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Tirosina Quinase/Adaptador

Tirosina Quinase/Adaptador

Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.

Subcategorias de "Tirosina Quinase/Adaptador"

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Foram encontrados 1370 produtos de "Tirosina Quinase/Adaptador"

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  • BMS-599626 2HCL(714971-09-2 Free base)
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    BMS-599626 2HCL(714971-09-2 Free base)

    CAS:
    <p>BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative.</p>
    Fórmula:C27H29Cl2FN8O3
    Pureza:99.11%
    Cor e Forma:Odour Solid
    Peso molecular:603.47

    Ref: TM-T2610L

  • KT5720
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    KT5720

    CAS:
    <p>KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).</p>
    Fórmula:C32H31N3O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:537.61

    Ref: TM-T15669

  • Kinase Inhibitor Library
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    Kinase Inhibitor Library

    <p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>
    Cor e Forma:Odour Solid

    Ref: TM-L1600

  • GIP (1-30) amide,human
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    GIP (1-30) amide,human

    CAS:
    <p>GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.</p>
    Fórmula:C162H240N40O47S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:3531.94

    Ref: TM-TP1584

  • PROTAC EGFR degrader 11
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    PROTAC EGFR degrader 11

    CAS:
    <p>PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.</p>
    Fórmula:C49H64ClFN10O7S
    Cor e Forma:Solid
    Peso molecular:991.61

    Ref: TM-T88077

  • PROTAC EGFR degrader 10
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    PROTAC EGFR degrader 10

    CAS:
    <p>PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.</p>
    Fórmula:C49H65ClN10O7S
    Cor e Forma:Solid
    Peso molecular:973.62

    Ref: TM-T88273

  • HER2/neu (654-662) GP2
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    HER2/neu (654-662) GP2

    CAS:
    <p>Phage display selected Affibody ligands for HER2/neu from a protein library based on a 58-residue Staphylococcal protein A Z domain.</p>
    Fórmula:C42H77N9O11
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:884.11

    Ref: TM-TP1583

  • Logotipo do CymitQuimica
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    Cixutumumab

    CAS:
    <p>Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impeding</p>
    Pureza:98.5% (SDS-PAGE); 97.5% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.5% (SEC-HPLC)
    Cor e Forma:Liquid

    Ref: TM-T78279

  • PKG inhibitor peptide
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    PKG inhibitor peptide

    CAS:
    <p>PKG inhibitor; mimics H2B phosphorylation site; Ki=86mM; blocks synthetic substrates, not histone phosphorylation; stops PKA activity on histones.</p>
    Fórmula:C38H74N18O10
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:943.12

    Ref: TM-TP1903

  • CREBtide
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    CREBtide

    CAS:
    <p>CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).</p>
    Fórmula:C73H129N29O19
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1716.99

    Ref: TM-TP1876

  • MS9427
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    MS9427

    CAS:
    <p>MS9427: PROTAC EGFR degrader, 7.1 nM (WT), 4.3 nM (L858R); targets mutant via UPS and autophagy; inhibits NSCLC cell growth; anticancer research.</p>
    Fórmula:C48H58ClFN8O12
    Cor e Forma:Solid
    Peso molecular:993.47

    Ref: TM-T74633

  • Tephrosin
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    Tephrosin

    CAS:
    <p>Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.</p>
    Fórmula:C23H22O7
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:410.42

    Ref: TM-T13126

  • GNF-8625 monopyridin-N-piperazine hydrochloride
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    GNF-8625 monopyridin-N-piperazine hydrochloride

    CAS:
    <p>GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.</p>
    Fórmula:C25H27ClFN7
    Pureza:98.97%
    Cor e Forma:Solid
    Peso molecular:479.98

    Ref: TM-T40034

  • Logotipo do CymitQuimica
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    DSPE-PEG2000-GE11

    <p>DSPE-PEG2000-GE11 is a PEG compound composed of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells that overexpress EGFR. DSPE-PEG2000-GE11 is utilized in drug delivery.</p>
    Cor e Forma:Odour Solid

    Ref: TM-TCL-01177

  • Logotipo do CymitQuimica
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    Anticancer agent 271

    <p>Anticanceragent 271 (compound 5C) exhibits antiproliferative activity against lung cancer (A549), colon cancer (Caco-2) cell lines, and human lung fibroblasts (WI38), with an IC50 value of 9.18 μM for A549 cells. This compound can downregulate PI3K and mTOR gene expression and is applicable in cancer research.</p>
    Cor e Forma:Odour Solid

    Ref: TM-T206744

  • Taletrectinib free base
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    Taletrectinib free base

    CAS:
    <p>Taletrectinib (AB-106) is a potent, selective oral ROS1/NTRK inhibitor with low IC50s against ROS1 and NTRK1-3, including Crizotinib-resistant mutations.</p>
    Fórmula:C23H24FN5O
    Pureza:99.98%
    Cor e Forma:Solid
    Peso molecular:405.47

    Ref: TM-T38995

  • KYL peptide
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    KYL peptide

    CAS:
    <p>EphA4 inhibitor, Kd 0.8 μM, blocks EphA4-EphrinA5; avoids AβO damage, preserves spines &amp; LTP; long half-life (8-12h), neuroprotective.</p>
    Fórmula:C74H108N14O17
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1465.75

    Ref: TM-TP1895

  • ARRY-380 (analog )
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    ARRY-380 (analog )

    CAS:
    <p>ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.</p>
    Fórmula:C29H27N7O4S
    Pureza:99.82%
    Cor e Forma:Solid
    Peso molecular:569.63

    Ref: TM-T2518

  • Logotipo do CymitQuimica
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    Istiratumab

    CAS:
    <p>Istiratumab (M-6495) is a bispecific antibody against IGF-1R/ErbB3 for cancer research, promoting receptor degradation.</p>
    Cor e Forma:Liquid

    Ref: TM-T77044

  • ALW-II-49-7
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    ALW-II-49-7

    CAS:
    <p>ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase with an EC50 value of 40 nM in cell.</p>
    Fórmula:C21H17F3N4O2
    Pureza:99.72%
    Cor e Forma:Soild
    Peso molecular:414.38

    Ref: TM-T67736