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Tirosina Quinase/Adaptador

Tirosina Quinase/Adaptador

Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.

Subcategorias de "Tirosina Quinase/Adaptador"

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Foram encontrados 1342 produtos de "Tirosina Quinase/Adaptador"

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  • Logotipo do CymitQuimica
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    EGFR/HER2-IN-5

    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Cor e Forma:Solid

    Ref: TM-T64254

  • Pimicotinib hydrochloride
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    Pimicotinib hydrochloride

    CAS:
    <p>Pimicotinib hydrochloride is an inhibitor of CSF1R, displaying antitumor activity.</p>
    Fórmula:C22H25ClN6O3
    Cor e Forma:Solid
    Peso molecular:456.925

    Ref: TM-T204920

  • LSD1/EGFR-IN-1
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    LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Fórmula:C21H20ClN3O4
    Cor e Forma:Solid
    Peso molecular:413.854

    Ref: TM-T204471

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    EGFR-IN-48

    <p>EGFR-IN-48: potent EGFR inhibitor, oral, IC50: 0.193-66.7 nM, blocks EGFR mutants &amp; BaF3/PC-9 cell proliferation.</p>
    Cor e Forma:Solid

    Ref: TM-T64255

  • EGFR-IN-126
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    EGFR-IN-126

    CAS:
    <p>EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.</p>
    Fórmula:C28H28BrFN4O3
    Cor e Forma:Solid
    Peso molecular:567.45

    Ref: TM-T200496

  • UniPR500
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    UniPR500

    CAS:
    <p>UniPR500, a derivative of UniPR129, is a competitive antagonist for the EphA2 receptor, with a Ki of 0.78 μM. It reduces the binding of biotinylated Ephrin-A1 to EphA2 in a dose-dependent manner, exhibiting an IC50 value of 1.1 μM.</p>
    Fórmula:C36H51N3O4
    Cor e Forma:Solid
    Peso molecular:589.808

    Ref: TM-T204989

  • GENZ-882706
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    GENZ-882706

    CAS:
    <p>GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.</p>
    Fórmula:C26H25N5O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:455.51

    Ref: TM-T11390

  • EGFR-IN-35
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    EGFR-IN-35

    CAS:
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Fórmula:C25H24ClN7O2
    Cor e Forma:Solid
    Peso molecular:489.96

    Ref: TM-T63282

  • EGFR-IN-147
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    EGFR-IN-147

    CAS:
    <p>EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.</p>
    Fórmula:C13H13N5O
    Cor e Forma:Solid
    Peso molecular:255.275

    Ref: TM-T204935

  • EGFR-IN-23
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    EGFR-IN-23

    CAS:
    <p>EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.</p>
    Fórmula:C36H44BrN10O3P
    Cor e Forma:Solid
    Peso molecular:775.68

    Ref: TM-T73104

  • AZ8010
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    AZ8010

    CAS:
    AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.
    Fórmula:C27H34N4O3
    Cor e Forma:Solid
    Peso molecular:462.58

    Ref: TM-T89951

  • HER2-IN-21
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    HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Fórmula:C20H18N4O3S
    Cor e Forma:Solid
    Peso molecular:394.447

    Ref: TM-T205331

  • KRC-00715
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    KRC-00715

    CAS:
    <p>KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.</p>
    Fórmula:C25H25F3N8O3
    Cor e Forma:Solid
    Peso molecular:542.51

    Ref: TM-T200380

  • Tyrphostin 63
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    Tyrphostin 63

    CAS:
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Fórmula:C10H8N2O
    Cor e Forma:Solid
    Peso molecular:172.183

    Ref: TM-T204167

  • ROS1-IN-2
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    ROS1-IN-2

    CAS:
    <p>ROS1-IN-2 (Compound 3), a ROS1 inhibitor, is utilized in cancer research.</p>
    Fórmula:C29H37ClN5O2P
    Cor e Forma:Solid
    Peso molecular:554.06

    Ref: TM-T89912

  • SST0116CL1
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    SST0116CL1

    CAS:
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Fórmula:C22H31ClN4O6
    Cor e Forma:Solid
    Peso molecular:482.96

    Ref: TM-T200022

  • TrkA-IN-9
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    TrkA-IN-9

    CAS:
    <p>TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.</p>
    Fórmula:C31H32N4O4
    Cor e Forma:Solid
    Peso molecular:524.61

    Ref: TM-T206381

  • EG31
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    EG31

    CAS:
    <p>EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.</p>
    Fórmula:C30H13Br2N3O6
    Cor e Forma:Solid
    Peso molecular:671.25

    Ref: TM-T207269

  • BIIB129
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    BIIB129

    CAS:
    <p>BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.</p>
    Fórmula:C19H22N6O2
    Pureza:98.56%
    Cor e Forma:Solid
    Peso molecular:366.42

    Ref: TM-T88336

  • BTK-IN-16
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    BTK-IN-16

    CAS:
    <p>BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.</p>
    Fórmula:C15H14N4O2
    Pureza:99.04%
    Cor e Forma:Soild
    Peso molecular:282.3

    Ref: TM-T60542