride
CAS:<p>Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.</p>Fórmula:C20H28N4OCor e Forma:SolidPeso molecular:340.46AAK1-IN-2 TFA
<p>AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.</p>Fórmula:C24H22F6N4O4Cor e Forma:SolidPeso molecular:544.45AChE/Aβ-IN-5
CAS:<p>Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].</p>Fórmula:C25H24N4Cor e Forma:SolidPeso molecular:380.48YM-31636 free base
CAS:<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Fórmula:C14H11N3SCor e Forma:SolidPeso molecular:253.32Zanapezil fumarate
CAS:<p>Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons.</p>Fórmula:C29H36N2O5Cor e Forma:SolidPeso molecular:492.61Flucopride
CAS:<p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>Fórmula:C22H33FN2O2Cor e Forma:SolidPeso molecular:376.51(+)-Sparteine sulfate pentahydrate
<p>(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.</p>Fórmula:C15H38N2O9SCor e Forma:SolidPeso molecular:422.54Beloxepin
CAS:<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Fórmula:C19H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:295.38AChE-IN-63
CAS:<p>AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].</p>Fórmula:C18H19N5OCor e Forma:SolidPeso molecular:321.38Monoamine Oxidase B inhibitor 2
<p>MAO-B inhibitor 2: potent, reversible, oral, selective (IC50=1.33 nM), BBB-penetrant, with anti-oxidant and anti-inflammatory effects for Parkinson's study.</p>Fórmula:C19H19FO3Cor e Forma:SolidPeso molecular:314.35R-137696
CAS:<p>R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.</p>Fórmula:C17H23N3O2Cor e Forma:SolidPeso molecular:301.38Etoperidone
CAS:<p>Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).</p>Fórmula:C19H28ClN5OCor e Forma:SolidPeso molecular:377.91AChE/BACE1/GSK3β-IN-1
<p>AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β.</p>Fórmula:C26H27FN2O4Cor e Forma:SolidPeso molecular:450.5MAO-A inhibitor 1
CAS:<p>MAO-A Inhibitor 1 (compound VIII) acts as a MAO-A inhibitor and exhibits an IC50 value of 100 μM [1].</p>Fórmula:C14H12O4Cor e Forma:SolidPeso molecular:244.24Metoquizine
CAS:<p>Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.</p>Fórmula:C22H27N5OPureza:98%Cor e Forma:SolidPeso molecular:377.48hAChE/Aβ1-42-IN-1
CAS:<p>Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and</p>Fórmula:C20H24N6OCor e Forma:SolidPeso molecular:364.44Desmethylflunitrazepam
CAS:<p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>Fórmula:C15H10FN3O3Cor e Forma:SolidPeso molecular:299.26(R)-Norfluoxetine
CAS:<p>(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine. It functions as a potent serotonin reuptake inhibitor, with a Ki value of 13 nM. This compound is utilized in the research of depression.</p>Fórmula:C16H16F3NOCor e Forma:SolidPeso molecular:295.299QP5020
CAS:<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Fórmula:C20H19FN6Peso molecular:362.40Mesulergine hydrochloride
CAS:<p>5-HT2A and 2C receptor antagonist</p>Fórmula:C18H27ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:398.95Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Fórmula:C35H49NO4Cor e Forma:SolidPeso molecular:547.77FP0429
CAS:<p>FP0429 is an agonist of mGlu4.</p>Fórmula:C10H12N2O7Pureza:98%Cor e Forma:SolidPeso molecular:272.212,6-Dimethoxybenzylamine hydrochloride
CAS:<p>2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.</p>Fórmula:C9H14ClNO2Cor e Forma:SolidPeso molecular:203.666CaMKK2-IN-1
CAS:<p>CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.</p>Fórmula:C22H22N2O3Peso molecular:362.42AChE-IN-10
<p>AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.</p>Fórmula:C23H27F2NO4SCor e Forma:SolidPeso molecular:451.53BMS-901715
CAS:<p>BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).</p>Fórmula:C22H28N10OPureza:98%Cor e Forma:SolidPeso molecular:448.52GABA-IN-4
CAS:<p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>Fórmula:C17H13ClN2O2Cor e Forma:SolidPeso molecular:312.75MAO-B-IN-5
CAS:<p>MAO-B-IN-5: potent, selective oral MAO-B inhibitor, IC50=0.204μM, potential for Parkinson's research.</p>Fórmula:C19H21FN2O2Pureza:97.68%Cor e Forma:SolidPeso molecular:328.38AChE/BuChE-IN-3
CAS:<p>AChE/BuChE-IN-3 inhibits AChE (IC50: 0.65 μM), BuChE (IC50: 5.77 μM), crosses BBB, and hinders Aβ1-42 aggregation for Alzheimer's research.</p>Fórmula:C30H30F3N3O6Cor e Forma:SolidPeso molecular:585.57AChE/BChE-IN-19
CAS:<p>AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.</p>Fórmula:C26H22N4O3Peso molecular:438.48Revexepride
CAS:<p>Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.</p>Fórmula:C21H32ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:425.95Serotonin maleate
CAS:<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Fórmula:C14H16N2O5Cor e Forma:SolidPeso molecular:292.287LY2794193
CAS:<p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>Fórmula:C16H18N2O6Pureza:98.15%Cor e Forma:SolidPeso molecular:334.32
