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Tirosina Quinase/Adaptador

Tirosina Quinase/Adaptador

Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.

Subcategorias de "Tirosina Quinase/Adaptador"

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Foram encontrados 1342 produtos de "Tirosina Quinase/Adaptador"

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  • c-Met-IN-26
    Targetmol
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    c-Met-IN-26

    CAS:
    c-Met-IN-26 (compound 1-170) is an effective inhibitor of c-Met, exhibiting an IC50 of 1.6 nM.
    Fórmula:C24H19F2N9
    Cor e Forma:Solid
    Peso molecular:471.46

    Ref: TM-T201085

  • Fanregratinib
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    Fanregratinib

    CAS:
    Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.
    Fórmula:C27H33ClN6O2
    Cor e Forma:Solid
    Peso molecular:509.04

    Ref: TM-T201139

  • ITK inhibitor 2
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    ITK inhibitor 2

    CAS:
    ITK inhibitor 2 (compound 4) is a potent and selective ITK inhibitor with an IC50= 2 nM.
    Fórmula:C25H33N5O2
    Pureza:99.67%
    Cor e Forma:Solid
    Peso molecular:435.56

    Ref: TM-T11690

  • WS-11
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    WS-11

    CAS:
    <p>WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.</p>
    Fórmula:C26H22FN9O2
    Cor e Forma:Solid
    Peso molecular:511.51

    Ref: TM-T201126

  • MerTK-IN-1
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    MerTK-IN-1

    CAS:
    <p>MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.</p>
    Fórmula:C23H26N8O4
    Cor e Forma:Solid
    Peso molecular:478.50

    Ref: TM-T200963

  • Dyrk1A-IN-11
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    Dyrk1A-IN-11

    CAS:
    <p>Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.</p>
    Fórmula:C23H23F5N8O
    Cor e Forma:Solid
    Peso molecular:522.47

    Ref: TM-T201128

  • c-Kit-IN-8
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    c-Kit-IN-8

    CAS:
    <p>C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.</p>
    Fórmula:C24H26FN5O4
    Cor e Forma:Solid
    Peso molecular:467.49

    Ref: TM-T200947

  • JBJ-09-063
    Targetmol
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    JBJ-09-063

    CAS:
    <p>JBJ-09-063: EGFR inhibitor, IC50s 0.147-0.396 nM for various mutants; hinders EGFR/Akt/ERK1/2 phosphorylation; targets TKI-sensitive/resistant lung cancer.</p>
    Fórmula:C31H29FN4O3S
    Cor e Forma:Solid
    Peso molecular:556.65

    Ref: TM-T63939

  • D-69491 hydrochloride
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    D-69491 hydrochloride

    CAS:
    <p>D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.</p>
    Fórmula:C25H26Cl2FN7O3
    Cor e Forma:Solid
    Peso molecular:562.42

    Ref: TM-T201568

  • Pred17
    Targetmol
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    Pred17

    <p>Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.</p>
    Fórmula:C27H22BN3O
    Cor e Forma:Solid
    Peso molecular:415.29

    Ref: TM-T201786

  • EGFR-IN-133
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    EGFR-IN-133

    CAS:
    <p>EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.</p>
    Fórmula:C27H29F2N7O3
    Cor e Forma:Solid
    Peso molecular:537.56

    Ref: TM-T201790

  • Logotipo do CymitQuimica
    Targetmol
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    DDR1-IN-8

    CAS:
    <p>DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, exhibiting IC50 values of 0.045 μM and 0.126 μM, respectively, and possesses antitumor activity.</p>
    Fórmula:C23H24F3N5O2
    Peso molecular:459.46

    Ref: TM-T209082

  • Logotipo do CymitQuimica
    Targetmol
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    c-Fms-IN-15

    CAS:
    <p>c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.</p>
    Fórmula:C29H28F3N7O2
    Peso molecular:563.57

    Ref: TM-T210059

  • EGFR-IN-132
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    EGFR-IN-132

    CAS:
    <p>EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.</p>
    Fórmula:C27H31N7O3
    Cor e Forma:Solid
    Peso molecular:501.58

    Ref: TM-T201638

  • CGP062464
    Targetmol
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    CGP062464

    CAS:
    <p>CGP062464 is an inhibitor of the tyrosine kinase c-Src, with an IC50 of less than 50 nM. It is utilized in research related to osteoporosis and tumor-induced hypercalcemia.</p>
    Fórmula:C18H14N4
    Cor e Forma:Solid
    Peso molecular:286.331

    Ref: TM-T205732

  • Logotipo do CymitQuimica
    Targetmol
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    Protein kinase inhibitor 4

    CAS:
    <p>Protein kinase inhibitor 4 (Compound 3) is a chemical that acts as a protein kinase inhibitor, specifically targeting TRK-A with an IC50 of 3.0 nM, and ROS1 with an IC50 of 104 nM.</p>
    Fórmula:C25H24F2N6O3S
    Peso molecular:526.56

    Ref: TM-T209488

  • NS-062
    Targetmol
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    NS-062

    CAS:
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Fórmula:C28H30Cl2F2N6O4
    Cor e Forma:Solid
    Peso molecular:623.48

    Ref: TM-T201773

  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Fórmula:C16H15N3OS
    Cor e Forma:Solid
    Peso molecular:297.375

    Ref: TM-T205658

  • FGFR-IN-15
    Targetmol
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    FGFR-IN-15

    <p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>
    Fórmula:C22H23N5O5S
    Cor e Forma:Solid
    Peso molecular:469.51

    Ref: TM-T201821

  • JBJ-02-112-05
    Targetmol
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    JBJ-02-112-05

    CAS:
    <p>JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].</p>
    Fórmula:C27H20N4O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:464.54

    Ref: TM-T11713