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Neurociência

Neurociência

Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.

Subcategorias de "Neurociência"

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Foram encontrados 5639 produtos de "Neurociência"

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  • AGH-107

    CAS:
    AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.
    Fórmula:C13H12IN3
    Cor e Forma:Solid
    Peso molecular:337.16

    Ref: TM-T201735

    10mg
    A consultar
    50mg
    A consultar
  • PDE4B/7A-IN-1

    CAS:
    5-HT1A antagonist; Ki=8nM, Kb=0.04nM. PDE4B IC50=80.4μM; PDE7A IC50=151.3μM. Good biofilm penetration, stable, anticognitive, antidepressant.
    Fórmula:C25H35N3O3
    Cor e Forma:Solid
    Peso molecular:425.56

    Ref: TM-T62303

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • RTIOXA-43

    CAS:
    RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.
    Fórmula:C37H37N5O5S
    Pureza:99.17%
    Cor e Forma:Solid
    Peso molecular:663.79

    Ref: TM-T87345

    1mg
    210,00€
    5mg
    516,00€
    1mL*10mM (DMSO)
    754,00€
    10mg
    833,00€
    25mg
    1.607,00€
    50mg
    2.582,00€
    100mg
    3.492,00€
  • VA012

    CAS:
    VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.
    Fórmula:C21H19N3
    Cor e Forma:Solid
    Peso molecular:313.40

    Ref: TM-T200241

    25mg
    1.564,00€
    50mg
    2.053,00€
    100mg
    2.535,00€
  • SEP-363856 mesylate

    CAS:
    SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.
    Fórmula:C10H17NO4S2
    Cor e Forma:Solid
    Peso molecular:279.38

    Ref: TM-T201258

    25mg
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    50mg
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  • SB 224289

    CAS:
    SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.
    Fórmula:C32H32N4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:520.62

    Ref: TM-T19690

    25mg
    2.178,00€
    50mg
    2.862,00€
    100mg
    3.870,00€
  • Aβ aggregation-IN-1

    CAS:
    Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.
    Fórmula:C9H8BF3O2
    Cor e Forma:Solid
    Peso molecular:215.965

    Ref: TM-T204182

    10mg
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    50mg
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  • hAChE/Aβ1-42-IN-1

    CAS:
    Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and
    Fórmula:C20H24N6O
    Cor e Forma:Solid
    Peso molecular:364.44

    Ref: TM-T61388

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Carlina oxide

    CAS:
    Carlina oxide is both an AChE inhibitor and an antioxidant, effective in eliminating mosquito larvae (LC50=1.39 μg/mL). Furthermore, Carlina oxide exhibits cytotoxicity in vertebrate cells, human dermis, and HCT116 and MDA-MB231 cell lines.
    Fórmula:C13H10O
    Cor e Forma:Solid
    Peso molecular:182.22

    Ref: TM-T88796

    10mg
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  • MAO-B-IN-40

    CAS:
    MAO-B-IN-40 (3a) is an inhibitor of MAOB, exhibiting an IC50 value of 0.493 μM against hMAOB, and demonstrates significant neuroprotective and antioxidant effects. MAO-B-IN-40 (3a) is applicable in Parkinson's disease research.
    Fórmula:C17H15N3O3
    Cor e Forma:Solid
    Peso molecular:309.319

    Ref: TM-T206123

    10mg
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  • Alixorexton

    CAS:
    Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.
    Fórmula:C21H30N2O5S
    Cor e Forma:Solid
    Peso molecular:422.538

    Ref: TM-T205053

    10mg
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  • hMAO-B-IN-10


    hMAO-B-IN-10 (compound 7) is an inhibitor of MAO-A/B with IC50 values of 424.1 nM and 177.9 nM, respectively. It has demonstrated neuroprotective effects in the MPTP-induced mouse model of Parkinson's Disease (PD).
    Fórmula:C16H12N4O4
    Cor e Forma:Solid
    Peso molecular:324.29

    Ref: TM-T201531

    10mg
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  • LRRK2-IN-2

    CAS:
    LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.
    Fórmula:C23H23Cl2F3N6O2
    Cor e Forma:Solid
    Peso molecular:543.37

    Ref: TM-T63824

    25mg
    1.927,00€
    50mg
    2.507,00€
    100mg
    3.168,00€
  • K027


    K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.
    Fórmula:C15H18Br2N4O2
    Cor e Forma:Solid
    Peso molecular:446.14

    Ref: TM-T62634

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Elzasonan hydrochloride

    CAS:
    Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.
    Fórmula:C22H24Cl3N3OS
    Cor e Forma:Solid
    Peso molecular:484.87

    Ref: TM-T201763

    10mg
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  • Dihydro-β-erythroidine

    CAS:
    Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolytic
    Fórmula:C16H21NO3
    Cor e Forma:Solid
    Peso molecular:275.34

    Ref: TM-T72382

    25mg
    2.448,00€
    50mg
    3.222,00€
    100mg
    4.410,00€
  • 5-HT6/5-HT2AR antagonist-1


    Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.
    Fórmula:C21H26N6S
    Cor e Forma:Solid
    Peso molecular:394.54

    Ref: TM-T61837

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • MMB-4

    CAS:
    MMB-4 is an oxime that can reactivate cholinesterases (cholinesterases) which have been inactivated due to exposure to organophosphates such as Sarin or Soman.
    Fórmula:C13H14Br2N4O2
    Cor e Forma:Solid
    Peso molecular:418.084

    Ref: TM-T204634

    10mg
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  • 5-HT1A modulator 4

    CAS:
    5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.
    Fórmula:C9H14N4
    Cor e Forma:Solid
    Peso molecular:178.234

    Ref: TM-T205724

    10mg
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  • AChE-IN-83

    CAS:
    AChE-IN-83 (compound f1) is an AChE inhibitor that suppresses nematode growth and acetylcholinesterase activity in rice seeds while being safe for the seeds. It specifically targets Aphelenchoides besseyi, with an LC50 of 19.0 μg/mL over 48 hours. AChE-IN-83 impedes nematode populations and behaviors in rice seeds, damages the nematode cuticle, and induces reactive oxygen species, lipofuscin, and lipid generation within the nematodes.
    Fórmula:C10H7ClN2O2S
    Cor e Forma:Solid
    Peso molecular:254.693

    Ref: TM-T205656

    10mg
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    50mg
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  • Thiazolo[5,4-c]pyridin-4(5H)-one

    CAS:
    Thiazolo[5,4-c]pyridin-4(5H)-one is a compound used for diagnostic imaging of TDP-43, in PET imaging of neurodegenerative diseases ALS、AD、FTD、LATE.
    Fórmula:C22H22FN5O2S
    Pureza:98.75%
    Cor e Forma:Solid
    Peso molecular:439.51

    Ref: TM-T88035

    1mg
    160,00€
    5mg
    386,00€
    10mg
    546,00€
    25mg
    856,00€
    50mg
    1.180,00€
  • AChE-IN-10


    AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.
    Fórmula:C23H27F2NO4S
    Cor e Forma:Solid
    Peso molecular:451.53

    Ref: TM-T62743

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • PTCA

    CAS:
    PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.
    Fórmula:C10H5Cl2NO2S
    Cor e Forma:Solid
    Peso molecular:274.123

    Ref: TM-T204835

    10mg
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    50mg
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  • Befiradol hydrochloride

    CAS:
    Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.
    Fórmula:C20H23Cl2F2N3O
    Pureza:99.64%
    Cor e Forma:Solid
    Peso molecular:430.32

    Ref: TM-T62385

    1mg
    99,00€
    5mg
    239,00€
    10mg
    349,00€
    25mg
    560,00€
    50mg
    775,00€
    100mg
    1.035,00€
    200mg
    1.395,00€
  • CaMKK2-IN-1

    CAS:
    CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.
    Fórmula:C22H22N2O3
    Peso molecular:362.42

    Ref: TM-T208827

    10mg
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    50mg
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  • LP 12 hydrochloride hydrate


    LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.
    Fórmula:C32H39N3O·HCl·xH2O
    Cor e Forma:Solid

    Ref: TM-T64269

    25mg
    828,00€
    50mg
    1.063,00€
    100mg
    1.611,00€
  • Tipindole

    CAS:
    Tipindole is a serotonin antagonist utilized in research related to depression.
    Fórmula:C16H20N2O2S
    Cor e Forma:Solid
    Peso molecular:304.41

    Ref: TM-T201819

    10mg
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    50mg
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  • BMS-901715

    CAS:
    BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).
    Fórmula:C22H28N10O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:448.52

    Ref: TM-T10571

    25mg
    2.682,00€
    50mg
    4.041,00€
    100mg
    4.869,00€
  • Zanapezil fumarate

    CAS:
    Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons.
    Fórmula:C29H36N2O5
    Cor e Forma:Solid
    Peso molecular:492.61

    Ref: TM-T29203

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • LRRK2-IN-14

    CAS:
    LRRK2-IN-14 (Compound 8), an orally active inhibitor of LRRK2, exhibits an IC 50 of 6.3 nM against LRRK2(G2019S) cell activity and demonstrates inhibitory effects on hERG with an IC 50 of 22 μM. Additionally, LRRK2-IN-14 is permeable to the blood-brain barrier [1].
    Fórmula:C17H18F3N5O2
    Cor e Forma:Solid
    Peso molecular:381.35

    Ref: TM-T86825

    10mg
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    50mg
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  • BACE-1 inhibitor 2

    CAS:
    BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].
    Fórmula:C21H21F4N5O3
    Cor e Forma:Solid
    Peso molecular:467.42

    Ref: TM-T62995

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • YM-31636 free base

    CAS:
    YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.
    Fórmula:C14H11N3S
    Cor e Forma:Solid
    Peso molecular:253.32

    Ref: TM-T201587

    10mg
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    50mg
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  • F 14679

    CAS:
    F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
    Fórmula:C21H25ClF2N4O
    Pureza:99.09%
    Cor e Forma:Solid
    Peso molecular:422.9

    Ref: TM-T62269

    25mg
    1.198,00€
    50mg
    1.555,00€
    100mg
    2.335,00€
  • Remlifanserin

    CAS:
    Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).
    Fórmula:C24H29F2N3O2
    Cor e Forma:Solid
    Peso molecular:429.50

    Ref: TM-T201055

    25mg
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    50mg
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    100mg
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  • AM9405


    AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.
    Fórmula:C24H33BrN2O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:461.44

    Ref: TM-T10294

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • γ-Secretase modulator 11 hydrochloride

    CAS:
    γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).
    Fórmula:C28H23ClF2N4O2
    Cor e Forma:Solid
    Peso molecular:520.96

    Ref: TM-T63638

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • LY3020371 hydrochloride

    CAS:
    LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.
    Fórmula:C15H16ClF2NO5S
    Cor e Forma:Solid
    Peso molecular:395.81

    Ref: TM-T11911

    25mg
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  • MAO-IN-4

    CAS:
    MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].
    Fórmula:C18H11Cl2N3OS
    Cor e Forma:Solid
    Peso molecular:388.27

    Ref: TM-T86859

    10mg
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    50mg
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  • β-CCM

    CAS:
    β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and convulsant effects. It enhances emotional reactivity and reduces interference sensitivity in spatial working memory tasks. β-CCM is applicable in research related to anxiety disorders.
    Fórmula:C13H10N2O2
    Cor e Forma:Solid
    Peso molecular:226.231

    Ref: TM-T206213

    10mg
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    50mg
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  • Amyloid-β-IN-3

    CAS:
    Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.
    Fórmula:C22H21F2N3O2
    Cor e Forma:Solid
    Peso molecular:397.42

    Ref: TM-T207233

    10mg
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    50mg
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  • AChE-IN-24


    AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.
    Fórmula:C22H30N2O4S2
    Cor e Forma:Solid
    Peso molecular:450.61

    Ref: TM-T62728

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Aprindine

    CAS:
    Aprindine, an arrhythmia inhibitor, stabilizes the cell membranes of heart muscle cells to prevent abnormal electrical impulses and irregular heartbeats. In hematological toxicity studies, aprindine demonstrated potential inhibitory effects on the replicative capacity of mouse and human blood cells at specific concentrations [1].
    Fórmula:C22H30N2
    Peso molecular:322.49

    Ref: TM-T85713

    25mg
    1.908,00€
    50mg
    2.502,00€
    100mg
    3.330,00€
  • PXS-5153A monohydrochloride

    CAS:
    PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.
    Fórmula:C20H25Cl2FN4O2S
    Pureza:98%
    Cor e Forma:Odour Solid
    Peso molecular:475.41

    Ref: TM-T12585L

    25mg
    888,00€
    50mg
    1.224,00€
    100mg
    1.674,00€
  • R-96544 hydrochloride

    CAS:
    5-HT2 receptor antagonist
    Fórmula:C22H29NO3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:355.47

    Ref: TM-T23219

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • CaMKIIα-IN-1


    CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.
    Fórmula:C14H11ClO4
    Cor e Forma:Solid
    Peso molecular:278.69

    Ref: TM-T60515

    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • HW161023

    CAS:
    HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.
    Fórmula:C20H24F2N4O
    Cor e Forma:Solid
    Peso molecular:374.428

    Ref: TM-T206896

    10mg
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    50mg
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  • AAZ-A 154

    CAS:
    AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.
    Fórmula:C14H20N2O
    Cor e Forma:Solid
    Peso molecular:232.32

    Ref: TM-T200737

    25mg
    1.458,00€
    50mg
    1.839,00€
    100mg
    2.322,00€
  • PF-06751979

    CAS:
    PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
    Fórmula:C18H19F2N5O3S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:455.5

    Ref: TM-T12429

    25mg
    1.108,00€
    50mg
    1.449,00€
  • VU6016235

    CAS:
    VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.
    Fórmula:C21H22N4OS
    Cor e Forma:Solid
    Peso molecular:378.49

    Ref: TM-T201326

    25mg
    1.969,00€
    50mg
    2.582,00€
    100mg
    3.436,00€
  • AChE-IN-25


    AChE-IN-25: selective, potent AChE inhibitor, non-competitive, IC50 = 2.95 μM, for Alzheimer's research.
    Fórmula:C20H15ClN4O4S
    Cor e Forma:Solid
    Peso molecular:442.88

    Ref: TM-T62590

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€