Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(648 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.029 produtos)
- BACE(37 produtos)
- Beta Amilóide(231 produtos)
- CaMK(73 produtos)
- COX(602 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(372 produtos)
- Gama-secretase(63 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(42 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(42 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5636 produtos de "Neurociência"
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TB-11
CAS:TB-11 is an inhibitor of Cathepsin D with IC50 values of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), and 48.8 nM (BACE1). It is primarily utilized in oncological research.Fórmula:C52H78N8O12Cor e Forma:SolidPeso molecular:1007.22β-Amyloid (1-34)
CAS:This is a fragment of beta-amyloid peptide. It has amino acids 1 through 34.Fórmula:C170H253N47O52Pureza:98%Cor e Forma:SolidPeso molecular:3787.2Tabernanthalog
CAS:TBG is a 5-HT2A agonist reducing alcohol/heroin cravings and promoting neuroplasticity with antidepressant effects in rodents.Fórmula:C14H18N2OPureza:99.82% - 99.89%Cor e Forma:SoildPeso molecular:230.31Ref: TM-T60221
1mg175,00€2mg264,00€1mL*10mM (DMSO)344,00€5mg404,00€10mg592,00€25mg888,00€50mg1.243,00€100mg1.701,00€500mg3.402,00€N-Methylcyclohexaneethaneamine
CAS:N-Methylcyclohexaneethaneamine is a useful organic compound for research related to life sciences.Fórmula:C9H19NCor e Forma:SolidPeso molecular:141.2539AChE-IN-36
AChE-IN-36 (compound A4) is an acetylcholinesterase inhibitor with an IC50 of 0.04 μM, influencing ROS levels and modulating the gene expression of NRF2 [1].Fórmula:C25H21ClO5SCor e Forma:SolidPeso molecular:468.95Trivalent GalNAc-DBCO
CAS:Trivalent GalNAc-DBCO is a synthetic ligand composed of three GalNAc units linked to DBCO. Trivalent GalNAc-DBCO undergoes strain-promoted alkyne–azide cycloaddition (SPAAC) reactions with azide-containing molecules without the need for copper catalysis. Trivalent GalNAc-DBCO binds specifically to the asialoglycoprotein receptor (ASGPR), thereby directing conjugated molecules into hepatocytes for lysosomal degradation through receptor-mediated endocytosis. Trivalent GalNAc-DBCO is extensively applied in studies of liver-targeted drug delivery, targeted degradation strategies, and hepatocyte-specific molecular engineering.Fórmula:C91H144N12O34Pureza:96.33%Peso molecular:1950.18Feralolide
CAS:Feralolide, a dihydroisocoumarin from the methanolic extract of aloe vera resin, functions as a dual inhibitor of acetylcholinesterase (AChE) andFórmula:C18H16O7Cor e Forma:SolidPeso molecular:344.32LU-32-176B
CAS:LU32-176B is a bioactive chemical.Fórmula:C23H24F2N2O2Cor e Forma:SolidPeso molecular:398.45BIBD-124
CAS:BIBD-124, with an IC50 value of 9.51 nM, effectively binds to amyloid beta (Aβ) plaques.Fórmula:C19H24FN3O3Cor e Forma:SolidPeso molecular:361.41MK-0969
CAS:MK-0969 (J-104135) is a possible M3 antagonist for the treatment of chronic obstructive pulmonary disease.Fórmula:C24H30F2N4O2Cor e Forma:SolidPeso molecular:444.52SQ-3
SQ-3, a quinoline analogue, prefers α-syn (Ki=39.3nM) to Aβ (Ki=230nM), and [18F]SQ3 is a lead for α-syn probes. [1]Fórmula:C21H21FN2OCor e Forma:SolidPeso molecular:336.4Cloxacepride
CAS:cloxacepride is a CaM antagonist that is used to treat asthma disease.Fórmula:C22H27Cl2N3O4Pureza:99.76%Cor e Forma:SolidPeso molecular:468.37Antidepressant agent 4
Antidepressant agent 4: orally active, has antidepressant, anxiolytic, and nootropic effects.Fórmula:C19H38ClN5O2SCor e Forma:SolidPeso molecular:436.06C2-8
CAS:C2-8 inhibits polyQ aggregation, IC50=25 μM (HDQ51), 0.05 μM (PC12 cells), reduces neurodegeneration in Huntington's models.Fórmula:C19H14Br2N2O3SCor e Forma:SolidPeso molecular:510.2Methyl ganoderate A acetonide
CAS:Methyl ganoderate A from Ganoderma lucidum is a natural AChE inhibitor (IC50=18.35 μM) for Alzheimer's research.Fórmula:C34H50O7Cor e Forma:SolidPeso molecular:570.76ANQ-9040
CAS:ANQ-9040 is a nondepolarizing neuromuscular relaxant of the steroid class.Fórmula:C36H58N2O5SCor e Forma:SolidPeso molecular:630.922-Methyl-N,N-dimethyltryptamine
CAS:2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) exhibits binding affinity for the serotonin (5-HT) receptor, with a pA2 value of 6.04. It plays a significant role in neurological disease research.Fórmula:C13H18N2Cor e Forma:SolidPeso molecular:202.3Anagyrine hydrochloride
CAS:Anagyrine hydrochloride, a quinolizidine from Lupinus albus, targets muscarinic/nicotinic receptors; IC50: 132/2096 µM. It desensitizes nAChR directly.Fórmula:C15H21ClN2OCor e Forma:SolidPeso molecular:280.79Sabirnetug
CAS:Sabirnetug is a humanized IgG2κ monoclonal antibody that specifically targets the amyloid-β (A4) precursor protein.Cor e Forma:LiquidNaratriptan D3 Hydrochloride
CAS:Naratriptan D3 Hydrochloride is the deuterium labeled Naratriptan, is a selective agonist of 5-HT1 receptor subtype.Fórmula:C17H26ClN3O2SPureza:98%Cor e Forma:SolidPeso molecular:374.94Orexin A (human, rat, mouse)
CAS:Orexin A, a 33 AA neuropeptide in humans, rats, mice, influences various processes, studied in pancreatic function and as an OX1R antagonist.Fórmula:C152H243N47O44S4Pureza:98%Cor e Forma:SolidPeso molecular:3561.1AAK1-IN-11
AAK1-IN-11 is an inhibitor of AAK1 (adaptor associated kinase 1) with an IC50 of 2 nM, and it exhibits antiviral activity.Cor e Forma:Odour SolidLtIA-F
LtIA-F, a fluorescent LtIA derivative, aids study of α3β2 nAChR's structure, distribution, and binding domain.Fórmula:C86H121N25O22S4Cor e Forma:SolidPeso molecular:1985.31PD24
PD24 serves as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with inhibitory concentrations (IC50) of 1.72 μM for humanFórmula:C24H22N2O6Cor e Forma:SolidPeso molecular:434.445-HT6R antagonist 6
5-HT6R antagonist 6 (Compound PP15) exhibits high affinity and selectivity for the 5-HT6R receptor, with a Ki of 42 nM. It demonstrates weak antiproliferative activity on tumor cells and low toxicity toward normal cells. 5-HT6R antagonist 6 is applicable in tumor research.Fórmula:C24H26N4O2SCor e Forma:SolidPeso molecular:434.55GABAA receptor modulator-4
GABAA receptor modulator-4 (Compound 4) acts as a negative allosteric modulator of the GABAA receptor. It inhibits the peak and steady-state currents mediated by the α1β3γ2 GABAA receptors, with an IC50 of 10 μM for both.Fórmula:C15H17BrO4SCor e Forma:SolidPeso molecular:373.265α-Androst-16-en-3α-ol
CAS:5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2ItFórmula:C19H30OCor e Forma:SolidPeso molecular:274.448Orexin B, human
CAS:Orexin B, human agonizes Orexin receptors (OX1 Ki=420 nM, OX2 Ki=36 nM), promotes feeding in rats, and is a neuropeptide.Fórmula:C123H212N44O35SPureza:98%Cor e Forma:SolidPeso molecular:2899.34Octamylamine
CAS:Octamylamine is a bioactive chemical.Fórmula:C13H29NCor e Forma:SolidPeso molecular:199.3761Aloveroside A
CAS:Aloveroside A, a triglucosylnaphthalene derivative extracted from Aloe vera using ethanol, exhibits modest inhibitory activity against bACE, demonstratingFórmula:C30H40O17Cor e Forma:SolidPeso molecular:672.63Antipsychotic agent-2
Compound 11: potent antipsychotic, binds 5-HT1A/2A/2C, D2, H1 receptors; K is 56.6-1140 nM, BBB permeable.Fórmula:C22H26FN5OCor e Forma:SolidPeso molecular:395.47CPN-267
CAS:CPN-267 (compound 7b) acts as a selective agonist for the neuromediatin U receptor 1 (NMUR1), exhibiting an EC50 value of 0.25 nM. It effectively inhibits weight gain in mice, making it useful for obesity research.Fórmula:C50H66N16O8SCor e Forma:SolidPeso molecular:1051.23Br-PBTC
CAS:Br-PBTC modulates nAChRs; targets α2/β2,4 subtypes; potent with 0.1-0.6 μM EC50; binds α subunit c-tail.Fórmula:C14H15BrN2OSCor e Forma:SolidPeso molecular:339.25nAChR modulator-2
CAS:nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] .Fórmula:C12H8ClN3O2Cor e Forma:SolidPeso molecular:261.66Iloperidone metabolite P95
CAS:Iloperidone metabolite P95, a non-brain penetrating compound, binds 5-HT2A, α1-, α2B-, α2C-receptors with Ki of 7.08-83.18 nM.Fórmula:C23H25FN2O5Cor e Forma:SolidPeso molecular:428.46Encecalinol
CAS:Encecalinol, a compound isolated from the aerial parts of Ageratina grandifolia, acts as a potent inhibitor of calmodulin [1].Fórmula:C14H18O3Cor e Forma:SolidPeso molecular:234.29β-Amyloid (1-9)
CAS:This is an N-terminal fragment of beta amyloid.Fórmula:C42H60N14O17Pureza:98%Cor e Forma:SolidPeso molecular:1033.01AChE-IN-37
AChE-IN-37 (compound A2) is an acetylcholinesterase inhibitor with an inhibitory concentration (IC50) of 0.23 µM.Fórmula:C21H12ClNO7SCor e Forma:SolidPeso molecular:457.84LY86057
CAS:LY86057 is a bioactive chemical.Fórmula:C20H26N2O3Cor e Forma:SolidPeso molecular:342.439I2-IRs ligand-1
I2-IRs ligand-1 (Compound 12d) is an orally active compound capable of crossing the blood-brain barrier. It exhibits high affinity for imidazoline I2 receptors (I2-IRs) with a pKi of 9.98. This compound can enhance cognitive deficits in aging mice and possesses analgesic, anti-inflammatory, and neuroprotective properties. I2-IRs ligand-1 is applicable for research in Alzheimer's disease and related pain disorders.Fórmula:C21H23ClFN2O4PCor e Forma:SolidPeso molecular:452.84Fasciculic acid A
CAS:Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Fórmula:C36H60O8Cor e Forma:SolidPeso molecular:620.868Pseudocoptisine acetate
CAS:Pseudocoptisine acetate is a quaternary alkaloid isolated from the tubers of Corydalis turtschaninovii,with anti-inflammatory properties.Fórmula:C21H17NO6Pureza:98%Cor e Forma:SolidPeso molecular:379.365-HT5AR/5-HT6R ligand-1
5-HT5AR/5-HT6R ligand-1 (Compound PP10) is a ligand for serotonin receptors, exhibiting high affinity for the 5-HT5A and 5-HT6 receptors with Ki values of 59 nM and 96 nM, respectively. It possesses some antiproliferative activity against tumor cells and can be utilized in cancer research.Fórmula:C25H30N4O2SCor e Forma:SolidPeso molecular:450.6Fluphenazine-N-2-chloroethane (hydrochloride)
CAS:Fluphenazine: antipsychotic, binds dopamine D2 (Ki=0.55nM), inhibits calmodulin. Its derivative adds irreversible D2 antagonism and anticancer potential.Fórmula:C22H27Cl3F3N3SCor e Forma:SolidPeso molecular:528.89α-Casozepine
CAS:α-Casozepine,Bioactive peptide from milk α-S1 casein. Binds GABA receptors. Anti-anxiety effects.Fórmula:C60H94N14O16Cor e Forma:SolidPeso molecular:1267.47Asenapine citrate
CAS:Asenapine citrate: atypical antipsychotic for schizophrenia, bipolar disorder; targets serotonin, adrenoceptors, dopamine, histamine (pKi: 8.2-10.5).Fórmula:C23H24ClNO8Cor e Forma:SolidPeso molecular:477.89Lesogaberan napadisylate
CAS:Lesogaberan (AZD-3355) is a selective GABAB agonist with EC50 of 8.6 nM, Ki of 5.1 nM in rats, and acts peripherally on the esophageal sphincter.Fórmula:C13H17FNO5PSCor e Forma:SolidPeso molecular:349.31Lupanine hydrochloride
CAS:Lupanine hydrochloride, a Sparteine derivative, binds to nAChR with a Ki of 500 nM and has ganglioplegic properties.Fórmula:C15H25ClN2OCor e Forma:SolidPeso molecular:284.83TAT-CN21
TatCN21, with an IC 50 of 77 nM, serves as a potent and selective inhibitor peptide of the calcium/calmodulin-dependent protein kinase II (CaMKII), a ubiquitously-expressed multifunctional serine/threonine protein kinase. It is particularly useful in research pertaining to ischemia and neurodegenerative diseases.Fórmula:C169H303N69O43Cor e Forma:SolidPeso molecular:3989.65
