Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(647 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.027 produtos)
- BACE(37 produtos)
- Beta Amilóide(230 produtos)
- CaMK(73 produtos)
- COX(602 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(373 produtos)
- Gama-secretase(62 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(43 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5639 produtos de "Neurociência"
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25E-NBOMe hydrochloride
CAS:25E-NBOMe hydrochloride is a derivative of 2C-E, featuring an N-(2-methoxybenzyl) addition to the amine group, and acts as a selective agonist of the 5-HT2A receptor.Fórmula:C20H28ClNO3Cor e Forma:SolidPeso molecular:365.8925N-NBOMe hydrochloride
CAS:25N-NBOMe hydrochloride is a derivative of 2C-N and acts as an agonist for the 5-HT2A and 5-HT2C receptors, with Ki values of 0.144 nM and 1.06 nM, respectively. It has minimal effect on the release of preloaded neurotransmitters from recombinant dopamine, serotonin, and norepinephrine transporters.Fórmula:C18H23ClN2O5Cor e Forma:SolidPeso molecular:382.846,7-dimethylisatin
CAS:6,7-Dimethylisatin (6,7-dimethyl-1H-indole-2,3-dione) inhibits hGAT3 with IC50 of 108 μM. 6,7-Dimethylisatin also inhibits hBGT1, hGAT2.Fórmula:C10H9NO2Pureza:98.98%Cor e Forma:SolidPeso molecular:175.18CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Fórmula:C17H19N3O2SPureza:99%Cor e Forma:SolidPeso molecular:329.42MAO-B-IN-36
MAO-B-IN-36 (Compound A6) is an effective MAO-B inhibitor with an IC50 of 13 nM.Fórmula:C20H14O3Cor e Forma:SolidPeso molecular:302.324-Chloromethamphetamine hydrochloride
CAS:4-Chloromethamphetamine hydrochloride is a novel psychoactive substance belonging to the amphetamine class.Fórmula:C10H15Cl2NCor e Forma:SolidPeso molecular:220.14MLCK Peptide
CAS:MLCK Peptide, a high-affinity (pM), fully reversible CaM-binding peptide, is derived from smooth muscle myosin light-chain kinase [1].Fórmula:C91H156N36O20Cor e Forma:SolidPeso molecular:2074.44Zanapezil free base
CAS:Zanapezil (TAK-147): potent, selective AChE inhibitor; reversible; IC50=51.2 nM; moderate M1/M2 inhibition; AD research potential.Fórmula:C25H32N2OCor e Forma:SolidPeso molecular:376.544Ro 12-5637
CAS:Ro 12-5637 is a metabolite of moclobemide.Fórmula:C13H17ClN2O3Cor e Forma:SolidPeso molecular:284.74CPN-267
CAS:CPN-267 (compound 7b) acts as a selective agonist for the neuromediatin U receptor 1 (NMUR1), exhibiting an EC50 value of 0.25 nM. It effectively inhibits weight gain in mice, making it useful for obesity research.Fórmula:C50H66N16O8SCor e Forma:SolidPeso molecular:1051.23Furosemide sodium
CAS:Furosemide sodium: potent NKCC inhibitor, loop diuretic, treats heart failure, hypertension, edema, selective GABAA antagonist.Fórmula:C12H10ClN2NaO5SPureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:352.73Desalkylgidazepam
CAS:Desalkylgidazepam, a benzodiazepine compound, is a metabolite of gidazepam. It is capable of activating both GABA A-type receptors and the translocator protein (TSPO).Fórmula:C15H11BrN2OCor e Forma:SolidPeso molecular:315.17Rilmazolam
CAS:Rilmazolam is a triazolobenzodiazepine compound and serves as the active metabolite of Rilmazafone.Fórmula:C19H15Cl2N5OCor e Forma:SolidPeso molecular:400.267-Methyl DMT
CAS:7-Methyl DMT (7-TMT) acts as a 5-HT2 receptor agonist. Structurally, it is a tryptamine derivative and serves as an analytical reference for the psychoactive substance DOM. It is also applicable in research related to neurological disorders.Fórmula:C13H18N2Cor e Forma:SolidPeso molecular:202.3PF-06827443
PF-06827443 is a orally bioavailable, CNS-penetrant M1-selective PAM with minimal agonist activity.Fórmula:C24H24N2O4Cor e Forma:SolidPeso molecular:404.47Pridinol hydrochloride
CAS:Pridinolhydrochloride is the hydrochloride form of Pridinol. Pridinol hydrochloride is an orally active anticholinergic agent, which can also be used as a muscle relaxant.Fórmula:C20H26ClNOCor e Forma:SolidPeso molecular:331.88β-Amyloid (12-28)
CAS:Amyloid β-peptide fragment; minimum section required to bind to brain proteins.Fórmula:C89H135N25O25Pureza:98%Cor e Forma:SolidPeso molecular:1955.18MMPIP hydrochloride
CAS:MMPIP hydrochloride is a selective antagonist of allosteric mGluR7.Fórmula:C19H16ClN3O3Pureza:99.88%Cor e Forma:SolidPeso molecular:369.8Ref: TM-T23008L
1mg56,00€5mg119,00€1mL*10mM (DMSO)133,00€10mg192,00€25mg394,00€50mg585,00€100mg833,00€200mg1.134,00€β-Amyloid (4-10)
CAS:Antibodies corresponding to beta-amyloid (4-10) are effective in vivo inhibitors of cytotoxicity, amyloid plaque formation and special memory disturbances inFórmula:C39H52N12O12Pureza:98%Cor e Forma:SolidPeso molecular:880.9Melatonin-Tamoxifen Conjugate
Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate made of Melatonin and Tamoxifen, serving as an effective antagonist of ERα (IC50 = 863 nM). In cells expressing the hMT1 receptor, it binds to MLT receptors (Ki = 3.1 nM) and exhibits the ability to promote β-arrestin activation (EC50 = 914 nM) and ERK activation (EC50 = 98 nM). The IC50 values for Melatonin-Tamoxifen Conjugate in MCF-7, MDA-MB-231, and HT-1080 cell lines are 6.8 μM, 6.4 μM, and 1.7 μM, respectively.Fórmula:C47H58N4O4Cor e Forma:SolidPeso molecular:742.99Methamnetamine hydrochloride
CAS:Methamnetamine (PAL-1046) hydrochloride is a psychoactive substance derived from phenethylamine, known to cause excessive serotonin release.Fórmula:C14H18ClNCor e Forma:SolidPeso molecular:235.75TZ4M
TZ4M, a 2,4-thiazolidinedione (TZD)-based anti-ADV agent, exhibits neuroprotective effects and acetylcholinesterase (AChE) inhibition in human plasma.Fórmula:C19H15NO4SCor e Forma:SolidPeso molecular:353.39β-Amyloid (1-40)
CAS:Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases.Fórmula:C194H295N53O58SPureza:98%Cor e Forma:SolidPeso molecular:4329.82PD07
PD07 is an orally active acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 of 0.29 μM against human AChE, and demonstrates inhibition of cholinesterasesFórmula:C23H21ClN2O4Cor e Forma:SolidPeso molecular:424.88Arisugacin G
CAS:Arisugacin G, a microbial metabolite, is a structural analogue of Arisugacin A. Unlike its analogue, Arisugacin G does not exhibit activity against AChE (acetylcholinesterase).Fórmula:C27H32O5Cor e Forma:SolidPeso molecular:436.54Dehydro Aripiprazole (hydrochloride)
CAS:Dehydro aripiprazole, an active atypical antipsychotic metabolite of aripiprazole, is formed by CYP3A4 and CYP2D6.Fórmula:C23H26Cl3N3O2Cor e Forma:SolidPeso molecular:482.83Tetrahydro-β-carboline
CAS:Compound Fr12161, with CAS No. 16502-01-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr12161 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C11H12N2Pureza:96.31%Cor e Forma:Tan SolidPeso molecular:172.22644-Hydroxy MET
CAS:4-Hydroxy MET (4-HO-MET) is a tryptamine-based new psychoactive substance (NPS), structurally similar to the endogenous neurotransmitter serotonin. It has hallucinogenic properties that affect mood, movement, and cognitive functions.Fórmula:C13H18N2OCor e Forma:SolidPeso molecular:218.3Cianopramine hydrochloride
CAS:Cianopramine hydrochloride is a bio-active chemical.Fórmula:C20H24ClN3Cor e Forma:SolidPeso molecular:341.88GM-60186
GM-60186, a potent inhibitor of the 5-HT receptor 2B (HTR2B) with an IC50 of 257 nM, effectively suppresses the proliferation and migration of colorectal cancer cells.Fórmula:C30H33FN2O4Cor e Forma:SolidPeso molecular:504.592-APB hydrochloride
CAS:2-APB is an analog of 6-APB and falls under the category of benzofuran derivatives, known for its psychoactive properties. Certain benzofuran derivatives also exhibit monoamine oxidase-A (MAO-A) inhibitory activity.Fórmula:C11H14ClNOCor e Forma:SolidPeso molecular:211.69MAO-B-IN-37
CAS:MAO-B-IN-37 (Compound 37) is a derivative of TT01001 and acts as a selective inhibitor of monoamine oxidase B (MAO-B), with an IC50 of 270 nM. It exhibits good metabolic stability in mouse microsomes and shows strong affinity for human serum albumin.Fórmula:C14H12FN3O3Cor e Forma:SolidPeso molecular:289.26Pellotine
CAS:Pellotine is an alkaloid isolated from Lophophora. It acts as an inverse agonist of the 5-HT7 receptor (5-HT7 receptor), with an EC50 of 291 nM. Pellotine shows strong affinity for the 5-HT1DR and 5-HT6R, with Ki values of 117 nM and 170 nM, respectively. Additionally, Pellotine reduces intracellular cAMP levels, thereby decreasing neuronal excitability and neurotransmitter release.Fórmula:C13H19NO3Cor e Forma:SolidPeso molecular:237.295BChE-IN-39
BChE-IN-39 (Compound 7c) selectively inhibits butyrylcholinesterase (BChE) with an IC50 of 0.08 μM, while showing an IC50 of 3.98 μM for acetylcholinesterase (AChE) inhibition. Additionally, BChE-IN-39 downregulates GSK-3β expression, thereby inhibiting the excessive phosphorylation of tau protein.Fórmula:C29H23ClFN3O3Cor e Forma:SolidPeso molecular:515.963Chrodrimanin B
CAS:Chrodrimanin B is a useful organic compound for research related to life sciences. The catalog number is T126052 and the CAS number is 132196-54-4.Fórmula:C27H32O8Cor e Forma:SolidPeso molecular:484.5455-AMAM-2-CP
CAS:5-AMAM-2-CP, a significant metabolite of Acetamiprid, serves as a global insecticide within the neonicotinoid class and acts as an nAChR agonist [1] [2].Fórmula:C9H11ClN2OCor e Forma:SolidPeso molecular:198.65β-Amyloid Protein Precursor 770 (135-155)
CAS:Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)
Fórmula:C116H172N35O31S2Pureza:98%Cor e Forma:SolidPeso molecular:2617.96AAK1-IN-11
AAK1-IN-11 is an inhibitor of AAK1 (adaptor associated kinase 1) with an IC50 of 2 nM, and it exhibits antiviral activity.Cor e Forma:Odour Solid2-Hydroxyalbrassitriol
CAS:2-Hydroxyalbrassitriol (Compound 6) is an AChE inhibitor with an IC 50 of 35.97 μM [1] .Fórmula:C15H26O4Cor e Forma:SolidPeso molecular:270.36Zalospirone
CAS:Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder.Fórmula:C24H29N5O2Pureza:98.24% - 99.82%Cor e Forma:SolidPeso molecular:419.52NPS ALX Compound 4a hydrochloride(1:1)
NPS ALX Compound 4a hydrochloride(1:1) is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.Fórmula:C25H26ClN3O2SPureza:99.84%Cor e Forma:SoildPeso molecular:468.01Ref: TM-T12262L1
1mg38,00€5mg84,00€1mL*10mM (DMSO)92,00€10mg113,00€25mg188,00€50mg273,00€100mg371,00€200mg494,00€AChE-IN-87
AChE-IN-87 is an AChE inhibitor with an IC50 of 0.05 μM and a Ki of 16.93 nM. It exhibits no cytotoxicity toward 3T3 cells and is suitable for Alzheimer's disease (AD) research.Fórmula:C32H39N3O12S2Cor e Forma:SolidPeso molecular:721.19752Fipronil sulfone
CAS:Fipronil sulfone is an insecticide fipronil. Its metabolite fipronil sulphone is an inhibitor of rat ɑ1β2γ2L GABA(A) receptor.Fórmula:C12H4Cl2F6N4O2SPureza:98%Cor e Forma:SolidPeso molecular:453.14Palonosetron N-oxide
CAS:Palonosetron N-oxide: metabolite and potential impurity of 5-HT3 antagonist palonosetron; forms under oxidative stress.Fórmula:C19H24N2O2Cor e Forma:SolidPeso molecular:312.41312,14-Dichlorodehydroabietic acid
CAS:12,14-Dichlorodehydroabietic acid activates BK channels, blocks GABA A receptors, and increases calcium and neurotransmitter release.Fórmula:C20H26Cl2O2Cor e Forma:SolidPeso molecular:369.33Brexanolone caprilcerbate
CAS:Brexanolone caprilcerbate is an effective positive allosteric modulator of the GABAA receptor.Fórmula:C48H78O12Cor e Forma:SolidPeso molecular:847.13SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Fórmula:C94H162N36O23SPureza:98%Cor e Forma:SolidPeso molecular:2196.586-Fluoro-N,N-diethyltryptamine
CAS:6-Fluoro-N,N-diethyltryptamine (6-F-DET) exhibits affinity for the 5-HT2A receptor.Fórmula:C14H19FN2Cor e Forma:SolidPeso molecular:234.31MAO-B-IN-18
MAO-B-IN-18 is a potent, selective inhibitor of MAO B, demonstrating IC50 values of 52 nM for hMAO B and 14 μM for hMAO A.Fórmula:C25H22N4O5Pureza:98%Cor e Forma:SolidPeso molecular:458.47DSP-1053
CAS:Dsp-1053 is a powerful SERT (Ki=1.02 nM) inhibitor with partial 5-HT1A receptor (Ki=5.05 nM) agonizing activity.Fórmula:C26H32BrNO4Pureza:98%Cor e Forma:SolidPeso molecular:502.44
