Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(647 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.027 produtos)
- BACE(37 produtos)
- Beta Amilóide(230 produtos)
- CaMK(73 produtos)
- COX(602 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(373 produtos)
- Gama-secretase(62 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(43 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5639 produtos de "Neurociência"
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α-Conotoxin imi
CAS:alpha-Conotoxin imi is a nicotinic acetylcholine receptor ligand.Fórmula:C52H78N20O15S4Pureza:98%Cor e Forma:SolidPeso molecular:1351.56Furosemide sodium
CAS:Furosemide sodium: potent NKCC inhibitor, loop diuretic, treats heart failure, hypertension, edema, selective GABAA antagonist.Fórmula:C12H10ClN2NaO5SPureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:352.73Olanzapine Lactam Impurity
CAS:Olanzapine lactam impurity, found in olanzapine, forms under heat or oxidative stress.Fórmula:C17H20N4O2Cor e Forma:SolidPeso molecular:312.373Millmerranone A
Millmerranone A shows the acetylcholinesterase inhibitory property.Fórmula:C27H28O9Cor e Forma:SolidPeso molecular:496.515H-Pyrido[4,3-b]indole
CAS:5H-Pyrido[4,3-b]indole is a potential AchE/ChE inhibitor with potential antiviral activity for the study of neurodegenerative diseases.Fórmula:C11H8N2Pureza:99.6%Cor e Forma:SolidPeso molecular:168.2Paecilomide
CAS:Paecilomide is a pyridone alkaloid and acetylcholinesterase inhibitor [1] .Fórmula:C12H15NO4Cor e Forma:SolidPeso molecular:237.25Osmanthuside B
CAS:Osmanthuside B, isolated from Pseuderanthemum carruthersii (Seem.) Guill.Fórmula:C29H36O13Cor e Forma:SolidPeso molecular:592.59Furosemide
CAS:Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.Fórmula:C12H11ClN2O5SPureza:99.32% - 99.89%Cor e Forma:Crystals From Aqueous Ethanol Tasteless (Ntp 1992)Peso molecular:330.744(Rac)-Oleoylcarnitine
CAS:(Rac)-Oleoylcarnitine, an endogenous acylcarnitine, acts as a potential non-competitive inhibitor of glycine transporter 2 (GLYT2) and can be used as a pain suppressant.Fórmula:C25H47NO4Peso molecular:425.65Cinanserin hydrochloride
CAS:Cinanserin hydrochloride (SQ 10643) is a 5-HT2 receptor blocker (Ki: 41 nM) and SARS-CoV 3C-like protease inhibitor.Fórmula:C20H25ClN2OSPureza:99.57%Cor e Forma:SolidPeso molecular:376.94Zalospirone
CAS:Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder.Fórmula:C24H29N5O2Pureza:98.24% - 99.82%Cor e Forma:SolidPeso molecular:419.52Atagabalin
CAS:Atagabalin (PD 0200390), a gabamimetic for insomnia treatment and related to gabapentin, was halted due to poor trial outcomes.Fórmula:C10H19NO2Cor e Forma:SolidPeso molecular:185.26Amyloid-β-IN-1
Amyloid-β-IN-1 (compound 13), a synthetic peptide featuring the hydrophobic C-terminal segment "VVIA-NH2" and its reversed sequence "AIVV-NH2" derived from Aβ 42, acts as an Aβ inhibitor. It effectively inhibits Aβ aggregation and exhibits neuroprotective effects.Fórmula:C18H35N5O4Peso molecular:385.5Eletriptan
CAS:Eletriptan, second-generation triptans used to treat migraines, is used as an abortion drug.Fórmula:C22H26N2O2SCor e Forma:SolidPeso molecular:382.52Sulamserod
CAS:Sulamserod (RS 100302) is a potent 5-HT4 receptor antagonist with antiarrhythmic activity for the study of atrial fibrillation and cardiovascular relatedFórmula:C19H28ClN3O5SPureza:98.76%Cor e Forma:SolidPeso molecular:445.96RA306
RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.Cor e Forma:Odour SolidOXA(17-33)
CAS:Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.Fórmula:C79H125N23O22Pureza:98%Cor e Forma:SolidPeso molecular:1749HDAC6-IN-49
HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.Cor e Forma:Odour SolidPolyglutamine binding peptide 1
CAS:Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor of polyglutamine (polyQ). It effectively inhibits polyQ protein aggregation in vitro and prevents polyQ-induced cell death in cell cultures.Fórmula:C72H90N16O16Cor e Forma:SolidPeso molecular:1435.58VU0483605
CAS:VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
Fórmula:C20H10Cl3N3O3Pureza:99.61%Cor e Forma:SolidPeso molecular:446.67DCCCyb
CAS:DCCCyb: oral GlyT1 inhibitor with high in vivo occupancy in rhesus monkeys, confirmed by PET tracer displacement.Fórmula:C22H29Cl2NO3SPureza:98%Cor e Forma:SolidPeso molecular:458.44Isonaringin
CAS:Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.
Fórmula:C27H32O14Cor e Forma:SolidPeso molecular:580.53MRS8209
MRS8209 is an antagonist of the serotonin receptor (serotonin receptor), with a Ki value of 4.27 nM specifically for 5-HT2BR. It provides protective effects on pulmonary airway opening pressure (PAO) and is applicable in pulmonary fibrosis studies.Fórmula:C17H19IN6O2Cor e Forma:SolidPeso molecular:466.276Hydroxytacrine maleate
CAS:Hydroxytacrine maleate (Velnacrine maleate) is a cholinesterase inhibitor used in the study of Alzheimer's type dementia (SDAT).Fórmula:C17H18N2O5Pureza:98.84%Cor e Forma:SolidPeso molecular:330.34Rocuronium
CAS:Rocuronium is an blocker of aminosteroid non-depolarizing neuromuscular.Fórmula:C32H53N2O4Pureza:98%Cor e Forma:SolidPeso molecular:529.77N-Ethyl-N-(3-pyridylmethyl)amine
CAS:N-Ethyl-N-(3-pyridylmethyl)amine has affinity for nAChR (Ki = 0.97 µM) and can be used in related research in the field of life sciences.Fórmula:C8H12N2Pureza:99.65%Cor e Forma:SolidPeso molecular:136.19Rasagiline 13C3 mesylate racemic
CAS:Rasagiline 13C3 mesylate racemic is the deuterium labeled Rasagiline, which is an irreversible monoamine oxidase inhibitor.Fórmula:C13H17NO3SPureza:98%Cor e Forma:SolidPeso molecular:270.32Anticonvulsant agent 8
Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.Fórmula:C15H11N5OCor e Forma:SolidPeso molecular:277.28rel-Sertraline-d3 hydrochloride
CAS:The compound rel-Sertraline-d3 (hydrochloride) is the deuterated form of Sertraline hydrochloride, a selective serotonin reuptake inhibitor (SSRI) antidepressant. Sertraline hydrochloride is utilized in the investigation of various conditions, including major depressive disorder and obsessive-compulsive disorder.Fórmula:C17H18Cl3NCor e Forma:SolidPeso molecular:345.71Choline Chloride-13C3
Choline Chloride-13C3 is a 13C-labeled variant of choline (chloride). This organic compound and quaternary ammonium salt serves as a substrate for acyl receptors and choline acetyltransferase. Additionally, it acts as a photosynthesis enhancer in plants and is employed as a feed additive for poultry and livestock, promoting egg and offspring production.Cor e Forma:Odour Solidα5-GABAA receptor modulator 1
α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.Fórmula:C21H20FN3O4Cor e Forma:SolidPeso molecular:397.4Isograndifoliol
CAS:Isograndifoliol: BChE inhibitor (IC50=0.9μM), weaker AChE inhibitor (IC50=342.9μM), with vasorelaxant and anti-tumor properties.Fórmula:C19H26O3Cor e Forma:SolidPeso molecular:302.41bPiDDB
CAS:bPiDDB (N,N'-Dodecylbis-Picolinium Bromide) is a nicotinic receptor (nAChR) antagonist.
Fórmula:C24H38Br2N2Pureza:98.72%Cor e Forma:SolidPeso molecular:514.38AChE-IN-43
AChE-IN-43 is a potent, selective AChE inhibitor with a K i of 0.41 μM, applicable in the study of neurological diseases [1].Cor e Forma:Odour SolidBuChE-IN-16
BuChE-IN-16 (Compound 6a) is an orally active, blood-brain barrier-permeable, and selective BuChE inhibitor with an IC50 of 0.33 μM. It exhibits anti-inflammatory and neuroprotective effects, improves cognitive function in Alzheimer's disease (AD) zebrafish models, and alleviates scopolamine-induced memory impairment in mice. BuChE-IN-16 is applicable for Alzheimer's disease research.Fórmula:C16H22N2O3Cor e Forma:SolidPeso molecular:290.36JNJ-67569762
CAS:JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket ( IC 50 = 2.7 nM).Fórmula:C22H22F4N4O5SCor e Forma:SolidPeso molecular:530.49Antidepressant agent 10
CAS:Compound PDK0386, with CAS No. 87691-87-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0386 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C11H13N3SPeso molecular:219.306Soclenicant
CAS:Soclenicant is a negative-altering modulator of α 7 -nAChR for anxiety, depression, and PTSD, due to its high selectivity, oral availabilityFórmula:C24H26N4O3Pureza:99.57%Cor e Forma:SoildPeso molecular:418.492'-O-Succinyl-cAMP
CAS:2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate is an immunogenic derivative of cAMP that has been used to generate anti-cAMP antisera and antibodies.1,2Fórmula:C14H16N5O9PCor e Forma:SolidPeso molecular:429.282VU6028418
CAS:VU6028418 is a highly selective, potent, orally active M4mAChR antagonist that acts on hM4 (IC50: 4.1 nM).Fórmula:C23H27F3N4OCor e Forma:SolidPeso molecular:432.491(Rac)-Norcisapride
CAS:Norcisapride, a 5-HT3 and 5-HT4 agonist, treats GI, orofacial, and ENT disorders.Fórmula:C14H20ClN3O3Pureza:99.32%Cor e Forma:SoildPeso molecular:313.78Nipecotic acid
CAS:Compound PDK0243, with CAS No. 498-95-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0243 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.
Fórmula:C6H11NO2Cor e Forma:Off-White To Pale Yellow-Beige PowderPeso molecular:129.16MIDD0301
CAS:MIDD0301 is a potent positive allosteric α5β3γ selective GABAA receptor (GABAAR) ligand with EC50 of 17 nM.Fórmula:C19H13BrFN3O2Pureza:98%Cor e Forma:SolidPeso molecular:414.23Cevimeline hydrochloride hemihydrate
CAS:Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
Fórmula:C20H38Cl2N2O3S2Pureza:97.00%Cor e Forma:SolidPeso molecular:489.55Dipentylone hydrochloride
CAS:Dipentylone hydrochloride (Bk-dmbdp HCl) is a psychoactive synthetic cathinone and sympathomimetic stimulant. Its inhibitory activity towards the dopamine transporter (IC50=0.233µM) is tenfold higher than that towards NET and SERT, inhibiting dopamine uptake and stimulating locomotor activity in mice.Fórmula:C14H20ClNO3Pureza:99.94%Cor e Forma:SolidPeso molecular:285.77β-Amyloid (35-42)
CAS:β-Amyloid (35-42) is a peptide derived from the beta-amyloid protein, encompassing amino acids 35 through 42.Fórmula:C33H60N8O9SPureza:98%Cor e Forma:SolidPeso molecular:744.94Xanthohumol I
Xanthohumol I is a natural product that can be used as a reference standard.Fórmula:C21H22O6Cor e Forma:SolidPeso molecular:370.401PD10
PD10 is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), exhibiting inhibitory potency at human AChE (hAChE IC50: 0.56 μM),Fórmula:C23H21BrN2O4Cor e Forma:SolidPeso molecular:469.33Mant-GTPγS
CAS:Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH.Fórmula:C18H23N6O14P3SCor e Forma:SolidPeso molecular:672.39
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