Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(940 produtos)
- ACK(1 produtos)
- AChR(574 produtos)
- ATP Citrato Liase(16 produtos)
- Receptor adrenérgico(2.942 produtos)
- BACE(36 produtos)
- Beta Amilóide(204 produtos)
- CaMK(68 produtos)
- COX(562 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor GABA(336 produtos)
- Gama-secretase(59 produtos)
- GluR(255 produtos)
- GlyT(24 produtos)
- Receptor de Histamina(358 produtos)
- LRRK2(33 produtos)
- Receptor de Melatonina(24 produtos)
- NMDAR(28 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(296 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5400 produtos de "Neurociência"
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Flufiprole
CAS:<p>Flufiprole is used as a phenylpyrazole pesticide. It has enantioselective metabolism in human and rat liver microsomes.</p>Fórmula:C16H10Cl2F6N4OSCor e Forma:SolidPeso molecular:491.24Aβ-IN-8
<p>Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1].</p>Fórmula:C22H16F3N3O3SCor e Forma:SolidPeso molecular:459.44AChE/BuChE/MAO-B-IN-2
<p>AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent inhibitor of AChE, BuChE, and hu MAO-B, with respective IC50 values of 5.3 μM, 12.4 μM, and 1.9±0.08 μM,</p>Fórmula:C19H18FNO3Cor e Forma:SolidPeso molecular:327.35(Rac)-Sabcomeline
CAS:<p>(Rac)-Sabcomeline ((Rac)-SB-202026) is an M1/M4 muscarinic agonist used in the study of neurologic disorders such as schizophrenia.</p>Fórmula:C10H15N3OPureza:99.14%Cor e Forma:SolidPeso molecular:193.25AChE/BChE-IN-26
<p>AChE/BChE-IN-26 (Compound 20aa) is a cholinesterase inhibitor with IC50 values of 0.75 μM for eeAChE and 4.11 μM for eqBChE. This compound possesses antioxidant properties and is applicable in research related to diseases such as Alzheimer's.</p>Cor e Forma:Odour SolidAChE-IN-43
<p>AChE-IN-43 is a potent, selective AChE inhibitor with a K i of 0.41 μM, applicable in the study of neurological diseases [1].</p>Cor e Forma:Odour SolidPD25
<p>PD25, an inhibitor of both AChE and BuChE, demonstrates inhibitory constants of hAChE IC50: 1.58 μM, eeAChE IC50: 1.63 μM, and eqBuChE IC50: 2.39 μM.</p>Fórmula:C25H24N2O4Cor e Forma:SolidPeso molecular:416.47Ro60-0175
CAS:<p>Ro60-0175 is a selective 5-HT2B and 5-HT2C serotonin receptor agonist, often used as fumarate.</p>Fórmula:C11H12ClFN2Pureza:97.09%Cor e Forma:SolidPeso molecular:226.68BI 1181181 MZ
<p>BI 1181181 MZ is a potent and selective BACE1 inhibitor. BI 1181181 MZ is applicable to Alzheimer's disease research.</p>Fórmula:C31H37FN4O5Cor e Forma:SolidPeso molecular:564.2748β-Amyloid (1-43)(human) TFA
<p>β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to its well-established counterpart, Aβ1-42.</p>Fórmula:C209H319F3N56O64SCor e Forma:SolidPeso molecular:4729.21hAChE-IN-4
<p>Compd 5d (hAChE-IN-4) is a potent hAChE inhibitor that readily crosses the blood-brain barrier, exhibiting an IC50 of 0.25 μM, and is utilized in the study of</p>Fórmula:C30H23Cl3N2O3Cor e Forma:SolidPeso molecular:565.87(D-Asp1)-Amyloid β-Protein (1-42)
CAS:<p>(D-Asp1)-Amyloid β-Protein (1-42), a peptide fragment of amyloid β-protein (Aβ), serves as the primary constituent of vascular and parenchymal amyloid deposits</p>Fórmula:C203H311N55O60SCor e Forma:SolidPeso molecular:4514.04Lycoramine hydrobromide
CAS:<p>Lycoramine is a natural alkaloid isolated from Lycoris chinensis.</p>Fórmula:C17H24BrNO3Cor e Forma:SolidPeso molecular:370.28Cytidine 5′-diphosphoethanolamine
CAS:<p>Cytidine 5′-diphosphoethanolamine, a key intermediate in phosphatidylethanolamine synthesis, also serves as a stimulant of Ach synthesis [1].</p>Fórmula:C11H20N4O11P2Cor e Forma:SolidPeso molecular:446.24BuChE-IN-8
<p>BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) and</p>Fórmula:C28H33ClN4O2SCor e Forma:SolidPeso molecular:525.11Peptide 401
CAS:<p>Peptide 401: AMP from bee/wasp venom, triggers histamine release, reduces paw swelling.</p>Fórmula:C110H192N40O24S4Pureza:98%Cor e Forma:SolidPeso molecular:2587.22β-Amyloid (22-40)
CAS:<p>This synthetic peptide consists of amino acids 22 to 40 of beta amyloid protein.</p>Fórmula:C78H135N21O26SPureza:98%Cor e Forma:SolidPeso molecular:1815.1(E/Z)-Sivopixant
CAS:<p>(E/Z)-Sivopixant ((E/Z)-S-600918)is a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.</p>Fórmula:C25H22ClN5O5Pureza:99.82%Cor e Forma:SolidPeso molecular:507.93K1833
<p>K1833 is an inhibitor and reactivator of human acetylcholinesterase (hrAChE), exhibiting an inhibition concentration (IC50) of 58$.</p>Cor e Forma:Odour SolidLY3020371
CAS:<p>LY3020371: potent, selective mGlu 2/3 receptor antagonist with Ki of 5.26 nM (hmGluR2) and 2.50 nM (hmGluR3); key in depression studies.</p>Fórmula:C15H15F2NO5SCor e Forma:SolidPeso molecular:359.34(Rac)-Sclerone
CAS:<p>(Rac)-Sclerone, a natural product isolated from the green husk of Carya illinoinensis, exhibits significant AChE inhibition activity with an IC50 value of 192.</p>Fórmula:C10H10O3Cor e Forma:SolidPeso molecular:178.18PSEN1-IN-1
<p>PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50</p>Fórmula:C20H19ClF3NO3SCor e Forma:SolidPeso molecular:445.88Muscarine
CAS:<p>Muscarine is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.</p>Fórmula:C9H20NO2Pureza:98%Cor e Forma:SolidPeso molecular:174.26Mosapride citrate dihydrate
CAS:<p>Mosapride Citrate, a 5-HT4 agonist, boosts gut movement by enhancing acetylcholine release.</p>Fórmula:C27H35ClFN3O11Pureza:98%Cor e Forma:SolidPeso molecular:632.04BMY-14802
CAS:<p>BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.</p>Fórmula:C18H22F2N4OPureza:99.84%Cor e Forma:SoildPeso molecular:348.39TAT-CN21 (scrambled)
<p>TAT-CN21(scrambled) is a control peptide lacking specific targeting activity and serves as a negative control for TatCN21. TatCN21 is an effective and selective inhibitory peptide for calcium/calmodulin-dependent protein kinase II (CaMKII).</p>Cor e Forma:Odour Solidβ-Amyloid (22-35)
CAS:<p>β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells.</p>Fórmula:C59H102N16O21SPureza:98%Cor e Forma:SolidPeso molecular:1403.62MAO-IN-6
<p>MAO-IN-6 (Compound 3f) is a reversible MAO-B inhibitor that can cross the blood-brain barrier, with an IC50 value of 0.09 μM. It also shows inhibitory activity against AChE and BChE, with IC50 values of 4.48 μM and 17.03 μM, respectively. MAO-IN-6 exhibits low cytotoxicity and is applicable in Alzheimer's disease research.</p>Fórmula:C22H14F3NO2Cor e Forma:SolidPeso molecular:381.35VVZ-149
<p>VVZ-149 is an antagonist of both serotonin receptor 2A (5HT2A) and glycine transporter type 2 (GlyT2), with potential anti-nociceptive activity.</p>Cor e Forma:Solid(-)-Eseroline fumarate
CAS:<p>(-)-Eseroline fumarate, a Physostigmine metabolite and AChE inhibitor, triggers cancer cell LDH release and neuronal cell death.</p>Fórmula:C17H22N2O5Cor e Forma:SolidPeso molecular:334.37(Rac)-Norcisapride
CAS:<p>Norcisapride, a 5-HT3 and 5-HT4 agonist, treats GI, orofacial, and ENT disorders.</p>Fórmula:C14H20ClN3O3Pureza:99.32%Cor e Forma:SoildPeso molecular:313.78DSP-1053
CAS:<p>Dsp-1053 is a powerful SERT (Ki=1.02 nM) inhibitor with partial 5-HT1A receptor (Ki=5.05 nM) agonizing activity.</p>Fórmula:C26H32BrNO4Pureza:98%Cor e Forma:SolidPeso molecular:502.44SAHM1
CAS:<p>Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.</p>Fórmula:C94H162N36O23SPureza:98%Cor e Forma:SolidPeso molecular:2196.58β-Amyloid Protein Precursor 770 (135-155)
CAS:<p>Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)</p>Fórmula:C116H172N35O31S2Pureza:98%Cor e Forma:SolidPeso molecular:2617.96Anticonvulsant agent 9
<p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>Fórmula:C22H24N4O2Cor e Forma:SolidPeso molecular:376.45γ-Secretase modulator 10
CAS:<p>γ-Secretase modulator 10 is a novel γ-secretase modulator.</p>Fórmula:C25H23F3N4O2Cor e Forma:SolidPeso molecular:468.48MIDD0301
CAS:<p>MIDD0301 is a potent positive allosteric α5β3γ selective GABAA receptor (GABAAR) ligand with EC50 of 17 nM.</p>Fórmula:C19H13BrFN3O2Pureza:98%Cor e Forma:SolidPeso molecular:414.23β-Amyloid (12-20)
CAS:<p>β-Amyloid (12-20) is a peptide fragment of β-Amyloid.Thsis peptide contain the amino acid residues VFF at position (18-20), suggesting that this triad has</p>Fórmula:C57H83N15O11Pureza:98%Cor e Forma:SolidPeso molecular:1154.36CUR-IPA
<p>CUR-IPA is a cholinesterase inhibitor with IC50 values of 5.99 μM for eAChE (electric eel), 59.30 μM for hAChE (human), and 60.66 μM for hBChE (human). It has free radical scavenging and antioxidant activity and is useful for researching cognitive dysfunction.</p>Fórmula:C43H38N2O8Cor e Forma:SolidPeso molecular:710.775-HT1AR/5-HT6R ligand-1
<p>5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.</p>Fórmula:C25H29ClN4O2SCor e Forma:SolidPeso molecular:485.04Atracurium
CAS:<p>Atracurium (BW-33A) is a competitive AChR antagonist and non-depolarizing muscle relaxant that may cause bronchoconstriction.</p>Fórmula:C53H72N2O122Cor e Forma:SolidPeso molecular:929.14Epiboxidine hydrochloride
CAS:<p>Epiboxidine HCl: potent α4β2 nAChR agonist; Ki 0.46 nM (rat), 1.2 nM (human); Epibatidine analog.</p>Fórmula:C10H15ClN2OCor e Forma:SolidPeso molecular:214.69Pozanicline hydrochloride
<p>Pozanicline hydrochloride is an oral α4β2 nAChR agonist with a 16.7 nM Ki, insignificantly binding to α7 nAChR.</p>Fórmula:C11H17ClN2OPureza:97.13% - 99.81%Cor e Forma:SolidPeso molecular:228.72hAChE-IN-5
<p>hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency with</p>Pureza:98%Cor e Forma:Odour Solid4-Butyl-α-agarofuran
CAS:<p>4-Butyl-alpha-agarofuran, a Gharu-wood derivative, is an anxiolytic, antidepressant, and aids neurological research.</p>Fórmula:C18H30OCor e Forma:SolidPeso molecular:262.43Deoxynojirimycin Tetrabenzyl Ether
CAS:<p>Deoxynojirimycin tetrabenzyl ether aids in making 1-dNM, a strong α-glucosidase I & II blocker.</p>Fórmula:C34H37NO4Cor e Forma:SolidPeso molecular:523.673AChE-IN-29
<p>AChE-IN-29, a 3-OH pyrrolidine derivative, acts as a cholinesterase (ChE) inhibitor with potent activity against human acetylcholinesterase (hAChE), electric</p>Fórmula:C18H19BrN2O2Cor e Forma:SolidPeso molecular:375.26(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
CAS:<p>(Rac)-5-Hydroxymethyl Tolterodine HCl, or (Rac)-Desfesoterodine HCl, is a potent mAChR blocker researched for overactive bladder.</p>Fórmula:C22H32ClNO2Cor e Forma:SolidPeso molecular:377.95β-Amyloid (1-17)
CAS:<p>This synthetic peptide consists of amino acids 1 to 17 of beta amyloid protein. This peptide can be employed in beta amyloid solubility studies.</p>Fórmula:C90H130N28O29Pureza:98%Cor e Forma:SolidPeso molecular:2068.2BChE-IN-21
<p>BChE-IN-21, a potent inhibitor of butyrylcholinesterase (BChE), exhibits an inhibition constant (IC50) of 0.14 ± 0.02 μM, indicating promise for research in</p>Cor e Forma:Odour Solid
