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Neurociência

Neurociência

Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.

Subcategorias de "Neurociência"

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Foram encontrados 5637 produtos de "Neurociência"

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  • SB 243213 hydrochloride

    CAS:
    SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It
    Fórmula:C22H20ClF3N4O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:464.87

    Ref: TM-T12859

    25mg
    2.043,00€
    50mg
    2.682,00€
    100mg
    3.600,00€
  • Jimscaline

    CAS:
    Jimscaline (compound R-(-)2) is a 5-HT2A agonist and a mescaline analogue, used in neuroscience research.
    Fórmula:C13H19NO3
    Cor e Forma:Solid
    Peso molecular:237.295

    Ref: TM-T204304

    10mg
    A consultar
    50mg
    A consultar
  • Azotomycin

    CAS:
    Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.
    Fórmula:C17H23N7O8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:453.41

    Ref: TM-T26729

    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • Aβ-IN-2


    Aβ-IN-2 is a peptide inhibitor of Aβ1-42.
    Fórmula:C37H51NO
    Cor e Forma:Solid
    Peso molecular:525.81

    Ref: TM-T63689

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • LRRK2-IN-5


    LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.
    Fórmula:C24H26F2N4O2S
    Cor e Forma:Solid
    Peso molecular:472.55

    Ref: TM-T63057

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • (S)-Praziquantel

    CAS:
    (S)-Praziquantel is the inactive isomer of R-praziquantel.
    Fórmula:C19H24N2O2
    Cor e Forma:Solid
    Peso molecular:312.406

    Ref: TM-T206068

    10mg
    A consultar
    50mg
    A consultar
  • ChEs/MAOs-IN-2

    CAS:
    ChEs/MAOs-IN-2 (compound a11) serves as an inhibitor for both cholinesterases and monoamine oxidases, exhibiting IC 50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for AChE, and 0.40 µM for BChE. This compound shows promise for Alzheimer's disease research [1].
    Fórmula:C15H12N2O3S
    Cor e Forma:Solid
    Peso molecular:300.33

    Ref: TM-T86047

    10mg
    A consultar
    50mg
    A consultar
  • SNRI-IN-1

    CAS:
    SNRI-IN-1 (Compound 7a) acts as a dual inhibitor of serotonin and noradrenaline monoamine reuptake, with a P-glycoprotein Efflux Ratio of 20 [1].
    Fórmula:C16H20Cl2N2O2
    Cor e Forma:Solid
    Peso molecular:343.25

    Ref: TM-T87412

    10mg
    A consultar
    50mg
    A consultar
  • VU6007496

    CAS:
    VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).
    Fórmula:C25H27N5O2
    Cor e Forma:Solid
    Peso molecular:429.51

    Ref: TM-T200762

    25mg
    1.602,00€
    50mg
    2.025,00€
    100mg
    2.600,00€
  • MAO-A inhibitor 1

    CAS:
    MAO-A Inhibitor 1 (compound VIII) acts as a MAO-A inhibitor and exhibits an IC50 value of 100 μM [1].
    Fórmula:C14H12O4
    Cor e Forma:Solid
    Peso molecular:244.24

    Ref: TM-T86857

    10mg
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    50mg
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  • AChE/BChE-IN-3 hydrochloride


    AChE/BChE-IN-3 (BMC-1) HCl is a dual inhibitor with IC50s: eqBChE 0.383 μM, elAChE 6.08 μM.
    Fórmula:C15H25ClN2O3
    Cor e Forma:Solid
    Peso molecular:316.82

    Ref: TM-T60831

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • AAZ-A 154

    CAS:
    AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.
    Fórmula:C14H20N2O
    Cor e Forma:Solid
    Peso molecular:232.32

    Ref: TM-T200737

    25mg
    1.458,00€
    50mg
    1.839,00€
    100mg
    2.322,00€
  • LY593093

    CAS:
    LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.
    Fórmula:C32H30FN3O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:507.6

    Ref: TM-T27961

    50mg
    A consultar
    5mg
    1.080,00€
    10mg
    1.620,00€
    25mg
    2.758,00€
  • eeAChE-IN-1


    eeAChE-IN-1 is a strong inhibitor of eeAChE (IC50: 23 nM).
    Fórmula:C27H30N6O5S
    Cor e Forma:Solid
    Peso molecular:550.63

    Ref: TM-T63889

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Lu 26-046

    CAS:
    Lu 26-046 is a muscarinic receptor agonist.
    Fórmula:C10H12N2OS
    Cor e Forma:Solid
    Peso molecular:208.28

    Ref: TM-T70651

    25mg
    2.178,00€
    50mg
    2.862,00€
    100mg
    3.870,00€
  • NY0116

    CAS:
    NY0116 is an agonist of the neuromedin U receptor 2 (NMUR2), exhibiting EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. In NMUR2 stably expressing HEK293 cells, NY0116 reduces cAMP levels while enhancing calcium signaling [1].
    Fórmula:C22H23N3O
    Cor e Forma:Solid
    Peso molecular:345.44

    Ref: TM-T87049

    10mg
    A consultar
    50mg
    A consultar
  • AChE/BChE-IN-1


    AChE/BChE-IN-1: dual AChE/BChE inhibitor, IC50 of 1.06 nM/7.3 nM, crosses blood-brain barrier, with antioxidant properties for Alzheimer's research.
    Fórmula:C32H35ClN6O3
    Cor e Forma:Solid
    Peso molecular:587.11

    Ref: TM-T64156

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • (E)-CHBO4

    CAS:
    (E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.
    Fórmula:C15H10BrFO
    Cor e Forma:Solid
    Peso molecular:305.142

    Ref: TM-T204977

    10mg
    A consultar
    50mg
    A consultar
  • (-)-5-HT2C agonist-3

    CAS:
    Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.
    Fórmula:C19H23ClFNO2
    Cor e Forma:Solid
    Peso molecular:351.84

    Ref: TM-T200458

    25mg
    1.564,00€
    50mg
    2.034,00€
    100mg
    2.517,00€
  • AChE-IN-47

    CAS:

    AChE-IN-47 (compound g17) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 0.24 μM. It prevents the self-aggregation of β-amyloid peptides and exhibits neuroprotective properties by effectively reducing the accumulation of intracellular reactive oxygen species (ROS).

    Fórmula:C20H17F3N4O4S
    Peso molecular:466.43

    Ref: TM-T208738

    10mg
    A consultar
    50mg
    A consultar
  • CaMKK2-IN-1

    CAS:
    CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.
    Fórmula:C22H22N2O3
    Peso molecular:362.42

    Ref: TM-T208827

    10mg
    A consultar
    50mg
    A consultar
  • AChE/BChE-IN-19

    CAS:
    AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.
    Fórmula:C26H22N4O3
    Peso molecular:438.48

    Ref: TM-T209831

    10mg
    A consultar
    50mg
    A consultar
  • Pareptide monohydrochloride

    CAS:
    Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).
    Fórmula:C14H27ClN4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:334.84

    Ref: TM-T13707

    25mg
    1.639,00€
    50mg
    2.142,00€
    100mg
    2.790,00€
  • Beloxepin

    CAS:
    Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.
    Fórmula:C19H21NO2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:295.38

    Ref: TM-T26765

    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • PXS-5153A monohydrochloride

    CAS:
    PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.
    Fórmula:C20H25Cl2FN4O2S
    Pureza:98%
    Cor e Forma:Odour Solid
    Peso molecular:475.41

    Ref: TM-T12585L

    25mg
    888,00€
    50mg
    1.224,00€
    100mg
    1.674,00€
  • DAPM

    CAS:
    DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.
    Fórmula:C20H20F2N2O4
    Pureza:99.76%
    Cor e Forma:Solid
    Peso molecular:390.38

    Ref: TM-T86161

    1mg
    74,00€
    5mg
    161,00€
    10mg
    231,00€
    25mg
    389,00€
  • (R)-(-)-Pirlindole mesylate

    CAS:
    (R)-(–)-Pirlindole acts as a monoamine oxidase A (MAO-A) inhibitor with an IC50 value of 0.43 µM, exhibiting selectivity for MAO-A compared to MAO-B. When administered at 50 mg/kg, it reduces immobility time in the forced swim test in mice and, at 25 mg/kg, inhibits reserpine-induced palpebral ptosis in mice.
    Fórmula:C16H22N2O3S
    Cor e Forma:Solid
    Peso molecular:322.42

    Ref: TM-T207765

    10mg
    A consultar
    50mg
    A consultar
  • LP 12 hydrochloride hydrate


    LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.
    Fórmula:C32H39N3O·HCl·xH2O
    Cor e Forma:Solid

    Ref: TM-T64269

    25mg
    828,00€
    50mg
    1.063,00€
    100mg
    1.611,00€
  • SB 224289

    CAS:
    SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.
    Fórmula:C32H32N4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:520.62

    Ref: TM-T19690

    25mg
    2.178,00€
    50mg
    2.862,00€
    100mg
    3.870,00€
  • BMS-986163

    CAS:
    BMS-986163, GluN2B negative allosteric modulator prodrug, converts to BMS-986169 (Ki=4 nM), antidepressant-like activity.
    Fórmula:C23H28FN2O5P
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:462.45

    Ref: TM-T14686

    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • CaMKIIα-IN-1


    CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.
    Fórmula:C14H11ClO4
    Cor e Forma:Solid
    Peso molecular:278.69

    Ref: TM-T60515

    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • MAO-A/SERT-IN-1

    CAS:
    MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.
    Fórmula:C19H14N2O5
    Cor e Forma:Solid
    Peso molecular:350.32

    Ref: TM-T200256

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • 5-HT2A/5-HT2C inverse agonist 1

    CAS:
    5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.
    Fórmula:C24H35N5O2
    Cor e Forma:Solid
    Peso molecular:425.57

    Ref: TM-T200089

    25mg
    2.248,00€
    50mg
    2.953,00€
    100mg
    3.993,00€
  • Dual AChE-MAO B-IN-1


    Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.
    Fórmula:C23H25F2NO4
    Cor e Forma:Solid
    Peso molecular:417.45

    Ref: TM-T62172

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • BACE-1 inhibitor 2

    CAS:
    BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].
    Fórmula:C21H21F4N5O3
    Cor e Forma:Solid
    Peso molecular:467.42

    Ref: TM-T62995

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • BMS-901715

    CAS:
    BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).
    Fórmula:C22H28N10O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:448.52

    Ref: TM-T10571

    25mg
    2.682,00€
    50mg
    4.041,00€
    100mg
    4.869,00€
  • AChE-IN-10


    AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.
    Fórmula:C23H27F2NO4S
    Cor e Forma:Solid
    Peso molecular:451.53

    Ref: TM-T62743

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • K027


    K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.
    Fórmula:C15H18Br2N4O2
    Cor e Forma:Solid
    Peso molecular:446.14

    Ref: TM-T62634

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • LRRK2-IN-2

    CAS:
    LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.
    Fórmula:C23H23Cl2F3N6O2
    Cor e Forma:Solid
    Peso molecular:543.37

    Ref: TM-T63824

    25mg
    1.927,00€
    50mg
    2.507,00€
    100mg
    3.168,00€
  • AChE/BuChE-IN-3

    CAS:
    AChE/BuChE-IN-3 inhibits AChE (IC50: 0.65 μM), BuChE (IC50: 5.77 μM), crosses BBB, and hinders Aβ1-42 aggregation for Alzheimer's research.
    Fórmula:C30H30F3N3O6
    Cor e Forma:Solid
    Peso molecular:585.57

    Ref: TM-T64137

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • LY 215840

    CAS:
    5-HT2/5-HT7 receptor antagonist
    Fórmula:C24H33N3O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:395.54

    Ref: TM-T22940

    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • MAO-B-IN-6


    MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.
    Cor e Forma:Solid

    Ref: TM-T64271

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • UB 165

    CAS:
    Subtype-selective nicotinic agonist
    Fórmula:C13H15ClN2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:234.72

    Ref: TM-T23485

    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • γ-secretase modulator 5


    Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.
    Cor e Forma:Solid

    Ref: TM-T64258

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Mesulergine hydrochloride

    CAS:
    5-HT2A and 2C receptor antagonist
    Fórmula:C18H27ClN4O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:398.95

    Ref: TM-T22970

    10mg
    862,00€
    50mg
    3.574,00€
  • HW161023

    CAS:
    HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.
    Fórmula:C20H24F2N4O
    Cor e Forma:Solid
    Peso molecular:374.428

    Ref: TM-T206896

    10mg
    A consultar
    50mg
    A consultar
  • TDI-11861

    CAS:
    TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.
    Fórmula:C22H25ClF2N6O3
    Cor e Forma:Solid
    Peso molecular:494.92

    Ref: TM-T73297

    500µg
    324,00€
  • R-96544 hydrochloride

    CAS:
    5-HT2 receptor antagonist
    Fórmula:C22H29NO3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:355.47

    Ref: TM-T23219

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Revexepride

    CAS:
    Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.
    Fórmula:C21H32ClN3O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:425.95

    Ref: TM-T16737

    25mg
    1.900,00€
    50mg
    2.565,00€
    100mg
    3.303,00€
  • PTCA

    CAS:
    PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.
    Fórmula:C10H5Cl2NO2S
    Cor e Forma:Solid
    Peso molecular:274.123

    Ref: TM-T204835

    10mg
    A consultar
    50mg
    A consultar