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Tirosina Quinase/Adaptador

Tirosina Quinase/Adaptador

Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.

Subcategorias de "Tirosina Quinase/Adaptador"

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Foram encontrados 1372 produtos de "Tirosina Quinase/Adaptador"

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  • FIIN-2
    Targetmol
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    FIIN-2

    CAS:
    <p>FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.</p>
    Fórmula:C35H38N8O4
    Pureza:97.82% - 99.65%
    Cor e Forma:Crystalline Solid
    Peso molecular:634.73

    Ref: TM-T6836

  • EGFR/ErbB-2/ErbB-4 inhibitor-2
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    EGFR/ErbB-2/ErbB-4 inhibitor-2

    CAS:
    <p>EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)</p>
    Fórmula:C23H21N3O3
    Pureza:99.55%
    Cor e Forma:Solid
    Peso molecular:387.43

    Ref: TM-T21954

  • Vactosertib
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    Vactosertib

    CAS:
    <p>Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.</p>
    Fórmula:C22H18FN7
    Pureza:98.85% - 99.81%
    Cor e Forma:Solid
    Peso molecular:399.42

    Ref: TM-T6496

  • G5-7
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    G5-7

    CAS:
    <p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>
    Fórmula:C22H19F2NO3
    Pureza:97.3%
    Cor e Forma:Solid
    Peso molecular:383.39

    Ref: TM-T8742

  • AZD8931 diFuMaric acid
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    AZD8931 diFuMaric acid

    CAS:
    <p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>
    Fórmula:C31H33ClFN5O11
    Pureza:99.92%
    Cor e Forma:Solid
    Peso molecular:706.1

    Ref: TM-T8751

  • Theliatinib
    Targetmol
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    Theliatinib

    CAS:
    <p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>
    Fórmula:C25H26N6O2
    Pureza:99.67%
    Cor e Forma:Solid
    Peso molecular:442.51

    Ref: TM-T7322

  • Theliatinib tartrate
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    Theliatinib tartrate

    CAS:
    <p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), &gt;50x kinase selectivity.</p>
    Fórmula:C29H32N6O8
    Cor e Forma:Solid
    Peso molecular:592.6

    Ref: TM-T72431

  • UNC2025 2HCl (1429881-91-3(free base))
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    UNC2025 2HCl (1429881-91-3(free base))

    <p>UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.</p>
    Fórmula:C28H42Cl2N6O
    Pureza:99.71%
    Cor e Forma:Solid
    Peso molecular:549.62

    Ref: TM-T4419

  • Decernotinib
    Targetmol
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    Decernotinib

    CAS:
    <p>Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.</p>
    Fórmula:C18H19F3N6O
    Pureza:99.28% - >99.99%
    Cor e Forma:Solid
    Peso molecular:392.38

    Ref: TM-T2636

  • RepSox
    Targetmol
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    RepSox

    CAS:
    <p>RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).</p>
    Fórmula:C17H13N5
    Pureza:98.8% - 99.73%
    Cor e Forma:Solid
    Peso molecular:287.32

    Ref: TM-T6337

  • SCR-1481B1
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    SCR-1481B1

    CAS:
    <p>SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitor</p>
    Fórmula:C32H40ClF2N6O13P
    Pureza:98.07%
    Cor e Forma:Solid
    Peso molecular:821.12

    Ref: TM-T5349

  • MSDC 0160
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    MSDC 0160

    CAS:
    <p>MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.</p>
    Fórmula:C19H18N2O4S
    Pureza:98.11% - 99.53%
    Cor e Forma:Solid
    Peso molecular:370.42

    Ref: TM-T2607

  • R112
    Targetmol
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    R112

    CAS:
    <p>R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase.</p>
    Fórmula:C16H13FN4O2
    Pureza:99.27% - 99.84%
    Cor e Forma:Solid
    Peso molecular:312.3

    Ref: TM-T3185

  • NRC-2694
    Targetmol
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    NRC-2694

    CAS:
    <p>NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.</p>
    Fórmula:C24H26N4O3
    Pureza:99.90%
    Cor e Forma:Solid
    Peso molecular:418.49

    Ref: TM-T16343

  • SYR127063
    Targetmol
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    SYR127063

    CAS:
    <p>SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.</p>
    Fórmula:C23H20ClF3N4O3
    Pureza:98.57%
    Cor e Forma:Solid
    Peso molecular:492.88

    Ref: TM-T34760

  • Ponatinib
    Targetmol
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    Ponatinib

    CAS:
    <p>Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively</p>
    Fórmula:C29H27F3N6O
    Pureza:98% - 99.60%
    Cor e Forma:Solid
    Peso molecular:532.56

    Ref: TM-T2372

  • Oritinib mesylate
    Targetmol
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    Oritinib mesylate

    CAS:
    <p>Oritinib mesylate (SH-1028), an oral pyrimidine EGFR blocker with 18 nM IC50, targets both sensitive and T790M resistant mutations.</p>
    Fórmula:C32H41N7O5S
    Cor e Forma:Solid
    Peso molecular:635.78

    Ref: TM-T39670

  • PRN1371
    Targetmol
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    PRN1371

    CAS:
    <p>PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).</p>
    Fórmula:C26H30Cl2N6O4
    Pureza:98.65%
    Cor e Forma:Solid
    Peso molecular:561.46

    Ref: TM-TQ0015

  • UNC2541
    Targetmol
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    UNC2541

    CAS:
    <p>UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.</p>
    Fórmula:C24H34FN7O2
    Pureza:98.33%
    Cor e Forma:Solid
    Peso molecular:471.57

    Ref: TM-T17205

  • PKI 14-22 amide, myristoylated Acetate
    Targetmol
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    PKI 14-22 amide, myristoylated Acetate

    <p>PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP. </p>
    Fórmula:C55H104N20O14
    Pureza:96.34%
    Cor e Forma:Solid
    Peso molecular:1269.54

    Ref: TM-T21983L