Tirosina Quinase/Adaptador
Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.
Subcategorias de "Tirosina Quinase/Adaptador"
- ALK(116 produtos)
- CSF-1R(42 produtos)
- EGFR(572 produtos)
- Receptor de Efrina(23 produtos)
- FLT(91 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(169 produtos)
- HER(5 produtos)
- Hck(3 produtos)
- IGF-1R(92 produtos)
- PDGFR(126 produtos)
- PYK2(7 produtos)
- Src(80 produtos)
- Receptor TAM(32 produtos)
- Tie-2(21 produtos)
- Receptor TrK(59 produtos)
- Tirosina Quinases(26 produtos)
- VEGFR(262 produtos)
- c-Fms(108 produtos)
- c-Kit(102 produtos)
- c-Met/HGFR(129 produtos)
- c-RET(51 produtos)
Exibir 13 mais subcategorias
Foram encontrados 1342 produtos de "Tirosina Quinase/Adaptador"
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NVP-BHG712 isomer
CAS:<p>NVP-BHG712 isomer shows conserved non-bonded binding to EPHA2 and EPHB4.</p>Fórmula:C26H20F3N7OPureza:99.14%Cor e Forma:SolidPeso molecular:503.48Milciclib
CAS:<p>Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.</p>Fórmula:C25H32N8OPureza:99.28%Cor e Forma:SolidPeso molecular:460.57Avitinib maleate
CAS:Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.Fórmula:C30H30FN7O6Pureza:98% - 99.74%Cor e Forma:SolidPeso molecular:603.61RN486
CAS:<p>RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).</p>Fórmula:C35H35FN6O3Pureza:99.38%Cor e Forma:SolidPeso molecular:606.69Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14H-89 dihydrochloride
CAS:<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Cor e Forma:SolidPeso molecular:519.28Spebrutinib
CAS:<p>Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic</p>Fórmula:C22H22FN5O3Pureza:97.02% - >99.99%Cor e Forma:SolidPeso molecular:423.44Alflutinib mesylate
CAS:<p>Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.</p>Fórmula:C29H35F3N8O5SPureza:97.94% - 99.63%Cor e Forma:SolidPeso molecular:664.7SU4984
CAS:<p>SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).</p>Fórmula:C20H19N3O2Pureza:97.20%Cor e Forma:SolidPeso molecular:333.38KRN-633
CAS:<p>KRN-633 is an effective VEGFR inhibitor. The IC50s of KRN-633(KRN633) for VEGFR1, VEGFR2, and VEGFR3 is 170, 160 and 125 nM, respectively.</p>Fórmula:C20H21ClN4O4Pureza:99.53% - 99.73%Cor e Forma:SolidPeso molecular:416.86Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Fórmula:C26H30N6O3Pureza:97.88% - 98.79%Cor e Forma:White PowderPeso molecular:474.55PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Fórmula:C18H17Cl2N3O2Pureza:99.86%Cor e Forma:SolidPeso molecular:378.25SGI-7079
CAS:<p>SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.</p>Fórmula:C26H26FN7Pureza:95.51% - 99.26%Cor e Forma:SolidPeso molecular:455.53FIIN-2
CAS:<p>FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.</p>Fórmula:C35H38N8O4Pureza:97.82% - 99.65%Cor e Forma:Crystalline SolidPeso molecular:634.73(E)-AG 556
CAS:<p>AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.</p>Fórmula:C20H20N2O3Pureza:99.93%Cor e Forma:Light Yellow PowderPeso molecular:336.38NSC 228155
CAS:<p>NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.</p>Fórmula:C11H6N4O4SPureza:99.84%Cor e Forma:SolidPeso molecular:290.25Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Fórmula:C32H33ClFN5O11Pureza:98.11% - 99.87%Cor e Forma:SolidPeso molecular:718.08AZD3229
CAS:<p>AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.</p>Fórmula:C24H26FN7O3Pureza:98.83%Cor e Forma:SolidPeso molecular:479.51Mubritinib
CAS:Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.Fórmula:C25H23F3N4O2Pureza:98.61% - 99.85%Cor e Forma:SolidPeso molecular:468.471-Naphthyl PP1 hydrochloride
CAS:<p>1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases v-Src</p>Fórmula:C19H20ClN5Pureza:98.63%Cor e Forma:SolidPeso molecular:353.85c-Kit-IN-1
CAS:<p>c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).</p>Fórmula:C26H21F2N5O3Pureza:98.72% - 98.73%Cor e Forma:SolidPeso molecular:489.47Nampt-IN-1
CAS:Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.Fórmula:C20H25N3O5SPureza:99.28% - 99.4%Cor e Forma:SolidPeso molecular:419.49Alectinib hydrochloride
CAS:<p>Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)</p>Fórmula:C30H35ClN4O2Pureza:99.61% - 99.96%Cor e Forma:SolidPeso molecular:519.08ALW-II-41-27
CAS:<p>ALW-II-41-27 (Eph receptor tyrosine kinase inhibitor), an Eph receptor tyrosine kinase inhibitor, is used for cancer therapy.</p>Fórmula:C32H32F3N5O2SPureza:97.01% - 99.52%Cor e Forma:SolidPeso molecular:607.69Dacomitinib
CAS:<p>Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.</p>Fórmula:C24H25ClFN5O2Pureza:99.4% - 99.72%Cor e Forma:SolidPeso molecular:469.94LDC1267
CAS:<p>LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).</p>Fórmula:C30H26F2N4O5Pureza:99.38% - 99.88%Cor e Forma:SolidPeso molecular:560.55Ruxolitinib (S enantiomer)
CAS:<p>Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.</p>Fórmula:C17H18N6Pureza:99.37% - 99.79%Cor e Forma:SolidPeso molecular:306.36Tyrphostin AG 528
CAS:<p>Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).</p>Fórmula:C18H14N2O3Pureza:99.64%Cor e Forma:SolidPeso molecular:306.32Tyrphostin A9
CAS:<p>Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor</p>Fórmula:C18H22N2OPureza:98.21% - 99.87%Cor e Forma:Yellow SolidPeso molecular:282.38HPK1-IN-2
CAS:<p>HPK1-IN-2 is a strong, oral HPK1 inhibitor (IC50<0.05 μM), also blocking Lck, Flt3 kinases, with anticancer properties.</p>Fórmula:C19H20N6OSPureza:97.31%Cor e Forma:SolidPeso molecular:380.47LY2874455
CAS:<p>LY2874455 has been used in trials studying the treatment of Advanced Cancer.</p>Fórmula:C21H19Cl2N5O2Pureza:97.22% - 99.46%Cor e Forma:SolidPeso molecular:444.31Glumetinib
CAS:<p>Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).</p>Fórmula:C21H17N9O2SPureza:99.79%Cor e Forma:SolidPeso molecular:459.48PP 3
CAS:<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Fórmula:C11H9N5Pureza:98.61%Cor e Forma:Whit To Off-White SolidPeso molecular:211.22Telatinib
CAS:<p>Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.</p>Fórmula:C20H16ClN5O3Pureza:97.61% - 99.81%Cor e Forma:SolidPeso molecular:409.83Ensartinib hydrochloride
CAS:<p>Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known</p>Fórmula:C26H29Cl4FN6O3Pureza:98.73%Cor e Forma:SolidPeso molecular:634.36MID-1
CAS:<p>MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.</p>Fórmula:C12H11N3O4SPureza:99.39%Cor e Forma:SolidPeso molecular:293.3Periplocin
CAS:<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Fórmula:C36H56O13Pureza:99.66% - 99.74%Cor e Forma:SolidPeso molecular:696.82UNC569
CAS:<p>UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.</p>Fórmula:C22H29FN6Pureza:98.91% - 99.67%Cor e Forma:SolidPeso molecular:396.5CGI-1746
CAS:<p>CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.</p>Fórmula:C34H37N5O4Pureza:97.69% - 97.88%Cor e Forma:SolidPeso molecular:579.69Altiratinib
CAS:<p>Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,</p>Fórmula:C26H21F3N4O4Pureza:99.67% - 99.75%Cor e Forma:SolidPeso molecular:510.46Ehp-inhibitor-2
CAS:<p>Ehp-inhibitor-2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors.</p>Fórmula:C17H13N5OPureza:97.88%Cor e Forma:SolidPeso molecular:303.32GIP (1-30) amide, porcine acetate
GIP (1-30) amide, porcine is a GIP receptor agonist that stimulates insulin and mildly inhibits gastric acid.Fórmula:C164H249N41O49SPureza:98.50%Cor e Forma:SolidPeso molecular:3611.04Osimertinib
CAS:Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Fórmula:C28H33N7O2Pureza:99.32% - >99.99%Cor e Forma:SolidPeso molecular:499.61EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS:<p>EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)</p>Fórmula:C23H21N3O3Pureza:99.55%Cor e Forma:SolidPeso molecular:387.43CHIR-98014
CAS:<p>CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.</p>Fórmula:C20H17Cl2N9O2Pureza:97.25% - 99.59%Cor e Forma:SolidPeso molecular:486.31CREBtide acetate(149155-45-3 free base)
<p>CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).</p>Fórmula:C75H133N29O21Pureza:96.13%Cor e Forma:SolidPeso molecular:1777.07SU5208
CAS:<p>SU5208 (3-[(Thien-2-yl)methylene]-2-indolinone) is a compound with bioactivity.SU5208 inhibits vascular endothelial growth factor receptor-2 (VEGFR2).</p>Fórmula:C13H9NOSPureza:99.62%Cor e Forma:SolidPeso molecular:227.28Olmutinib
CAS:Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorFórmula:C26H26N6O2SPureza:99.14%Cor e Forma:SolidPeso molecular:486.59Taletrectinib
CAS:<p>Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3.</p>Fórmula:C29H34FN5O5Pureza:99.87% - 99.96%Cor e Forma:SolidPeso molecular:551.61WHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Fórmula:C16H15N3O3Pureza:99.21%Cor e Forma:SolidPeso molecular:297.31
