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Tirosina Quinase/Adaptador

Tirosina Quinase/Adaptador

Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.

Subcategorias de "Tirosina Quinase/Adaptador"

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Foram encontrados 1372 produtos de "Tirosina Quinase/Adaptador"

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  • Logotipo do CymitQuimica
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    EGFR/HER2-IN-7

    <p>EGFR/HER2-IN-7: Potent, selective dual inhibitor for MCF-7 cancer; IC50: EGFR 0.18μM, HER2 0.146μM, DHFR 0.907μM.</p>
    Fórmula:C19H21N3O2S
    Cor e Forma:Solid
    Peso molecular:355.45

    Ref: TM-T61272

  • TrkC-IN-1
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    TrkC-IN-1

    CAS:
    <p>TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.</p>
    Fórmula:C28H20BrN5O2
    Cor e Forma:Solid
    Peso molecular:538.395

    Ref: TM-T206472

  • BIIB129
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    BIIB129

    CAS:
    <p>BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.</p>
    Fórmula:C19H22N6O2
    Pureza:98.56%
    Cor e Forma:Solid
    Peso molecular:366.42

    Ref: TM-T88336

  • DDR1-IN-10
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    DDR1-IN-10

    CAS:
    <p>DDR1-IN-10 (compound 7q) is an inhibitor of DDR1. It is applicable in research related to pancreatic cancer, non-small cell lung cancer, and gastric cancer.</p>
    Fórmula:C24H25F4N5O2
    Cor e Forma:Solid
    Peso molecular:491.481

    Ref: TM-T204839

  • NSC381467
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    NSC381467

    CAS:
    <p>NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Fórmula:C20H16O7
    Cor e Forma:Solid
    Peso molecular:368.34

    Ref: TM-T61441

  • Logotipo do CymitQuimica
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    EGFR-IN-18

    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Fórmula:C33H28N6O3S
    Cor e Forma:Solid
    Peso molecular:588.68

    Ref: TM-T64170

  • Logotipo do CymitQuimica
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    EGFR/HER2/DHFR-IN-1

    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Fórmula:C14H11BrN4O2S
    Cor e Forma:Solid
    Peso molecular:379.23

    Ref: TM-T61596

  • Logotipo do CymitQuimica
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    EGFR-IN-17

    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Fórmula:C27H31ClN7O3P
    Cor e Forma:Solid
    Peso molecular:568.01

    Ref: TM-T64020

  • Logotipo do CymitQuimica
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    EGFR-IN-24

    <p>EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).</p>
    Fórmula:C30H35FN6O3
    Cor e Forma:Solid
    Peso molecular:546.64

    Ref: TM-T63857

  • TrkA-IN-7
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    TrkA-IN-7

    CAS:
    <p>TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.</p>
    Fórmula:C16H13N3O3
    Cor e Forma:Solid
    Peso molecular:295.293

    Ref: TM-T204489

  • JBJ-02-112-05
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    JBJ-02-112-05

    CAS:
    <p>JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].</p>
    Fórmula:C27H20N4O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:464.54

    Ref: TM-T11713

  • TRK-IN-26
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    TRK-IN-26

    CAS:
    <p>TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].</p>
    Fórmula:C30H22F2N6O4
    Cor e Forma:Solid
    Peso molecular:568.53

    Ref: TM-T87569

  • Lucitanib dihydrochloride
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    Lucitanib dihydrochloride

    CAS:
    <p>Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient VEGFR1-3, FGFR1-3, and PDGFRalpha/β inhibitor, used in metastatic breast cancer research.</p>
    Fórmula:C26H27Cl2N3O4
    Cor e Forma:Solid
    Peso molecular:516.42

    Ref: TM-T89507

  • PET-cGMP
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    PET-cGMP

    CAS:
    <p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>
    Fórmula:C18H16N5O7P
    Cor e Forma:Solid
    Peso molecular:445.323

    Ref: TM-T204785

  • HER2-IN-6
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    HER2-IN-6

    CAS:
    <p>HER2-IN-6, a potent HER2 inhibitor, may target wild/mutant EGFR and HER2-mediated tumors. (Patent WO2021164697A1, compound 11)</p>
    Fórmula:C26H32N8O3
    Cor e Forma:Solid
    Peso molecular:504.58

    Ref: TM-T63441

  • AMG-25
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    AMG-25

    CAS:
    <p>AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.</p>
    Fórmula:C23H17N5O2
    Pureza:98.16%
    Cor e Forma:Solid
    Peso molecular:395.41

    Ref: TM-T22256

  • HER2-IN-8
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    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Fórmula:C26H25F2N9O3
    Cor e Forma:Solid
    Peso molecular:549.53

    Ref: TM-T63881

  • EGFR-IN-159
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    EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Fórmula:C21H23N3O5
    Cor e Forma:Solid
    Peso molecular:397.424

    Ref: TM-T206989

  • EGFR-IN-38
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    EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Fórmula:C25H24ClN7O2
    Cor e Forma:Solid
    Peso molecular:489.96

    Ref: TM-T63283

  • EGFR-IN-125
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    EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Fórmula:C30H26N8O
    Cor e Forma:Solid
    Peso molecular:514.58

    Ref: TM-T204450