Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(1.025 produtos)
- ACK(1 produtos)
- AChR(645 produtos)
- ATP Citrato Liase(17 produtos)
- Receptor adrenérgico(3.018 produtos)
- BACE(37 produtos)
- Beta Amilóide(228 produtos)
- CaMK(73 produtos)
- COX(600 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor GABA(372 produtos)
- Gama-secretase(61 produtos)
- GluR(265 produtos)
- GlyT(26 produtos)
- Receptor de Histamina(385 produtos)
- LRRK2(43 produtos)
- Receptor de Melatonina(26 produtos)
- NMDAR(10 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5523 produtos de "Neurociência"
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4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).Fórmula:C14H11BrN2SPureza:98%Cor e Forma:SolidPeso molecular:319.22Catestatin
CAS:Non-competitive inhibitor of nicotinic receptors; blocks cationic signalling and catecholamine release; stimulates histamine release. IC50 ~200-250nM.Fórmula:C107H173N37O26SPureza:98%Cor e Forma:SolidPeso molecular:2425.84VU0477886
CAS:VU0477886: Potent mGlu4 PAM, effective in preclinical Parkinson's model HIC.Fórmula:C20H13ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:392.806-hydroxy Buspirone
CAS:6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4.Fórmula:C21H31N5O3Cor e Forma:SolidPeso molecular:401.50Pardoprunox
CAS:Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties.Fórmula:C12H15N3O2Pureza:98%Cor e Forma:SolidPeso molecular:233.27Hydroxy ziprasidone
CAS:Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a 5-HT and dopamine receptor antagonist.Fórmula:C21H21ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:428.94VU0029767
CAS:VU0029767 is an allosteric enhancer of the M1 muscarinic receptor, capable of modulating the receptor's activity. This compound enhances M1 receptor activity by increasing agonist affinity. However, VU0029767 demonstrates distinct characteristics from other compounds, particularly under varying experimental conditions such as its interaction with mutated M1 receptors and its effects on downstream signaling pathways.
Fórmula:C21H21N3O3Cor e Forma:SolidPeso molecular:363.41MCI-225 dehydratase
CAS:MCI-225 dehydratase is an oral, selective inhibitor of noradrenaline reuptake, and functions as a 5-HT3 antagonist, exhibiting antidepressant effects in vivo .Fórmula:C17H18ClFN4SCor e Forma:SolidPeso molecular:364.87Nicardipine pyridine metabolite II
CAS:Nicardipine pyridine metabolite II is a biaoctive chemical.Fórmula:C26H27N3O6Cor e Forma:SolidPeso molecular:477.51Diclofensine
CAS:Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine.Fórmula:C17H17Cl2NOPureza:97.01% - 98.13%Cor e Forma:SolidPeso molecular:322.23Dianicline dihydrochloride
CAS:Dianicline dihydrochloride is a partial agonist of α4β2 nicotinic acetylcholine receptor. It increases cessation rates in a dose-dependent manner.Fórmula:C13H16N2OPureza:98%Cor e Forma:SolidPeso molecular:216.28Eprodisate
CAS:Eprodisate disrupts protein-glycosaminoglycan binding, halting amyloid fibril formation, potentially delaying AA amyloidosis progression.Fórmula:C3H8O6S2Cor e Forma:SolidPeso molecular:204.22Penbutolol sulfate
CAS:Penbutolol sulfate ((-)-Terbuclomine) is able to bind to both β2-adrenergic receptor and β1-adrenergic receptor, thus making it a non-selective β blocker.Fórmula:C18H29NO2H2O4SPureza:99.95%Cor e Forma:SolidPeso molecular:340.47SB 271046 hydrochloride
CAS:SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist and is > 200-fold selective over 55 other receptors, enzymes and ion channels.Fórmula:C20H22ClN3O3S2·HClPureza:99.77%Cor e Forma:SolidPeso molecular:488.45AN317
CAS:AN317 is a selective agonist for the nicotinic acetylcholine receptor (nAChR) containing α6β2, with dissociation constants (Ki) of 6.2 nM and 4.1 nM for the α6/α3β2β3 and α4β2 receptor subtypes, respectively. It induces dopamine release in rat striatal synaptosomes, enhances the activity of dopaminergic neurons in the substantia nigra, and exhibits protective effects against the dopaminergic neurotoxin MPP+ in rat neurons. AN317 also demonstrates favorable pharmacokinetic properties in rats and permeability across the blood-brain barrier (BB).Fórmula:C13H19N3Cor e Forma:SolidPeso molecular:217.31Aftin-5
CAS:Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.Fórmula:C19H26N6OCor e Forma:SolidPeso molecular:354.45Biperiden lactate
CAS:Biperiden lactate is a biochemical.Fórmula:C24H35NO4Cor e Forma:SolidPeso molecular:401.547-Desmethyl-3-hydroxyagomelatine
CAS:7-Desmethyl-3-hydroxyagomelatine, less active than parent drug Agomelatine, is a melatonergic agonist and 5-HT2C antagonist.Fórmula:C14H15NO3Pureza:98%Cor e Forma:SolidPeso molecular:245.27Phenglutarimide hydrochloride
CAS:Phenglutarimide hydrochloride is an anticholinergic. It is used as an antiparkinsonian agent.Fórmula:C17H25ClN2O2Cor e Forma:SolidPeso molecular:324.85Aprofene
CAS:Aprofene blocks acetylcholine receptors, used for peptic ulcers, endarteritis, cholecystitis, and colitis.Fórmula:C21H27NO2Cor e Forma:SolidPeso molecular:325.44Aβ1-42 aggregation inhibitor 1
CAS:Aβ1-42 aggregation inhibitor 1 effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), demonstrating IC50 values of 2.64 μM and 1.29Fórmula:C29H32N4SCor e Forma:SolidPeso molecular:468.66(4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid
CAS:Produto ControladoApplications (4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid (CAS# 53587-33-0) is a useful isotopically labeled research compound.
Fórmula:C9H8D2O4Cor e Forma:NeatPeso molecular:184.196S-Nalfurafine
CAS:Produto ControladoApplications 6S-Nalfurafine is a stereoisomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.
References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)Fórmula:C28H32N2O5Cor e Forma:NeatPeso molecular:476.562-(4-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride
CAS:Produto ControladoFórmula:C13H17Cl2NOCor e Forma:NeatPeso molecular:274.192-(3-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride
CAS:Produto ControladoFórmula:C13H17Cl2NOCor e Forma:NeatPeso molecular:274.192Z-Nalfurafine
CAS:Produto ControladoApplications 2Z-Nalfurafine is a geometric isomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.
References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)Fórmula:C28H32N2O5Cor e Forma:NeatPeso molecular:476.56Dolasetron Mesylate
CAS:Dolasetron Mesylate (MDL-73147EF) is an antagonist of the 5-HT3 receptor and can be used in research on the treatment of vomiting and nausea followingFórmula:C20H24N2O6SPureza:99.05%Cor e Forma:White PowderPeso molecular:420.48Paroxetine hydrochloride hemihydrate
CAS:Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).Fórmula:C38H44Cl2F2N2O7Pureza:99.949%Cor e Forma:SolidPeso molecular:749.67LY 344864
CAS:LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.Fórmula:C21H22FN3OPureza:98%Cor e Forma:SolidPeso molecular:351.42(R)-Baclofen hydrochloride
CAS:Arbaclofen HCl, a GABA-B agonist, treats spasticity from spinal injury by reducing excitatory transmission.Fórmula:C10H13Cl2NO2Pureza:98%Cor e Forma:SolidPeso molecular:250.12MHP 133
CAS:MHP 133 is a drug with multiple CNS targets(AChE with Ki of 69 μM).Fórmula:C17H20ClN5O3Pureza:98%Cor e Forma:SolidPeso molecular:377.83PD-102807
CAS:PD-102807 is a selective and competitive M4 muscarinic receptor antagonist for Parkinson's disease research, inhibit airway smooth muscle (ASM) contraction.Fórmula:C23H24N2O4Pureza:98.90%Cor e Forma:SolidPeso molecular:392.45Lintopride
CAS:Lintopride is an antagonist of 5HT4. It has moderate 5HT3 antagonist properties.Fórmula:C14H19ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:310.78Org-12962
CAS:Org-12962: 5-HT2C agonist (pEC50: 7.01), anti-panic in rats, affects 5-HT2A/B (pEC50: 6.38/6.28).Fórmula:C10H11ClF3N3Pureza:98.34%Cor e Forma:SolidPeso molecular:265.66Iferanserin
CAS:Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors.Fórmula:C23H28N2OCor e Forma:SolidPeso molecular:348.48Cinitapride Hydrogen Tartrate
CAS:Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptorsFórmula:C25H36N4O10Pureza:98%Cor e Forma:SolidPeso molecular:552.581Darenzepine
CAS:Darenzepine is a muscarinic receptor inhibitor.Fórmula:C21H21N3O2Pureza:99.87%Cor e Forma:SolidPeso molecular:347.41Ref: TM-T10961
1mg203,00€5mg404,00€10mg567,00€25mg842,00€50mg1.125,00€100mg1.521,00€1mL*10mM (DMSO)447,00€Metixene hydrochloride
CAS:Metixene hydrochloride is an anticholinergic antiparkinsonian agent.Fórmula:C20H24ClNSPureza:98%Cor e Forma:SolidPeso molecular:345.93WAY208466 dihydrochloride
CAS:WAY208466 dihydrochloride is a 5-HT6 receptor agonist (EC50=7.3 nM) with antidepressant and anxiolytic activity.Fórmula:C17H20Cl2FN3O2SPureza:98.43% - 99.56%Cor e Forma:SolidPeso molecular:420.33LP44 hydrochloride
CAS:LP44 hydrochloride is a 5-HT7 agonist with analgesic effects on formalin-induced orofacial pain in mice and can be used to study neuroinflammation.Fórmula:C27H38ClN3OSPureza:98.06%Cor e Forma:SolidPeso molecular:488.135-HT7 agonist 1
CAS:5-HT7 agonist 1 (4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole) is a selective agonist of 5-HT7 (IC50 = 222.93 nM).Fórmula:C19H20ClN3Pureza:98.61%Cor e Forma:SolidPeso molecular:325.84Ref: TM-T10170
1mg109,00€2mg163,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€1mL*10mM (DMSO)241,00€Piperilate HCl
CAS:Piperilate HCl is an antispasmodic, antimuscarinic agent. It is a muscarinic cholinergic receptor antagonist.Fórmula:C21H26ClNO3Cor e Forma:SolidPeso molecular:375.89UB 165 fumarate
CAS:UB 165 fumarate is a nAChR agonist, α4β2 partial, α3β2 full, with a 0.27 nM Ki for [3H]-nicotine in rat brain.Fórmula:C17H19ClN2O4Pureza:99.72%Cor e Forma:SolidPeso molecular:350.8Methiothepin maleate
CAS:Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.Fórmula:C24H28N2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:472.62Deramciclane
CAS:Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors.Fórmula:C20H31NOCor e Forma:SolidPeso molecular:301.47JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Fórmula:C22H24N2O3Pureza:≥98% - ≥98.0%Cor e Forma:SolidPeso molecular:364.44AP521
CAS:AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM).Fórmula:C20H19ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:402.89PRX-08066 Maleic acid
CAS:PRX-08066 Maleic acid is the salt form of PRX-08066.PRX-08066 is a 5-HT receptor 2B antagonist that induces selective vasodilation of the pulmonary artery.Fórmula:C23H21ClFN5O4SPureza:97.59%Cor e Forma:SolidPeso molecular:517.96Ref: TM-T6959
1mg79,00€5mg168,00€10mg220,00€25mg398,00€50mg587,00€100mg835,00€200mg1.134,00€1mL*10mM (DMSO)380,00€(S)-MCPG
CAS:(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.Fórmula:C10H11NO4Pureza:98.72%Cor e Forma:SolidPeso molecular:209.20Amitifadine hydrochloride
CAS:Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).Fórmula:C11H12Cl3NPureza:98%Cor e Forma:SolidPeso molecular:264.58
