Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(648 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.028 produtos)
- BACE(37 produtos)
- Beta Amilóide(231 produtos)
- CaMK(73 produtos)
- COX(602 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(372 produtos)
- Gama-secretase(63 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(42 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(42 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5637 produtos de "Neurociência"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
SB 243213 hydrochloride
CAS:SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).ItFórmula:C22H20ClF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:464.87Jimscaline
CAS:Jimscaline (compound R-(-)2) is a 5-HT2A agonist and a mescaline analogue, used in neuroscience research.Fórmula:C13H19NO3Cor e Forma:SolidPeso molecular:237.295Azotomycin
CAS:Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.Fórmula:C17H23N7O8Pureza:98%Cor e Forma:SolidPeso molecular:453.41Aβ-IN-2
Aβ-IN-2 is a peptide inhibitor of Aβ1-42.Fórmula:C37H51NOCor e Forma:SolidPeso molecular:525.81LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Fórmula:C24H26F2N4O2SCor e Forma:SolidPeso molecular:472.55(S)-Praziquantel
CAS:(S)-Praziquantel is the inactive isomer of R-praziquantel.Fórmula:C19H24N2O2Cor e Forma:SolidPeso molecular:312.406ChEs/MAOs-IN-2
CAS:ChEs/MAOs-IN-2 (compound a11) serves as an inhibitor for both cholinesterases and monoamine oxidases, exhibiting IC 50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for AChE, and 0.40 µM for BChE. This compound shows promise for Alzheimer's disease research [1].Fórmula:C15H12N2O3SCor e Forma:SolidPeso molecular:300.33SNRI-IN-1
CAS:SNRI-IN-1 (Compound 7a) acts as a dual inhibitor of serotonin and noradrenaline monoamine reuptake, with a P-glycoprotein Efflux Ratio of 20 [1].Fórmula:C16H20Cl2N2O2Cor e Forma:SolidPeso molecular:343.25VU6007496
CAS:VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).Fórmula:C25H27N5O2Cor e Forma:SolidPeso molecular:429.51MAO-A inhibitor 1
CAS:MAO-A Inhibitor 1 (compound VIII) acts as a MAO-A inhibitor and exhibits an IC50 value of 100 μM [1].Fórmula:C14H12O4Cor e Forma:SolidPeso molecular:244.24AChE/BChE-IN-3 hydrochloride
AChE/BChE-IN-3 (BMC-1) HCl is a dual inhibitor with IC50s: eqBChE 0.383 μM, elAChE 6.08 μM.Fórmula:C15H25ClN2O3Cor e Forma:SolidPeso molecular:316.82AAZ-A 154
CAS:AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.Fórmula:C14H20N2OCor e Forma:SolidPeso molecular:232.32LY593093
CAS:LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.Fórmula:C32H30FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:507.6eeAChE-IN-1
eeAChE-IN-1 is a strong inhibitor of eeAChE (IC50: 23 nM).Fórmula:C27H30N6O5SCor e Forma:SolidPeso molecular:550.63Lu 26-046
CAS:Lu 26-046 is a muscarinic receptor agonist.Fórmula:C10H12N2OSCor e Forma:SolidPeso molecular:208.28NY0116
CAS:NY0116 is an agonist of the neuromedin U receptor 2 (NMUR2), exhibiting EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. In NMUR2 stably expressing HEK293 cells, NY0116 reduces cAMP levels while enhancing calcium signaling [1].Fórmula:C22H23N3OCor e Forma:SolidPeso molecular:345.44AChE/BChE-IN-1
AChE/BChE-IN-1: dual AChE/BChE inhibitor, IC50 of 1.06 nM/7.3 nM, crosses blood-brain barrier, with antioxidant properties for Alzheimer's research.Fórmula:C32H35ClN6O3Cor e Forma:SolidPeso molecular:587.11(E)-CHBO4
CAS:(E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.Fórmula:C15H10BrFOCor e Forma:SolidPeso molecular:305.142(-)-5-HT2C agonist-3
CAS:Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.Fórmula:C19H23ClFNO2Cor e Forma:SolidPeso molecular:351.84AChE-IN-47
CAS:AChE-IN-47 (compound g17) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 0.24 μM. It prevents the self-aggregation of β-amyloid peptides and exhibits neuroprotective properties by effectively reducing the accumulation of intracellular reactive oxygen species (ROS).
Fórmula:C20H17F3N4O4SPeso molecular:466.43CaMKK2-IN-1
CAS:CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.Fórmula:C22H22N2O3Peso molecular:362.42AChE/BChE-IN-19
CAS:AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.Fórmula:C26H22N4O3Peso molecular:438.48Pareptide monohydrochloride
CAS:Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).Fórmula:C14H27ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:334.84Beloxepin
CAS:Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.Fórmula:C19H21NO2Pureza:98%Cor e Forma:SolidPeso molecular:295.38PXS-5153A monohydrochloride
CAS:PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.Fórmula:C20H25Cl2FN4O2SPureza:98%Cor e Forma:Odour SolidPeso molecular:475.41DAPM
CAS:DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Fórmula:C20H20F2N2O4Pureza:99.76%Cor e Forma:SolidPeso molecular:390.38(R)-(-)-Pirlindole mesylate
CAS:(R)-(–)-Pirlindole acts as a monoamine oxidase A (MAO-A) inhibitor with an IC50 value of 0.43 µM, exhibiting selectivity for MAO-A compared to MAO-B. When administered at 50 mg/kg, it reduces immobility time in the forced swim test in mice and, at 25 mg/kg, inhibits reserpine-induced palpebral ptosis in mice.Fórmula:C16H22N2O3SCor e Forma:SolidPeso molecular:322.42LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.Fórmula:C32H39N3O·HCl·xH2OCor e Forma:SolidSB 224289
CAS:SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.Fórmula:C32H32N4O3Pureza:98%Cor e Forma:SolidPeso molecular:520.62BMS-986163
CAS:BMS-986163, GluN2B negative allosteric modulator prodrug, converts to BMS-986169 (Ki=4 nM), antidepressant-like activity.Fórmula:C23H28FN2O5PPureza:98%Cor e Forma:SolidPeso molecular:462.45CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Fórmula:C14H11ClO4Cor e Forma:SolidPeso molecular:278.69MAO-A/SERT-IN-1
CAS:MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.Fórmula:C19H14N2O5Cor e Forma:SolidPeso molecular:350.325-HT2A/5-HT2C inverse agonist 1
CAS:5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.Fórmula:C24H35N5O2Cor e Forma:SolidPeso molecular:425.57Dual AChE-MAO B-IN-1
Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.Fórmula:C23H25F2NO4Cor e Forma:SolidPeso molecular:417.45BACE-1 inhibitor 2
CAS:BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].Fórmula:C21H21F4N5O3Cor e Forma:SolidPeso molecular:467.42BMS-901715
CAS:BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).Fórmula:C22H28N10OPureza:98%Cor e Forma:SolidPeso molecular:448.52AChE-IN-10
AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.Fórmula:C23H27F2NO4SCor e Forma:SolidPeso molecular:451.53K027
K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.Fórmula:C15H18Br2N4O2Cor e Forma:SolidPeso molecular:446.14LRRK2-IN-2
CAS:LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.Fórmula:C23H23Cl2F3N6O2Cor e Forma:SolidPeso molecular:543.37AChE/BuChE-IN-3
CAS:AChE/BuChE-IN-3 inhibits AChE (IC50: 0.65 μM), BuChE (IC50: 5.77 μM), crosses BBB, and hinders Aβ1-42 aggregation for Alzheimer's research.Fórmula:C30H30F3N3O6Cor e Forma:SolidPeso molecular:585.57LY 215840
CAS:5-HT2/5-HT7 receptor antagonistFórmula:C24H33N3O2Pureza:98%Cor e Forma:SolidPeso molecular:395.54MAO-B-IN-6
MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.Cor e Forma:SolidUB 165
CAS:Subtype-selective nicotinic agonistFórmula:C13H15ClN2Pureza:98%Cor e Forma:SolidPeso molecular:234.72γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Cor e Forma:SolidMesulergine hydrochloride
CAS:5-HT2A and 2C receptor antagonistFórmula:C18H27ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:398.95HW161023
CAS:HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.Fórmula:C20H24F2N4OCor e Forma:SolidPeso molecular:374.428TDI-11861
CAS:TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.Fórmula:C22H25ClF2N6O3Cor e Forma:SolidPeso molecular:494.92R-96544 hydrochloride
CAS:5-HT2 receptor antagonistFórmula:C22H29NO3Pureza:98%Cor e Forma:SolidPeso molecular:355.47Revexepride
CAS:Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.Fórmula:C21H32ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:425.95PTCA
CAS:PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.Fórmula:C10H5Cl2NO2SCor e Forma:SolidPeso molecular:274.123
