Neurociência
Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.
Subcategorias de "Neurociência"
- Receptor 5-HT(939 produtos)
- ACK(1 produtos)
- AChR(575 produtos)
- ATP Citrato Liase(16 produtos)
- Receptor adrenérgico(2.945 produtos)
- BACE(36 produtos)
- Beta Amilóide(205 produtos)
- CaMK(69 produtos)
- COX(561 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor GABA(336 produtos)
- Gama-secretase(59 produtos)
- GluR(255 produtos)
- GlyT(24 produtos)
- Receptor de Histamina(358 produtos)
- LRRK2(33 produtos)
- Receptor de Melatonina(24 produtos)
- NMDAR(28 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
Exibir 12 mais subcategorias
Foram encontrados 5398 produtos de "Neurociência"
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Ecopipam
CAS:<p>Ecopipam: orally active, selective dopamine D1/D5 antagonist (Ki: 1.2 nM/2.0 nM). 40x more selective over D2/D4/5-HT/α2a. For schizophrenia, obesity research.</p>Fórmula:C19H20ClNOPureza:99.68%Cor e Forma:SolidPeso molecular:313.82PPI-1019
CAS:<p>PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).</p>Fórmula:C36H54N6O5Pureza:95.16% - 98.16%Cor e Forma:SolidPeso molecular:650.85SPD-473 citrate
CAS:<p>SPD-473 citrate is an inhibitior of serotonin/dopamine/norepinephrine reuptake.</p>Fórmula:C23H31Cl2NO8SPureza:99.37%Cor e Forma:SolidPeso molecular:552.47LSN2463359
CAS:<p>LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.</p>Fórmula:C16H15N3OPureza:99.26%Cor e Forma:SolidPeso molecular:265.31Suriclone
CAS:<p>Suriclone (RP 31264), a cyclic pyrrolidone for anxiety, modulates GABA-A receptors without major sedation.</p>Fórmula:C20H20ClN5O3S2Pureza:99.21% - 99.73%Cor e Forma:SolidPeso molecular:477.99Riluzole hydrochloride
CAS:<p>Riluzole hydrochloride, an anticonvulsant Na+ channel blocker, inhibits GABA uptake (IC50: 43 µM).</p>Fórmula:C8H6ClF3N2OSPureza:99.76%Cor e Forma:SolidPeso molecular:270.66McN-A 343
CAS:<p>McN-A 343: Selective M1 muscarinic agonist; reduces inflammation in colitis models.</p>Fórmula:C14H18Cl2N2O2Pureza:99.65%Cor e Forma:SolidPeso molecular:317.21MNI 137
CAS:<p>MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.</p>Fórmula:C15H9BrN4OPureza:97.49%Cor e Forma:SolidPeso molecular:341.16MM 77 dihydrochloride
CAS:<p>MM 77 dihydrochloride is an effecitve 5-HT1A receptor postsynaptic antagonist with anxiolytic-like activity.</p>Fórmula:C19H29Cl2N3O3Pureza:99.91%Cor e Forma:SolidPeso molecular:418.36Aplindore Fumarate
CAS:<p>Aplindore Fumarate (DAB-452), a selective dopamine D2/D3 partial agonist, is used in Parkinson's and schizophrenia research.</p>Fórmula:C22H22N2O7Pureza:>99.99%Cor e Forma:SolidPeso molecular:426.42UNC9994 hydrochloride
CAS:<p>UNC9994 hydrochloride is a selective β-arrestin-biased D2R agonist, Ki of 79 nM, that stimulates β-arrestin and modulates cAMP.</p>Fórmula:C21H23Cl3N2OSCor e Forma:SolidPeso molecular:457.84CP-409092
CAS:<p>CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.</p>Fórmula:C17H19N3O2Pureza:98%Cor e Forma:SolidPeso molecular:297.35mGluR5 antagonist-1
CAS:<p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>Fórmula:C23H18N4O2Cor e Forma:SolidPeso molecular:382.41FPPQ
CAS:<p>FPPQ blocks 5-HT3 and 5-HT6 receptors (Ki: 0.9 & 3 nM) and may improve psychosis and cognition.</p>Fórmula:C21H19FN4O2SCor e Forma:SolidPeso molecular:410.46CGP 64213
CAS:<p>CGP 64213 is a GABAb receptor agonist.</p>Fórmula:C26H36IN2O7PPureza:98%Cor e Forma:SolidPeso molecular:646.45GSM-1
CAS:<p>GSM-1 is a modulator of γ-Secretase.</p>Fórmula:C26H31ClF3NO2Cor e Forma:SolidPeso molecular:481.98CGP36216 hydrochloride
CAS:<p>CGP36216 hydrochloride acts as a selective antagonist at the presynaptic GABA receptor, specifically binding to the GABAB receptor with a Ki value of 0.3 μM. This compound is leveraged in research focused on anxiety and trauma-related disorders [1] [2].</p>Fórmula:C5H15ClNO2PCor e Forma:SolidPeso molecular:187.6BACE1-IN-10
CAS:<p>BACE1-IN-10 is a potent inhibitor of BACE1, demonstrating sub-micromolar activity against recombinant BACE1 (rBACE1) [1].</p>Fórmula:C33H49N5O8SPureza:98%Cor e Forma:SolidPeso molecular:675.84Quinolactacin A1
CAS:<p>Quinolactacin A1, a strong AChE inhibitor from Penicillium citrinum, aids Alzheimer's research.</p>Fórmula:C16H18N2O2Cor e Forma:SolidPeso molecular:270.33QM-FN-SO3
CAS:<p>QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].</p>Fórmula:C29H25N4NaO3S2Cor e Forma:SolidPeso molecular:564.65VU6005649
CAS:<p>VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).</p>Fórmula:C16H12F5N3OPureza:99.87%Cor e Forma:SolidPeso molecular:357.28MIN-117
CAS:<p>MIN-117, a SSRI/5-HT receptor antagonist, is potentially used for the treatment of depression.</p>Fórmula:C25H26Cl3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:538.85L-AP4
CAS:<p>L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).</p>Fórmula:C4H10NO5PPureza:98%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:183.15-HT2C agonist-3
CAS:<p>5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced</p>Fórmula:C19H23ClFNO2Pureza:98%Cor e Forma:SolidPeso molecular:351.84cis-PDA
CAS:<p>cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.</p>Fórmula:C7H11NO4Pureza:98.71%Cor e Forma:White SolidPeso molecular:173.17Facinicline hydrochloride
CAS:<p>Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).</p>Fórmula:C15H19ClN4OPureza:98.70%Cor e Forma:SolidPeso molecular:306.79NO-711ME
CAS:<p>NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.</p>Fórmula:C22H24N2O3Pureza:99.54%Cor e Forma:SolidPeso molecular:364.44MFZ 10-7
CAS:<p>MFZ 10-7 is anegative allosteric modulator of the mGluR5.</p>Fórmula:C15H9FN2Pureza:99.80%Cor e Forma:SolidPeso molecular:236.24AChE-IN-19
CAS:<p>AChE-IN-19: strong AChE blocker (IC50: 0.56 μM), hinders Aβ clumps, neuro-protective, non-toxic to SH-SY5Y, for Alzheimer's research.</p>Fórmula:C30H33NO7Cor e Forma:SolidPeso molecular:519.59U 89843A
CAS:<p>U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.</p>Fórmula:C16H23N5Pureza:99.62%Cor e Forma:SolidPeso molecular:285.392-Methyl-5-HT
CAS:<p>2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Fórmula:C11H14N2OPureza:97.18%Cor e Forma:SolidPeso molecular:190.24R-96544
CAS:<p>R-96544 is an orally active antagonist of the 5-HT2A receptor that has demonstrated the ability to inhibit platelet aggregation in vitro [1].</p>Fórmula:C22H30ClNO3Cor e Forma:SolidPeso molecular:391.93FPTQ
CAS:<p>FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].</p>Fórmula:C17H12FN5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:305.315-HT3-In-1
CAS:<p>5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.</p>Fórmula:C16H21ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:352.82NAS-181
CAS:<p>NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM).NAS-181 enhances the accumulation of 5-HTP in rat brain regions.</p>Fórmula:C20H30N2O7SCor e Forma:SolidPeso molecular:442.53NP-1815-PX
CAS:<p>NP-1815-PX is a P2X4R antagonist with anti-inflammatory and analgesic properties, inhibiting guinea pig tracheal, and can be used in chronic pain research.</p>Fórmula:C21H13N4NaO3SPureza:97.82% - 99.39%Cor e Forma:SolidPeso molecular:424.41Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Fórmula:C31H23Cl7N2OPureza:98.53%Cor e Forma:SolidPeso molecular:687.7Nemonapride
CAS:<p>Nemonapride is a dopamine D2-like receptor antagonist.</p>Fórmula:C21H26ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.9AAK1-IN-3
CAS:<p>AAK1-IN-3: Brain-penetrant AAK1 inhibitor for neuropathic pain research; IC50=11 nM.</p>Fórmula:C20H20N4Cor e Forma:SolidPeso molecular:316.4CAY10649
CAS:<p>1CAY10649, a thiazolinone compound, directly inhibits 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.28 μM and in a soluble fraction of an S100 PMNL cell lysate with an IC50 value of 0.09 μM, following stimulation by calcium and arachidonic acid. This activity highlights its potential in mitigating inflammatory responses by targeting the biosynthesis of leukotrienes, substances implicated in various inflammatory processes such as neutrophil chemotaxis, increased vascular permeability, and smooth muscle contraction.</p>Fórmula:C17H12ClNO2SCor e Forma:SolidPeso molecular:329.8Physostigmine hemisulfate
CAS:<p>cholinesterase inhibitor</p>Fórmula:C15H21N302H204SPureza:98%Cor e Forma:SolidPeso molecular:324.39Cyclophostin
CAS:<p>Cyclophostin is an irreversible inhibitor of acetylcholinesterase (AChE).</p>Fórmula:C8H11O6PPureza:98%Cor e Forma:SolidPeso molecular:234.14YM348
CAS:<p>YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).</p>Fórmula:C14H17N3OPureza:98%Cor e Forma:SolidPeso molecular:243.3AChE-IN-44
CAS:<p>AChE-IN-44 (Compound Tap4), an AChE inhibitor, is convertible into its thiazole salt form known as Tat2 [1].</p>Fórmula:C31H38ClN3OS2Cor e Forma:SolidPeso molecular:568.24NAD 299 hydrochloride
CAS:<p>Selective, high affinity 5-HT1A receptor antagonist</p>Fórmula:C18H24ClFN2O2Pureza:98%Cor e Forma:SolidPeso molecular:354.85rel-HDMP 28 hydrochloride
CAS:<p>Rel-HDMP-28 hydrochloride (Compound 2g) is an analogue of methylphenidate, exhibiting selective affinity for the serotonin transporter (SERT) with a binding constant (Ki) of 105 nM [1].</p>Fórmula:C18H22ClNO2Cor e Forma:SolidPeso molecular:319.83(+)-Bicuculline methiodide
CAS:<p>(+)-Bicuculline methiodide is a GABAA receptor blocker that blocks epileptogens and may be used in the study of neurological disorders.</p>Fórmula:C21H20INO6Pureza:99.24%Cor e Forma:SolidPeso molecular:509.29AAK1-IN-4
CAS:<p>AAK1-IN-4 selectively inhibits AAK1 with IC50 of 4.6 nM; penetrates CNS, oral bioactive, potential for studying neuropathic pain.</p>Fórmula:C20H28N4O3Cor e Forma:SolidPeso molecular:372.46QR-0217
CAS:<p>QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.</p>Fórmula:C19H13NO3Cor e Forma:SolidPeso molecular:303.31SCS
CAS:<p>SCS is a GABAA receptor antagonist.</p>Fórmula:C14H12N2O3Pureza:99.73%Cor e Forma:SolidPeso molecular:256.26
