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Tirosina Quinase/Adaptador

Tirosina Quinase/Adaptador

Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.

Subcategorias de "Tirosina Quinase/Adaptador"

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Foram encontrados 1372 produtos de "Tirosina Quinase/Adaptador"

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  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Fórmula:C16H15N3OS
    Cor e Forma:Solid
    Peso molecular:297.375

    Ref: TM-T205658

  • NS-062
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    NS-062

    CAS:
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Fórmula:C28H30Cl2F2N6O4
    Cor e Forma:Solid
    Peso molecular:623.48

    Ref: TM-T201773

  • FGFR-IN-15
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    FGFR-IN-15

    <p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>
    Fórmula:C22H23N5O5S
    Cor e Forma:Solid
    Peso molecular:469.51

    Ref: TM-T201821

  • Tesevatinib tosylate
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    Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Fórmula:C31H33Cl2FN4O5S
    Cor e Forma:Solid
    Peso molecular:663.59

    Ref: TM-T201865

  • Logotipo do CymitQuimica
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    EGFR/HER2-IN-8

    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Fórmula:C16H16N4O2S
    Cor e Forma:Solid
    Peso molecular:328.39

    Ref: TM-T60938

  • LSD1/EGFR-IN-1
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    LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Fórmula:C21H20ClN3O4
    Cor e Forma:Solid
    Peso molecular:413.854

    Ref: TM-T204471

  • Logotipo do CymitQuimica
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    EGFR-IN-48

    <p>EGFR-IN-48: potent EGFR inhibitor, oral, IC50: 0.193-66.7 nM, blocks EGFR mutants &amp; BaF3/PC-9 cell proliferation.</p>
    Cor e Forma:Solid

    Ref: TM-T64255

  • MerTK/Axl-IN-1
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    MerTK/Axl-IN-1

    CAS:
    <p>MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.</p>
    Fórmula:C40H47FN6O4
    Cor e Forma:Solid
    Peso molecular:694.84

    Ref: TM-T200517

  • UniPR500
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    UniPR500

    CAS:
    <p>UniPR500, a derivative of UniPR129, is a competitive antagonist for the EphA2 receptor, with a Ki of 0.78 μM. It reduces the binding of biotinylated Ephrin-A1 to EphA2 in a dose-dependent manner, exhibiting an IC50 value of 1.1 μM.</p>
    Fórmula:C36H51N3O4
    Cor e Forma:Solid
    Peso molecular:589.808

    Ref: TM-T204989

  • EGFR-IN-147
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    EGFR-IN-147

    CAS:
    <p>EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.</p>
    Fórmula:C13H13N5O
    Cor e Forma:Solid
    Peso molecular:255.275

    Ref: TM-T204935

  • HER2-IN-21
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    HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Fórmula:C20H18N4O3S
    Cor e Forma:Solid
    Peso molecular:394.447

    Ref: TM-T205331

  • EGFR-IN-35
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    EGFR-IN-35

    CAS:
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Fórmula:C25H24ClN7O2
    Cor e Forma:Solid
    Peso molecular:489.96

    Ref: TM-T63282

  • EG31
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    EG31

    CAS:
    <p>EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.</p>
    Fórmula:C30H13Br2N3O6
    Cor e Forma:Solid
    Peso molecular:671.25

    Ref: TM-T207269

  • Tyrphostin 63
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    Tyrphostin 63

    CAS:
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Fórmula:C10H8N2O
    Cor e Forma:Solid
    Peso molecular:172.183

    Ref: TM-T204167

  • TrkA-IN-9
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    TrkA-IN-9

    CAS:
    <p>TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.</p>
    Fórmula:C31H32N4O4
    Cor e Forma:Solid
    Peso molecular:524.61

    Ref: TM-T206381

  • Pimicotinib hydrochloride
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    Pimicotinib hydrochloride

    CAS:
    <p>Pimicotinib hydrochloride is an inhibitor of CSF1R, displaying antitumor activity.</p>
    Fórmula:C22H25ClN6O3
    Cor e Forma:Solid
    Peso molecular:456.925

    Ref: TM-T204920

  • EGFR-IN-23
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    EGFR-IN-23

    CAS:
    <p>EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.</p>
    Fórmula:C36H44BrN10O3P
    Cor e Forma:Solid
    Peso molecular:775.68

    Ref: TM-T73104

  • FMP-API-1
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    FMP-API-1

    CAS:
    <p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>
    Fórmula:C13H14N2O2
    Cor e Forma:Solid
    Peso molecular:230.262

    Ref: TM-T204439

  • GENZ-882706
    Targetmol
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    GENZ-882706

    CAS:
    <p>GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.</p>
    Fórmula:C26H25N5O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:455.51

    Ref: TM-T11390

  • Logotipo do CymitQuimica
    Targetmol
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    EGFR/HER2-IN-7

    <p>EGFR/HER2-IN-7: Potent, selective dual inhibitor for MCF-7 cancer; IC50: EGFR 0.18μM, HER2 0.146μM, DHFR 0.907μM.</p>
    Fórmula:C19H21N3O2S
    Cor e Forma:Solid
    Peso molecular:355.45

    Ref: TM-T61272